Becker muscular dystrophy
Information
- Disease name
- Becker muscular dystrophy
- Disease ID
- DOID:9883
- Description
- "A muscular dystrophy that involves slowly worsening muscle weakness of the legs and pelvis, and has_material_basis_in X-linked recessive inheritance of mutation in the dystrophin gene on chromosome Xp21." [url:https\://www.ncbi.nlm.nih.gov/pubmed/19461958, url:https\://www.omim.org/entry/300376]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| DMD | X | 31,119,222 | 33,211,549 | 10 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT01081080 | Completed | Cardiac Magnetic Resonance in Children With Muscular Dystrophy | April 2010 | October 2011 | |
| NCT00104078 | Completed | Phase 1/Phase 2 | Study Evaluating MYO-029 in Adult Muscular Dystrophy | February 2005 | January 2007 |
| NCT00592553 | Completed | Phase 2 | Phase 2B Study of PTC124 (Ataluren) in Duchenne/Becker Muscular Dystrophy (DMD/BMD) | February 29, 2008 | December 31, 2009 |
| NCT00873782 | Completed | Phase 1 | Safety Study of Transvenous Limb Perfusion in Human Muscular Dystrophy | March 2009 | February 2014 |
| NCT00893334 | Completed | Evaluation of Limb-Girdle Muscular Dystrophy | April 2009 | December 2013 | |
| NCT01066455 | Completed | Cardiac Outcome Measures in Children With Muscular Dystrophy | January 2010 | May 2012 | |
| NCT01070511 | Completed | Phase 4 | Tadalafil in Becker Muscular Dystrophy | January 2010 | December 2012 |
| NCT00005574 | Completed | Phase 1 | Gentamicin Treatment of Muscular Dystrophy | February 2000 | January 2001 |
| NCT01126697 | Completed | Phase 2/Phase 3 | Clinical Trial of Coenzyme Q10 and Lisinopril in Muscular Dystrophies | February 2010 | December 2017 |
| NCT01350154 | Completed | Phase 2 | Effect of Modulating the nNOS System on Cardiac, Muscular and Cognitive Function in Becker Muscular Dystrophy Patients | November 2011 | April 2013 |
| NCT01519349 | Completed | Phase 1 | Follistatin Gene Transfer to Patients With Becker Muscular Dystrophy and Sporadic Inclusion Body Myositis | January 2012 | October 2017 |
| NCT01540604 | Completed | Phase 2 | CRD007 for the Treatment of Duchenne Muscular Dystrophy, Becker Muscular Dystrophy and Symptomatic Carriers | ||
| NCT01557400 | Completed | Phase 3 | Study of Ataluren for Previously Treated Participants With Nonsense Mutation Duchenne/Becker Muscular Dystrophy (nmDBMD) in Europe, Israel, Australia, and Canada | May 20, 2012 | January 19, 2018 |
| NCT01856868 | Completed | Phase 1/Phase 2 | Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) | May 2013 | September 2018 |
| NCT02147639 | Completed | Phase 2/Phase 3 | Effects of Sodium Nitrate on Blood Flow in Becker Muscular Dystrophy | October 2013 | May 2014 |
| NCT02165358 | Completed | Muscle MRI in Becker Muscular Dystrophy and in Limb-girdle Muscular Dystrophy Type 2I | June 2014 | January 2015 | |
| NCT02434627 | Completed | Phase 1 | Sodium Nitrate for Muscular Dystrophy | June 2015 | April 2018 |
| NCT02847975 | Completed | Phase 1 | Sodium Nitrate to Improve Blood Flow | October 2013 | December 2014 |
| NCT03236662 | Completed | Phase 2 | (-)- Epicatechin Becker Muscular Dystrophy | November 2016 | December 2017 |
| NCT03238235 | Completed | Phase 2 | Clinical Study to Evaluate the Efficacy and Safety of Givinostat in Ambulant Patients With Becker Muscular Dystrophy | December 12, 2017 | March 19, 2021 |
| NCT04054375 | Completed | Phase 2 | Weekly Steroids in Muscular Dystrophy | July 1, 2019 | March 1, 2022 |
| NCT04349566 | Completed | Fast Troponin as a Biomarker to Assess Exercise-induced Muscle Damage in Muscle Diseases | June 1, 2020 | December 20, 2021 | |
| NCT04386304 | Completed | Phase 1 | Safety and Biomarker Response to (+)-Epicatechin in Becker Muscular Dystrophy | July 13, 2020 | March 1, 2022 |
| NCT04585464 | Completed | Phase 1 | A Study to Assess Safety, Tolerability, and PK of EDG-5506 in Healthy Volunteers and Becker Muscular Dystrophy Adults | October 12, 2020 | December 27, 2021 |
| NCT05160415 | Completed | Phase 1 | A Study of EDG-5506 in Adult Males With Becker Muscular Dystrophy | December 28, 2021 | March 1, 2024 |
| NCT06066580 | Enrolling by invitation | Phase 2 | Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy | November 2, 2023 | March 2028 |
| NCT06363526 | Not yet recruiting | N/A | Effectiveness of 5-week Digital Respiratory Practice in a Group of Children With Duchenne Muscular Dystrophy and Becker Muscular Dystrophy. | May 5, 2024 | November 30, 2024 |
| NCT05715957 | Not yet recruiting | Follow-up Study on Female Carriers With DMD Gene Variants | March 1, 2023 | August 1, 2025 | |
| NCT03057002 | Recruiting | UTSW HP [13-C] Pyruvate Injection in HCM | May 1, 2018 | November 8, 2024 | |
| NCT05257473 | Recruiting | Defining Endpoints in Becker Muscular Dystrophy | April 13, 2022 | May 2026 | |
| NCT05291091 | Recruiting | Phase 2 | Phase 2 Study of EDG-5506 in Becker Muscular Dystrophy (GRAND CANYON) | July 6, 2022 | June 2026 |
| NCT05409079 | Recruiting | N/A | Schulze Muscular Dystrophy Ability Clinical Study | May 26, 2022 | June 30, 2023 |
| NCT06378203 | Recruiting | N/A | Rehabilitation in Muscular Dystrophies From the Hospital Facility to the Home: Pilot Project [RIMUDI] | December 15, 2023 | April 15, 2025 |
| NCT05166109 | Recruiting | Phase 2 | A Study to Assess Vamorolone in Becker Muscular Dystrophy (BMD) | July 7, 2022 | January 31, 2025 |
| NCT02972580 | Recruiting | Characterization of Clinical Skeletal and Cardiac Impairment in Carriers of DMD and BMD | June 2016 | December 2025 | |
| NCT01484678 | Recruiting | Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy | September 1, 2020 | August 31, 2025 | |
| NCT04583917 | Recruiting | Brain Involvement in Dystrophinopathies Part 1 | March 30, 2021 | December 2023 | |
| NCT04668716 | Recruiting | Brain Involvement in Dystrophinopathies Part 2 | October 11, 2021 | May 2024 | |
| NCT02069756 | Recruiting | The Duchenne Registry | October 2007 | October 2047 | |
| NCT04972604 | Recruiting | CureDuchenne Link®: A Resource for Research | July 9, 2021 | July 9, 2031 | |
| NCT05019625 | Recruiting | Biomarker Development for Muscular Dystrophies | February 20, 2015 | June 2027 | |
| NCT01168908 | Terminated | Phase 2 | Revatio for Heart Disease in Duchenne Muscular Dystrophy and Becker Muscular Dystrophy | September 2010 | January 2014 |
| NCT01009294 | Terminated | Phase 2 | Study of Ataluren (PTC124) in Nonambulatory Participants With Nonsense-Mutation-Mediated Duchenne/Becker Muscular Dystrophy (nmDMD/BMD) | January 13, 2010 | March 23, 2010 |
| NCT00847379 | Terminated | Phase 2 | Phase 2B Extension Study of Ataluren (PTC124) in Duchenne/Becker Muscular Dystrophy (DMD/BMD) | January 31, 2009 | May 24, 2010 |
| NCT02109692 | Unknown status | N/A | Evaluation of Muscle miRNA as Biomarkers in Dystrophinopathies | May 19, 2014 | November 2019 |
| NCT01539772 | Unknown status | Becker Muscular Dystrophy - A Natural History Study to Predict Efficacy of Exon Skipping | April 2012 | August 2018 | |
| NCT00819845 | Unknown status | Phase 4 | Ramipril Versus Carvedilol in Duchenne and Becker Patients | December 2008 | December 2016 |
- Disase is a (Disease Ontology)
- DOID:9884
- Cross Reference ID (Disease Ontology)
- GARD:5900
- Cross Reference ID (Disease Ontology)
- MIM:300376
- Cross Reference ID (Disease Ontology)
- ORDO:98895
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:111501005
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0699741
- Exact Synonym (Disease Ontology)
- benign congenital myopathy
- Exact Synonym (Disease Ontology)
- Benign pseudohypertrophic muscular dystrophy
- OrphaNumber from OrphaNet (Orphanet)
- 98895
- MedGen concept unique identifier (MedGen Concept name)
- C0917713
- MedGen unique identifier (MedGen Concept name)
- 182959