Hyponatremia
Information
- Disease name
- Hyponatremia
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03636568 | Active, not recruiting | N/A | Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery) | June 2, 2016 | December 2024 |
| NCT03557957 | Active, not recruiting | N/A | Targeted Correction of Plasma Sodium Levels in Hospitalized Patients With Hyponatremia | August 20, 2018 | April 2025 |
| NCT00264914 | Completed | Phase 3 | Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion | July 2005 | August 2007 |
| NCT00264927 | Completed | Phase 3 | Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion | May 2004 | September 2007 |
| NCT00379847 | Completed | Phase 3 | An Open-Label Study of YM087 (Conivaptan) in Patients With Euvolemic or Hypervolemic Hyponatremia | February 2004 | June 2005 |
| NCT00380575 | Completed | Phase 3 | Study of IV YM087 to Assess Efficacy and Safety in Patients With Euvolemic or Hypervolemic Hyponatremia | August 2000 | February 2003 |
| NCT00435591 | Completed | Phase 4 | A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia | January 2007 | September 2008 |
| NCT00478192 | Completed | Phase 3 | Study of Efficacy & Safety for 3 Infusion Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia | April 2007 | August 2008 |
| NCT00492037 | Completed | Phase 3 | Study of Efficacy & Safety of Oral YM087 in Subjects With Euvolemic or Hypervolemic Hyponatremia | January 2000 | February 2002 |
| NCT00541944 | Completed | Establishment of an Algorithm for a Clinical Classfication of Hypoosmolar Hyponatremia | April 2007 | December 2008 | |
| NCT00550459 | Completed | Phase 3 | Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic Patients | August 2007 | March 2009 |
| NCT00555685 | Completed | Phase 2 | Hypertonic Saline Solution in Heart Failure | February 2008 | December 2010 |
| NCT00578695 | Completed | Phase 3 | THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation | January 2007 | |
| NCT00621348 | Completed | Phase 3 | Maintenance Intravenous Fluids in Children | September 2006 | May 2008 |
| NCT00632775 | Completed | Phase 3 | 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Hospitalized Children | December 2007 | September 2012 |
| NCT00032734 | Completed | Phase 2 | Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion | June 2001 | July 2003 |
| NCT00201994 | Completed | Phase 3 | "SALT-2 Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia | November 2003 | July 2005 |
| NCT00885430 | Completed | Phase 4 | Pico-Salax Colonic Preparation Study: Quantifying Electrolyte and Volume Status Changes | July 2008 | September 2008 |
| NCT00887627 | Completed | Phase 1 | Study to Compare Conivaptan Pharmacokinetics in Subjects With Mild & Moderate Kidney Function Impairment to Subjects With Normal Kidney Function | April 2009 | July 2010 |
| NCT01212211 | Completed | N/A | Hyponatremia in the Elderly: Benefit From a Change in Drug Therapy? | December 2010 | May 2012 |
| NCT01251770 | Completed | Phase 3 | Variation in Natremia Using Two Different Maintenance Intravenous Fluids in Postsurgical Hospitalized Children | December 2010 | July 2011 |
| NCT01299779 | Completed | N/A | Incidence of Hyponatremia in PEG-SD Compared to PEG-ELS | June 2010 | September 2012 |
| NCT01301274 | Completed | N/A | 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children | February 2011 | November 2011 |
| NCT01341665 | Completed | Subclassification of the Syndrome of Inappropriate ADH Secretion | March 2008 | April 2011 | |
| NCT01370473 | Completed | Institutional Registry of Hyponatremia | December 2006 | May 2014 | |
| NCT01456533 | Completed | Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients | October 2011 | April 2015 | |
| NCT01456832 | Completed | Post Operative Hyponatremia in the Renal Transplant Population | January 2010 | October 2011 | |
| NCT01556646 | Completed | Phase 3 | Effect of Tolvaptan on Cognitive Function in Cirrhosis | April 2011 | June 2013 |
| NCT01838759 | Completed | Bioimpedance Spectroscopy for the Differential Diagnosis of Hyponatremia | February 2013 | September 2013 | |
| NCT01850940 | Completed | Efficacy and Safety of Tolvaptan in Cirrhotic Patients With Hyponatremia | January 2013 | May 2015 | |
| NCT01879774 | Completed | N/A | Characterisation of Neuropsychological and Motoric Performance in Patients With Hyponatremia | June 2012 | April 2022 |
| NCT01909336 | Completed | Phase 3 | Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia | July 2013 | April 2014 |
| NCT02012660 | Completed | Relationship Between Heat Wave and Hyponatremia | February 2014 | April 2015 | |
| NCT02084797 | Completed | N/A | V2 Receptor Effects on Fluid Regulation and Performance | June 2011 | October 2012 |
| NCT02103491 | Completed | N/A | Effects of Oral Salt Supplementation on Physical Performance During a Half-ironman | June 2013 | August 2013 |
| NCT02242604 | Completed | Characterization of Neuropsychologic and Physical Performance in Geriatric Patients With Hyponatremia. | April 2014 | August 2017 | |
| NCT02263586 | Completed | Influence of Triathlon on the Electrolyte Balance | August 2014 | May 2015 | |
| NCT02449044 | Completed | Phase 3 | International, Multicenter, Study of One-year, Open-label, Titrated Oral Tolvaptan Tablet Administration in Patients With Chronic Hyponatremia | May 2004 | October 2009 |
| NCT02545101 | Completed | An Observational Study on Real-world Use and Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to SIADH | November 2015 | April 2016 | |
| NCT02548845 | Completed | An Observational Study to Describe the Adherence to the SEOM Algorithm for the Treatment of Hyponatraemia in Spain | December 2015 | June 2016 | |
| NCT02573077 | Completed | An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy | October 2015 | December 13, 2017 | |
| NCT02727686 | Completed | N/A | Post-Operative Water Load Following Transsphenoidal Pituitary Surgery | March 7, 2016 | December 13, 2018 |
| NCT02765061 | Completed | Hyponatremia and Hypoalbuminemia is Morbimortality Predictors in Coronary Artery Bypass Graft Surgery | May 2013 | May 2015 | |
| NCT02926989 | Completed | Phase 4 | Intravenous Fluids in Hospitalised Children | October 3, 2016 | April 15, 2019 |
| NCT03032445 | Completed | N/A | Beer for Endurance Exercise Recovery | March 1, 2017 | May 21, 2017 |
| NCT03202667 | Completed | Phase 2/Phase 3 | Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study | December 15, 2017 | December 6, 2021 |
| NCT03265691 | Completed | N/A | Hyponatremia in the Prevention of Hospitalized Patients Falls | December 2014 | December 2016 |
| NCT03371199 | Completed | N/A | The Association Between Hyponatremia and Osteoporosis in Patients With Epilepsy. | December 1, 2017 | December 31, 2018 |
| NCT03787888 | Completed | Hyponatremia Due to Poly Ethylene Glycol (PEG) | March 1, 2019 | September 30, 2019 | |
| NCT03840629 | Completed | Fluid Tonicity and Hyponatraemia Post Surgery | November 13, 2014 | November 12, 2015 | |
| NCT04022486 | Completed | Seizures in Infants Hospitalized in Pediatric Intensive Care Unit for Bronchiolitis | April 1, 2018 | May 1, 2019 | |
| NCT04035564 | Completed | Phase 4 | Early Sodium Intake in Preterm Newborns | March 30, 2018 | March 20, 2020 |
| NCT04119206 | Completed | Tolvaptan Versus Fluid Restriction in SIADH | January 1, 2009 | December 31, 2013 | |
| NCT04256499 | Completed | Water Load Test Value for Hyponatremia | January 1, 2001 | December 31, 2019 | |
| NCT04402190 | Completed | Hypotonic Hyponatremia: Criteria for the Correct Classification of Its Etiology and of Patient Volume Status | June 1, 2018 | February 28, 2020 | |
| NCT04493268 | Completed | HYPONATREMIA IN COVID-19 PATIENTS | March 7, 2020 | July 21, 2020 | |
| NCT04744987 | Completed | Changes in Serum Creatinine Levels Can Help Distinguish Hypovolemic From Euvolemic Hyponatremia | July 30, 2019 | October 30, 2020 | |
| NCT05277584 | Completed | Analysis of Factors Determining Increase of Serum Sodium in Hyponatremic Patients | December 1, 2021 | March 31, 2022 | |
| NCT05815550 | Completed | Delirium Related to Proton Pump Inhibitors Use | February 9, 2022 | February 10, 2022 | |
| NCT00734214 | Completed | Phase 3 | Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial | March 2008 | December 2009 |
| NCT00839358 | Completed | Phase 4 | Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation | August 2008 | February 2016 |
| NCT00851227 | Completed | Phase 1 | Study to Compare Conivaptan in Subjects With Mild & Moderate Liver Impairment Versus Subjects With Normal Liver Function | February 2009 | January 2010 |
| NCT06020495 | Not yet recruiting | Phase 3 | Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia: a Multicenter Open-label Randomized Controlled Trial | January 1, 2024 | March 31, 2026 |
| NCT02709031 | Not yet recruiting | Phase 1/Phase 2 | Cicletanine in Hypertension With Diabetes: Added Magnesium Preserves Potassium and Sodium | June 2022 | September 2024 |
| NCT06277336 | Recruiting | N/A | Effects of Intravenous [Pyr1]Apelin-13 on Healthy Volunteers With Artificially Induced SIAD | March 1, 2024 | December 2025 |
| NCT06408077 | Recruiting | N/A | Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges | July 1, 2023 | June 30, 2025 |
| NCT06013800 | Recruiting | Hyponatremia Volume Status Analysis by Point-of-care Ultrasound | October 1, 2023 | October 1, 2025 | |
| NCT04227301 | Recruiting | Influence of Serum Sodium Levels on Bone Metabolism and Turnover in Hospitalized Patients | November 14, 2019 | October 2024 | |
| NCT06037928 | Recruiting | Plasma Sodium and Sodium Administration in the ICU | September 4, 2023 | January 31, 2024 | |
| NCT04447911 | Recruiting | Phase 4 | Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia | February 4, 2021 | February 2025 |
| NCT06109532 | Recruiting | Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation. | January 1, 2016 | October 31, 2023 | |
| NCT04552873 | Recruiting | N/A | Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage | December 3, 2020 | December 2024 |
| NCT06171100 | Recruiting | Low-dose Tolvaptan for Inpatient Hyponatraemia. | March 15, 2024 | December 30, 2024 | |
| NCT00727090 | Terminated | Phase 4 | Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients | August 2008 | February 2010 |
| NCT01708811 | Terminated | Hyponatremia and Myometrium Contractility. An Invitro Study | October 2012 | October 2015 | |
| NCT00728091 | Terminated | Phase 3 | A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia | July 2008 | December 2008 |
| NCT01890694 | Terminated | Phase 4 | Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia | March 2012 | March 2015 |
| NCT04020926 | Terminated | Impact of Hyponatremia on Muscle Strength, Gait and Cognitive Function | October 1, 2019 | March 31, 2020 | |
| NCT02012959 | Terminated | Phase 3 | Study of the Safety and Effectiveness of SAMSCA® (Tolvaptan) in Children and Adolescents With Euvolemic or Hypervolemic Hyponatremia | September 22, 2015 | July 24, 2017 |
| NCT02020278 | Terminated | Phase 3 | An Extension Follow-up Trial to Evaluate the Long-term Safety of Children and Adolescent Participants With Euvolemic or Hypervolemic Hyponatremia | April 22, 2016 | October 23, 2017 |
| NCT03703713 | Terminated | Colloid Osmotic Pressure and Osmolality in Hyponatremia | October 9, 2018 | December 31, 2020 | |
| NCT04588207 | Terminated | Phase 2 | Urea for Chronic Hyponatremia | December 28, 2021 | September 29, 2022 |
| NCT00843986 | Terminated | Phase 3 | Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF) | April 2009 | August 2009 |
| NCT02215148 | Terminated | Pharmacokinetics and Clinical Response of Tolvaptan in Neurocritical Care Patients | November 2014 | August 2016 | |
| NCT01227512 | Terminated | Phase 3 | Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia | October 2010 | May 2013 |
| NCT02545114 | Terminated | N/A | Tolvaptan for Patients With Acute Neurological Injuries | August 2015 | September 2016 |
| NCT01386372 | Terminated | Phase 2 | Tolvaptan for In-hospital Hyponatremia | June 2011 | November 2012 |
| NCT01451411 | Terminated | Phase 3 | A Study to Assess the Efficacy, Safety and Pharmacokinetics of Intravenous Conivaptan (Vaprisol®) in Pediatric Subjects With Euvolemic or Hypervolemic Hyponatremia | February 2012 | January 2014 |
| NCT02959411 | Terminated | Phase 4 | Tolvaptan for Advanced or Refractory Heart Failure | October 2016 | June 30, 2020 |
| NCT04409626 | Unknown status | Hyponatraemia and Mortality in Schizophrenic and Bipolar Patients: Protocol for a Bayesian Causal Inference Study | January 1, 2011 | August 2020 | |
| NCT02666651 | Unknown status | Phase 4 | Regional Tolvaptan Registry | May 2016 | January 2020 |
| NCT04561531 | Unknown status | N/A | Efficacy and Safety of Bolus Comparing With Continuous Drip of 3% NaCl in Patients With Severe Symptomatic Hyponatremia. | September 30, 2020 | September 30, 2021 |
| NCT01716611 | Unknown status | Phase 4 | Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites | November 2012 | February 2014 |
| NCT01748331 | Unknown status | N/A | The Effect of Fluid Restriction in Congestive Heart Failure Complicated With Hyponatremia | November 2012 | November 2016 |
| NCT02432157 | Unknown status | Phase 1/Phase 2 | Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage: | January 2015 | |
| NCT02936167 | Unknown status | N/A | Comparison of Ringer Lactate and Isotonic Acetate Solution as Perioperative Maintenance Fluid for Children | September 2016 | February 2017 |
| NCT00636857 | Unknown status | N/A | Postoperative Hyponatremia - Are There Gender Differences? | March 2008 | December 2013 |
| NCT01509170 | Unknown status | The Clinical and Laboratory Characteristics of Recurrent Drug- Related Hyponatremia | February 2012 | January 2017 | |
| NCT02399358 | Unknown status | Factors Associated With Hyponatremia Induced by High-dose Cyclophosphamide | December 2015 | November 2017 | |
| NCT02667977 | Withdrawn | N/A | Reexamining Hypotonic Intravenous Fluid Use | October 2014 | June 2016 |
| NCT01326429 | Withdrawn | Frequency and Origin of Dysnatremias in the Emergency Department | October 2011 | March 2013 | |
| NCT02442674 | Withdrawn | Phase 3 | A Trial of Tolvaptan in Children and Adolescent Subjects With Euvolemic and Hypervolemic Hyponatremia | November 2015 | June 22, 2017 |
| NCT00684164 | Withdrawn | Phase 3 | Safety and Efficacy of Conivaptan for the Correction of Hyponatremia in Neurological Patients | May 2008 | June 2010 |
| NCT02614807 | Withdrawn | N/A | Protein Supplementation in Thiazide-induced Hyponatremia | June 2016 | May 2018 |
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0002902
- MeSH unique ID (MeSH (Medical Subject Headings))
- D007010