Chloroquine
Information
- Drug Name
- Chloroquine
- Description
- Entry(CIViC)
- 1
CIViC
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| 90% out of 700 sarcoma samples (comprising 45 hist... | ASS1 | ASS1 LOSS ASS1 LOSS | Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04397679 | Active, not recruiting | Phase 1 | Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma | August 12, 2021 | April 27, 2026 |
| NCT03529396 | Active, not recruiting | Phase 2 | Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients | July 20, 2018 | November 2023 |
| NCT00131703 | Completed | Phase 3 | Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women | March 2003 | March 2005 |
| NCT00132535 | Completed | N/A | Influence of Chloroquine on HIV Viral Load Among Pregnant Women in Uganda | August 2003 | June 2007 |
| NCT00137514 | Completed | Phase 4 | Chloroquine and Amodiaquine for Treatment of Malaria in Children | March 2001 | May 2004 |
| NCT00140517 | Completed | N/A | Relationships Between the Use of Antimalarial Drugs in Pregnancy and Plasmodium Falciparum Resistance | October 2002 | March 2008 |
| NCT00169078 | Completed | N/A | Impact of Insecticide-treated Curtains on Antimalarial Drug Resistance | July 2002 | December 2002 |
| NCT00224978 | Completed | Phase 3 | Chloroquine for Treatment of Glioblastoma Multiforme | January 2005 | August 2005 |
| NCT00379821 | Completed | Phase 3 | Chloroquine Alone or in Combination for Malaria in Children in Malawi | February 2007 | September 2012 |
| NCT00426439 | Completed | Phase 4 | Chloroquine and Coartem for Treatment of Symptomatic Children With Plasmodium Falciparum in Guinea Bissau | December 2006 | November 2008 |
| NCT00440999 | Completed | Phase 3 | Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria | March 2007 | September 2008 |
| NCT00455403 | Completed | N/A | Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS) | April 2006 | December 2009 |
| NCT00473837 | Completed | N/A | Chloroquine and Post Malaria Anaemia Study | July 2007 | December 2009 |
| NCT00486694 | Completed | Phase 2 | Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malaria | March 2004 | August 2004 |
| NCT00730366 | Completed | Phase 3 | New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa | March 2004 | December 2006 |
| NCT00811096 | Completed | Phase 2 | Pilot Human Study of Tinidazole Efficacy For Radical Cure Of Plasmodium Vivax | November 2008 | April 2009 |
| NCT00819390 | Completed | Phase 2 | Chloroquine for Reducing Immune Activation in HIV- Infected Individuals | March 2009 | May 2013 |
| NCT00972725 | Completed | Phase 2 | Evaluation of the Immune Response of a HIV Candidate Vaccine After Administration of One Chloroquine Dose | December 1, 2009 | October 4, 2010 |
| NCT00127998 | Completed | N/A | Antimalarial Drug Resistance in Mali | July 2005 | |
| NCT02080026 | Completed | N/A | Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis | June 2014 | July 2015 |
| NCT02143934 | Completed | Phase 4 | Effect of Liver and Blood-stage Treatment on Subsequent Plasmodium Reinfection and Morbidity | August 2009 | May 2014 |
| NCT02192944 | Completed | Phase 4 | Comparison of the ECG Effects Related to Pharmacokinetic Profile of Chloroquine and Piperaquine | July 2014 | September 2015 |
| NCT02216123 | Completed | Phase 3 | Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria | April 30, 2015 | November 4, 2016 |
| NCT02378532 | Completed | Phase 1 | The Addition of Chloroquine to Chemoradiation for Glioblastoma | August 2016 | July 30, 2019 |
| NCT02389374 | Completed | Phase 4 | A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh | August 2014 | March 2015 |
| NCT02563496 | Completed | Phase 2 | A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria | February 6, 2017 | February 17, 2020 |
| NCT02564471 | Completed | Phase 4 | Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis. | November 11, 2016 | February 2019 |
| NCT02691910 | Completed | Phase 2/Phase 3 | Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infection | August 2014 | September 2015 |
| NCT02698748 | Completed | Phase 2/Phase 3 | Evaluating the Role of Chloroquine for Malaria Elimination | January 2015 | June 2015 |
| NCT02773979 | Completed | Phase 1 | PfSPZ Challenge in Healthy Malaria-Naïve Adults in the United States | September 12, 2016 | January 22, 2018 |
| NCT02876549 | Completed | Phase 4 | G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malaria | September 1, 2016 | November 2018 |
| NCT02996695 | Completed | Phase 1 | Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian Adults | April 6, 2017 | June 22, 2018 |
| NCT03070470 | Completed | Phase 1 | CiPA Phase 1 ECG Biomarker Validation Study | March 14, 2017 | June 26, 2017 |
| NCT03449758 | Completed | Phase 4 | Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis | March 5, 2018 | July 31, 2019 |
| NCT04222088 | Completed | TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014 | May 1, 2013 | December 30, 2014 | |
| NCT04351295 | Completed | Phase 2/Phase 3 | Efficacy of Faviprevir in COVID-19 Treatment | April 20, 2020 | September 28, 2020 |
| NCT04420247 | Completed | Phase 3 | Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19 | April 16, 2020 | September 3, 2020 |
| NCT04627467 | Completed | Phase 2 | Prevention With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19) (TS-COVID) | March 28, 2020 | September 30, 2021 |
| NCT05244954 | Completed | Phase 4 | Comparing Chemoprevention Approaches for School-based Malaria Control | February 1, 2022 | August 26, 2022 |
| NCT05958797 | Completed | TES of Chloroquine for Pv in the Philippines in 2016 | January 4, 2016 | December 29, 2016 | |
| NCT05980156 | Completed | Phase 4 | Comparing Chemoprevention Drugs for School-based Malaria Control | February 13, 2023 | July 28, 2023 |
| NCT06044805 | Completed | Phase 4 | Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivax | December 19, 2022 | March 15, 2023 |
| NCT01019408 | Completed | Phase 4 | Extended-dose Chloroquine (ECQ) for Resistant Falciparum Malaria Among Afghan Refugees in Pakistan | November 1993 | January 1995 |
| NCT01074905 | Completed | Phase 3 | Study on the Treatment of Vivax Malaria | May 2010 | October 2012 |
| NCT01178021 | Completed | Phase 4 | Estimating the Risk of Plasmodium Vivax Relapses in Afghanistan | August 2009 | February 2014 |
| NCT01205178 | Completed | Phase 1 | G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine) | July 2, 2009 | April 1, 2013 |
| NCT01378286 | Completed | Phase 3 | Efficacy and Tolerability of Artesunate Amodiaquine Versus Chloroquine in the Treatment of Uncomplicated Plasmodium Vivax Malaria | January 2012 | June 2013 |
| NCT01443130 | Completed | Phase 3 | Chloroquine for Malaria in Pregnancy | February 2012 | January 2015 |
| NCT01500980 | Completed | Phase 1 | Malaria Challenge in Healthy Volunteers | December 2011 | November 2012 |
| NCT01546389 | Completed | Phase 1 | Sanaria™ PfSPZ Challenge Vaccine | April 2012 | April 2013 |
| NCT01546961 | Completed | N/A | Chloroquine Population Pharmacokinetics in Pre and Post-partum Women | June 2011 | May 2017 |
| NCT01640574 | Completed | Phase 3 | Comparison Between 7 and 14 Day Primaquine Combined With Dihydroartemisinin-piperaquine or 3 Day Chloroquine Radical Cure of P. Vivax (BPD) | February 2012 | December 2015 |
| NCT01680406 | Completed | Phase 4 | Ethiopia Antimalarial in Vivo Efficacy Study 2012 | October 2012 | December 2014 |
| NCT01708876 | Completed | Phase 3 | P. Knowlesi Trial of Artesunate-mefloquine Versus Chloroquine | October 2012 | December 2014 |
| NCT01716260 | Completed | Safety and Efficacy of Chloroquine and Primaquine for Vivax Malaria in Bhutan | January 2013 | October 2015 | |
| NCT01777477 | Completed | Phase 1 | Adjuvant Effect of Chloroquine on Gemcitabine | July 2012 | May 2015 |
| NCT01887821 | Completed | Phase 4 | Antimalarial Drug Susceptibility and Molecular Characterization of Plasmodium Vivax Isolates in Vietnam | February 2013 | June 2015 |
| NCT01941095 | Completed | Phase 3 | A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis | November 20, 2013 | July 10, 2016 |
| NCT02001012 | Completed | Phase 3 | P. Knowlesi Trial of Artemether-lumefantrine vs Chloroquine | January 2014 | March 2015 |
| NCT02004314 | Completed | N/A | Chloroquine as a Modulator of T Cell Immune Activation | October 2009 | March 2012 |
| NCT02043652 | Completed | N/A | Plasmodium Vivax Efficacy Trial in Cruzeiro do Sul, Acre, Brazil | February 2014 | December 2014 |
| NCT02058173 | Completed | Phase 4 | "Pharmacoepidemiological Evaluation of Autophagy Inhibition in Treatment of HCV Patients Resistant to Standard Therapy. Pilot Study" | January 2014 | June 2014 |
| NCT02071537 | Completed | Phase 1 | Chloroquine in Combination With Carboplatin/Gemcitabine in Advanced Solid Tumors | May 13, 2014 | December 2018 |
| NCT04704999 | Not yet recruiting | Phase 4 | Southeast Asia Dose Optimization of Tafenoquine | August 1, 2024 | December 31, 2027 |
| NCT06083688 | Not yet recruiting | Phase 4 | Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi | October 2024 | December 2025 |
| NCT00442403 | Suspended | Phase 3 | Safety and Efficacy of Chloroquine Associated With Dehydroepiandrosterone Sulphate to Treat Uncomplicated Falciparum Malaria | April 2002 | September 2002 |
| NCT04368910 | Terminated | Phase 3 | Safety and Efficacy of Pyronaridine Artesunate Vs Chloroquine in Children and Adult Patients With Acute Vivax Malaria | September 6, 2007 | November 15, 2010 |
| NCT01107145 | Terminated | Phase 4 | Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Vivax in Pregnancy in Brazil (PAACT-PV) | February 2011 | January 2012 |
| NCT00391313 | Terminated | Phase 3 | CuraChik : A Trial of the Efficacy and Safety of Chloroquine as Therapeutic Treatment of Chikungunya Disease | May 2006 | March 2007 |
| NCT01438177 | Terminated | Phase 2 | Chloroquine in Combination With VELCADE and Cyclophosphamide for Relapsed and Refractory Multiple Myeloma | October 2011 | February 2014 |
| NCT01894633 | Terminated | Phase 2 | Study of Whole-brain Irradiation With Chloroquine for Brain Metastases | May 2011 | January 2013 |
| NCT04333628 | Terminated | Phase 2/Phase 3 | Chloroquine for Mild Symptomatic and Asymptomatic COVID-19 | June 1, 2020 | September 1, 2020 |
| NCT04346667 | Terminated | Phase 4 | Post-Exposure Prophylaxis for Asymptomatic SARS-CoV-2 COVID-19 Patients With choloroquinE Compounds | April 14, 2020 | August 30, 2020 |
| NCT01575782 | Terminated | Phase 1 | Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung Cancer | May 2014 | July 2017 |
| NCT04349371 | Terminated | Phase 2 | Saved From COVID-19 - Chloroquine (CQ) Prophylaxis for Health Care Workers at Risk for COVID | April 21, 2020 | February 10, 2021 |
| NCT04351191 | Terminated | Phase 4 | PRophylaxis of Exposed COVID-19 Individuals With Mild Symptoms Using choloroquinE Compounds | April 15, 2020 | August 30, 2020 |
| NCT00082563 | Terminated | Phase 2 | Azithromycin in Combination With Chloroquine Versus Chloroquine in the Eradication of Asymptomatic Plasmodium Falciparum | August 2004 | November 2004 |
| NCT00849602 | Unknown status | Phase 1/Phase 2 | The Effect of Chloroquine in the Treatment of Patients With Dengue | February 2008 | June 2009 |
| NCT01078779 | Unknown status | Phase 2 | The Chloroquine for Influenza Prevention Trial | November 2009 | August 2010 |
| NCT03687905 | Unknown status | Proliferative Lupus Nephritis Treatment With Chloroquine and Hydroxychloroquine | September 18, 2018 | September 30, 2019 | |
| NCT02610686 | Unknown status | Phase 4 | Evaluating the Efficacy of Chloroquine for the Treatment of Plasmodium Vivax Infections in Central Vietnam | March 2015 | December 2016 |
| NCT01662700 | Unknown status | Phase 4 | Comparison of Two Antimalarial Drugs Regimens in Patient With Plasmodium Vivax Malaria in Thailand | October 2012 | December 2014 |
| NCT02333890 | Unknown status | Phase 2 | A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer | July 2015 | March 2018 |
| NCT01718054 | Unknown status | Phase 2/Phase 3 | Vascular Function Intervention Trial in Sickle Cell Disease | August 2012 | September 2017 |
| NCT02432417 | Withdrawn | Phase 2 | The Addition of Chloroquine to Chemoradiation for Glioblastoma, | November 10, 2023 | November 10, 2023 |
| NCT01785979 | Withdrawn | Phase 3 | Prednisone Plus Chloroquine for the Treatment of Hyper-reactive Malarial Splenomegaly | January 2016 | February 2017 |