Chlorambucil
Information
- Drug Name
- Chlorambucil
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| pancreatic cancer | FANCC LOSS-OF-FUNCTION FANCC LOSS-OF-FUNCTION | D |
Predictive
|
Supports
|
Sensitivity/Response |
Unknown
|
3 | 16243825 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| In the pancreatic cell lines PL11 (FANCC homozygou... | FANCC | FANCC LOSS-OF-FUNCTION FANCC LOSS-OF-FUNCTION | Sensitivity | true | CIViC Evidence | detail |
| Results were based on both expression and inhibiti... | GSTM1 | GSTM1 EXPRESSION | Resitance or Non-Reponse | true | MMMP | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02242942 | Active, not recruiting | Phase 3 | Comparison of the Treatments of Obinutuzumab + Venetoclax Versus Obinutuzumab + Chlorambucil in Patients With Chronic Lymphocytic Leukemia | December 31, 2014 | August 31, 2025 |
| NCT01808599 | Active, not recruiting | Phase 2 | Phase II Study of Chlorambucil and Subcutaneous Rituximab in Patients With Extranodal MALT Lymphoma | December 2013 | September 2028 |
| NCT03462719 | Active, not recruiting | Phase 3 | A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) | April 17, 2018 | April 5, 2027 |
| NCT04075292 | Active, not recruiting | Phase 3 | Study of Acalabrutinib Versus Chlorambucil Plus Rituximab in Adult Subjects With Previously Untreated Chronic Lymphocytic Leukemia | January 20, 2020 | November 29, 2024 |
| NCT02475681 | Active, not recruiting | Phase 3 | Acalabrutinib, Obinutuzumab and Chlorambucil in Treatment naïve CLL | June 26, 2015 | September 30, 2025 |
| NCT00003421 | Completed | Phase 3 | Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Disease | June 1998 | November 2005 |
| NCT00004218 | Completed | Phase 3 | Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia | October 1999 | July 2007 |
| NCT00285389 | Completed | Phase 2 | Treatment of Mantle Cell Lymphoma at Diagnosis for Patients Under 65 Years | February 2002 | December 2008 |
| NCT00532129 | Completed | Phase 2 | A Study of MabThera (Rituximab) Plus Chlorambucil in Participants With Chronic Lymphocytic Leukemia. | November 2007 | April 2012 |
| NCT00566332 | Completed | Phase 3 | Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia | June 2001 | December 2014 |
| NCT00608374 | Completed | Phase 3 | Chlorambucil or Fludarabine as First-Line Therapy in Treating Patients With Previously Untreated Waldenström Macroglobulinemia, Splenic Lymphoma, or Lymphoplasmacytic Lymphoma | June 2006 | January 2013 |
| NCT00738374 | Completed | Phase 2 | A Study of MabThera (Rituximab) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia. | November 3, 2008 | January 14, 2013 |
| NCT00910910 | Completed | Phase 3 | Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial) | October 13, 2009 | May 9, 2018 |
| NCT01010061 | Completed | Phase 3 | CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1a) | December 21, 2009 | August 23, 2017 |
| NCT01056510 | Completed | Phase 4 | A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) | March 2010 | March 2014 |
| NCT01088048 | Completed | Phase 1 | Study to Investigate Idelalisib in Combination With Chemotherapeutic Agents, Immunomodulatory Agents and Anti-CD20 Monoclonal Antibody (mAb) in Participants With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma or Chronic Lymphocytic Leukemia | March 25, 2010 | April 28, 2015 |
| NCT01109264 | Completed | Phase 2 | Bendamustine Hydrochloride Injection for Initial Treatment of Chronic Lymphocytic Leukemia | March 2010 | August 2013 |
| NCT01722487 | Completed | Phase 3 | Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL | March 2013 | May 2015 |
| NCT01868893 | Completed | Phase 2 | An Expanded Access, Open-Label Study of Obinutuzumab (GA101) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia | August 2013 | January 2014 |
| NCT01905943 | Completed | Phase 3 | A Safety and Efficacy Study of Obinutuzumab Alone or in Combination With Chemotherapy in Participants With Chronic Lymphocytic Leukemia | November 4, 2013 | October 8, 2018 |
| NCT01998880 | Completed | Phase 3 | CLL11: A Study of Rituximab With Chlorambucil or Chlorambucil Alone in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1b) | December 22, 2009 | August 23, 2017 |
| NCT02053610 | Completed | Phase 3 | CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 2) | December 31, 2009 | August 23, 2017 |
| NCT02264574 | Completed | Phase 3 | A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) | October 6, 2014 | September 3, 2019 |
| NCT02915224 | Completed | A Study of Obinutuzumab Evaluating Efficacy, Safety and Cost of Disease Management in Participants With Chronic Lymphocytic Leukemia and Comorbidities | November 23, 2016 | June 8, 2021 | |
| NCT00262795 | Completed | Phase 3 | Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia | September 2003 | October 2005 |
| NCT04578613 | Recruiting | Phase 3 | ICP-022 Versus Chlorambucil Combined With Rituximab in the Treatment of Untreated CLL/SLL | January 8, 2021 | June 30, 2025 |
| NCT06319456 | Recruiting | Phase 3 | A Global Study of Lisaftoclax (APG-2575) Combined With Acalabrutinib Versus Immunochemotherapy for Newly Diagnosed CLL/SLL. | April 7, 2024 | August 2028 |
| NCT01980875 | Terminated | Phase 3 | Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic Leukemia | April 21, 2015 | May 13, 2016 |
| NCT00151736 | Terminated | Phase 2 | Safety and Efficacy of SDX-101 (R-Etodolac) in Combination With Chlorambucil, and That of Chlorambucil Alone, in Patients With Chronic Lymphocytic Leukemia (CLL) | September 2004 | February 2008 |
| NCT02336048 | Terminated | Phase 1 | A Study Evaluating the Safety of Tocilizumab in Addition to Standard of Care Premedication Given Before Obinutuzumab + Chlorambucil in Participants With Untreated B-Cell Chronic Lymphocytic Leukemia (B-CLL) and Comorbidities | June 26, 2015 | September 21, 2018 |
| NCT01283386 | Terminated | Phase 4 | A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Participants With Chronic Lymphocytic Leukemia and Unfavorable Somatic Status | April 27, 2011 | March 16, 2016 |
| NCT02612311 | Terminated | Phase 3 | Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Participants With Untreated and Previously Treated Chronic Lymphocytic Leukemia | November 19, 2015 | February 22, 2023 |
| NCT00003617 | Unknown status | Phase 3 | Chlorambucil Compared With No Further Therapy Following Anti-Helicobacter Therapy in Treating Patients With Low-Grade Lymphoma of the Stomach | March 1995 | |
| NCT00017108 | Unknown status | Phase 3 | Chlorambucil in Treating Patients With Advanced Chronic Lymphocytic Leukemia | March 2001 | |
| NCT00028691 | Unknown status | Phase 3 | Chlorambucil Compared With Radiation Therapy in Treating Patients With Previously Untreated Stage III or Stage IV Follicular Lymphoma | December 2002 | |
| NCT01657955 | Unknown status | Phase 3 | Bendamustine Hydrochloride Injection for Previously Untreated Chronic Lymphocytic Leukemia | January 2011 | December 2013 |
| NCT01678430 | Unknown status | Phase 3 | A Trial Looking at Ofatumumab for People With Chronic Lymphocytic Leukaemia Who Cannot Have More Intensive Treatment | December 2011 | December 2017 |
| NCT00006250 | Unknown status | Phase 3 | Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Non-Hodgkin's Lymphoma | May 2000 | |
| NCT00416377 | Unknown status | N/A | Radiation Therapy or Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma | ||
| NCT00417014 | Unknown status | N/A | Combination Chemotherapy and/or Radiation Therapy in Treating Young Patients With Hodgkin's Lymphoma | ||
| NCT00025064 | Unknown status | Phase 2 | Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma | January 2000 | |
| NCT00003639 | Unknown status | Phase 3 | Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma | November 1993 |