urea cycle disorder
Information
- Disease name
- urea cycle disorder
- Disease ID
- DOID:9267
- Description
- "An amino acid metabolic disorder that involves a deficiency of one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream." [url:http\://en.wikipedia.org/wiki/Urea_cycle_disorder]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00472732 | Completed | Neurologic Injuries in Adults With Urea Cycle Disorders | March 2007 | July 2010 | |
| NCT02246218 | Completed | Phase 4 | A Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders | December 31, 2014 | July 17, 2017 |
| NCT03064048 | Completed | N/A | Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD | September 15, 2017 | January 31, 2023 |
| NCT03179878 | Completed | Phase 1 | Safety and Tolerability of SYNB1020-CP-001 | June 16, 2017 | April 11, 2018 |
| NCT03335488 | Completed | Phase 4 | Study of Glycerol Phenylbutyrate & Sodium Phenylbutyrate in Phenylbutyrate Naïve Patients With Urea Cycle Disorders (UCDs) | February 20, 2018 | December 20, 2022 |
| NCT03721367 | Completed | Chronic Liver Disease in Urea Cycle Disorders | November 29, 2017 | June 1, 2020 | |
| NCT03911089 | Completed | N/A | A Collection of Case Studies in Infants With UCD to Evaluate Infant Growth and the Safety of a New Medical Food for UCD | May 28, 2013 | November 2019 |
| NCT04248062 | Completed | Patient and Observer Reported Outcome Measurements in Inborn Errors of Metabolism | August 1, 2019 | October 16, 2020 | |
| NCT05330039 | Completed | Characterization of Intestinal Microbiota in Children With Inborn Errors of Metabolism (IEM) | November 30, 2021 | February 27, 2024 | |
| NCT05706714 | Completed | Th1, Th2, Th17 Phenotype in Urea Cycle Disorders | April 6, 2021 | September 1, 2023 | |
| NCT04908319 | Recruiting | Hepatic Histopathology in Urea Cycle Disorders | February 24, 2022 | June 30, 2025 | |
| NCT04602325 | Recruiting | Systemic Biomarkers of Brain Injury From Hyperammonemia | July 9, 2020 | May 2027 | |
| NCT05076318 | Recruiting | N/A | Dysregulated Urea-synthesis at Terminal Uremia | March 1, 2021 | December 1, 2024 |
| NCT04612764 | Recruiting | Liver Disease in Urea Cycle Disorders | November 4, 2021 | December 31, 2024 | |
| NCT01948427 | Terminated | Observational Study That Will Collect Information on Patients With Urea Cycle Disorders (UCDs) | September 25, 2013 | February 24, 2020 | |
| NCT03933410 | Terminated | Phase 2 | UNLOCKED: A Phase 2, Open-label Trial With KB195 in Subjects With a Urea Cycle Disorder | September 17, 2019 | March 2, 2021 |
| NCT03181828 | Terminated | Phase 1/Phase 2 | Manipulating the Gut Microbiome Study | March 24, 2017 | June 5, 2018 |
| NCT03343756 | Terminated | HepaStem Long-Term Safety Registry | April 4, 2018 | May 23, 2024 | |
| NCT03884959 | Withdrawn | Phase 2 | A Safety and Efficacy Study of Infusions of HepaStem in Urea Cycle Disorders Pediatric Patients | July 12, 2018 | November 4, 2020 |
- Disase is a (Disease Ontology)
- DOID:9252
- Cross Reference ID (Disease Ontology)
- GARD:7837
- Cross Reference ID (Disease Ontology)
- ICD10CM:E72.2
- Cross Reference ID (Disease Ontology)
- ICD9CM:270.6
- Cross Reference ID (Disease Ontology)
- MESH:D056806
- Cross Reference ID (Disease Ontology)
- NCI:C84785
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:36444000
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0154246
- Exact Synonym (Disease Ontology)
- disorder of metabolism of ornithine, citrulline, argininosuccinic acid, arginine and ammonia
- Exact Synonym (Disease Ontology)
- disorder of urea cycle metabolism
- Exact Synonym (Disease Ontology)
- urea cycle defect