AZD3463
Information
- Drug Name
- AZD3463
- Description
- Entry(CIViC)
- 2
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| lung non-small cell carcinoma | ROS1 CD74-ROS1 G2032R | D |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 26372962 | Detail |
| neuroblastoma |
ALK p.Phe1174Leu (p.F1174L) ( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) ALK p.Phe1174Leu (p.F1174L) ( ENST00000618119.4, ENST00000642122.1, ENST00000389048.8 ) |
D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 26786851 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Preclinical study analyzing the efficacy of dual R... | ROS1 | ROS1 CD74-ROS1 G2032R | Resitance or Non-Reponse | true | CIViC Evidence | detail |
| The SH-SY5Y neuroblastoma cell line containing the... | ALK |
ALK p.Phe1174Leu (p.F1174L) ( ENST00000389048.8, ENST00000618119.4, ENST00000642122.1 ) ALK p.Phe1174Leu (p.F1174L) ( ENST00000618119.4, ENST00000642122.1, ENST00000389048.8 ) |
Sensitivity | true | CIViC Evidence | detail |