Acute heart failure

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Information
Disease name
Acute heart failure
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04886128 Active, not recruiting Improving Diagnostic Accuracy for Acute Heart Failure August 31, 2021 June 30, 2025
NCT05518396 Active, not recruiting Prospective Validation of the CoDE-HF Algorithm for the Diagnosis of Acute Heart Failure April 25, 2021 August 31, 2024
NCT00348504 Completed Phase 3 Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support: a Multicentre, Parallel-Group, Randomised, Double-Blind, Double-Dummy Study of Levosimendan Versus Dobutamine in Patients With Acute Heart Failure. March 2003 June 2005
NCT06024889 Completed Phase 1/Phase 2 Acute Effects of Furosemide on Hemodynamics and Pulmonary Congestion in Acute Decompensated Heart Failure. September 1, 2023 February 9, 2024
NCT00498472 Completed Phase 4 NT-proBNP in the Optimization of Treatment After Recent Acute Heart Failure Trial July 2006 April 2010
NCT00512759 Completed Phase 4 Goal-directed Afterload Reduction in Acute Congestive Cardiac Decompensation Study December 10, 2007 February 21, 2019
NCT00514384 Completed Serial Measurements of Biomarker in Patients With Acute Decompensated Heart Failure February 2007 December 2014
NCT00524433 Completed Phase 3 Tezosentan in the Treatment of Acute Heart Failure April 2003 January 2005
NCT00525707 Completed Phase 3 Tezosentan in Acute Heart Failure April 2003 January 2005
NCT00561483 Completed Sequential Cystatin C Levels and Renal Impairment in Acute Heart Failure November 2007 October 2014
NCT00568165 Completed N/A EMEPIC : Value of a Mobile Team of Cardiologist Using Echocardiography for Managing Patients With Acute Heart Failure February 2008 July 2010
NCT06012279 Completed Phase 4 Clinical Outcomes of Dapagliflozin in Acute Heart Failure With Reduced Ejection Fraction (CODA-HFrEF) August 1, 2023 February 26, 2024
NCT00911703 Completed Determining When Patients Hospitalized With Acute Heart Failure Can Be Safely Sent Home (The DECIDE Study) August 2008 October 2015
NCT05710302 Completed Prospective Validation of the Emergency Heart Failure Mortality Risk Grade (EHMRG) Score in Patients With Acute Heart Failure in the Emergency Department July 29, 2022 January 24, 2023
NCT05410990 Completed Eosinophil Indices in Patients With Acute Heart Failure January 2, 2017 April 5, 2022
NCT05406505 Completed Phase 2/Phase 3 Effect of Dapagliflozin in Patients With Acute Heart Failure (DAPA-RESPONSE-AHF) April 25, 2022 July 1, 2023
NCT01080937 Completed French Observatory of Acute Heart Failure March 2009 February 2011
NCT01091441 Completed Permanent Observatory of Heart Failure February 2007 July 2014
NCT01127945 Completed N/A Study to Evaluate the Effectiveness of High Dose Statin Loading in Acute Heart Failure Patients May 2010 November 2013
NCT01132846 Completed Phase 2 Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) Study August 2010 June 2013
NCT01193998 Completed N/A Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department September 2010 June 2014
NCT05364190 Completed Phase 3 Canagliflozin in Patients With Acute Decompansted Heart Failure June 4, 2022 December 1, 2023
NCT01227317 Completed BIOmarkers of Dyspnea IN Emergency Room April 2010 September 2011
NCT05189119 Completed Use of PARniv for Early Diagnosis of LVF in AECOPD January 3, 2022 May 3, 2022
NCT05027360 Completed Sodium NItroPrusside Treatment in Acute Heart Failure June 1, 2021 November 23, 2021
NCT01363505 Completed Bladder Pressure Predicting Renal Failure in Critically Ill Patients as Compared to Hemodynamic Parameters May 2011 April 2013
NCT01441245 Completed Phase 4 Loop Diuretics Administration and Acute Heart Failure April 2010 December 28, 2017
NCT01467973 Completed Gulf Acute Heart Failure Registry February 2012 November 2013
NCT01543854 Completed Phase 2 Hemodynamic Responses to RLX030 Infusion in Subjects With Acute Heart Failure March 2012 January 2013
NCT01614860 Completed Identification of Patient Phenotypes Associated With Elevated Aldosterone Levels May 2012 June 2014
NCT01619540 Completed N/A Valsalva Manœuvre in the Diagnosis of Left Ventricular Failure in Chronic Obstructive Pulmonary Disease Exacerbation May 2011 June 2013
NCT04740242 Completed Metabolic Alkalosis in Heart Failure January 1, 2021 September 30, 2021
NCT04549701 Completed N/A Inferior Vena CAVA and Lung UltraSound-guided Therapy in Acute Heart Failure March 20, 2022 February 28, 2023
NCT04252404 Completed FranceLEVO - Zimino Registry (FZR) February 3, 2020 May 6, 2021
NCT01800968 Completed Phase 2 Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT) April 2013 October 2015
NCT04245605 Completed Invasive Coronary Angiography Early in Ischemic Heart Failure April 1, 2010 September 30, 2021
NCT01834833 Completed N/A Consultation at 8 Days to Reduce Hospitalisations in Heart Failure Patient May 2013 July 2017
NCT01870778 Completed Phase 3 Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF October 2, 2013 February 1, 2017
NCT01981655 Completed Phase 2 0.5M Na Lactate Solution in Acute Heart Failure (AHF) December 2009 August 2013
NCT02002702 Completed Phase 2 Study of Safety, Tolerability and Pharmacokinetics of Serelaxin in Japanese Acute Heart Failure (AHF) Patients January 2014 August 2014
NCT03903198 Completed Care Pathways of Acute Heart Failure Patients: Impact on In-hospital Mortality. June 2014 October 2018
NCT02122640 Completed Evaluation of Acute Cardiogenic Dyspnoea With Thorax Echography and Pro-BNP in the Emergency Department September 2012 September 2013
NCT02135835 Completed Phase 4 A Study to Evaluate the Efficacy and Safety of Shenfu Zhusheye in Patients With Acute Heart Failure September 3, 2014 March 24, 2017
NCT02141607 Completed Evolution of Molecular Biomarkers in Acute Heart Failure Induced by Shock October 2014 September 2017
NCT03806972 Completed Short and Long Term Prognosis of Patients Admitted to the ED With Acute Heart Failure June 1, 2009 October 1, 2021
NCT02157506 Completed Phase 2 A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure June 30, 2014 July 31, 2015
NCT02170961 Completed Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure February 2013 December 2016
NCT03683212 Completed N/A Early and Comprehensive Care Bundle in Elderly for Acute Heart Failure: a Stepped Wedge Cluster Randomized Trial December 10, 2018 November 12, 2019
NCT03517514 Completed Heart Failure Hospital Readmissions and Physical Therapy February 1, 2018 August 28, 2019
NCT02350114 Completed N/A An Observational Study of the Functional Capacity of Heart Failure November 2014 July 2015
NCT03302910 Completed N/A Short Stay Unit vs Hospitalization in Acute Heart Failure December 6, 2017 July 22, 2021
NCT03243773 Completed Evaluation of Lung Ultrasound in Acute Heart Failure March 1, 2016 September 30, 2018
NCT02554890 Completed Phase 4 Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode. April 29, 2016 July 24, 2018
NCT03241069 Completed N/A Dynamic Variation of Impedance Cardiography(DYVIC) as a Diagnostic Tool of Acute Heart Failure (AHF) July 2016 December 2016
NCT03234647 Completed N/A First In Human Study of the Doraya Catheter for the Treatment of AHF Patients January 1, 2018 April 30, 2021
NCT02728739 Completed N/A Incidence of Significant Mitral Regurgitation in Acute Heart Failure Patients June 6, 2016 February 2018
NCT03110042 Completed HILO-HF Registry: High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure November 2016 April 2019
NCT03048032 Completed Lithuanian Echocardiography Study of Dyspnea in Acute Settings April 2015 November 2018
NCT02877095 Completed Phase 1 Subcutaneous Furosemide in Acute Decompensated Heart Failure Pilot December 19, 2016 November 7, 2017
NCT02782572 Completed N/A Safety of Aerobic Exercise in Acute Heart Failure July 2010 December 2011
NCT06397404 Completed VExUS in Patients With Acute Heart Failure May 18, 2023 December 25, 2023
NCT06463964 Enrolling by invitation Predictors of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure in Emergency June 1, 2024 December 1, 2024
NCT04062760 Not yet recruiting Phase 4 Safety and Efficacy of Early, seQUential Oral dIuretic Nephron blockAde In Acute Heart Failure December 1, 2019 December 1, 2024
NCT06203236 Not yet recruiting Phase 4 Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease January 2024 November 2025
NCT05865665 Not yet recruiting Registry Of Best Up-titration STrategies in Acute Heart Failure June 2023 December 2027
NCT06166654 Not yet recruiting Phase 4 Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload April 1, 2024 March 31, 2027
NCT05411991 Recruiting Phase 4 Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment June 12, 2022 April 30, 2024
NCT05392764 Recruiting Phase 3 Early Treatment With a Sodium-glucose Co-transporter 2 Inhibitor in High-risk Patients With Acute Heart Failure September 10, 2022 June 30, 2025
NCT05305495 Recruiting Phase 4 Empagliflozin in Acute Heart Failure December 22, 2022 July 2025
NCT05276219 Recruiting Phase 4 Optimized Treatment of Pulmonary Edema or Congestion September 14, 2023 December 31, 2026
NCT04829591 Recruiting A Multicenter Registry to Study the Characteristics and Outcomes of Jordanian Heart Failure Patients. July 1, 2021 December 30, 2024
NCT02444416 Recruiting Prospective Registry of Acute Heart Failure December 2014 November 2026
NCT03327532 Recruiting N/A Acute Heart Failure - COngestion Repeated Evaluation (AHF-CORE) February 13, 2018 February 2026
NCT06008197 Recruiting Phase 3 A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients January 17, 2024 April 2026
NCT06006819 Recruiting Prognostic Markers of Acute Heart Failure With Chronic Kidney Disease January 1, 2023 December 23, 2025
NCT06006754 Recruiting Influence of Enteral Microbiome on Mortality of Patients With Cardiogenic Shock August 30, 2023 June 2024
NCT05991128 Recruiting Phase 4 The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life August 1, 2023 August 1, 2025
NCT05986773 Recruiting Phase 4 Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance October 10, 2023 December 31, 2025
NCT05972746 Recruiting N/A Telemonitoring Program in the Vulnerable Phase After Hospitalization for Heart Failure October 7, 2022 November 7, 2023
NCT05971732 Recruiting Phase 4 The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life(COREVIVE-HFrEF) August 1, 2023 August 1, 2025
NCT05962255 Recruiting Phase 3 Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure February 1, 2022 May 2024
NCT03793257 Recruiting The EXCEL Registry of Patients Requiring ECMO February 1, 2019 December 31, 2027
NCT06162247 Recruiting Naples Federico II Intensive Cardiac Care Unit Registry (Naples FED2-ICCU Registry) November 20, 2023 November 20, 2033
NCT03836079 Recruiting N/A SVC Occlusion in Subjects With Acute Decompensated Heart Failure July 31, 2019 October 2024
NCT05919225 Recruiting N/A Risk Stratification Using MEESSI-AHF Scale in ED and Impact on AHF Outcomes June 27, 2023 December 31, 2024
NCT06447467 Recruiting Short Term Outcome of Acute Heart Failure in Diabetic and Non Diabetic Patients June 1, 2024 December 1, 2024
NCT03999138 Recruiting MRI Assessment of Pulmonary Edema in Acute Heart Failure January 2, 2019 June 1, 2024
NCT04000061 Recruiting Heart Failure-USB: Prediction and Progression June 13, 2019 July 2027
NCT05916586 Recruiting N/A Effect of Short-term Prednisone Therapy on C-reactive Protein in Patients With Acute Heart Failure August 11, 2023 October 2024
NCT05871138 Recruiting Prognostic Value of Delta LUS Score of Patients Hospitalized for Acute Heart Failure March 30, 2023 December 30, 2023
NCT02544815 Recruiting Phase 3 Digoxin Short Term Treatment Assessment Randomized Trial in AHF May 1, 2023 July 31, 2025
NCT04363697 Recruiting Phase 4 Dapagliflozin and Effect on Cardiovascular Events in Acute Heart Failure -Thrombolysis in Myocardial Infarction 68 (DAPA ACT HF-TIMI 68) September 24, 2020 March 2024
NCT04442555 Recruiting Phase 1 Treatment With the Ketone Body 3-hydroxybutyrate in Patients With Acute Heart Failure February 1, 2020 March 30, 2023
NCT05461547 Recruiting N/A Pre-Hospital Lung Ultrasound Impact on Diagnosis February 9, 2023 February 2024
NCT04481919 Recruiting Phase 2 Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE) May 1, 2022 December 31, 2026
NCT05556044 Recruiting Phase 3 Empagliflozin for New On-set Heart Failure Study Regardless of Ejection Fraction September 27, 2022 May 31, 2024
NCT05809011 Recruiting Phase 2/Phase 3 Efficacy and Safety of corticoSTEROids Added to Standard Therapy in Patients With Acute Heart Failure (STERO-AHF) April 24, 2023 December 2025
NCT05668676 Recruiting Phase 2/Phase 3 Effect of Short-Term Prednisone Therapy on C-Reactive Protein Change in Emergency Department Patients With Acute Heart Failure and Elevated Inflammatory Markers ( CORTAHF ) February 16, 2023 March 2024
NCT05613218 Recruiting Phase 2/Phase 3 Oxygen Targets in Acute Heart Failure With Pulmonary Congestion February 1, 2024 August 31, 2025
NCT04329234 Recruiting Korean Heart Failure Registry III October 1, 2018 December 31, 2027
NCT05586048 Recruiting Effectiveness of Yiqi Fumai Lyophilized Injection for Acute Heart Failure April 1, 2023 November 30, 2025
NCT04332692 Recruiting N/A Acute Heart Failure - COngestion Discharge Evaluation July 15, 2020 May 20, 2028
NCT04343430 Recruiting N/A Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation August 29, 2020 August 29, 2028
NCT04343443 Recruiting N/A Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation August 21, 2020 August 21, 2028
NCT03736421 Suspended Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients November 10, 2018 April 2021
NCT02769351 Terminated Global rEgistry on decongestioN Therapy Using Less invasivE UltraFiltration December 3, 2015 March 4, 2019
NCT03161158 Terminated N/A PURE-HF: Peripheral Ultrafiltration for the RElief From Congestion in Heart Failure November 3, 2017 August 26, 2019
NCT03170219 Terminated Phase 2 Subcutaneous Furosemide in Acute Decompensated Heart Failure: The SUBQ-HF Study April 27, 2018 September 20, 2018
NCT02595814 Terminated Global Non-interventional Heart Failure Disease Registry July 23, 2014 March 31, 2018
NCT03554200 Terminated Phase 2 EMPA Acute Heart Failure June 11, 2018 October 29, 2020
NCT03621436 Terminated N/A Clinical Evaluation of the TRVD™ System in ADHF August 7, 2015 May 2019
NCT02151383 Terminated Phase 2 Pharmacokinetics & Safety of Serelaxin on Top of Standard of Care Therapy in Pediatric Patients With Acute Heart Failure September 5, 2014 April 3, 2017
NCT02007720 Terminated Phase 3 Efficacy, Safety and Tolerability of Sexelaxin When Added to Standard Therapy in AHF March 12, 2014 June 16, 2017
NCT04174794 Terminated Investigating Reduction of aCute heArt Failure Readmission With Lung UltraSound-preliminary Trial October 8, 2019 March 16, 2020
NCT01615926 Terminated Assessment of The Clinical Course of Dyspnea in Acute Heart Failure Patients June 2012 August 2012
NCT01301313 Terminated Phase 2 Efficacy and Safety of Levosimendan in Severe Acute Heart Failure in Critical Children February 2011 February 2012
NCT01264159 Terminated N/A Preemptive Lung Impedance-guided Therapy of Evolving Acute Heart Failure in Acute Myocardial Infarction Patients January 1, 2011 July 1, 2015
NCT01067859 Terminated Phase 2 A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF) March 2010 November 2010
NCT01065077 Terminated Phase 2 BAY58-2667 Dose Finding Trial Investigating Fixed Doses in Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF) March 2010 February 2011
NCT00449423 Terminated Phase 2 Metabolic Modulation as Treatment in Acute Heart Failure March 2007 October 2007
NCT00221819 Terminated N/A Gases Humidification During Noninvasive Ventilation : Heat and Moisture Exchanger or Heated Humidifier ? June 2004 December 2004
NCT00083772 Terminated Phase 4 Use of Nesiritide in the Management of Acute Diastolic Heart Failure May 17, 2004 April 24, 2006
NCT04694092 Unknown status N/A Landiolol for Rate Control in Decompensated Heart Failure Due to Atrial Fibrillation November 5, 2020 December 31, 2023
NCT01211886 Unknown status Utility of Brain Natriuretic Peptide (BNP) in Patients With Type IV Cardio-renal Syndrome Admitted to the Intensive Care Unit (ICU) September 2010
NCT04900584 Unknown status N/A Optimize Heart Failure Care During TRANSitional Period in Patients With Acute Heart Failure. June 23, 2020 February 28, 2023
NCT02638142 Unknown status Loop Diuretic Therapy in Acutely Decompensated Heart Failure December 2015 December 2020
NCT05090930 Unknown status N/A Innovative Technologies for the Treatment of Pulmonary and Heart Failure January 1, 2021 December 1, 2023
NCT03189901 Unknown status Phase 4 Early Management Strategies of Acute Heart Failure for Patients With NSTEMI July 1, 2017 December 31, 2021
NCT04633629 Unknown status LUS in Acute Heart Failure Therapeutic Adaptation December 2020 October 2021
NCT03157219 Unknown status Manipal Heart Failure Registry (MHFR) September 10, 2015 May 31, 2019
NCT01704131 Unknown status Levosimendan Pharmacokinetics in Children November 2012 September 1, 2019
NCT04465123 Unknown status Phase 3 Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study August 13, 2020 December 31, 2022
NCT00937092 Unknown status Phase 4 Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial January 2009 July 2012
NCT04405804 Unknown status Phase 2 Early Administration of Ivabradine in Children With Heart Failure June 20, 2020 May 2021
NCT04331132 Unknown status N/A Tolvaptan add-on Therapy to Overcome Loop Diuretic Resistance in Acute Heart Failure With Renal Dysfunction December 1, 2021 July 26, 2023
NCT04252937 Unknown status Phase 2 Adrecizumab Dose Escalation Safety and Tolerability Evaluation (ADESTE) December 15, 2019 March 31, 2022
NCT01733134 Unknown status Phase 3 Acute Heart Failure Patients With High Copeptin Treated With Tolvaptan Targets Increased AVP Activation for Treatment (ACTIVATE) January 2013 December 2014
NCT01822808 Unknown status Phase 3 Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure January 2013 July 2016
NCT04240067 Unknown status Multimarker Approach for Acute Dyspnea in Elderly Patients Admitted in the Emergency Department June 1, 2018 December 2022
NCT04163588 Unknown status Phase 3 Sequential Nephron Blockade in Acute Heart Failure October 1, 2019 December 31, 2020
NCT04146701 Unknown status Metabolomics and Microbiomics in Cardiovascular Diseases February 1, 2019 December 31, 2022
NCT03892148 Unknown status Phase 4 Protocol of Diuretics Use in Congestive Therapy in Heart Failure May 17, 2019 December 2021
NCT03720288 Unknown status Phase 3 Acetazolamide in Patients With Acute Heart Failure October 1, 2018 October 1, 2020
NCT03717636 Unknown status N/A Early or Non-revoked in Hospital-day in Patients With Acute Heart Failure October 1, 2018 October 1, 2021
NCT03696875 Unknown status N/A Discharge Planning in Emergency Department for Frail Older With AHF May 20, 2019 May 15, 2022
NCT02258984 Unknown status N/A Can the Venus 1000 Help Clinicians Treat Patients With Severe Sepsis or Acute Heart Failure? The CVP Trial October 2014 December 2015
NCT03681379 Unknown status Pharmacokinetics of Levosimendan in Pediatric Intensive Care Units October 1, 2018 October 1, 2020
NCT03508505 Unknown status Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation January 1, 2018 December 31, 2020
NCT03490994 Unknown status Phase 4 Rivaroxaban Once Daily Versus Dose-adjusted Vitamin K Antagonist on the Biomarkers in Acute Decompensated Heart Failure and Atrial Fibrillation (ROAD HF-AF) April 10, 2018 January 2020
NCT00692718 Unknown status Phase 4 N-3 Fatty Acids for the Prevention of Atrial Fibrillation in Patients With Acute Heart Failure July 2008
NCT01625403 Unknown status Phase 2 Recombinant BNP on Heart and Renal Function in Acute Heart Failure July 2012 December 2013
NCT04698005 Unknown status Phase 3 Exogenous Ketones for Acutely Decompensated HEart Failure December 2, 2020 December 31, 2021
NCT04592380 Withdrawn Phase 3 Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHF August 2014 November 2016
NCT06181968 Withdrawn N/A Ultrasound-guided Treatment in Acute Heart Failure March 13, 2019 November 30, 2020
NCT02299726 Withdrawn Phase 2 Early Aldosterone Blockade in Acute Heart Failure: An Exploratory Safety Study May 2015 November 2018
NCT02767024 Withdrawn Phase 4 Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure May 1, 2018 June 1, 2018
NCT00922402 Withdrawn N/A Heart & Diabetes - Feasibility Study June 2009 September 2011