Hepatic Insufficiency
Information
- Disease name
- Hepatic Insufficiency
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT01043887 | Completed | Phase 1 | Ridaforolimus in Patients With Hepatic Insufficiency (MK-8669-046) | January 2010 | April 2010 |
| NCT00314054 | Completed | Phase 1 | Study Evaluating the Safety of HCV-796 in Subjects With Liver Disease and in Healthy Adults | May 2006 | October 2007 |
| NCT00416702 | Completed | Phase 1 | Safety and Pharmacokinetics of Indacaterol in Healthy Subjects and Those With Impaired Liver Function | November 2006 | March 2008 |
| NCT00509210 | Completed | Phase 1 | Study of Telaprevir in Subjects With Hepatic Impairment | September 2007 | June 2008 |
| NCT03968848 | Completed | Phase 1 | Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolite | November 12, 2018 | March 29, 2019 |
| NCT04097704 | Completed | Pharmacogenetics Sampling of the CC-90007-CP-003 Study Cohort | September 4, 2019 | November 1, 2019 | |
| NCT04147936 | Completed | N/A | Study of the Safety and Tolerability of AXA1665 in Subjects With Mild and Moderate Hepatic Insufficiency | March 30, 2019 | June 24, 2020 |
| NCT04170309 | Completed | Collection of Data of Ceftobiprole Treated Patients: Comparison of Patients With and Without Certain Diseases | March 30, 2020 | June 9, 2023 | |
| NCT04226833 | Completed | Phase 1 | A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Function | February 11, 2020 | September 27, 2021 |
| NCT04867941 | Completed | Phase 1 | A Study to Evaluate the Effect of Hepatic Insufficiency on the Pharmacokinetics (PK) of ACP-196 | October 21, 2014 | February 2, 2015 |
| NCT04993404 | Completed | Phase 1 | Pharmacokinetics Of Jaktinib In Subjects With Hepatic Impairment And Normal Hepatic Function | August 27, 2021 | September 19, 2022 |
| NCT05440344 | Completed | Phase 1 | A Study of Imlunestrant (LY3484356) in Female Participants With Impaired Liver Function | July 5, 2022 | February 28, 2024 |
| NCT05661344 | Completed | Phase 1 | A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problems | February 7, 2023 | September 13, 2023 |
| NCT05731895 | Completed | Phase 1 | A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Liver Problems | March 8, 2023 | December 11, 2023 |
| NCT06190691 | Completed | Phase 1 | Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participants | December 18, 2020 | December 30, 2021 |
| NCT00645021 | Completed | Phase 1 | Study Examining The Effect Of Hepatic Impairment On Safety, Toleration And How The Body Processes An Experimental Drug | April 2008 | October 2008 |
| NCT00692341 | Completed | Phase 1 | Evaluation Of Hepatic Impairment On AG-013736 Pharmacokinetics | May 2008 | October 2008 |
| NCT00781430 | Completed | Phase 1 | Study Evaluating The PK And Safety Of Neratinib In Healthy Subjects And Subjects With Chronic Liver Disease | April 2009 | February 2010 |
| NCT00805090 | Completed | Phase 1 | Open-Label, Single-Dose Study to Evaluate the Safety and PK of DIC075V in Subjects With Renal Insufficiency and Hepatic Impairment Compared to Healthy Subjects and Evaluate the Safety and Pharmacokinetics of HPβCD When Administered in DIC075V Compared to Sporanox® in Healthy Subjects | December 2008 | April 2009 |
| NCT00859053 | Completed | Phase 1 | Single-Dose Pharmacokinetics of BMS-790052 in Participants With Hepatic Impairment | March 2009 | September 2009 |
| NCT00929032 | Completed | Liver Transplantation and Reticuloendothelial Clearance Capacity | September 2009 | August 2010 | |
| NCT00931060 | Completed | N/A | Effects of Branched-Chain Amino Acids on Muscle Ammonia Metabolism in Patients With Cirrhosis and Healthy Subjects | November 2007 | June 2009 |
| NCT00968591 | Completed | Phase 1 | Pharmacokinetics of Everolimus in Subjects With Hepatic Insufficiency | November 2009 | |
| NCT00969813 | Completed | Phase 1 | A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function | November 2009 | January 2010 |
| NCT01019070 | Completed | Phase 1 | Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032 | December 2009 | August 2011 |
| NCT00144248 | Completed | Phase 4 | A Pharmacokinetic Study to Assess Nevirapine [Viramune] Levels in HIV Infected Patients With Impaired Hepatic Functions | June 25, 2004 | |
| NCT01043926 | Completed | Phase 1 | Pharmacokinetics of Suvorexant in Participants With Hepatic Insufficiency (MK-4305-017) | February 22, 2010 | April 14, 2010 |
| NCT01111318 | Completed | Phase 1 | Pharmacokinetics of Empagliflozin (BI 10773) in Patients With Impaired Liver Function | July 2010 | |
| NCT01186588 | Completed | Phase 1 | A Study of Canagliflozin in Study Participants With Various Degrees of Impaired Hepatic (Liver) Function | August 2010 | April 2011 |
| NCT01261923 | Completed | Phase 1/Phase 2 | Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic Disease | December 2010 | August 2011 |
| NCT01273493 | Completed | Phase 1 | A Pharmacokinetic Study of Trabectedin in Patients With Advanced Malignancies and Hepatic Dysfunction | December 2010 | April 2014 |
| NCT01475136 | Completed | Phase 1 | A Study of LY2140023 in Hepatically-Impaired Participants | November 2011 | December 2012 |
| NCT01512693 | Completed | Phase 1 | Assessment of Pharmacokinetics of Single Dose Odanacatib (MK-0822) in Participants With Moderate Hepatic Insufficiency (MK-0822-070) | February 23, 2012 | April 24, 2012 |
| NCT01751399 | Completed | Phase 1 | A Single Dose Study of LY2605541 in Participants With Liver Impairment | December 2012 | September 2013 |
| NCT01797536 | Completed | Phase 1 | The Influence of Hepatic Insufficiency on the Pharmacokinetics of Elbasvir (MK-8742) (MK-8742-009) | March 6, 2013 | August 20, 2014 |
| NCT01836185 | Completed | Phase 1 | A Study of Evacetrapib (LY2484595) in Participants With Hepatic (Liver) Impairment | April 2013 | October 2013 |
| NCT01860326 | Completed | Phase 1 | Evaluate the Pharmacokinetics, Safety, and Tolerability of Alisporivir in Subjects With Hepatic Impairment Compared to Healthy Subjects | March 2011 | September 2011 |
| NCT01870388 | Completed | Phase 1 | A Pharmacokinetic Study of Baricitinib in Participants With Liver Disease | June 2013 | July 2013 |
| NCT01891526 | Completed | Single Dose of 9-cis-retinoic Acid in Hepatic Patients | December 2010 | June 2012 | |
| NCT02090621 | Completed | Phase 2 | Extracorporeal Photopheresis After Liver Transplant | October 2012 | March 2015 |
| NCT02161224 | Completed | Phase 1 | A Study to Investigate the Exposure and Safety and Tolerability of a Single Dose of FG-4592 in Subjects With Moderately Diminished Liver Function Compared to Those With Normal Liver Function | September 2013 | December 2013 |
| NCT02170571 | Completed | Phase 1 | Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function | July 2005 | |
| NCT02183376 | Completed | Phase 1 | Pharmacokinetics and Pharmacodynamics of BI 1356 in Subjects With Different Degrees of Liver Impairment as Compared to Healthy Subjects | July 2008 | |
| NCT02184091 | Completed | Phase 1 | Study to Evaluate the Effects of Underlying Renal or Hepatic Dysfunction on the Pharmacokinetics of Nevirapine | January 1999 | |
| NCT02191865 | Completed | Phase 1 | Nintedanib in Volunteers With Hepatic Impairment Compared With Healthy Volunteers | July 2014 | January 2015 |
| NCT02249442 | Completed | Phase 1 | Study to Determine the Pharmacokinetics on TPV/r in Subjects With Mild and Moderate Hepatic Insufficiency | October 2003 | |
| NCT02259855 | Completed | Phase 1 | Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic Impairment | January 2006 | |
| NCT02265627 | Completed | Phase 1 | Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Patients With Hepatic Impairment in Comparison to Healthy Volunteers | March 2000 | |
| NCT02387814 | Completed | Phase 1 | A Study of Abemaciclib in Participants With Varying Degrees of Liver Impairment | March 2015 | August 2015 |
| NCT02800421 | Completed | Prognostic Impact of Organ Damage in STEMI Patients | January 2007 | July 2015 | |
| NCT02813538 | Completed | Major Liver Resection: Early Clotting Disorders and Functional Impairment. | February 5, 2016 | April 2019 | |
| NCT02894385 | Completed | Phase 1 | Effect of Hepatic and Renal Impairment on the Pharmacokinetics, Safety and Tolerability of BAY1841788 (ODM-201) | September 13, 2016 | December 15, 2017 |
| NCT03306667 | Completed | Phase 1 | Clinical Pharmacology of FYU-981 (Subjects With Hepatic Insufficiency) | October 6, 2017 | June 25, 2018 |
| NCT03341884 | Completed | Phase 1 | A Study of Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants | November 9, 2017 | June 26, 2018 |
| NCT03842761 | Completed | Phase 1 | A Study to Test How Different Doses of BI 685509 Are Tolerated in Patients With Liver Problems | March 6, 2019 | May 20, 2021 |
| NCT03940742 | Completed | Phase 1 | A Study of Tirzepatide in Participants With Impaired Liver Function | July 22, 2019 | September 22, 2020 |
| NCT06390410 | Not yet recruiting | Phase 1 | A Pharmacokinetic Study of Simufilam in Subjects With Impaired Hepatic Function | July 10, 2024 | January 28, 2025 |
| NCT05093972 | Not yet recruiting | Phase 1 | Ulonivirine (MK-8507) in Participants With Mild or Moderate Hepatic Impairment (MK-8507-014) | April 7, 2025 | September 10, 2025 |
| NCT06176716 | Recruiting | Phase 1 | Phase 1 Hepatic Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride | December 6, 2023 | April 30, 2024 |
| NCT05882032 | Recruiting | Phase 1 | A Study of LY3502970 in Participants With Impaired and Normal Liver Function | June 13, 2023 | July 1, 2024 |
| NCT05209295 | Recruiting | Phase 1 | A Study to Evaluate CC-486/Onureg in Participants With Moderate or Severe Hepatic Impairment Compared With Normal Hepatic Function in Participants With Myeloid Malignancies | July 31, 2024 | June 1, 2025 |
| NCT05916560 | Recruiting | Phase 1 | A Study of LY3437943 in Participants With Impaired and Normal Liver Function | July 13, 2023 | November 2024 |
| NCT03295266 | Terminated | Phase 1 | Single-Dose Pharmacokinetics of MK-3866 in Participants With Hepatic Impairment (MK-3866-006) | December 19, 2017 | March 15, 2018 |
| NCT02457702 | Terminated | N/A | Mitochondrial Function in Patients With Severe Liver Disease | October 2015 | December 2021 |
| NCT02753517 | Unknown status | N/A | Hepato Biliary Scintigraphy to Assess the Risk of Postoperative Liver Failure Hepatectomies | December 8, 2015 | November 2023 |
| NCT00948558 | Unknown status | Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT | March 2009 | September 2011 | |
| NCT00623662 | Unknown status | N/A | Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection | February 2008 | March 2019 |
- MeSH unique ID (MeSH (Medical Subject Headings))
- D048550