Arabinosylguanine

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Information
Drug Name
Arabinosylguanine
Description
Entry(CIViC)
3
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
T-cell acute lymphoblastic leukemia NT5C2 p.Arg375Gln (p.R375Q)
( ENST00000675985.1, ENST00000675326.1, ENST00000674860.1, ENST00000674696.1, ENST00000676449.1, ENST00000404739.8, ENST00000675645.1, ENST00000676428.1, ENST00000343289.9 ) NT5C2 p.Arg375Gln (p.R375Q)
( ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 ) 		D Predictive Does Not Support Resistance Somatic 4 23377281 Detail
T-cell acute lymphoblastic leukemia NT5C2 p.Asp415Ala (p.D415A)
( ENST00000676428.1, ENST00000674860.1, ENST00000676449.1, ENST00000343289.9, ENST00000675985.1, ENST00000674696.1, ENST00000675326.1, ENST00000675645.1, ENST00000404739.8 ) NT5C2 p.Asp415Ala (p.D415A)
( ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 ) 		D Predictive Does Not Support Resistance Somatic 4 23377281 Detail
T-cell acute lymphoblastic leukemia NT5C2 p.Lys367Gln (p.K367Q)
( ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 ) NT5C2 p.Lys367Gln (p.K367Q)
( ENST00000343289.9, ENST00000675645.1, ENST00000676449.1, ENST00000675985.1, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000676428.1, ENST00000404739.8 ) 		D Predictive Does Not Support Resistance Somatic 4 23377281 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
CCRF-CEM and CUTLL1 T-ALL cell lines expressing NT... NT5C2 NT5C2 p.Arg375Gln (p.R375Q)
( ENST00000675985.1, ENST00000675326.1, ENST00000674860.1, ENST00000674696.1, ENST00000676449.1, ENST00000404739.8, ENST00000675645.1, ENST00000676428.1, ENST00000343289.9 ) NT5C2 p.Arg375Gln (p.R375Q)
( ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 ) 		Resitance or Non-Reponse false CIViC Evidence detail
CCRF-CEM and CUTLL1 T-ALL cell lines expressing NT... NT5C2 NT5C2 p.Asp415Ala (p.D415A)
( ENST00000676428.1, ENST00000674860.1, ENST00000676449.1, ENST00000343289.9, ENST00000675985.1, ENST00000674696.1, ENST00000675326.1, ENST00000675645.1, ENST00000404739.8 ) NT5C2 p.Asp415Ala (p.D415A)
( ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 ) 		Resitance or Non-Reponse false CIViC Evidence detail
CCRF-CEM and CUTLL1 T-ALL cell lines expressing NT... NT5C2 NT5C2 p.Lys367Gln (p.K367Q)
( ENST00000343289.9, ENST00000404739.8, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000675645.1, ENST00000675985.1, ENST00000676428.1, ENST00000676449.1 ) NT5C2 p.Lys367Gln (p.K367Q)
( ENST00000343289.9, ENST00000675645.1, ENST00000676449.1, ENST00000675985.1, ENST00000674696.1, ENST00000674860.1, ENST00000675326.1, ENST00000676428.1, ENST00000404739.8 ) 		Resitance or Non-Reponse false CIViC Evidence detail