recurrent adult acute lymphoblastic leukemia

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Information
Disease name
recurrent adult acute lymphoblastic leukemia
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT00792948 Active, not recruiting Phase 2 Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia September 1, 2009 January 6, 2025
NCT01139970 Active, not recruiting Phase 1 Veliparib and Temozolomide in Treating Patients With Acute Leukemia May 21, 2010 February 22, 2025
NCT02484430 Active, not recruiting Phase 2 Sapanisertib in Treating Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia October 20, 2016 February 28, 2025
NCT00588991 Active, not recruiting Phase 1 Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders November 28, 2007 March 7, 2025
NCT02446964 Active, not recruiting Phase 1 Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia June 25, 2015 June 15, 2024
NCT00010192 Completed Phase 1 Rituximab Plus Interleukin-2 in Treating Patients With Hematologic Cancer December 2000
NCT00014235 Completed N/A Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies December 2000
NCT00016016 Completed Phase 1/Phase 2 Flavopiridol, Cytarabine, and Mitoxantrone in Treating Patients With Acute Leukemia February 2001
NCT00017472 Completed Phase 1 Monoclonal Antibody Therapy in Treating Patients With Chronic Lymphocytic Leukemia, Lymphocytic Lymphoma, Acute Lymphoblastic Leukemia, or Acute Myeloid Leukemia April 2001
NCT00025415 Completed Phase 1 Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction August 2001
NCT00027820 Completed Phase 1/Phase 2 Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer August 2001 September 5, 2004
NCT00031655 Completed Phase 2 Reduced Intensity Donor Stem Cell Transplant in Treating Patients With High Risk Acute Lymphocytic Leukemia in Complete Remission September 2001 November 2012
NCT00036738 Completed Phase 2 Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, Dasatinib, or Nilotinib July 13, 2001 May 2018
NCT00052520 Completed Phase 1/Phase 2 Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation September 2002 June 2013
NCT00060372 Completed Phase 1 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer April 2003
NCT00068718 Completed Phase 1/Phase 2 Donor Lymphocyte Infusion in Treating Patients With Persistent, Relapsed, or Progressing Cancer After Donor Hematopoietic Cell Transplant May 2003 April 2013
NCT00077181 Completed Phase 1 3-AP and High-Dose Cytarabine in Treating Patients With Advanced Hematologic Malignancies January 2004
NCT00078858 Completed Phase 1/Phase 2 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant September 2003
NCT00084916 Completed Phase 2 CCI-779 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Chronic Myelogenous Leukemia in Blastic Phase April 2004
NCT00087204 Completed Phase 1 Rebeccamycin Analog in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia May 2004
NCT00089011 Completed Phase 2 Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer April 2004 July 2018
NCT00095797 Completed Phase 1 XK469R in Treating Patients With Refractory Hematologic Cancer October 2004
NCT00098423 Completed Phase 1 Tanespimycin and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, Chronic Myelomonocytic Leukemia, or Myelodysplastic Syndromes November 2004
NCT00098826 Completed Phase 1 SB-715992 in Treating Patients With Acute Leukemia, Chronic Myelogenous Leukemia, or Advanced Myelodysplastic Syndromes December 2004
NCT00003196 Completed N/A Low-Dose Total Body Irradiation and Donor Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Patients With Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma September 1997 April 2002
NCT00118352 Completed Phase 2 Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer March 2005 May 26, 2015
NCT00131989 Completed Phase 1 Sorafenib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia June 2005
NCT00217646 Completed Phase 1 Sorafenib in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndromes, or Blastic Phase Chronic Myelogenous Leukemia October 2005
NCT00275080 Completed Phase 1 Vorinostat and Decitabine in Treating Patients With Advanced Solid Tumors or Relapsed or Refractory Non-Hodgkin's Lymphoma, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Chronic Myelogenous Leukemia February 2006 August 2014
NCT00278330 Completed Phase 1 Flavopiridol and Vorinostat in Treating Patients With Relapsed or Refractory Acute Leukemia or Chronic Myelogenous Leukemia or Refractory Anemia January 2006
NCT00301938 Completed Phase 1 7-Hydroxystaurosporine and Perifosine in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia or High Risk Myelodysplastic Syndromes December 2005
NCT00331513 Completed Phase 1 Vorinostat and Idarubicin in Treating Patients With Relapsed or Refractory Leukemia or Myelodysplastic Syndromes March 2006
NCT00351975 Completed Phase 1 Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases June 2006 March 2013
NCT00357305 Completed Phase 1 Vorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or Myelodysplastic Syndromes or Myeloproliferative Disorders May 2006
NCT00357708 Completed Phase 1 Vorinostat and Decitabine in Treating Patients With Relapsed, Refractory, or Poor-Prognosis Hematologic Cancer or Other Diseases June 2006
NCT00383474 Completed Phase 1 Tipifarnib and Bortezomib in Treating Patients With Acute Leukemia or Chronic Myelogenous Leukemia in Blast Phase August 2006 June 2012
NCT00408681 Completed N/A Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant June 2006 May 1, 2015
NCT00459212 Completed Phase 1 GTI-2040 in Treating Patients With Relapsed, Refractory, or High-Risk Acute Leukemia, High-Grade Myelodysplastic Syndromes, or Refractory or Blastic Phase Chronic Myelogenous Leukemia March 2007
NCT00462605 Completed Phase 2 MS-275 and GM-CSF in Treating Patients With Myelodysplastic Syndrome and/or Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphocytic Leukemia April 2007 March 2011
NCT00470197 Completed Phase 1 Flavopiridol, Cytarabine, and Mitoxantrone in Treating Patients With Relapsed or Refractory Acute Leukemia April 2007
NCT00489203 Completed Phase 2 Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer April 2007
NCT00536601 Completed N/A High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid Tumors June 29, 2006 July 9, 2018
NCT00105001 Completed Phase 2 Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer November 2004 May 8, 2015
NCT00005064 Completed Phase 1 PS-341 in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia in Blast Phase, or Myelodysplastic Syndrome February 2000
NCT00005799 Completed N/A Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer November 1999
NCT00006213 Completed Phase 1 BMS-214662 in Treating Patients With Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myeloid Leukemia April 2000
NCT00006251 Completed Phase 1/Phase 2 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer May 2000
NCT00918333 Completed Phase 1/Phase 2 Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma June 2009 July 16, 2019
NCT00929695 Completed Phase 3 Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease June 2009 December 14, 2015
NCT00988715 Completed Phase 1 Donor Peripheral Blood Stem Cell Transplant and Pretargeted Radioimmunotherapy in Treating Patients With High-Risk Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome April 21, 2010
NCT01093586 Completed Phase 2 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies September 2007 December 2015
NCT01132573 Completed Phase 1 Entinostat and Clofarabine in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Poor-Risk Acute Lymphoblastic Leukemia or Bilineage/Biphenotypic Leukemia April 2010
NCT01177371 Completed Phase 2 High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma March 1988 February 2010
NCT01199562 Completed Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant December 2010 December 2013
NCT01233921 Completed N/A Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer September 2010
NCT01258998 Completed Phase 2 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma December 2010 August 2015
NCT01273766 Completed Phase 2 Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies January 2011 December 2014
NCT01300572 Completed Phase 1 Yttrium-90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk AML, ALL, or MDS January 2012 November 22, 2019
NCT01326702 Completed Phase 1/Phase 2 Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors July 2011 April 2015
NCT01384513 Completed Phase 2 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies August 4, 2011 November 16, 2022
NCT01427881 Completed Phase 2 Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies September 2011 July 2015
NCT01475058 Completed Phase 1/Phase 2 CD19 CAR T Cells for B Cell Malignancies After Allogeneic Transplant April 2012 July 2014
NCT01523223 Completed Phase 1 Donor Peripheral Stem Cell Transplant in Treating Patients With Hematolymphoid Malignancies January 2012 October 2016
NCT01527045 Completed Phase 2 Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological Malignancies September 25, 2012 April 2019
NCT01529827 Completed Phase 2 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies February 28, 2012 August 29, 2019
NCT01567709 Completed Phase 1 Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma April 16, 2012 March 29, 2018
NCT01588015 Completed Phase 1 Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant October 29, 2012 February 2, 2024
NCT01839916 Completed Phase 2 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies April 4, 2013 August 2018
NCT01858740 Completed Phase 2 Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children April 10, 2014 July 30, 2023
NCT01865617 Completed Phase 1/Phase 2 Laboratory Treated T Cells in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma, or Acute Lymphoblastic Leukemia May 22, 2013 March 26, 2021
NCT01925131 Completed Phase 1 S1312, Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Leukemia June 13, 2014 January 1, 2023
NCT02122081 Completed Phase 1 Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies July 27, 2015 September 6, 2022
NCT02168140 Completed Phase 1 CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma September 2014 September 15, 2022
NCT00608361 Completed Phase 1 Dasatinib in Treating Patients With Solid Tumors or Lymphomas That Are Metastatic or Cannot Be Removed By Surgery October 2008 August 2014
NCT00702403 Completed Phase 1/Phase 2 Nilotinib and Imatinib Mesylate After Donor Stem Cell Transplant in Treating Patients With ALL or CML August 14, 2008 December 1, 2013
NCT00795769 Completed Phase 2 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant August 8, 2008 June 10, 2009
NCT00799461 Completed Phase 3 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications August 2008
NCT00856388 Completed N/A Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders January 14, 2009 March 13, 2019
NCT00860574 Completed Phase 2 Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia February 2009
NCT00867529 Completed Phase 2 Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma February 2009 March 26, 2015
NCT00873093 Completed Phase 2 Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma March 2009 September 2014
NCT00890747 Completed Phase 1 Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy August 2009
NCT00897325 Completed Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma September 25, 2006 December 31, 2019
NCT03241940 Recruiting Phase 1 Phase I Dose Escalation Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell Malignancies October 20, 2017 August 1, 2035
NCT02094794 Recruiting Phase 2 Total Marrow and Lymphoid Irradiation and Chemotherapy Before DSCT in Treating Patients With High-Risk ALL or AML May 12, 2014 February 28, 2025
NCT02333162 Recruiting Phase 1 Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant December 5, 2014 December 1, 2028
NCT03504644 Recruiting Phase 1/Phase 2 Venetoclax and Vincristine Liposomal in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia August 13, 2018 December 31, 2028
NCT02129062 Terminated Phase 2 Ibrutinib in Treating Patients With Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia April 2014 November 2015
NCT01408160 Terminated Phase 1 Immunotoxin Therapy and Cytarabine in Treating Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia April 2013 June 26, 2018
NCT02168907 Terminated Phase 1 CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma December 2014 February 2015
NCT00103272 Terminated Phase 1 17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With Relapsed or Refractory Hematologic Cancer April 2005
NCT01564277 Terminated Phase 2 Rasburicase and Allopurinol in Treating Patients With Hematologic Malignancies September 29, 2011 May 28, 2016
NCT02109224 Terminated Phase 1 Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection September 2014 July 2015
NCT00301769 Terminated Phase 1 SJG-136 in Treating Patients With Relapsed or Refractory Acute Leukemia, Myelodysplastic Syndromes, Blastic Phase Chronic Myelogenous Leukemia, or Chronic Lymphocytic Leukemia December 2005
NCT01383447 Terminated Phase 1/Phase 2 Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia October 2010 April 2012
NCT00262925 Terminated Phase 2 Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia June 2006 February 2013
NCT01159067 Terminated Phase 2 Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload July 2010 August 9, 2011
NCT02728700 Terminated Phase 1 Sirolimus and Mycophenolate Mofetil in Preventing GVHD in Patients With Hematologic Malignancies Undergoing HSCT February 2016 July 2018
NCT02819804 Terminated Phase 1 Nivolumab and Dasatinib in Treating Patients With Relapsed or Refractory Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia August 17, 2017 August 30, 2018
NCT03103971 Terminated Phase 1 huJCAR014 CAR-T Cells in Treating Adult Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia November 3, 2017 March 23, 2024
NCT00387426 Terminated Phase 2 Sunitinib in Treating Patients With Idiopathic Myelofibrosis September 2006 February 2009
NCT00101231 Terminated Phase 1 Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia October 2004
NCT01044745 Terminated Phase 2 Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer December 10, 2009 October 10, 2017
NCT01076270 Terminated N/A Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies June 2010 February 2011
NCT01558778 Withdrawn N/A Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant May 2012
NCT02538926 Withdrawn Phase 2 Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hydrochloride With Asparaginase in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma July 1, 2018 July 30, 2021
NCT01652014 Withdrawn Phase 2 Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies January 2014 January 2017
NCT02861040 Withdrawn Phase 1 Volasertib and Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia August 2016
NCT02281279 Withdrawn Phase 1/Phase 2 Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma October 2016