Ototoxicity

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Information
Disease name
Ototoxicity
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT00683319 Active, not recruiting Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy April 2008
NCT00477607 Completed Phase 2/Phase 3 Alpha-Lipoic Acid in Preventing Hearing Loss in Cancer Patients Undergoing Treatment With Cisplatin October 2007 June 2011
NCT00458887 Completed Assessing Ear Damage in Young Cancer Patients Treated With Cisplatin May 2007 February 28, 2017
NCT00652132 Completed Phase 3 Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, II, or III Childhood Liver Cancer December 15, 2007 February 28, 2018
NCT00716976 Completed Phase 3 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy June 23, 2008 June 30, 2021
NCT01139281 Completed Phase 2 The Protective Effect of Ginkgo Biloba Extract on Cisplatin-induced Ototoxicity in Humans June 2007 June 2008
NCT04262336 Completed Phase 1 Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment February 21, 2020 May 23, 2023
NCT01263262 Completed A Comparison of Infection Rates Between Two Surgical Sites January 2011 August 2013
NCT01848457 Completed Phase 2 Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy April 2013 October 1, 2016
NCT02819856 Enrolling by invitation Phase 2 SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity July 21, 2017 April 2023
NCT05641441 Recruiting Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma January 24, 2023 November 15, 2030
NCT04226456 Terminated Phase 4 Intratympanic Administration of N-acetylcysteine for Protection of Cisplatin-induced Ototoxicity July 10, 2021 September 3, 2023
NCT01451853 Unknown status Phase 2 SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss January 15, 2018 September 23, 2019
NCT01285674 Unknown status N/A Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Systemic Treatment With Cisplatin. January 2011 January 2012
NCT03480971 Unknown status Phase 2 Treatment of Radiation and Cisplatin Induced Toxicities With Tempol May 13, 2019 April 2023
NCT00578760 Unknown status N/A Does Aspirin Have a Protective Role Against Chemotherapeutically Induced Ototoxicity? February 2008 February 2010
NCT01624324 Unknown status Aminoglycoside Plasma Level Measurement in Neonates With Infection November 2010
NCT01216800 Unknown status Phase 3 Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors August 2008
NCT02382068 Withdrawn N/A Dexamethasone in Preventing Hearing Loss in Patients Receiving Cisplatin August 2014 July 2017