Heart failure with reduced ejection fraction
Information
- Disease name
- Heart failure with reduced ejection fraction
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04903717 | Active, not recruiting | N/A | Pragmatic Trial Of Alerts for Use of Mineralocorticoid Receptor Antagonists | November 3, 2021 | August 6, 2024 |
| NCT05204238 | Active, not recruiting | Follow Up of acuTe Heart failUre: a pRospective Echocardiographic and Clinical Study (FUTURE) | September 1, 2020 | November 30, 2022 | |
| NCT04498780 | Active, not recruiting | Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure | July 21, 2020 | December 31, 2025 | |
| NCT05592392 | Active, not recruiting | N/A | RECOVER-HF Pilot Study of SDS in Heart Failure | August 23, 2022 | February 28, 2025 |
| NCT05134701 | Active, not recruiting | Dapagliflozin Post Marketing Surveillance in HF and CKD | March 10, 2022 | October 31, 2024 | |
| NCT04676646 | Active, not recruiting | Phase 4 | Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone | March 8, 2021 | July 31, 2024 |
| NCT06273280 | Active, not recruiting | N/A | Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction. | February 14, 2024 | March 2026 |
| NCT03345446 | Active, not recruiting | Circulating RNAs in Acute Congestive Heart Failure | August 17, 2016 | December 31, 2024 | |
| NCT06382571 | Completed | Factors Associated With Sub - Targeted Therapeutic Dose Of Renin - Angiotensin Blockage Among Chronic Heart Failure With Reduced Ejection Fraction Patients | January 1, 2016 | December 31, 2021 | |
| NCT03228030 | Completed | Phase 1 | Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial | April 2, 2018 | April 30, 2021 |
| NCT05757193 | Completed | Phase 1 | Ketone Pharmacokinetic Study in HFrEF | June 2, 2023 | January 11, 2024 |
| NCT05077293 | Completed | Building Electronic Tools To Enhance and Reinforce Cardiovascular Recommendations - Heart Failure | September 9, 2021 | January 1, 2022 | |
| NCT05275920 | Completed | N/A | Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure (BETTER CARE-HF) | April 28, 2022 | October 26, 2022 |
| NCT02113033 | Completed | Phase 2 | VAgal Nerve Stimulation: safeGUARDing Heart Failure Patients | October 7, 2014 | September 20, 2016 |
| NCT03141567 | Completed | LYmphangiogenesis FacTors in Heart Failure States | May 18, 2017 | January 24, 2023 | |
| NCT03198585 | Completed | Phase 2 | Empagliflozin in Heart Failure Patients With Reduced Ejection Fraction | June 29, 2017 | January 17, 2020 |
| NCT05348226 | Completed | The ENVI Study: Effect of Entresto on Left Ventricular Remodelling on Cardiac MRI | June 9, 2021 | March 23, 2023 | |
| NCT05348460 | Completed | N/A | Effects of a Single Oral Dose of KETone Ester ON Exercise Performance in Patients With Chronic Heart Failure | February 15, 2022 | July 1, 2023 |
| NCT03759392 | Completed | Phase 3 | Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure | April 9, 2019 | January 6, 2022 |
| NCT03780803 | Completed | N/A | Effect of Home Rehabilitation on State of Patients With PAH, HFREF and IHD | February 1, 2016 | September 30, 2021 |
| NCT03791593 | Completed | Phase 2 | EVOlocumab in Stable Heart Failure With Reduced Ejection Fraction of Ischemic Etiology: EVO-HF Pilot | December 3, 2018 | July 20, 2022 |
| NCT06233695 | Completed | Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure | October 15, 2022 | December 1, 2023 | |
| NCT03816306 | Completed | Six Months Clinical and Echocardiographic Outcome of ARNI LCZ696 Therapy in HFrEF Patients | June 1, 2018 | December 1, 2019 | |
| NCT03870074 | Completed | CPET Predicts Long-term Survival and Positive Response to CRT | October 2009 | October 2017 | |
| NCT03951740 | Completed | N/A | Validation of Two Wrist-worn Devices for the Assessment of Energy Expenditure in Cardiac Patients. | October 11, 2017 | June 27, 2018 |
| NCT04112316 | Completed | Phase 1/Phase 2 | Developing Oral LT3 Therapy for Heart Failure - HFrEF | February 11, 2020 | August 31, 2023 |
| NCT04112849 | Completed | Electronic S3 Prediction of Hospital Readmissions for HF Exacerbation | March 11, 2020 | September 1, 2022 | |
| NCT04141800 | Completed | Spanish Study of Hyperkalaemia Incidence and Prognosis in Patients With Heart Failure and Reduced Ejection Fraction | April 30, 2019 | March 31, 2021 | |
| NCT04197635 | Completed | Phase 4 | Short-term Effects of Dapagliflozin on Peak VO2 in HFrEF | June 1, 2019 | April 19, 2022 |
| NCT04210375 | Completed | Phase 1 | Study of JK07 in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) | September 21, 2020 | July 7, 2023 |
| NCT02695420 | Completed | Phase 2 | Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction | April 14, 2016 | May 8, 2017 |
| NCT01922089 | Completed | Phase 2 | Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients | November 2013 | August 2014 |
| NCT04281849 | Completed | N/A | Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) Program | June 15, 2020 | September 14, 2022 |
| NCT04371731 | Completed | N/A | A Single-centre Research Study to Evaluate the Care4Today® Heart Failure Platform. | May 18, 2015 | April 4, 2018 |
| NCT04391491 | Completed | Neuregulin-1 in Patient With Different Forms of Cardiovascular Diseases: a Pilot Study | March 1, 2019 | February 1, 2023 | |
| NCT06068166 | Completed | N/A | Thoracic Epidural Anesthesia Reduces Mortality and Rehospitalization for Patients With Heart Failure With Reduced Ejection Fraction | July 1, 2013 | August 31, 2023 |
| NCT04514458 | Completed | N/A | Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure | January 25, 2021 | October 20, 2022 |
| NCT04539093 | Completed | Endothelial Function in Mechanical Circulatory Support | January 1, 2022 | November 11, 2022 | |
| NCT04547244 | Completed | CRTd Responders Optimization | January 1, 2015 | June 1, 2020 | |
| NCT05981144 | Completed | Exploration of Clonal Hematopoiesis of Indeterminate Potential in Non-ischemic Heart Failure With Reduced Ejection Fraction | November 23, 2021 | January 31, 2023 | |
| NCT04736329 | Completed | N/A | Telmisartan Versus Enalapril in Heart Failure With Reduced Ejection Fraction Patients With Moderately Impaired Kidney Functions | February 1, 2021 | October 31, 2022 |
| NCT04820556 | Completed | Gut Microbiota in Chronic Noncommunicable Diseases | April 12, 2021 | December 1, 2021 | |
| NCT05952089 | Completed | Phase 1 | A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure | August 17, 2023 | March 19, 2024 |
| NCT05827172 | Completed | N/A | AF Ablation for HF With Reduced EF | June 1, 2020 | January 31, 2023 |
| NCT05001165 | Completed | N/A | Dashboard Activated Services and Tele-Health for Heart Failure | September 17, 2021 | June 16, 2022 |
| NCT05799638 | Completed | Strategy, Efficacy and Safety of Medication Usage in Heart Failure Patients Who Were Intolerable to GDMT | January 1, 2023 | December 31, 2023 | |
| NCT03334188 | Completed | N/A | Electronic Health Record-leveraged, Patient-centered, Intensification of Chronic Care for HF | January 11, 2018 | April 13, 2021 |
| NCT03380156 | Completed | N/A | Effect of Transcutaneous Vagal Stimulation (TVS) on Endothelial Function and Arterial Stiffness in HFrEF | December 4, 2017 | May 30, 2020 |
| NCT03387813 | Completed | N/A | Hemodynamic-GUIDEd Management of Heart Failure | March 15, 2018 | May 17, 2023 |
| NCT03447990 | Completed | Phase 1/Phase 2 | v4 Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491 | February 6, 2018 | October 24, 2019 |
| NCT02661217 | Completed | Phase 4 | Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event | February 12, 2016 | June 20, 2018 |
| NCT06330103 | Completed | N/A | Efficacy of AI EF Screening by Using Smartphone Application Recorded PLAX View Cardiac Ultrasound Video Clips | May 1, 2023 | July 31, 2023 |
| NCT03614169 | Completed | N/A | Direct HIS-pacing as an Alternative to BiV-pacing in Symptomatic HFrEF Patients With True LBBB | September 9, 2018 | December 10, 2020 |
| NCT06195982 | Enrolling by invitation | Phase 2 | Ketones in Heart Failure With Reduced Ejection Fraction | March 6, 2024 | February 2026 |
| NCT06361524 | Enrolling by invitation | Gut Microbiome Profiling in Patients With Chronic Heart Failure | August 1, 2018 | December 2028 | |
| NCT06348043 | Not yet recruiting | N/A | Pumps for Kids, Infants and Neonates (PumpKIN): The Jarvik 2015 Pivotal Trial | August 2024 | December 2029 |
| NCT04420065 | Not yet recruiting | N/A | Effects of Preferential Left Ventricular Pacing on Ventriculoarterial Coupling and Clinical Course of Heart Failure | September 1, 2020 | December 31, 2024 |
| NCT05580510 | Not yet recruiting | Phase 2/Phase 3 | " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD " | February 6, 2023 | March 29, 2024 |
| NCT06344910 | Not yet recruiting | PRagmatic Study Of Messaging to Providers of Patients With Heart Failure in Amsterdam UMC | May 2024 | December 2025 | |
| NCT06035978 | Not yet recruiting | Phase 4 | Determination of Drug Levels for Pharmacotherapy of Heart Failure | March 2024 | April 2026 |
| NCT06384963 | Not yet recruiting | N/A | Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF | June 1, 2024 | April 1, 2025 |
| NCT06103565 | Not yet recruiting | N/A | EHR Nudges to Improve Quality of Care in HF | July 2024 | July 2025 |
| NCT06342492 | Not yet recruiting | Conduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead Failure | April 2024 | December 2024 | |
| NCT06405555 | Not yet recruiting | Phase 2/Phase 3 | Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension | August 1, 2024 | July 1, 2026 |
| NCT06103539 | Not yet recruiting | Pacertool Early Feasibility Study - Safety and Performance | December 1, 2023 | December 30, 2024 | |
| NCT06299436 | Not yet recruiting | Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure | September 1, 2024 | March 31, 2029 | |
| NCT06299176 | Not yet recruiting | Phase 1 | Whole Heart Radiotherapy for End-stage Heart Failure | April 1, 2024 | December 31, 2024 |
| NCT05974566 | Not yet recruiting | Efficacy and Safety of Finerenone in Heart Failure With Reduced Ejection Fraction | August 1, 2023 | October 30, 2023 | |
| NCT06249932 | Not yet recruiting | Phase 4 | Empagliflozin in Heart Failure With Reduced Ejection Fraction and End Stage Renal Disease | February 1, 2024 | December 31, 2030 |
| NCT06241430 | Not yet recruiting | N/A | The CardioClip Study | February 2024 | December 2025 |
| NCT06433687 | Not yet recruiting | Evaluation of the HekaHeart Platform in Medication Management for Heart Failure Patients | September 2024 | June 2025 | |
| NCT06442280 | Not yet recruiting | Phase 4 | SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF | June 2024 | March 30, 2026 |
| NCT05987670 | Not yet recruiting | N/A | Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope | October 1, 2023 | October 1, 2025 |
| NCT06455878 | Not yet recruiting | N/A | Mobile Applet for Weight Management in Obese Heart Failure Patients | June 6, 2024 | December 31, 2026 |
| NCT06427200 | Not yet recruiting | Phase 4 | Efficacy and Safety of Lactoferrin in Heart Failure Patients | July 2024 | July 2027 |
| NCT05632198 | Not yet recruiting | The Effect of Uncertainty in Heart Failure | November 28, 2022 | November 1, 2023 | |
| NCT06174623 | Not yet recruiting | N/A | Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistance | August 2024 | December 2024 |
| NCT06128980 | Not yet recruiting | Phase 2/Phase 3 | Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy | January 2024 | January 2032 |
| NCT06359938 | Not yet recruiting | N/A | Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF | June 1, 2024 | April 1, 2025 |
| NCT04705337 | Not yet recruiting | Phase 4 | Levosimendan In Ambulatory Heart Failure Patients | January 1, 2021 | December 31, 2024 |
| NCT06355388 | Not yet recruiting | N/A | TRAnscutaneous vaGUS Nerve Stimulation in Patients With Chronic Heart Failure | May 1, 2024 | May 1, 2027 |
| NCT05689086 | Recruiting | A Virtual Heart Failure Optimization Program for Guideline Directed Medical Therapy and Cardiac Rehabilitation | January 1, 2020 | December 31, 2023 | |
| NCT03057002 | Recruiting | UTSW HP [13-C] Pyruvate Injection in HCM | May 1, 2018 | November 8, 2024 | |
| NCT03136029 | Recruiting | Early Phase 1 | Exercise and NO in HFrEF | June 1, 2018 | May 31, 2025 |
| NCT03480633 | Recruiting | Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure | April 7, 2016 | October 6, 2027 | |
| NCT04237701 | Recruiting | Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System | October 1, 2019 | December 30, 2025 | |
| NCT04249648 | Recruiting | Hyperkalaemia and Its Impact on Therapy With RAASi | July 12, 2021 | April 30, 2025 | |
| NCT04342832 | Recruiting | N/A | Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial Fibrillation | July 16, 2020 | September 1, 2024 |
| NCT04590001 | Recruiting | N/A | Effect of the MobiusHD® in Patients With Heart Failure | October 2, 2020 | June 2026 |
| NCT04921293 | Recruiting | N/A | Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With Reduced Ejection Fraction | June 1, 2023 | December 1, 2024 |
| NCT05004363 | Recruiting | Phase 3 | Lokelma for RAAS Maximisation in CKD & Heart Failure. | January 19, 2022 | December 31, 2023 |
| NCT05152940 | Recruiting | Phase 4 | ERTU-SODIUM: Study on the Effects of Ertugliflozin on Sodium Storage, Interstitial Volume, and Plasma Volume in HFrEF | March 20, 2023 | December 2024 |
| NCT05278962 | Recruiting | Phase 4 | HF Patients With LVADs Being Treated With SGLT2i | September 8, 2022 | September 2024 |
| NCT05284955 | Recruiting | Phase 4 | Screening for Advanced Heart Failure IN Stable outPatientS - The SAINTS Study (SAINTS B) | March 2, 2023 | December 31, 2025 |
| NCT05299879 | Recruiting | Screening for Advanced Heart Failure IN Stable ouTpatientS - The SAINTS Study | October 24, 2022 | December 2025 | |
| NCT05365568 | Recruiting | N/A | Left Bundle Branch Area Pacing for Cardiac Resynchronization Therapy: A Randomized Study | September 1, 2022 | September 1, 2024 |
| NCT05539898 | Recruiting | N/A | Improving the Criteria for Selecting Patients for Primary Prevention of Sudden Cardiac Death by Arrhythmic Risk Stratification | January 13, 2017 | December 29, 2024 |
| NCT05564793 | Recruiting | N/A | Improving CRT Outcome With Non-Invasive Cardiac Mapping | December 20, 2023 | June 2026 |
| NCT05575557 | Recruiting | N/A | Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment | November 1, 2022 | April 1, 2025 |
| NCT05583773 | Recruiting | Phase 4 | SHengXIaN-QuYu DEcoction in the Treatment of Heart Failure With Reduced Ejection Fraction | March 29, 2023 | December 31, 2025 |
| NCT05602454 | Recruiting | N/A | Virtual Care to Improve Heart Failure Outcomes (VITAL-HF) | December 2, 2022 | November 2024 |
| NCT05609097 | Recruiting | N/A | PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction | April 14, 2023 | March 31, 2027 |
| NCT05623358 | Recruiting | N/A | PHARM Optimal-HF Pilot | March 13, 2023 | September 30, 2024 |
| NCT05637853 | Recruiting | Telemonitored Fast Track Medical Sequencing for Heart Failure With Reduced Ejection Fraction | October 22, 2022 | October 22, 2024 | |
| NCT05642507 | Recruiting | Phase 1/Phase 2 | Phase Ib/IIa Trial With AC01 in Patients With HFrEF | February 23, 2023 | June 30, 2025 |
| NCT05650658 | Recruiting | N/A | Left vs Left Randomized Clinical Trial | September 13, 2023 | June 30, 2029 |
| NCT05752760 | Recruiting | N/A | Pilot Study Lp299v Supplementation in Chronic Heart Failure | February 20, 2023 | March 1, 2025 |
| NCT05770167 | Recruiting | Effects of Dapagliflozin on Cardiorespiratory Parameters in Heart Failure | May 6, 2022 | April 2025 | |
| NCT05774509 | Recruiting | Phase 1 | Treatment of Non-ischemic Cardiomyopathies by Intravenous Extracellular Vesicles of Cardiovascular Progenitor Cells | May 31, 2023 | July 15, 2026 |
| NCT05778084 | Recruiting | Phase 4 | Effect of Empagliflozin on NT-Pro Brain Natriuretic Peptide in Heart Failure Patients With Reduced Ejection Fraction | December 15, 2022 | December 15, 2024 |
| NCT05795400 | Recruiting | N/A | Administration of the SGLT-2 Inhibitor Dapagliflozin in the Patients With Amyloid Cardiomyopathy | June 1, 2022 | June 2025 |
| NCT05824923 | Recruiting | Phase 3 | A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hypertension Associated With Left Heart Failure | August 14, 2023 | February 2027 |
| NCT05828719 | Recruiting | N/A | Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction | June 16, 2023 | December 31, 2030 |
| NCT05833581 | Recruiting | N/A | Consistently Assess Signs and Symptom of Heart Failure | March 17, 2023 | June 17, 2024 |
| NCT05855135 | Recruiting | N/A | Assessment of Combined CCM and ICD Device in HFrEF | May 17, 2023 | December 2025 |
| NCT05884411 | Recruiting | N/A | Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response | April 30, 2023 | March 31, 2028 |
| NCT05888688 | Recruiting | The Sarcopenia Study | December 6, 2023 | September 1, 2026 | |
| NCT05942287 | Recruiting | N/A | The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction. | May 24, 2023 | December 31, 2026 |
| NCT05971732 | Recruiting | Phase 4 | The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life(COREVIVE-HFrEF) | August 1, 2023 | August 1, 2025 |
| NCT05989503 | Recruiting | Phase 4 | Initiation of ARNi and SGLT2i in Patients With HFrEF | August 4, 2023 | February 2025 |
| NCT05990296 | Recruiting | N/A | Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care | August 1, 2023 | January 2025 |
| NCT05992116 | Recruiting | Iron Deficiency in Patients With Heart Failure and Reduced and Mildly Reduced Ejection Fraction | September 1, 2023 | February 28, 2025 | |
| NCT06021587 | Recruiting | Interest of Levosimendan Preconditioning for Cardiac Surgery Under CEC in Heart Failure Patients With Impaired Ejection Fraction | July 1, 2023 | October 10, 2023 | |
| NCT06029712 | Recruiting | Phase 2 | Heart Failure Polypill at a Safety Net Hospital | February 27, 2024 | July 2024 |
| NCT06078436 | Recruiting | N/A | Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEF | January 2024 | March 2028 |
| NCT06215911 | Recruiting | Phase 2 | A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF) | February 13, 2024 | October 2025 |
| NCT06229678 | Recruiting | Early Phase 1 | Ketones, SGLT2, HFrEF | January 25, 2024 | March 1, 2027 |
| NCT06278844 | Recruiting | N/A | Exercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inDication | December 12, 2023 | December 2027 |
| NCT06286423 | Recruiting | Phase 4 | Colchicine in Acutely Decompensated HFREF | June 2024 | June 2028 |
| NCT06316661 | Recruiting | CMR Assessment of Cardiac Microvascular Dysfunction in Patients With HFpEF | March 1, 2019 | December 30, 2024 | |
| NCT06321094 | Recruiting | Phase 4 | Effect of Vericiguat on Endpoint Events in Acute Coronary Syndrome( ACS）Patients With Ejection Fraction <45% | October 1, 2023 | December 1, 2025 |
| NCT06369298 | Recruiting | Phase 2 | Study of JK07 in Patients With Chronic Heart Failure | March 28, 2024 | June 30, 2026 |
| NCT06398964 | Recruiting | N/A | Effects of 2-week Ketosis on the Heart's Ketone Body Consumption, Utilization, and Energetic Efficiency in Patients With Chronic Heart Failure | November 21, 2023 | August 1, 2026 |
| NCT06423599 | Recruiting | Phase 2/Phase 3 | Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure | May 17, 2024 | December 30, 2026 |
| NCT04600921 | Terminated | Phase 3 | Ertugliflozin to Reduce Arrhythmic Burden in ICD/CRT patientS (ERASe-Trial) - a Phase III Study | June 24, 2021 | October 18, 2023 |
| NCT03524001 | Terminated | N/A | Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction. The Study Tests the Superiority of Right Ventricular Bifocal Stimulation Over VVI Implantable Defibrillator in Right Bundle Branch Block and Heart Failure. | February 1, 2018 | July 10, 2022 |
| NCT03479424 | Terminated | Home Outpatient Monitoring and Engagement to Predict HF Exacerbation | October 8, 2018 | March 1, 2019 | |
| NCT03945058 | Terminated | N/A | Neuromodulation of Inflammation and Vascular Function in Systolic Heart Failure | February 4, 2020 | December 16, 2021 |
| NCT01035255 | Terminated | Phase 3 | This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure | December 2009 | May 2014 |
| NCT05737186 | Terminated | Phase 4 | SGLT2 Inhibitors and Treatment of Heart Failure in Severe Renal Insufficiency | March 9, 2023 | April 16, 2024 |
| NCT03574857 | Terminated | Phase 4 | Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance | June 1, 2018 | January 1, 2021 |
| NCT05751772 | Terminated | N/A | Improving Knowledge in Heart Failure Inpatient With Therapeutic Education | December 13, 2022 | January 31, 2024 |
| NCT05409183 | Terminated | Phase 2 | Effectiveness of CRD-740 in Heart Failure | May 26, 2022 | July 25, 2023 |
| NCT03877887 | Unknown status | Finding Gab in the Treatment of Heart Failure in Assiut University Hospital | March 2019 | May 2020 | |
| NCT03213821 | Unknown status | N/A | Safety and Efficacy of High Protein Diet Versus GFR Based Protein Diet in Heart Failure Patients With Renal Insufficiency | November 1, 2017 | December 30, 2019 |
| NCT03209180 | Unknown status | Phase 4 | Immediate Release Versus Slow Release Carvedilol in Heart Failure | October 27, 2016 | December 31, 2018 |
| NCT05072054 | Unknown status | Phase 4 | Comparison of Effects of Atorvastatin Versus Rosuvastatin on Cardiac Function in Heart Failure Patients | October 16, 2019 | August 31, 2022 |
| NCT03746938 | Unknown status | Phase 1 | First in Humans to Evaluate Collagen Patches With Stem Cells in Patients With Ischemic Left Ventricular Dysfunction | November 13, 2018 | October 30, 2020 |
| NCT03701880 | Unknown status | N/A | Early Use of Ivabradine in Heart Failure | September 16, 2018 | December 23, 2019 |
| NCT03644446 | Unknown status | Bisoprolol Plasma Residual Concentrations in Chronic Heart Failure | November 2, 2017 | November 2, 2020 | |
| NCT05021419 | Unknown status | N/A | Efficacy of a Streamlined Heart Failure Optimization Protocol | August 2021 | February 2023 |
| NCT03072693 | Unknown status | N/A | Daily Ambulatory Remote Monitoring System For Post-Dischage Management Of ADHF | November 2, 2020 | April 30, 2023 |
| NCT04974021 | Unknown status | Iron Intravenous Therapy in Reducing the Burden of Severe Arrhythmias in Heart Failure With Reduced Ejection Fraction | June 20, 2019 | September 30, 2021 | |
| NCT04398563 | Unknown status | Heart Failure in Norway: Clinical Characteristics, Mortality and Health Care Resource Use | January 20, 2020 | December 2023 | |
| NCT03289637 | Unknown status | N/A | Supplementation With Vitamin D to Patients With Heart Failure (D-Heart). | February 1, 2018 | February 1, 2020 |
| NCT03235700 | Unknown status | N/A | Hyperemic Efficacy of IV Adenosine in HFrEF | March 1, 2017 | February 28, 2020 |
| NCT03332888 | Unknown status | Phase 2 | Safety of HMA-CD20 in Patients With HFrEF | January 1, 2021 | July 15, 2021 |
| NCT03082508 | Unknown status | N/A | A Pivotal Trial to Establish the Efficacy and Safety of Algisyl in Patients With Moderate to Severe Heart Failure | August 2017 | January 2024 |
| NCT04200586 | Unknown status | Phase 4 | The Effects of SGLTi on Diabetic Cardiomyopathy | April 9, 2020 | September 30, 2021 |
| NCT04160624 | Unknown status | N/A | Transcatheter Aortic Valve Replacement With Extracorporeal Life System Support | August 1, 2018 | December 1, 2020 |
| NCT05344963 | Unknown status | Deformation Imaging by Strain in Chronic Heart Failure Over Gliflozins: an Echocardiographic Register on Sodium-GLucose coTransporter-2 Inhibitors | April 1, 2022 | April 2024 | |
| NCT03894683 | Unknown status | Phase 2 | Effect of Melatonin on Cardiovascular and Muscle Mass and Function in Patients With Heart Failure | November 30, 2018 | December 2020 |
| NCT03061747 | Unknown status | Multi-centre Observational Registry on Patients With Implantable Devices Remotely Monitored | June 1, 2016 | April 30, 2017 | |
| NCT03099889 | Unknown status | N/A | WHISH-2-Prevent Heart Failure | April 15, 2015 | July 1, 2021 |
| NCT04900584 | Unknown status | N/A | Optimize Heart Failure Care During TRANSitional Period in Patients With Acute Heart Failure. | June 23, 2020 | February 28, 2023 |
| NCT04803968 | Unknown status | N/A | The Effect of Combined Upper and Lower Extremity Endurance Training in Patients With ICD | January 1, 2021 | January 1, 2022 |
| NCT04638764 | Unknown status | N/A | Resistance Training in Cardiovascular Disease Patients | November 23, 2020 | November 26, 2021 |
| NCT03359967 | Unknown status | Changes in Intrathoracic Impedance During Sacubitril/Valsartan Treatment | February 12, 2018 | August 31, 2018 | |
| NCT03551756 | Unknown status | Assessment of Biomarkers in Patients With Decompensated Heart Failure and Underlying Coronary Artery Disease | July 10, 2018 | July 2020 | |
| NCT03119623 | Withdrawn | Phase 4 | Comparing ARNI With ACE Inhibitor on Endothelial Function | June 1, 2017 | August 2019 |
| NCT05806970 | Withdrawn | N/A | Email Nudges to Improve GDMT (MRA) Adherence in Heart Failure | April 2023 | July 2023 |
| NCT03803111 | Withdrawn | N/A | Effects of Iron Therapy and Exercise Training in Patients With Heart Failure and Iron Deficiency | January 1, 2021 | March 15, 2022 |
| NCT03317314 | Withdrawn | Cardiopulmonary Interactions in Patients With Heart Failure | July 1, 2017 | December 31, 2017 | |
| NCT04455828 | Withdrawn | Wearable Remote Monitoring of Heart Rate and Respiratory Rate for Heart Failure | March 1, 2021 | April 14, 2022 | |
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