systemic lupus erythematosus

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Information
Disease name
systemic lupus erythematosus
Disease ID
DOID:9074
Description
"A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart." [url:http\://en.wikipedia.org/wiki/Systemic_lupus_erythematosus] {comment="ls:IEDB"}
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT06029335 Active, not recruiting Clinical Risk Assessment of Cognitive Function in Systemic Autoimmune Diseases September 1, 2020 August 30, 2023
NCT05155345 Active, not recruiting Phase 1 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered Mosunetuzumab to Participants With Systemic Lupus Erythematosus January 11, 2022 June 1, 2025
NCT03938324 Active, not recruiting N/A Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions October 29, 2019 May 2024
NCT05162586 Active, not recruiting Phase 2 The WILLOW Study With M5049 in SLE and CLE (SCLE and/or DLE) (WILLOW) March 31, 2022 August 16, 2024
NCT04294667 Active, not recruiting Phase 3 A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus August 12, 2020 September 30, 2024
NCT03735238 Active, not recruiting Implementing the Decision-Aid for Lupus (IDEAL Strategy) December 15, 2018 December 15, 2025
NCT05328557 Active, not recruiting Phase 1 A Phase Ia Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneously Administered CUG252 in Normal Healthy Volunteers November 7, 2021 December 31, 2023
NCT05116163 Active, not recruiting N/A Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology June 17, 2022 August 15, 2024
NCT05347992 Active, not recruiting ELEVATE - (Empower Lupus Erythematosus Patients Via Allowing RemoTe Evaluation) May 3, 2022 March 1, 2025
NCT04335643 Active, not recruiting N/A Telehealth CBT for Adolescents and Young Adults With Childhood-onset Systemic Lupus Erythematosus August 4, 2020 August 24, 2024
NCT01729455 Active, not recruiting Safety and Effectiveness of BENLYSTA (Belimumab) in Systemic Lupus Erythematosus (SLE) Registry February 21, 2013 February 17, 2025
NCT03030118 Active, not recruiting Phase 2 Study of Anti-Malarials in Incomplete Lupus Erythematosus December 28, 2017 January 2025
NCT01649765 Active, not recruiting Phase 2 Pediatric Lupus Trial of Belimumab Plus Background Standard Therapy September 7, 2012 April 5, 2028
NCT05478018 Active, not recruiting N/A Type 1 Interferon Induced Changes to Exercise Adaptations in Systemic Lupus Erythematosus Patients April 1, 2022 September 1, 2024
NCT04179032 Active, not recruiting Phase 2 Study of Subcutaneous (SC) Belimumab in Pediatric Participants With Systemic Lupus Erythematosus (SLE) November 28, 2019 April 23, 2027
NCT03684564 Active, not recruiting Phase 2 RIvaroxaban for Stroke Patients With AntiPhospholipid Syndrome July 9, 2021 August 2025
NCT03920267 Active, not recruiting Phase 2 Long-Term Safety and Efficacy Study of Deucravacitinib in Participants With Systemic Lupus Erythematosus March 26, 2019 March 31, 2025
NCT05087628 Active, not recruiting Phase 2 PRV-3279-2a Trial in Systemic Lupus January 24, 2022 September 2025
NCT03734055 Active, not recruiting N/A Peer Approaches to Lupus Self-management November 30, 2018 September 25, 2024
NCT04882878 Active, not recruiting Phase 2 A Study of Nipocalimab in Adult Participants With Active Systemic Lupus Erythematosus August 20, 2021 December 26, 2024
NCT03915652 Active, not recruiting N/A Addressing Disparities in Lupus Care Through an Integrated Care Management Program June 21, 2019 December 30, 2023
NCT04835441 Active, not recruiting Phase 2 ALPN-101 (Acazicolcept) in Systemic Lupus Erythematosus June 22, 2021 January 2025
NCT04184258 Completed Phase 1/Phase 2 Treatment of Systemic Lupus Erythematosus With Pooled Allogenic Mesenchymal Stem Cells July 1, 2019 December 31, 2020
NCT04186871 Completed Phase 2 Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis January 7, 2020 December 5, 2022
NCT04239521 Completed The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata October 1, 2020 November 28, 2022
NCT00000416 Completed N/A Prevention of Arthritis-Related Work Disability September 1997 August 2001
NCT00418587 Completed Phase 1 Vitamin D Therapy in Patients With Systemic Lupus Erythematosus (SLE) December 2006 August 2014
NCT04305197 Completed Phase 1/Phase 2 A Study of ICP-022 in Patients With Systemic Lupus Erythematosus (SLE) July 9, 2020 April 28, 2022
NCT04345159 Completed Association Between Long-term Hydroxychloroquine Treatment and Outcome of a History of Symptoms Suggestive of COVID-19 Infection During the Epidemic Period in France in Patients With Autoimmune Disease April 17, 2020 November 30, 2020
NCT04355702 Completed Covid-19 in Lupus Patients March 1, 2020 December 30, 2020
NCT00342095 Completed Hormonal and Environmental Risk Factors for Developing Systemic Lupus Erythematosus: The Carolina Lupus (CLU) Study December 17, 1996 March 7, 2007
NCT04358302 Completed N/A Individual Patient Exposure and Response in Pediatric Lupus September 28, 2020 June 16, 2021
NCT04397107 Completed N/A The Therapeutic Value and Mechanism of Recombinant Human Interleukin-2 on Children With Rheumatic Diseases August 15, 2020 June 30, 2022
NCT00371501 Completed Phase 4 Aspirin and Statins for Prevention of Atherosclerosis and Arterial Thromboembolism in Systemic Lupus Erythematosus June 2006 December 2009
NCT04400240 Completed N/A Care Coordination Approaches to Learning Lupus Self-management January 1, 2018 December 31, 2019
NCT04411407 Completed N/A PROM Collected Via a WebApp Versus a Touch Screen Solution Among Patients With SLE July 15, 2020 November 25, 2020
NCT04433585 Completed Phase 2 A Study of LY3471851 in Adults With Systemic Lupus Erythematosus (SLE) August 19, 2020 February 16, 2023
NCT04440566 Completed N/A O-GlcNAcylation Role in the Pathophysiology of Systemic Lupus Erythematosus October 13, 2020 February 14, 2022
NCT04453215 Completed N/A Laser Therapy for Patients With Systemic Lupus Erythematosus January 12, 2019 March 15, 2020
NCT00417430 Completed Phase 2 Efficacy of Faslodex in Treatment of SLE Clinical, Serologic, and Molecular Studies September 2004 December 2006
NCT00383513 Completed Phase 2 Study of Epratuzumab in Systemic Lupus Erythematosus June 2006 January 2012
NCT04570306 Completed Transcriptional and Immune Parameters of Response to Belimumab December 16, 2020 December 16, 2023
NCT04580108 Completed Highly Sensitive Serum Cardiac Troponin T and Cardiovascular Events in Patients With Systemic Lupus Erythematosus July 3, 2007 June 26, 2019
NCT00004665 Completed Phase 2 Phase II Study of Long-Term Dehydroepiandrosterone for Systemic Lupus Erythematosus June 1995
NCT04647708 Completed Phase 1 Study of M5049 in CLE and SLE Participants December 16, 2020 December 19, 2023
NCT00392093 Completed Phase 4 Effect of Hormone Replacement Therapy on Lupus Activity November 1997 December 2001
NCT00413361 Completed Phase 4 The Reduction of Systemic Lupus Erythematosus Flares :Study PLUS June 2007 January 2011
NCT00493753 Completed N/A Feasibility and Safety of Acupuncture for Systemic Lupus November 2004 April 2006
NCT03802578 Completed N/A The Impact of Exercise on Hand Function, Daily Activities Performance and Quality of Life of SLE' Patients September 28, 2016 September 30, 2018
NCT00235378 Completed Genetic Study of Lupus Patients and Their Families July 1996 March 2013
NCT06073613 Completed Periodontal Status in Patients With Chronic Skin Diseases January 20, 2023 April 28, 2023
NCT03817424 Completed Phase 1 A Study to Evaluate VIB7734 in Participants With Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythematosus (CLE), Sjogren's Syndrome, Systemic Sclerosis, Polymyositis, and Dermatomyositis December 13, 2018 July 20, 2020
NCT00000417 Completed Phase 2 Psychoeducational Approach to Improve Health in Lupus April 1997 March 2001
NCT03845517 Completed Phase 2 A DOSE-RANGING STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-06700841 IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) April 18, 2019 October 5, 2023
NCT00271934 Completed Phase 2 Immune Ablation and Hematopoietic Stem Cell Support in Patients With Systemic Lupus Erythematosus: A Phase II Study September 2002 April 2012
NCT00278538 Completed Phase 2 Cyclophosphamide and Rabbit Antithymocyte Globulin (rATG)/Rituximab in Patients With Systemic Lupus Erythematosus September 23, 2005 May 2019
NCT05048238 Completed Phase 1 Evaluation of Tofacitinib in Prevention of Photosensitivity in Lupus September 30, 2022 February 29, 2024
NCT03941184 Completed Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity January 1, 1995 November 10, 2020
NCT03942718 Completed N/A Systemic Lupus Erythematosus Exercise Program March 21, 2018 August 1, 2020
NCT03949426 Completed Phase 1 Safety, Tolerability and Pharmacokinetics of KPG-818 in Healthy Subjects May 1, 2019 September 29, 2019
NCT03951259 Completed Phase 2 Safety and Efficacy of SM934 Compared to Placebo in Adult Subjects With Active Systemic Lupus Erythematosus July 24, 2019 October 19, 2023
NCT00424476 Completed Phase 3 A Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE) May 2007 March 2010
NCT03979976 Completed Phase 2/Phase 3 Ramipril, Endothelial Function and Endothelial Progenitor Cells in Patients With Systemic Lupus Erythematosus March 2011 September 2013
NCT00280137 Completed Health-related Quality of Life Measure in Pediatric Lupus June 2004 December 2013
NCT04082416 Completed Phase 3 Study of Recombinant Human B Lymphocyte(RC18) Administered Subcutaneously to Subjects With Systemic Lupus Erythematosus(SLE) October 16, 2019 June 30, 2022
NCT00293072 Completed Phase 2 Pilot Study of Rituximab Therapy for Systemic Lupus Erythematosus (SLE) and Vasculitis March 2002 May 2005
NCT04136145 Completed Phase 1 Single Dose Study to Investigate the Pharmacokinetics (PK) and Safety of Belimumab 200 Milligrams (mg) Intravenous and 200 mg Subcutaneous Via Auto-injector in Chinese Healthy Subjects October 28, 2019 January 14, 2020
NCT05001698 Completed Phase 1 Anifrolumab PK Study for Systemic Lupus Erythematosus (SLE) July 27, 2021 June 2, 2022
NCT04180228 Completed Human Papilloma Virus Vaccination and Chronic Inflammatory Rheumatic Diseases. January 23, 2020 May 4, 2021
NCT02908100 Completed Phase 2 A Study of the Safety and Efficacy of GDC-0853 in Participants With Moderate to Severe Active Systemic Lupus Erythematosus January 19, 2017 July 16, 2019
NCT05146414 Completed Clonal Hematopoiesis of Indeterminate Potential and Accelerated Atherosclerosis in Systemic Lupus Erythematosus July 10, 2007 February 10, 2021
NCT02925351 Completed Early Phase 1 Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases January 25, 2016 April 30, 2018
NCT02932137 Completed N/A Anti-infection of Low-does IL-2 in SLE May 5, 2016 August 30, 2017
NCT02950714 Completed N/A Dissemination of the Lupus Interactive Navigator October 30, 2017 July 31, 2018
NCT02955615 Completed Phase 2 ILT-101 in Patients With Active Moderate to Severe Systemic Lupus Erythematosus (SLE) January 18, 2017 February 11, 2019
NCT02962960 Completed Phase 2 A Study to Characterize the Pharmacokinetics, Pharmacodynamics, and Safety of Anifrolumab in Adult Type I Interferon Test High Systemic Lupus Erythematosus Subject With Active Skin Manifestations February 14, 2017 December 17, 2018
NCT05123586 Completed Phase 2 A IMMA Master Protocol: A Study of LY3361237 in Participants With at Least Moderately Active Systemic Lupus Erythematosus March 7, 2022 December 29, 2023
NCT03093402 Completed Phase 2 JBT-101 in Systemic Lupus Erythematosus (SLE) December 21, 2017 July 28, 2021
NCT03107442 Completed N/A Exercise and Arterial Stiffness in Systemic Lupus Erythematosus April 12, 2017 July 21, 2017
NCT00119678 Completed Phase 2 Abatacept in the Treatment and Prevention of Active Systemic Lupus Erythematosus (SLE) Flares in Combination With Prednisone September 2005 November 2008
NCT03142711 Completed Validation of a Mobile Phone Based on EPRO Tool in Subjects With Systemic Lupus Erythematosus August 21, 2017 July 3, 2018
NCT00120887 Completed Phase 4 Lupus Atherosclerosis Prevention Study April 2002 December 2005
NCT00124514 Completed Phase 2 Triptorelin for Ovary Protection in Childhood Onset Lupus June 2003 March 2014
NCT00155532 Completed Phase 1 Skin Denervation in Systemic Lupus Erythematosus April 2002 March 2004
NCT03179046 Completed Cardiac and Laboratory Findings in Patients With Systemic Lupus Erythematosus April 1, 2018 July 1, 2019
NCT05115370 Completed Vaccination Perception in Inflammatory Conditions - Flu, Pneumonia and COVID-19 November 1, 2021 January 14, 2022
NCT03189017 Completed Phase 1 A Phase I Study of ICP-022 in Healthy Subjects July 3, 2017 October 30, 2018
NCT03189875 Completed Systemic Lupus Erythematosus (SLE) Prospective Observational Cohort Study (SPOCS) June 28, 2017 November 18, 2022
NCT03206359 Completed GADD34 and Type I IFN Response Genes in SLE January 25, 2012 April 3, 2015
NCT00001212 Completed Phase 2 Drug Therapy in Lupus Nephropathy November 1986 September 2004
NCT03252587 Completed Phase 2 An Investigational Study to Evaluate BMS-986165 in Participants With Systemic Lupus Erythematosus September 21, 2017 October 28, 2021
NCT03254784 Completed Phase 1 A Study to Evaluate BMS-986165 Tablet Formulation Relative to BMS-986165 Capsule Formulation and the Effect of a High-Fat/ High-Calorie Meal and Increased Gastric pH on the BMS-986165 Tablet Formulation September 13, 2017 November 15, 2017
NCT03262727 Completed Phase 1 The Effect of BMS-986165 Combined With an Oral Contraceptive (Ethinyl Estradiol/Norethindrone) in Healthy Female Patients September 1, 2017 December 19, 2017
NCT03288324 Completed Phase 1/Phase 2 Open-label Study of Tofacitinib for Moderate to Severe Skin Involvement in Young Adults With Lupus August 23, 2017 December 1, 2022
NCT00181298 Completed N/A Memantine in Systemic Lupus Erythematosus March 2006 May 2007
NCT03312907 Completed Phase 3 A Study to Evaluate the Efficacy and Safety of Belimumab Administered in Combination With Rituximab to Adult Subjects With Systemic Lupus Erythematosus (SLE) - BLISS-BELIEVE March 1, 2018 July 7, 2021
NCT03334851 Completed Phase 1 Safety and Tolerability Study Of PF-06835375 In Subjects With Seropositive Systemic Lupus Erythematosus Or Rheumatoid Arthritis November 17, 2017 February 15, 2022
NCT03371251 Completed Phase 1/Phase 2 Study of BOS161721 in Systemic Lupus Erythematosus (SLE) Patients on a Background of Limited Standard of Care January 10, 2018 November 26, 2020
NCT03374618 Completed N/A Neutrophil Extracellular Traps in Systemic Sclerosis February 23, 2018 April 29, 2021
NCT03393013 Completed Phase 1/Phase 2 A Study of KZR-616 in Patients With SLE With and Without Lupus Nephritis February 20, 2018 August 4, 2022
NCT00001676 Completed Phase 1 Cyclophosphamide and Fludarabine to Treat Lupus Nephritis January 1998 November 2002
NCT00189124 Completed Phase 2/Phase 3 Dehydroepiandrosterone (DHEA) in Systemic Lupus Erythematosus (SLE) for Coronary Artery Disease (CAD) Prevention September 2003 July 2006
NCT03451422 Completed Phase 1 Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Efavaleukin Alfa in Participants With Systemic Lupus Erythematosus April 10, 2018 October 12, 2021
NCT06046534 Completed Retrospective Medical Chart Review Study to Describe the Experience of SLE Patients Treated With Anifrolumab in the Early Access Programs. October 27, 2023 June 10, 2024
NCT03480529 Completed Monitoring the IMmUological TOXicity of Drugs March 1, 2018 March 10, 2018
NCT03537638 Completed N/A Multicomponent Strategy to Implement a Clinical Practice Guideline and Improve Health Outcomes in People With SLE April 16, 2018 December 31, 2020
NCT03541564 Completed Phase 1 An Investigational Study of Experimental Medication BMS-986165 in Healthy Participants to Study Electrocardiogram Effects May 30, 2018 September 4, 2018
NCT03556007 Completed Phase 1 A Study of NKTR-358 (LY3471851) in Participants With Systemic Lupus Erythematosus (SLE) April 18, 2018 August 29, 2019
NCT03575156 Completed N/A Microparticles's Role in the Pathophysiology of Systemic Lupus Erythematosus and Systemic Sclerosis September 20, 2018 September 14, 2021
NCT00470522 Completed Phase 3 Study of Methotrexate in Lupus Erythematosus June 1995 December 2001
NCT00004662 Completed Phase 3 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone in Women With Active Systemic Lupus Erythematosus March 1996
NCT03616964 Completed Phase 3 A Study of Baricitinib in Participants With Systemic Lupus Erythematosus (SLE-BRAVE II) August 2, 2018 October 20, 2021
NCT03618056 Completed Phase 1 Evaluating HIV-1 Neutralization Antibody Breadth in Response to HIV gp120 Protein Vaccine in HIV-uninfected Adults With Quiescent Systemic Lupus Erythematosus December 19, 2018 July 17, 2020
NCT03724916 Completed Phase 1 A Study to Evaluate the Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of TAK-079 in Combination With Standard Background Therapy in Participants With Moderate to Severe Systemic Lupus Erythematosus (SLE) November 26, 2018 November 4, 2021
NCT03738826 Completed N/A Reducing Disparities in Medication Adherence in SLE October 2, 2019 June 7, 2020
NCT03742037 Completed Phase 2 Efficacy and Safety of Four Doses of Cenerimod Compared to Placebo in Adult Subjects With Active Systemic Lupus Erythematosus December 21, 2018 August 25, 2022
NCT00541749 Completed Phase 1 A Study of rhuMAb IFNalpha in Adults With Systemic Lupus Erythematosus February 2007
NCT04786431 Completed Shotgun Mass Spectrometry-based Lipid Profiling in Chronic Inflammatory Diseases March 1, 2015 March 1, 2021
NCT00401141 Completed N/A Abnormalities of B Lymphocytes During Systemic Lupus April 2004
NCT00410384 Completed Phase 3 A Study of Belimumab in Subjects With Systemic Lupus Erythematosus December 2006 March 2010
NCT00544102 Completed Insulin Resistance and Atherosclerosis in Women With Lupus October 11, 2007 September 7, 2017
NCT00556192 Completed Phase 2 Can Targeted Elimination of B-cell Depletion Therapy and/or Combination Therapy on Systemic Lupus Erythematosus June 2006 December 2009
NCT04857151 Completed Early Phase 1 Stress, Inflammation and Immune Response Pilot Study- Aim 3 February 2, 2022 March 31, 2024
NCT04873739 Completed AS-OCT Study of Cornea and Tear Film Parameters in SLE Patients July 1, 2020 March 30, 2021
NCT00583362 Completed Phase 2 A Continuation Trial for Subjects With Systemic Lupus Erythematosus That Have Completed Protocol LBSL02 May 4, 2005 February 23, 2016
NCT00588393 Completed Phase 2 FolateScan in Autoimmune Disease September 2006 December 2007
NCT00594932 Completed Phase 1/Phase 2 Biomarker-Linked Outcomes of Cellcept in Lupus Arthritis November 2006 April 2009
NCT00611611 Completed BLYS and IFN in SLE October 2007 April 2009
NCT00624351 Completed Phase 2 Study of Epratuzumab in Serologically-positive Systemic Lupus Erythematosus (SLE) Patients With Active Disease January 2008 August 2009
NCT00657007 Completed Phase 1 Phase 1 Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE) February 2002 March 2003
NCT00660881 Completed Phase 2 Open-label Study of Epratuzumab in Serologically-positive Systemic Lupus Erythematosus Patients With Active Disease May 2008 December 2011
NCT00668330 Completed Phase 4 Steroid Induced Osteoporosis in Patients With Systemic Lupus Erythematosus April 2007 May 2009
NCT00004756 Completed N/A Study of Individualized Instruction Versus Pamphlet in Systemic Lupus Erythematosus December 1994
NCT00710021 Completed Phase 2 Vitamin D3 in Systemic Lupus Erythematosus November 2008 July 2011
NCT00712933 Completed Phase 3 A Continuation Trial for Subjects With Lupus That Completed Protocol HGS1006-C1056 or HGS1006-C1057 May 30, 2008 December 9, 2016
NCT00723671 Completed N/A Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus November 2006 December 2013
NCT00724867 Completed Phase 3 A Continuation Trial for Subjects With Lupus Who Completed Protocol HGS1006-C1056 in the United States August 2008 March 2015
NCT00731302 Completed Phase 1 Aspirin Resistance in Systemic Lupus Erythematosus (SLE) April 2005 April 2017
NCT00004795 Completed Phase 2/Phase 3 Phase II/III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone in Women With Mild to Moderate Systemic Lupus Erythematosus August 1994
NCT00774943 Completed Phase 1 A Study of AMG 557 in Adults With Systemic Lupus Erythematosus December 2008 May 2012
NCT00786409 Completed N/A Immunogenicity and Safety of HPV Vaccine Gardasil in Young Women November 2008 December 2011
NCT00815282 Completed Phase 4 Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease February 2009 January 2015
NCT00818948 Completed Phase 1 Safety Study of AMG 811 in Subjects With Systemic Lupus Erythematosus With and Without Glomerulonephritis March 2009 August 2014
NCT00828178 Completed Phase 4 Efficacy of Fish Oil in Lupus Patients February 2009 February 2011
NCT05430087 Completed Phase 2 Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients March 1, 2020 January 31, 2022
NCT00006133 Completed N/A Randomized Study of Oral Contraceptives or Hormone Replacement Therapy in Women With Systemic Lupus Erythematosus June 2000
NCT00911521 Completed Phase 4 Immunogenicity and Safety of a Quadrivalent Human Papillomavirus (HPV) Vaccine in Patients With SLE: a Controlled Study October 2009 June 2011
NCT00962832 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of Rontalizumab in Patients With Moderately to Severely Active Systemic Lupus Erythematosus September 2009 August 2013
NCT00976300 Completed Phase 2 Cyclosporine A or Intravenous Cyclophosphamide for Lupus Nephritis: The Cyclofa-Lune Study January 2002 April 2009
NCT00976729 Completed Phase 1 NOX-E36 First-in-Human (FIH) Study May 2009 December 2009
NCT00979654 Completed Phase 2 A Study to Evaluate the Long-Term Safety of MEDI-545 in Adult Participants With Systemic Lupus Erythematosus or Myositis August 2010 March 2015
NCT00982670 Completed A Study of the Metabolic Syndrome in Patients With Systemic Lupus Erythematosus July 2008 June 2009
NCT00006134 Completed Study of the Predictors of the Course and Early Outcome of Patients With Systemic Lupus Erythematosus: Nature Versus Nurture September 1993
NCT00987831 Completed Phase 1/Phase 2 Biomarkers of Lupus Disease: Serial Biomarker Sampling in Patients With Active Systemic Lupus Erythematosus (SLE) May 2009 December 2012
NCT00997100 Completed Phase 2 Exploratory Study of Changes in Disease Activity and Biomarkers With ABR-215757 in Patients With Mild Active Systemic Lupus Erythematosus (SLE) August 2009 September 2010
NCT01031836 Completed Phase 2 A Study to Evaluate Safety and Tolerability of IV or SC Dose of MEDI-545 in Patients With Systemic Lupus Erythematosus. November 25, 2009 July 11, 2016
NCT01058343 Completed Phase 1/Phase 2 Safety of IFNa Kinoid in Systemic Lupus Erythematosus March 2010 June 2016
NCT01076101 Completed Autoimmunity in Sisters of Lupus Patients February 2009 December 31, 2016
NCT01101802 Completed Phase 4 Mycophenolate Mofetil in Systemic Lupus Erythematosus (MISSILE) March 2006 October 2008
NCT01112215 Completed Phase 4 Enteric-coated Mycophenolate Sodium Versus Azathioprine for the Extra-renal Lupus Manifestations December 2009 December 2015
NCT01120652 Completed N/A Reducing Depressive Symptoms in Systemic Lupus Erythematosus November 2009 September 2015
NCT01135459 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of CEP-33457 in Participants With Systemic Lupus Erythematosus (SLE) June 24, 2010 June 30, 2012
NCT01157468 Completed Catalytic Antibodies and Lupus in Martinique January 2012 December 2013
NCT01162681 Completed Phase 2 PEARL-SC Trial: A Study of the Efficacy, Safety, and Tolerability of A 623 Administration in Subjects With Systemic Lupus Erythematosus July 2010 April 2012
NCT05426902 Completed N/A Utilizing Qualitative and Quantitative Methods to Understand a New Model of Type 1 and 2 Systemic Lupus Erythematosus (SLE) January 3, 2022 June 30, 2022
NCT01170585 Completed Phase 2 A Trial of Rosuvastatin in Systemic Lupus Erythematosus July 2010 June 2014
NCT01176643 Completed N/A Development and Evaluation of Modified Yoga in Systemic Lupus Erythematosus (SLE) August 2010 August 2013
NCT01196091 Completed Phase 3 A Study of LY2127399 in Participants With Systemic Lupus Erythematosus December 2010 June 2015
NCT01205438 Completed Phase 3 A Study of LY2127399 in Participants With Systemic Lupus Erythematosus January 2011 March 2015
NCT01230112 Completed The Role of ITGAM in Systemic Lupus Erythematosus December 2009 April 2012
NCT01261793 Completed Phase 3 Study of Epratuzumab Versus Placebo in Subjects With Moderate to Severe General Systemic Lupus Erythematosus (SLE) December 2010 June 2015
NCT01262365 Completed Phase 3 Study of Epratuzumab Versus Placebo in Subjects With Moderate to Severe General Systemic Lupus Erythematosus December 2010 May 2015
NCT01269866 Completed N/A Study of Duloxetine in the Reduction of Pain in Patient With Systemic Lupus Erythematosus December 2010 May 2012
NCT01283139 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of Sifalimumab in Adults With Systemic Lupus Erythematosus March 31, 2011 April 17, 2014
NCT01305746 Completed Phase 2 A Trial for Subjects With Systemic Lupus Erythematosus Who Have Completed Protocol AN-SLE3321 April 2011 October 2013
NCT01322308 Completed Phase 4 Effect of Pioglitazone on Endothelial Function in Premenopausal Women With Uncomplicated Systemic Lupus Erythematosus March 2007 January 2012
NCT01330368 Completed Spine Quantitative Computed Tomography (QCT) for the Assessment of Osteoporosis on Children October 2010 June 2017
NCT01345253 Completed Phase 3 GSK1550188 A 52 Week Study of Belimumab Versus Placebo in the Treatment of Subjects With Systemic Lupus Erythematosus (SLE) Located in Northeast Asia May 23, 2011 September 21, 2018
NCT01351662 Completed Phase 1/Phase 2 Balancing Lupus Experiences With Stress Strategies August 2010 October 2011
NCT01381536 Completed Phase 1 Phase I Study of GSK1550188 in Japanese Subjects With Systemic Lupus Erythematosus (SLE) July 20, 2010 November 27, 2010
NCT01395745 Completed Phase 3 CHABLIS-SC1: A Study of the Efficacy and Safety of Subcutaneous Blisibimod in Subjects With Systemic Lupus Erythematosus February 2013 October 2016
NCT01408576 Completed Phase 3 Open Label Extension Study of Epratuzumab in Subjects With Systemic Lupus Erythematosus July 2011 February 2016
NCT01425775 Completed N/A The Effect of Vitamin D Supplementation on Disease Activity Markers in Systemic Lupus Erythematosus (SLE) April 2010 May 2011
NCT01438489 Completed Phase 2 A Study of the Efficacy and Safety of MEDI-546 in Systemic Lupus Erythematosus January 2012 April 2015
NCT01449071 Completed Phase 1/Phase 2 Study Evaluating the Pharmacokinetics and Safety of Epratuzumab in Japanese Systemic Lupus Erythematosus (SLE) October 2011 March 2013
NCT00010335 Completed Phase 1 Pilot Study of Total Body Irradiation in Combination With Cyclophosphamide, Anti-thymocyte Globulin, and Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation in Children With Refractory Autoimmune Disorders November 2000 May 2011
NCT01474720 Completed Phase 1 Zostavax in Systemic Lupus Erythematosus November 2011 October 2012
NCT01475149 Completed Effect of HCQ on AnxA5 Resistance Assay in Antiphospholipid (aPL) Positive Patients With and Without Systemic Lupus Erythematosus (SLE) September 2010 August 2016
NCT01484496 Completed Phase 3 A Study of Belimumab Administered Subcutaneously in Subjects With Systemic Lupus Erythematosus (SLE) November 16, 2011 October 1, 2015
NCT00522002 Completed CLUE Study: Connective Tissue Disease Leg Ulcer Etiology Study August 2007 June 2010
NCT01509989 Completed International Prospective Study on Adherence to Treatment in Patients With Active Systemic Lupus Erythematosus January 2013 March 2016
NCT00010400 Completed N/A Pilot Study of Cyclophosphamide in Patients With Life-Threatening Systemic Lupus Erythematosus or Antiphospholipid Antibody Syndrome April 1997
NCT01516450 Completed Phase 1 Japanese phase1 Study of Belimumab (IV vs SC) December 26, 2011 April 11, 2012
NCT01520155 Completed CArdiovascular Risk Assessment STudy in Lupus Erythemathodes (CASTLE) December 2011 December 2012
NCT01532310 Completed Belimumab (BENLYSTA®) Pregnancy Registry July 16, 2012 November 11, 2022
NCT01534403 Completed Phase 2 Open Label Extension Study of Epratuzumab in Japanese Systemic Lupus Erythematosus (SLE) Subjects January 2012 February 2015
NCT00004663 Completed Epidemiologic Study of Reproductive Outcome in Women With Systemic Lupus Erythematosus February 1994
NCT01549184 Completed Retrospective Analysis of the Safety and Efficacy of Hydroxychloroquine in Immune Thrombocytopenia December 2010 December 2011
NCT01559090 Completed Phase 2 Safety and Tolerability of Intravenous Dose of MEDI-546 in Japanese Subjects With Systemic Lupus Erythematosus. April 20, 2012 February 21, 2017
NCT01597492 Completed Phase 4 A Study to Evaluate the Effect of Belimumab on Vaccine Responses in Subjects With Systemic Lupus Erythematosus (SLE) May 31, 2012 September 24, 2015
NCT01597622 Completed Phase 3 BEL114333, a Continuation Study of BEL113750 in Subjects With Systemic Lupus Erythematosus (SLE) in Northeast Asia, and in Japan Subjects Completing the Open-label Extension of HGS1006-C1115 June 11, 2012 September 13, 2018
NCT01616472 Completed WEUKBRE5716: Steroid-related Damage in Systemic Lupus Erythematosus (Hopkins) April 2012 January 2016
NCT01632241 Completed Phase 4 Efficacy and Safety of Belimumab in Black Race Patients With Systemic Lupus Erythematosus (SLE) February 19, 2013 January 28, 2019
NCT00011908 Completed Phase 1 Humanized LL2IGG to Treat Systemic Lupus Erythematosus February 2001 January 2003
NCT00000420 Completed Phase 3 Safety of Estrogens in Lupus: Birth Control Pills June 1997 August 2003
NCT01687309 Completed Phase 1 A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of GSK2586184 and the Effect of Food and Gender April 30, 2012 July 31, 2012
NCT00519363 Completed Phase 1/Phase 2 Statins and Lupus: Effects of Statins on Clinical Lupus Parameters, Serological Markers and Toll-like Receptors September 2007 December 2008
NCT01689350 Completed N/A A Prospective Study of Cyclophosphamide in Systemic Lupus Erythematosus Treatment October 2012 March 2014
NCT01697254 Completed The CARRA Registry August 2009 October 2015
NCT01705977 Completed Phase 4 Belimumab Assessment of Safety in SLE November 27, 2012 August 10, 2022
NCT00513591 Completed Duke Autoimmunity in Pregnancy Registry August 2007 November 19, 2018
NCT00035308 Completed Phase 3 Safety and Efficacy Study of LJP 394 (Abetimus Sodium) to Treat Lupus Kidney Disease December 2002
NCT01741012 Completed Phase 1 Study to Determine if Gardasil Vaccine is Safe and Effective in Lupus Patients January 2013 November 2015
NCT00000421 Completed Phase 2 Serologically Active, Clinically Stable Systemic Lupus Erythematosus September 1997 August 2003
NCT05329831 Completed N/A Effects of Telehealth Initiative on Lupus Patients March 15, 2022 June 30, 2022
NCT01837875 Completed N/A Intervention to Improve Quality of Life in African American Lupus Patients April 2013 August 31, 2016
NCT00042523 Completed Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus July 2002 January 2005
NCT00046774 Completed Phase 1 Monoclonal Antibody Treatment for Systemic Lupus Erythematosus September 2, 2002 September 7, 2017
NCT01892748 Completed N/A Cholecalciferol Supplementation on Disease Activity, Fatigue and Bone Mass on Juvenile Systemic Lupus Erythematosus. July 2012 February 2014
NCT01894360 Completed Phase 1 A Study to Estimate the Relative Bioavailability, Tolerability and Safety of a Single Dose of Belimumab Self-Administered Subcutaneously (SC) by Healthy Subjects October 14, 2013 May 13, 2014
NCT01911169 Completed Phase 2 Vitamin D to Improve Endothelial Function in SLE June 2011 January 2014
NCT01914770 Completed Effectiveness of Belimumab Treatment in a Subpopulation of Systemic Lupus Erythematosus (SLE) Patients: a Pooled Analysis of BLISS-52 and BLISS-76 July 2009 November 2010
NCT01931644 Completed At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions July 2013 April 2024
NCT01953835 Completed Phase 1 A Two-part Study to Investigate the Interaction and Pharmacokinetics of GSK2586184 October 4, 2013 March 10, 2014
NCT00054938 Completed Phase 2 Prevention of Atherosclerosis and Heart Disease in Patients With Systemic Lupus Erythematosis (SLE) March 2003 December 2005
NCT01988506 Completed Phase 2 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases January 6, 2014 April 1, 2021
NCT02021513 Completed Phase 2 Pilot Study - Effect of Omega-3 on Systemic Lupus Erythematosus January 2012 June 2013
NCT00055055 Completed Study of Families With Twins or Siblings Discordant for Rheumatic Disorders April 21, 2003
NCT05287581 Completed N/A Motivating Individuals With Lupus to Exercise January 17, 2022 October 31, 2023
NCT02084238 Completed N/A Low-dose IL-2( Interleukin-2) Treatment in SLE August 2013 October 2015
NCT02106897 Completed Phase 1 Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses and Multiple Doses of BIIB059 (Litifilimab) in Healthy Volunteers and Participants With Systemic Lupus Erythematosus April 30, 2014 May 24, 2016
NCT02119156 Completed Phase 3 Belimumab Treatment Holiday and Treatment Re-start Study in Lupus Patients May 13, 2014 December 14, 2018
NCT02124798 Completed Phase 2 A Phase 2B Open-Label, Single-Arm, Repeat-Dose Study to Evaluate the Reliability of an Autoinjector May 20, 2014 April 13, 2015
NCT02151409 Completed Phase 1 Dose-escalation Trial of Anti-C5aR Antibody in Healthy Subjects June 2008 October 2009
NCT02185040 Completed Phase 2 A Pilot Study of CC-220 to Treat Systemic Lupus Erythematosus. September 16, 2014 September 25, 2018
NCT02194400 Completed Phase 1 Dose Escalation Study of RSLV-132 in Subjects With Systemic Lupus Erythematosus July 2014 November 2015
NCT02270957 Completed Phase 2 Clarification of Abatacept Effects in SLE With Integrated Biologic and Clinical Approaches January 2014 December 2021
NCT00069342 Completed Health Beliefs and Health Behaviors Among Minorities With Rheumatic Diseases September 22, 2003 April 12, 2018
NCT02281513 Completed N/A Activity and Nutrition Trial in Lupus to Energize and Renew October 2014 September 11, 2023
NCT02291588 Completed Phase 1 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 811 in Subjects With Systemic Lupus Erythematosus December 2007 June 2010
NCT02306629 Completed Phase 1 Study to Compare Properties of Epratuzumab When Given as an Injection Under the Skin or Directly Into the Blood November 2014 April 2015
NCT02307643 Completed Phase 1 Exploratory Study of MT-1303 in Systemic Lupus Erythematosus Patients February 2015 May 2017
NCT02319525 Completed N/A Individualized Patient Decision Making for Treatment Choices Among Minorities With Lupus January 2014 December 2016
NCT02321709 Completed Phase 1 Multiple Ascending Dose Study To Assess The Safety Profile Of SAR113244 Versus Placebo In Lupus Male And Female Patients November 2014 March 2016
NCT02330250 Completed N/A Effectiveness of Pharmaceutical Care in the Adherence of Systemic Lupus Erythematosus Treatment July 2014 June 2016
NCT02338999 Completed Phase 1/Phase 2 Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE) June 18, 2015 July 14, 2020
NCT02350491 Completed Study During Pregnancy of Expression of miRNAs in RA or SLE December 17, 2017 October 14, 2018
NCT02364908 Completed N/A Prospective Evaluation of Decision and Compliance With Antimalarials in Patients With Systemic Lupus December 2014 December 2016
NCT02391259 Completed Phase 1 A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of AMG 557 in Subjects With Systemic Lupus Erythematosus November 2006 November 2011
NCT00071175 Completed Lupus Genetics Studies October 1995 November 2013
NCT05247203 Completed Phase 1 Telitacicept Study in Chinese Subjects With Systemic Lupus Erythematosus May 11, 2022 November 13, 2023
NCT02411136 Completed Phase 1 A Study to Examine the Safety, Pharmacokinetics and Pharmacodynamics of AMG 623 in Subjects With Systemic Lupus Erythematosus May 2005 October 2007
NCT02443506 Completed Phase 1 A Study to Examine the Safety, Pharmacokinetics and Pharmacodynamics of Single Dose of AMG 623 in Subjects With Systemic Lupus Erythematosus October 2004 June 2007
NCT02453880 Completed N/A Web-based CBT for Symptoms of Mild-to-Moderate Anxiety and Depression in Youth With Chronic Illness January 2014 August 2015
NCT02456168 Completed Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus January 21, 2014 October 28, 2020
NCT00074373 Completed The Research Registry for Neonatal Lupus May 27, 2010 June 2016
NCT02472795 Completed Phase 1/Phase 2 Clinical Study to Investigate the Biological Activity, Safety, Tolerability, and Pharmacokinetics of ACT-334441 in Subjects With Systemic Lupus Erythematosus June 1, 2015 February 28, 2017
NCT02477150 Completed Phase 4 Safety and Immunogenicity of a Zoster Vaccine in SLE November 2015 January 2019
NCT02477254 Completed Long-term Immunogenicity of a HPV Vaccine in SLE July 2015 October 2016
NCT05203692 Completed Phase 1 A Study of a Single Ascending Dose Study of DS-7011a in Healthy Subjects February 2, 2022 March 22, 2023
NCT02524795 Completed N/A Omega 3 Fatty Acids and Systemic Lupus Erythematosus March 2009 March 2014
NCT02530944 Completed Web-based Genetic Research on Lupus May 2015 October 31, 2017
NCT03757065 Completed Cell Surface Marker Expression in Autoimmune Diseases June 12, 2019 October 25, 2019
NCT02535689 Completed Phase 1 Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Systemic Lupus Erythematosus August 28, 2015 April 26, 2018
NCT02554019 Completed Phase 2 Proof-of-Concept Study With BT063 in Subjects With Systemic Lupus Erythematosus September 28, 2015 October 25, 2017
NCT02554474 Completed N/A OPAM-IA: Using Digital Activity Trackers to Improve Physical Activity in Inflammatory Arthritis January 1, 2017 August 25, 2019
NCT00082511 Completed Phase 3 GL701 (Prestara™) in Women With Systemic Lupus Erythematosus Receiving Treatment With Glucocorticoids July 2003 August 2005
NCT02609789 Completed Phase 1 A Single Ascending Dose Study in Healthy Participants and Multiple Dose Study of JNJ-55920839 in Participants With Mild to Moderate Systemic Lupus Erythematosus December 2015 September 2018
NCT02618967 Completed Phase 1 Single Ascending Dose Study of AMG 570 in Healthy Subjects March 28, 2016 December 3, 2018
NCT02631005 Completed N/A Walk With Ease Program For Patients With Systemic Lupus Erythematosus March 2016 August 30, 2018
NCT02660944 Completed Phase 2 A Phase 2a of RSLV-132 in Subjects With Systemic Lupus Erythematosus (SLE) January 3, 2016 August 10, 2020
NCT02708095 Completed Phase 2 A Study of Baricitinib (LY3009104) in Participants With Systemic Lupus Erythematosus (SLE) March 24, 2016 November 9, 2017
NCT02725515 Completed Phase 2 A Study of the Effect of XmAb®5871 in Patients With Systemic Lupus Erythematosus February 16, 2016 July 17, 2018
NCT00483613 Completed N/A Effects of Treatment of Chronic Stress in Patients With Lupus December 2003 July 2005
NCT02741960 Completed Phase 4 The Effect of Metformin on Reducing Lupus Flares May 24, 2016 December 7, 2018
NCT02769195 Completed Utility of a Measure of Lupus Low Disease Activity State (LLDAS) in SLE April 2016 January 2019
NCT02842814 Completed N/A Prediction of Relapse Risk in Stable Systemic Lupus Erythematosus October 2016 September 28, 2022
NCT02847598 Completed Phase 2 Study to Evaluate BIIB059 (Litifilimab) in Cutaneous Lupus Erythematosus (CLE) With or Without Systemic Lupus Erythematosus (SLE) October 20, 2016 November 18, 2019
NCT02880852 Completed Phase 1 Belimumab Phase I Study in Chinese Subjects With Systemic Lupus Erythematosus January 23, 2017 September 8, 2017
NCT02885610 Completed Phase 2 Study of RC18 Administered Subcutaneously to Subjects With Systemic Lupus Erythematosus(SLE) December 2015 July 9, 2019
NCT04976322 Enrolling by invitation Phase 3 A Study to Evaluate the Safety and Tolerability of Dapirolizumab Pegol in Study Participants With Systemic Lupus Erythematosus July 27, 2021 April 10, 2029
NCT06294483 Enrolling by invitation Comparison Between Early-onset and Late-onset Patients With Systemic Lupus Erythematosus. January 10, 2024 August 30, 2024
NCT04750057 No longer available Anifrolumab Early Access Program
NCT03125486 No longer available Compassionate Use for Subcutaneous (SC) Belimumab
NCT06106906 Not yet recruiting Phase 1/Phase 2 A Clinical Study of CD19 CAR-T in Refractory/Moderate-to-severe Systemic Lupus Erythematosus December 2023 December 2026
NCT06417398 Not yet recruiting Early Phase 1 Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases May 14, 2024 May 1, 2025
NCT05613582 Not yet recruiting N/A The Effectiveness of Transcranial Direct Current Stimulation as Adjunctive Treatment for Chronic Daily Headache in Systemic Lupus Erythematosus November 20, 2022 September 20, 2023
NCT06404723 Not yet recruiting The Predictive and Prognostic Values of the Fibrinogen to Albumin Ratio and C-reactive Protien to Albumin Ratio in Systemic Lupus Erythematosus Patients June 1, 2024 April 1, 2025
NCT04902807 Not yet recruiting Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation June 2021 December 2024
NCT06350110 Not yet recruiting Phase 1/Phase 2 Fourth-gen CAR T Cells Targeting BCMA/CD19 for Refractory Systemic Lupus Erythematosus (SLE) November 10, 2024 December 28, 2025
NCT06255028 Not yet recruiting Phase 1 A Study of CNTY-101 in Participants With Moderate to Severe Systemic Lupus Erythematosus (SLE) August 2024 August 2028
NCT04671706 Not yet recruiting Belimumab in Patients With Systemic Lupus Erythematosus January 2021 December 2026
NCT04893161 Not yet recruiting Phase 4 A Model About the Response of Belimumab in SLE June 1, 2024 January 31, 2026
NCT06411639 Not yet recruiting Phase 1 Pharmacokinetics Study of Ianalumab in Chinese Participants With Autoimmune Diseases November 25, 2024 June 24, 2028
NCT06340750 Not yet recruiting Phase 1 BAFF CAR-T Cells (LMY-920) for Systemic Lupus Erythematosus June 1, 2024 April 15, 2026
NCT06227559 Not yet recruiting The Role of Some Hematological Parameters in Juvenile Systemic Lupue Erythematosus February 1, 2024 June 1, 2024
NCT06413511 Not yet recruiting Phase 1 A Study to Investigate the Safety and Pharmacological Effect of a Single Intravenous Infusion of Belantamab in Male and Female Participants Aged 18 to 75 With Moderate to Severe Systemic Lupus Erythematosus May 29, 2024 November 24, 2025
NCT06456567 Not yet recruiting Phase 3 A Study of Telitacicept for the Treatment of Moderately to Severely Active Systemic Lupus Erythematosus (REMESLE-2) July 2024 April 2027
NCT05544448 Not yet recruiting N/A In Vitro Effect Study of Interleukin-2 Muteins on Regulatory T Cells of Patients With Different Autoimmune, Allo-immune or Inflammatory Diseases October 15, 2022 April 15, 2023
NCT06340490 Not yet recruiting Phase 1 A Study of RJMty19 in Refractory Systemic Lupus Erythematosus (SLE) May 15, 2024 December 31, 2027
NCT06365359 Not yet recruiting Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique April 15, 2024 November 15, 2025
NCT05516511 Not yet recruiting Serum Levels of Angiotensin Converting Enzyme in Systemic Lupus Erythematous Patients January 2023 March 2023
NCT06394063 Not yet recruiting N/A Efficacy and Safety of Telitacicept for Prevention of Flares in SLE Patients June 30, 2024 June 30, 2027
NCT05929248 Not yet recruiting Phase 2 Exploring the Therapeutic Effect of Telitacicept on Lupus Erythematosus Complicated With Thrombocytopenia July 1, 2023 December 30, 2024
NCT06465147 Not yet recruiting Phase 1 REACT-01: Reversing Autoimmunity Through Cell Therapy July 2024 July 2041
NCT06293365 Not yet recruiting Phase 2 Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease June 26, 2024 February 8, 2029
NCT05799378 Not yet recruiting Phase 3 Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease April 2024 December 21, 2028
NCT05504187 Not yet recruiting Phase 2 Study to Evaluate Safety, Tolerability and Pharmacodynamics of KP104 in Participants With Thrombotic Microangiopathy Secondary to Systemic Lupus Erythematosus October 2023 October 2024
NCT06458075 Not yet recruiting N/A Intervention to Improve Communication and Medication Adherence in Lupus July 2024 December 2028
NCT06349343 Not yet recruiting Phase 1 CD19/BCMA HLA-independent TCR-T Cell Therapy for Refractory/Moderate-to-severe Systemic Lupus Erythematosus April 2024 January 2026
NCT05465707 Not yet recruiting Phase 1/Phase 2 A Study of CM313 Injection in Subjects With Systemic Lupus Erythematosus October 30, 2022 October 30, 2023
NCT06448273 Not yet recruiting Phase 1 A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacokinetic of TQB3702 Tablets in Healthy Adult Subjects July 2024 October 2024
NCT06228222 Not yet recruiting Predictors of Remission and Renal Outcomes in Lupus Nephritis in Assuit University Hospitals. January 25, 2024 October 1, 2025
NCT05818254 Not yet recruiting N/A The HOP-STEP Intervention: Improving Maternal Health in Women With Lupus sIRB May 31, 2024 March 31, 2026
NCT06238531 Not yet recruiting Phase 1 A Clinical Trial to Evaluate Safety of Gusacitinib in Patients With Systemic Lupus Erythematosus (SLE) or Lupus June 23, 2024 October 1, 2028
NCT05424627 Not yet recruiting Myeloid Derived Suppressor Cells in Systemic Lupus Erythematosus July 15, 2022 January 15, 2027
NCT06379646 Not yet recruiting N/A An Clinical Study of YTS109 Cell Injection in Subjects With Recurrent/Refractory Autoimmune Disease April 22, 2024 April 21, 2026
NCT06356740 Not yet recruiting Phase 2 Efficacy and Tolerance of Abacavir/Lamivudine Treatment in Patients With Systemic Lupus Erythematosus September 1, 2024 June 1, 2029
NCT06188507 Not yet recruiting Phase 1 A First Time in Human Study to Evaluate the Safety and Tolerability of GSK3996401 Following Dosing With GSK4347859 in Healthy Participants January 11, 2024 March 31, 2025
NCT06421701 Not yet recruiting Phase 1 Anti-CD19 CAR-NK Cells in Refractory/Relapsed Systemic Lupus Erythematosus June 1, 2024 May 31, 2026
NCT06429800 Not yet recruiting Phase 1 A Study to Evaluate the Safety and Preliminary Efficacy of ATA3219 in Participants With Lupus Nephritis October 31, 2024 April 2029
NCT05917288 Not yet recruiting Phase 1 A Study of Belimumab in Chinese Pediatric Participants With Systemic Lupus Erythematosus June 29, 2023 January 4, 2025
NCT04749875 Not yet recruiting Study of Leukocyte Populations in Patients With Chronic Inflammatory March 1, 2021 March 1, 2026
NCT06360068 Not yet recruiting Phase 2 A Prospective, Single Arm, Open Label, Proof of Concept Clinical Study of Sulfasalazine in the Treatment of Active Systemic Lupus Erythematosus May 6, 2024 May 1, 2025
NCT05791799 Not yet recruiting Phase 2/Phase 3 Etonogestrel Implants Protect Ovarian Reserve Function in Systemic Lupus Erythematosus April 1, 2023 October 31, 2025
NCT06297408 Not yet recruiting Phase 1 Relma-cel for Moderate to Severe Active Systemic Lupus Erythematosus March 2024 May 2026
NCT06400537 Not yet recruiting Phase 1 Clinical Study of A-319 in the Treatment of Active/Refractory Systemic Lupus Erythematosus May 2024 May 2026
NCT05620407 Recruiting Phase 3 A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus January 12, 2023 December 17, 2027
NCT05631717 Recruiting Phase 3 The Study of Comparing the Efficacy and Safety of Human Umbilical Cord MSCs and Low-dose IL-2 in the Treatment of LN October 1, 2022 December 31, 2025
NCT05632029 Recruiting N/A Laser Acupuncture in Egyptian Systemic Lupus Females With Insulin Resistance October 20, 2022 March 30, 2023
NCT05637112 Recruiting A Treatment Effectiveness Study Among SLE Patients Receiving Anifrolumab in Routine Clinical Practice February 27, 2023 March 15, 2029
NCT05638802 Recruiting Phase 1/Phase 2 A Study of DS-7011a in Patients With Systemic Lupus Erythematosus June 7, 2023 March 15, 2025
NCT05639114 Recruiting Phase 3 Phase 3 Study to Evaluate Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1) March 2, 2023 January 16, 2029
NCT05659407 Recruiting BAFF-var as a Biomarker of Response to B-depletive Treatment in Systemic Lupus Erythematosus and Rheumatoid Arthritis July 24, 2020 January 31, 2023
NCT05666336 Recruiting Phase 4 Multi-omics Studies on the Efficacy of Telitacicept in Chinese SLE Patients December 31, 2022 June 30, 2024
NCT05687526 Recruiting Phase 1 A Study of Telitacicept in Subjects With Childhood-onset Systemic Lupus Erythematosus May 25, 2023 December 2024
NCT05689580 Recruiting N/A The Influence of Ketogenic Diet on Lupus Nephritis Patients' Immunity September 1, 2022 September 2024
NCT05698173 Recruiting N/A Systemic Lupus Erythematosus and Accelerated Aging September 8, 2023 September 2025
NCT05704153 Recruiting N/A Modelling and Control of Non-invasive Vagus Nerve Stimulation for Autoimmune Diseases (1A) September 30, 2022 October 2024
NCT05714930 Recruiting N/A LUPUS-BEST - Treat-to-target in Systemic Lupus Erythematosus December 12, 2023 September 30, 2026
NCT05748899 Recruiting N/A Effect of Applying Ujjayi Pranayama on Cortisol in Lupus Patients December 15, 2022 March 15, 2023
NCT05765006 Recruiting Phase 1 CD19-CART(Relma-cel) for Moderate to Severe Active Systemic Lupus Erythematosus February 24, 2023 December 30, 2025
NCT05796206 Recruiting Phase 2/Phase 3 A Clinical Study of MIL62 in Systemic Lupus Erythematosus May 26, 2023 July 2026
NCT05798117 Recruiting Phase 1/Phase 2 An Open-label, Study to Assess Safety, Efficacy and Cellular Kinetics of YTB323 in Severe, Refractory Systemic Lupus Erythematosus February 28, 2023 October 9, 2026
NCT05828147 Recruiting Phase 4 Anti-CD20 Antibodies for Treatment of SLE-PAH May 25, 2023 March 2026
NCT05835310 Recruiting Phase 3 An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants March 14, 2024 January 15, 2030
NCT05835986 Recruiting Phase 1 A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7507062 in Participants With Systemic Lupus Erythematosus December 18, 2023 November 30, 2027
NCT05843643 Recruiting Phase 3 Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus July 19, 2023 October 31, 2027
NCT05856448 Recruiting Phase 2 A Study Evaluating the Effects of GLPG3667 Administered as Oral Treatment in Adult Participants With Active Systemic Lupus Erythematosus June 28, 2023 April 2026
NCT05859191 Recruiting Study of Neonatal IgG Fc Receptor Expression in Natural Killer T Cells Expressing an Invariant T Receptor : Implication in the Pathophysiology of Systemic Lupus July 21, 2023 July 2029
NCT05866861 Recruiting Phase 1 A Study in Participants With Mild-to-moderate Systemic Lupus Erythematosus April 24, 2023 July 2024
NCT05869955 Recruiting Phase 1 A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases September 13, 2023 November 15, 2027
NCT05879419 Recruiting Phase 4 Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases May 23, 2023 May 22, 2027
NCT05880121 Recruiting Neuron-specific Humoral and Cellular Immune Correlates of Structural and Functional Brain Connectomics in Neuropsychiatric Lupus April 30, 2023 April 29, 2026
NCT05900232 Recruiting N/A Anti KU Antibodies and Its Relationship With Systemic Lupus Erythematosus May 15, 2023 November 1, 2023
NCT05916781 Recruiting Phase 4 Effectiveness of Mycophenolate Mofetil Combined With Tacrolimus for Steroid Tapering in Systemic Lupus Erythematosus July 1, 2023 July 31, 2026
NCT05927688 Recruiting Assessment of Physician Consideration of ePRO's, From Patients With Gout, Rheumatoid Arthritis, Sjogren's Syndrome or Systemic Lupus, on the Frequency of Therapeutic Adjustments July 18, 2023 July 2027
NCT05971498 Recruiting Assessment of Anxiety, Depression, Sleep Quality and Quality of Life in Systemic Lupus Erythematosus Patients August 14, 2023 March 1, 2024
NCT06001606 Recruiting Phase 3 Immunogenicity, Reactogenicity of Shingrix in SLE May 8, 2023 April 24, 2025
NCT06041568 Recruiting Phase 1 A Study of Imvotamab in Severe Systemic Lupus Erythematosus August 15, 2023 May 2026
NCT06056778 Recruiting The Prevalence Evaluation of Systemic Lupus Erythematosus in Russian Patients With Reproductive Issues (PRISMA) September 28, 2023 June 30, 2024
NCT06106893 Recruiting Phase 1/Phase 2 A Clinical Study of CD19 Universal CAR-γδT Cells in Active Systemic Lupus Erythematosus January 12, 2024 December 2026
NCT06119763 Recruiting AntiDFS70 Lupus Nephritis October 15, 2023 October 25, 2024
NCT06121297 Recruiting Phase 1/Phase 2 RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus February 16, 2024 December 2027
NCT06133972 Recruiting Phase 3 Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension). May 21, 2024 December 23, 2031
NCT06137053 Recruiting Effect of Telitacicept on Transitional Regulatory B Cells in Patients With Systemic Lupus Erythematosus November 1, 2022 December 31, 2025
NCT06151990 Recruiting Assessment of Lipid Profile in Juvenile Systemic Lupus Erythematosus December 2023 October 2025
NCT06153095 Recruiting Phase 1/Phase 2 A Study of IMPT-514 in Active Refractory Systemic Lupus Erythematosus (SLE) February 15, 2024 February 2027
NCT06161116 Recruiting Phase 2 Efficacy And Safety Of MK-6194 In Adult Participants With Systemic Lupus Erythematosus (MK-6194-006) December 27, 2023 July 9, 2027
NCT06222853 Recruiting Phase 1 Study of Therapeutic Efficacy of Anti-CD19 CAR-T Cells in Children With Refractory Systemic Lupus Erythematosus January 4, 2024 December 30, 2026
NCT06226324 Recruiting fMRI Study of Early Brain Injury in Systemic Lupus Erythematosus January 1, 2023 December 2024
NCT06255743 Recruiting N/A (Anti-Ribosomal P Protein,Anti-U1 RNP, Anti-Nucleosome and Anti-ds DNA Antibodies) and Relation to Depression and Anxiety in SLE February 14, 2024 February 14, 2025
NCT06294236 Recruiting Phase 1 Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM) April 29, 2024 March 2028
NCT06308770 Recruiting N/A Fatigue in Lupus Intervention Programmes (FLIP) April 8, 2024 April 2027
NCT06308978 Recruiting Phase 1 FT819 in Moderate to Severe Active Systemic Lupus Erythematosus February 24, 2024 September 30, 2042
NCT06316076 Recruiting Phase 1 Safety and Efficacy Study of CD19-CAR-DNT Cells in Autoimmune Diseases October 30, 2023 June 2026
NCT06327724 Recruiting Belimumab in SLE Synovial Inflammation and Lymph Nodes September 1, 2023 March 1, 2025
NCT06333483 Recruiting Phase 1 A Study of CD19 Targeted CAR T Cell Therapy in Patients With Severe, Refractory Systemic Lupus Erythematosus (SLE) February 2, 2024 October 2025
NCT06347718 Recruiting Phase 1/Phase 2 CAR-T Cells in Systemic B Cell Mediated Autoimmune Disease July 17, 2023 May 31, 2026
NCT06361745 Recruiting N/A Early Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases April 2, 2024 March 1, 2025
NCT06378736 Recruiting Electroencephalogram Recording in Patients With Systemic Lupus Erythematosus January 22, 2024 March 23, 2026
NCT06449794 Recruiting Neuropsycatric Disorders Among Children With Systemic Lupus Erythematosus in Sohag University Hospital June 1, 2024 June 1, 2025
NCT00756769 Recruiting Systemic Lupus Erythematosus in Gullah Health April 2003 June 2027
NCT00775476 Recruiting Phase 2 Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine March 31, 2022 December 2027
NCT06428188 Recruiting Phase 1/Phase 2 Sequential CAR-T Cells Targeting BCMA/CD19 in Patients With Relapsed/ Refractory Autoimmune Diseases May 29, 2024 December 28, 2026
NCT06411249 Recruiting Phase 4 A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE) June 4, 2024 May 29, 2029
NCT02450396 Recruiting Pregnancy and Medically Assisted Conception in Rare Diseases June 2014 December 2025
NCT02633163 Recruiting Phase 2 Phase 2 Trial of Mesenchymal Stem Cells in Systemic Lupus Erythematosus (MiSLE) October 26, 2018 June 2025
NCT03138941 Recruiting Validation of the Lupus Low Disease Activity State (LLDAS) in the Asia Pacific Region September 1, 2013 December 31, 2032
NCT03276923 Recruiting Maternal Autoimmune Disease Research Alliance (MADRA) Registry January 1, 2018 January 1, 2027
NCT00001372 Recruiting Study of Systemic Lupus Erythematosus February 10, 1994
NCT03370263 Recruiting BENLYSTA® Special Drug Use Investigation January 15, 2018 June 26, 2025
NCT00198068 Recruiting Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) September 2003 March 2025
NCT03802188 Recruiting Hydroxychloroquine in Systemic Lupus Erythematosus May 9, 2018 March 31, 2025
NCT03816345 Recruiting Phase 1 Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer July 16, 2019 August 31, 2024
NCT06462768 Recruiting Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis November 27, 2023 April 27, 2029
NCT04077684 Recruiting Phase 2 Efficacy and Safety of Low-dose IL-2 in Patients With SLE: a Multicenter, Randomised, Placebo-controlled Trial September 10, 2019 December 31, 2024
NCT04276701 Recruiting N/A Immune Mediators and Metabolites to Stratify Systemic Lupus Erythematosus Patients at High Risk of Cardio Vascular Diseases March 10, 2021 March 2026
NCT04320680 Recruiting N/A Systemic Lupus Erythematosus Within the Framework of the Multidisciplinary Consultation October 13, 2020 May 13, 2025
NCT04402086 Recruiting Rheumatology Patient Registry and Biorepository August 4, 2020 June 1, 2030
NCT06458972 Recruiting Safety, Efficacy, and Compliance of Telitacicept in the Treatment of Systemic Lupus Erythematosus (SLE) January 1, 2024 August 31, 2024
NCT04447053 Recruiting Phase 4 Sequential Belimumab and T-cell Based Therapy in SLE November 8, 2021 May 20, 2025
NCT04486118 Recruiting Phase 2 Centrally Acting ACE Inhibition in SLE October 1, 2021 November 1, 2025
NCT04516408 Recruiting N/A Recombinant Zoster Vaccine in Stable SLE Patients April 20, 2021 September 30, 2023
NCT04532541 Recruiting Monogenic Lupus in Childhood Onset Systemic Lupus Erythematosus November 25, 2020 September 30, 2025
NCT04582136 Recruiting Phase 2 Efficacy and Safety of Sirolimus in Active Systemic Lupus Erythematosus March 4, 2021 May 1, 2025
NCT04747288 Recruiting Objective Measurement With TCM Pattern for AIDDES February 1, 2021 December 31, 2024
NCT04751396 Recruiting Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors April 20, 2022 April 15, 2025
NCT04833465 Recruiting Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions July 16, 2021 December 1, 2023
NCT04835883 Recruiting Phase 2 Exploring the Efficacy and Safety of CS20AT04 (Allogenic Bone Marrow-Derived Stem Cell) in Systemic Lupus Erythematosus Patients September 26, 2019 January 20, 2026
NCT04877691 Recruiting Phase 3 Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus June 8, 2021 November 16, 2026
NCT04895696 Recruiting Phase 2 A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE) October 11, 2021 April 22, 2029
NCT04908865 Recruiting Phase 4 Open-label Study of Belimumab Plus Standard Therapy in Chinese Pediatric Participants With Active Systemic Lupus Erythematosus (SLE) October 21, 2021 September 4, 2024
NCT04951427 Recruiting PRediction Of Flares In Lupus With autoantibodiEs and Chemokines September 15, 2021 August 1, 2024
NCT04963296 Recruiting Phase 3 A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus October 26, 2021 November 30, 2027
NCT04976465 Recruiting Phase 1 Treatment and Clinical Outcomes Among SLE Patients in Pregnancy January 1, 2018 December 31, 2026
NCT05001737 Recruiting Phase 3 Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE December 15, 2021 September 2025
NCT05007340 Recruiting ILD-SARDs Registry and Biorepository August 24, 2021 August 2026
NCT05029336 Recruiting Phase 2 Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases December 2024 May 2031
NCT05039840 Recruiting Phase 2 Efficacy and Safety of SAR441344 in the Treatment of Systemic Lupus Erythematosus November 10, 2021 November 30, 2026
NCT05236491 Recruiting Phase 2/Phase 3 COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases March 9, 2022 December 2023
NCT05243875 Recruiting N/A Lupus Education Alliance Program November 1, 2023 August 31, 2024
NCT05292456 Recruiting Monıtorıng Glucocortıcoıd Treatment In Patıents Followed In Rheumatology Clınıc February 1, 2021 December 2022
NCT05306574 Recruiting Phase 3 A Study of Telitacicept for the Treatment of Moderately to Severely Active Systemic Lupus Erythematosus (REMESLE-1) June 20, 2022 September 21, 2025
NCT05306873 Recruiting Phase 2 Examining Distinct Immunophenotypes to Validate and Enhance Rational Treatment in Systemic Lupus October 28, 2022 June 20, 2026
NCT00512694 Recruiting Duke Lupus Registry July 2007 June 2027
NCT05339217 Recruiting Phase 3 Efficacy and Immunological Evaluation of Telitacicept and Low Dose IL2 in the Treatment of Systemic Lupus Erythematosus February 7, 2023 July 1, 2025
NCT05392790 Recruiting N/A Progressive Resisted Exercise Plus Aerobic Exercise on Osteoporotic Systemic Lupus Erythmatosus May 23, 2022 December 30, 2023
NCT05433857 Recruiting Phase 2 Probiotics in Systemic Lupus Erythematosus June 10, 2022 December 30, 2023
NCT05440422 Recruiting Phase 2 The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD December 7, 2023 August 1, 2024
NCT05451277 Recruiting At the Heart of the Matter - Speckle Tracking Echocardiography in Lupus Mothers and Their Offspring April 1, 2021 September 30, 2023
NCT05539001 Recruiting Screening Biomarkers for Severe Lupus Based on Multi-omics Studies February 1, 2023 June 30, 2025
NCT05540327 Recruiting Phase 2 The Willow LTE Study With M5049 in Participants With SCLE, DLE and/or SLE (WILLOW LTE) September 16, 2022 April 15, 2025
NCT05559671 Recruiting Phase 4 Safety of the Herpes Zoster Subunit Vaccine in Lupus December 21, 2023 January 2027
NCT05617677 Recruiting Phase 3 A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE) January 12, 2023 December 17, 2027
NCT05624749 Recruiting Phase 3 Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2) April 21, 2023 January 23, 2029
NCT00479622 Terminated Phase 1 Study of TRU-015 in Subjects With Membranous Nephropathy Secondary to Systemic Lupus Erythematosus August 2007 May 2008
NCT02917265 Terminated Phase 2 Transcutaneous Vagus Nerve Stimulation for the Treatment of Lupus November 2015 November 2018
NCT00111306 Terminated Phase 3 Study of Epratuzumab in Systemic Lupus Erythematosus June 2005 March 2007
NCT02741362 Terminated Phase 1 Safety and Efficacy of Adipose Derived Stem Cells in Refractory Rheumatoid Arthritis, Systemic Lupus Erythematosus or Sharp's Syndrome December 2015 December 31, 2016
NCT02665364 Terminated Phase 2 Phase IIb Study of IFN-K in Systemic Lupus Erythematosus September 23, 2015 February 4, 2020
NCT02533570 Terminated Phase 2 Dose Ranging Study of Brentuximab Vedotin in Adults With Lupus July 2015 June 5, 2017
NCT02514967 Terminated Phase 3 CHABLIS7.5: A Study of the Efficacy and Safety of Subcutaneous Blisibimod in Subjects With Systemic Lupus Erythematosus With or Without Nephritis June 2016 February 28, 2017
NCT00849745 Terminated Phase 1 Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases January 2003 July 2015
NCT05430854 Terminated Phase 2 Study of Daxdilimab (HZN-7734) for the Treatment of Systemic Lupus Erythematosus in an Open-label Extension Study June 1, 2022 October 31, 2023
NCT02408471 Terminated N/A Ascension® Post- Approval Study; PyroCarbon Metacarpophalangeal Total Joint Prosthesis June 2002 January 2015
NCT00504244 Terminated Phase 3 Myfortic Versus Azathioprine in Systemic Lupus Erythematosus July 2007 August 2009
NCT02102594 Terminated Phase 2 Therapy of Antibody-mediated Autoimmune Diseases by Bortezomib (TAVAB) October 2014 August 30, 2019
NCT02066311 Terminated Phase 2 Nelfinavir in Systemic Lupus Erythematosus September 2014 June 2018
NCT00684255 Terminated Phase 1 Reduced Intensity Transplant in Medically Refractory Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc) August 2007 July 2008
NCT00626197 Terminated Phase 3 A Study to Evaluate Ocrelizumab in Patients With Nephritis Due to Systemic Lupus Erythematosus (BELONG) February 15, 2008 October 28, 2013
NCT00539838 Terminated Phase 3 A Study to Evaluate Two Doses of Ocrelizumab in Patients With Active Systemic Lupus Erythematosus (BEGIN) December 19, 2007 July 12, 2011
NCT00000419 Terminated Phase 3 Safety of Estrogens in Lupus: Hormone Replacement Therapy April 1996 August 2002
NCT01946880 Terminated Phase 2 Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE) November 20, 2013 July 3, 2019
NCT01781611 Terminated N/A Dipyridamole Assessment for Flare Reduction in Systemic Lupus Erythematosus (SLE) February 2013 November 2017
NCT00739050 Terminated Phase 4 Effect of Simvastatin on Endothelial Function in Premenopausal Women With Systemic Lupus Erythematosus (0733-271)(TERMINATED) September 19, 2007 February 1, 2008
NCT04839315 Terminated Early Phase 1 COVID-19 Vaccination in Rheumatic Disease Patients February 15, 2021 February 9, 2022
NCT01777256 Terminated Phase 2 An Adaptive Phase II Study to Evaluate the Efficacy, Pharmacodynamics, Safety and Tolerability of GSK2586184 March 1, 2013 March 31, 2014
NCT04700267 Terminated Phase 1 A Study Evaluating the Effects of GLPG3970 Given as Oral Treatment for 12 Weeks in Adults With Systemic Lupus Erythematosus December 28, 2020 October 6, 2021
NCT01709474 Terminated Phase 2 Vitamin D3 Treatment in Pediatric Systemic Lupus Erythematosus June 2013 July 2014
NCT01689025 Terminated Phase 1 An Investigation of Safety and Tolerability of NNC0114-0006 in Subjects With Systemic Lupus Erythematosus (SLE) September 2012 February 2014
NCT00383214 Terminated Phase 3 Study of Epratuzumab in Systemic Lupus Erythematosus (SLE) May 2005 March 2007
NCT04335747 Terminated COVID-19 Infection in Vulnerable Patients With Inflammatory Rheumatic Diseases April 23, 2020 July 1, 2021
NCT01541670 Terminated Phase 1 Safety Study of Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody in Lupus Nephritis November 28, 2011 December 31, 2012
NCT00297284 Terminated N/A Memory and Attention Problems in Lupus: New Treatment Trial With Modafinil February 2006 February 2007
NCT04141046 Terminated N/A LUPUS Brain: tACS to Target the Neurophysiology of Depression, Cognitive Deficits, and Pain in Patients With SLE January 1, 2019 March 8, 2024
NCT00732940 Terminated Phase 2 Phase 2 Study of Belimumab Administered Subcutaneously to Subjects With Systemic Lupus Erythematosus (SLE) October 2008 March 2012
NCT01488708 Terminated Phase 3 On Open-Label Study in Participants With Systemic Lupus Erythematosus January 2012 October 2015
NCT01240694 Terminated Phase 3 A Long-Term Study of the Safety and Tolerability of Repeated Administration of CEP-33457 in Participants With Systemic Lupus Erythematosus December 9, 2010 June 14, 2012
NCT03953261 Terminated Phase 2 Effect of Curcumin on Systemic Lupus Erythematosus September 1, 2019 April 13, 2022
NCT01164917 Terminated Phase 1 Safety Study of AMG 811 in Subjects With Discoid Lupus Erythematosus August 2010 March 2013
NCT00430677 Terminated Phase 2/Phase 3 Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis June 2007 August 2011
NCT03937856 Terminated N/A Smartphone Mindfulness Meditation for Patients With Rheumatic Diseases May 7, 2019 April 22, 2021
NCT03843125 Terminated Phase 3 A Study of Baricitinib in Participants With Systemic Lupus Erythematosus (SLE) September 9, 2019 April 1, 2022
NCT03656627 Terminated Phase 1 Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease June 27, 2019 March 18, 2021
NCT03616912 Terminated Phase 3 A Study of Baricitinib (LY3009104) in Participants With Systemic Lupus Erythematosus August 2, 2018 March 9, 2022
NCT00203151 Terminated Phase 2 A Study to Evaluate the Tolerability, Safety and Effectiveness of Edratide in the Treatment of Lupus July 2005 February 2007
NCT03186794 Terminated N/A Aerobic Exercise in Women With Systemic Lupus Erythematosus February 22, 2018 February 25, 2021
NCT03159936 Terminated Early Phase 1 Oral Tofacitinib in Adult Subjects With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) April 3, 2017 June 10, 2020
NCT02975336 Terminated Phase 2 A Phase II Study of M2951 in SLE January 4, 2017 March 23, 2020
NCT04275193 Unknown status Phase 2/Phase 3 The Safety and Efficacy of Zishenqing in Subjects With Active Systemic Lupus Erythematosus October 22, 2019 September 1, 2022
NCT00004375 Unknown status Phase 2 Ultraviolet Light Therapy for Systemic Lupus Erythematosus September 1991
NCT00006055 Unknown status N/A Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases March 2000
NCT00017641 Unknown status Phase 1 Phase I Study of Immune Ablation and CD34+ Peripheral Blood Stem Cell Support in Patients With Systemic Lupus Erythematosus April 2001
NCT00037128 Unknown status Phase 3 Study of GL701 in Men With Systemic Lupus Erythematosus March 1998
NCT00172666 Unknown status Decoy Receptor 3 (DcR3) Polymorphisms in Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) August 2005 July 2006
NCT00188188 Unknown status Phase 4 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease March 2002
NCT00188357 Unknown status N/A HIPP Learning to Live Better With Lupus: The Health Improvement and Prevention Program in Systemic Lupus Erythematosus August 2003
NCT00432354 Unknown status Phase 2/Phase 3 An Open Labeled Pilot Study of Atorvastatin in Systemic Lupus Erythematosus March 2007 March 2009
NCT00441220 Unknown status Cyclophosphamide in Lupus Nephritis October 2006 October 2010
NCT00519454 Unknown status Estrogen and Gender Biased Autoimmunity April 2005 December 2013
NCT00527176 Unknown status Pulse Corticosteroid Therapy and Effect on Brain Water Diffusivity September 2007 September 2007
NCT00671047 Unknown status The Systemic Lupus Erythematosus (SLE) Activity Gene Expression (SAGE) Study December 2007 June 2010
NCT00747578 Unknown status Health-Related Quality of Life and Disease-Related Costs: Comparison Between Ankylosing Spondylitis, Rheumatoid Arthritis and Systemic Lupus Erythematosus in Taiwan September 2008
NCT00750971 Unknown status Phase 2 Autologous Stem Cell Transplantation for Refractory Systemic Lupus Erythematosus (ASSIST) August 2008 August 2020
NCT00866229 Unknown status Phase 4 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level April 2008 June 2010
NCT00985803 Unknown status Phase 1 Physical Activity in Patients With Systemic Lupus Erythematosus November 2009 March 2010
NCT01460680 Unknown status Membrane Polyunsaturated Fatty Acid Content in Fibromyalgia and Systemic Lupus Erythematosus (SLE) November 2011 June 2013
NCT01515163 Unknown status N/A Exercise and Systemic Lupus Erythematosus May 2010 July 2016
NCT01642706 Unknown status Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments July 2, 2012 December 2020
NCT01687192 Unknown status Phase 2 Multicenter Trial Evaluating the Immunogenicity of HPV Vaccination in Girls on Immunosuppressive Therapy. October 2012 November 2016
NCT01712529 Unknown status N/A Physical Exercise, Endothelial Function and Progenitor Endothelial Cells in Systemic Lupus Erythematosus Patients September 2010 November 2012
NCT01741857 Unknown status Phase 1/Phase 2 Umbilical Cord Derived Mesenchymal Stem Cells Transplantation for Active and Refractory Systemic Lupus Erythematosus January 2012 December 2013
NCT01840709 Unknown status N/A Effectiveness Study of Psychotherapy in Systemic Lupus Erythematosus August 2010 February 2014
NCT01863641 Unknown status Phase 2 The Effect of Calcitriol on Progress and Activity of Lupus Nephritis April 2013 April 2014
NCT01956188 Unknown status N/A Omega 3 in LES and APS May 2014 December 2017
NCT02037971 Unknown status N/A Aerobic Exercise on Improving Sleep in Systemic Lupus Erythematosus. February 2013 March 2015
NCT02270970 Unknown status Phase 4 Evaluation of Belimumab Impact on a BLyS Activity Signature Test in the Absence of Confounding Polypharmacy October 2014 December 2019
NCT02403115 Unknown status Prediction of Outcome of Lupus Nephritis October 2014 November 2022
NCT02465580 Unknown status Phase 2 A Pilot-Study With Low-dose hrIL-2 for the Treatment of Systemic Lupus Erythematosus June 2015 December 2017
NCT02558517 Unknown status Phase 3 Evaluation of the Discontinuation of Maintenance Corticosteroid Treatment in Quiescent Systemic Lupus January 2014 January 2018
NCT02801812 Unknown status Observational Multicenter Case-control Study to Assess Nailfold Capillary Abnormalities in Systemic Lupus Erythematosus January 2016 June 2018
NCT03142412 Unknown status Lupus Interval Monitoring to Manage Disease Flare and Enable Treatment Optimization April 17, 2017 October 17, 2021
NCT03165682 Unknown status Fatigue, Depression, and Cortical Excitability in Systemic Lupus December 1, 2018 December 30, 2019
NCT03171103 Unknown status Systemic Lupus and Adverse Pregnancy Outcome May 1, 2017 May 1, 2020
NCT03178721 Unknown status Regulatory BCells in Systemic Lupus Erythematosus June 25, 2017 July 25, 2018
NCT03219801 Unknown status Early Phase 1 Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Systemic Lupus Erythematosus August 1, 2017 December 30, 2019
NCT03296995 Unknown status N/A Accuracy, Feasibility and Acceptance of CGM Lupus July 1, 2017 October 1, 2019
NCT03348774 Unknown status Scrutinizing the Heterogeneity of SLE: Defining Phenotypes February 9, 2017 July 30, 2018
NCT03396393 Unknown status Phase 2 Exploratory Study of DHA in Systemic Lupus Erythematosus Patients March 2018 December 2022
NCT03446339 Unknown status Pulmonary Hypertension Screening for Rheumatology Patients (SOPHIE) August 3, 2017 December 2023
NCT03459274 Unknown status Feasibility of an Immersive Virtual Reality Based Biofeedback Intervention for Outpatients in Rheumatology March 16, 2018 June 2018
NCT03583853 Unknown status Autophagy in Systemic Lupus Erythematosus July 1, 2019 December 1, 2020
NCT03746028 Unknown status The Lupus prEGnAnCY Cohort: An International Prospective Cohort of Lupus Pregnancies June 6, 2018 January 30, 2024
NCT03804723 Unknown status N/A Glucocorticoids Withdrawal in Early Systemic Lupus Erythematosus June 2019 September 2023
NCT03878303 Unknown status Phase 1 Study of AC0058TA in Patients With Systemic Lupus Erythematosus (SLE) November 28, 2018 December 2021
NCT03919643 Unknown status BAFF and APRIL and RESPONSE TO BELIMUMAB in SLE May 1, 2019 July 1, 2020
NCT04022655 Unknown status Predictors of Mortality in Patients With Autoimmune Diseases Admitted to the Intensive Care Unit July 22, 2019 October 2019
NCT04046172 Unknown status N/A Treatment of Periodontal Disease in Systemic Lupus Erythematosus November 1, 2021 June 1, 2023
NCT04110184 Unknown status Haematological Indices in Systemic Lupus Erythematosus December 1, 2019 February 1, 2023
NCT04293510 Unknown status Evaluation of Janus Kinase_3 in Juvenile Onset Systemic Lupus Erythematosus July 15, 2020 July 15, 2022
NCT04356014 Unknown status Telangiectatic Palmoplantar Keratoderma in Systemic and Subacute Lupus Erythematosus April 1, 2020 December 30, 2020
NCT04397237 Unknown status Prevalence and Seroconversion of COVID-19 in Autoimmune Diseases in Europe June 10, 2020 January 2021
NCT04431167 Unknown status N/A Healthy Lifestyle Intervention in Patients With Systemic Lupus Erythematosus: The Living Well With Lupus Study September 1, 2020 December 1, 2022
NCT04515719 Unknown status Phase 4 Efficacy and Safety of Belimumab in SLE Patients March 19, 2021 June 1, 2023
NCT04530461 Unknown status Serologic Profile of SARS CoV2 in COVID-19 Patients With Systemic Diseases June 1, 2020 January 31, 2021
NCT04558814 Unknown status N/A Evaluation of Serum Galectin-9 Level in Systemic Lupus Erythematosus Patients and it's Association With Disease Activity and Organ Damage January 2021 December 2022
NCT04648059 Unknown status Epigenetics in Lupus Nephritis December 1, 2020 June 30, 2023
NCT04799730 Unknown status Expression of CXCR4 in Patients With Systemic Lupus Erythematosus May 2021 May 2022
NCT04810754 Unknown status Phase 2 An Open Label Study to Evaluate Daratumumab in Participants With Moderate to Severe Systemic Lupus Erythematosus June 30, 2021 December 31, 2023
NCT04942314 Unknown status Practice of Treat-to-target on Pediatric Systemic Lupus Erythematosus: a Two-center Retrospective Study July 1, 2021 June 1, 2023
NCT04971590 Unknown status Study to Assess Demographic, Pharmacologic, Biomarker, Clinical Features and Quality of Life (QoL) of Participants With Lupus Nephritis September 14, 2021 January 30, 2023
NCT04983784 Unknown status N/A The Effectiveness of Walking in Patients With Systemic Lupus Erythematosus November 1, 2020 July 30, 2021
NCT05030779 Unknown status Early Phase 1 A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Systemic Lupus Erythematosus September 10, 2021 September 10, 2022
NCT05045417 Unknown status IL17 in Systemic Lupus Erythematosus Patients: Association With Disease Activity and Organ Damage October 1, 2021 April 30, 2022
NCT05057481 Unknown status Phase 3 Reappraisal of the Therapies of Refractory Autoimmune Hemolytic Anemia in Systemic Lupus Erythematosus September 15, 2021 January 15, 2023
NCT05090189 Unknown status N/A Exercise and Nutrition Recommendations for Patients Using Glucocorticoids (ENRG) August 27, 2021 November 2023
NCT05105217 Unknown status Evaluation of Slit2 in Systemic Lupus Erythematosus and Systemic Sclerosis Patients December 1, 2021 February 1, 2023
NCT05132621 Unknown status The Genital Tract Microflora in Women With Systemic Lupus Erythematosus (SLE) and Immunoglobulin A (IgA) Nephropathy. November 2021 December 2023
NCT05157334 Unknown status N/A The Effect of Deep Breathing and Transcutaneus Electrical Nerve Stimulation on Heart Rate Variability September 1, 2021 September 2022
NCT05179018 Unknown status Clinical and Diagnostic Value of Ribosomal p2 Autoantibodies in Systemic Lupus Erythematosus March 1, 2022 August 1, 2023
NCT05253638 Unknown status N/A Evaluation Of Serum MIF Level in SLE Patients February 22, 2022 December 28, 2022
NCT05262686 Unknown status Phase 3 Efficacy and Immunological Evaluation of Belimumab Plus Low Dose IL-2 in the Treatment of Systemic Lupus Erythematosus April 1, 2022 June 1, 2023
NCT05315739 Unknown status N/A Vagus Nerve Stimulation for Systemic Lupus Erythematous May 2022 September 2023
NCT05358652 Unknown status Precision Medicine in LN: A Multicenter Proof-of-concept Study for Histopathological Biomarkers Analysis in Renal Biopsy October 15, 2021 January 15, 2023
NCT05362812 Unknown status Prediction of Lupus Renal Flares Study February 28, 2022 April 1, 2023
NCT05381545 Unknown status N/A Laser Puncture and Program of Lifestyle Modification in Lupus Females February 28, 2022 July 1, 2022
NCT05418855 Unknown status Clinical Characteristics and Outcomes of SLE Patients Admitted to Critical Care Unit July 1, 2022 February 1, 2023
NCT03937271 Withdrawn Objective Measurement Methods for Autoimmune Disease and Dry Eye Syndrome April 1, 2019 December 31, 2020
NCT03204448 Withdrawn Clinical Performance of BioCLIA Ro60 May 8, 2017 April 16, 2020
NCT02525835 Withdrawn N/A Tissue Sodium in Autoimmune Disease December 1, 2018 August 2020
NCT02331810 Withdrawn Phase 1 Pharmacodynamics Assessment Study After Single Subcutaneous Dose Of SAR113244 Versus Placebo In Lupus Male And Female Patients April 2016 May 2017
NCT02270710 Withdrawn Molecular Mechanisms Characteristics in Systemic Lupus Erythematous Autoimmune Disease April 2013 October 2016
NCT02074020 Withdrawn Phase 3 CHABLIS-SC2: A Study of the Efficacy and Safety of Subcutaneous Blisibimod in Subjects With Systemic Lupus Erythematosus With or Without Nephritis December 2015
NCT01440231 Withdrawn Phase 2 Atacicept Demonstrating Dose RESponSe February 2012 February 2014
NCT01359826 Withdrawn Phase 4 The Effect of Milnacipran on Fatigue and Quality of Life in Lupus Patients October 2011 November 2013
NCT01276782 Withdrawn Phase 4 Levothyroxine in Pregnant SLE Patients January 2011 June 2011
NCT01018238 Withdrawn Phase 1 An Investigation of NNC 0151-0000-0000 in Subjects With Systemic Lupus Erythematosus (SLE) November 2009 November 2009
NCT00858884 Withdrawn N/A Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus August 2006 August 2006
NCT00752999 Withdrawn Phase 2 Efficacy and Safety Study of R935788 Tablets to Treat Systemic Lupus Erythematosus November 2008 March 2010
NCT00610805 Withdrawn N/A Cardiology Prevention in Systemic Lupus Erythematosus (SLE) November 2009 November 2009
NCT00508898 Withdrawn Phase 4 The Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent Proteinuria May 2008 September 2009
NCT00390091 Withdrawn Phase 2 Study of LJP 394 (Abetimus Sodium) in Lupus Patients September 2006
NCT00382837 Withdrawn Phase 3 Study of Epratuzumab in Systemic Lupus Erythematosus January 2007
NCT00278590 Withdrawn Phase 1 Allogeneic Stem Cell Transplantation in Systemic Lupus Erythematosus July 2004 July 2015
NCT00230035 Withdrawn Phase 2 Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST) September 2005
Disase is a (Disease Ontology)
DOID:8857
Cross Reference ID (Disease Ontology)
GARD:10253
Cross Reference ID (Disease Ontology)
ICD10CM:M32.9
Cross Reference ID (Disease Ontology)
ICD9CM:710.0
Cross Reference ID (Disease Ontology)
KEGG:05322
Cross Reference ID (Disease Ontology)
MESH:D008180
Cross Reference ID (Disease Ontology)
MIM:152700
Cross Reference ID (Disease Ontology)
MIM:300809
Cross Reference ID (Disease Ontology)
MIM:605480
Cross Reference ID (Disease Ontology)
MIM:608437
Cross Reference ID (Disease Ontology)
MIM:609903
Cross Reference ID (Disease Ontology)
MIM:609939
Cross Reference ID (Disease Ontology)
MIM:610065
Cross Reference ID (Disease Ontology)
MIM:610066
Cross Reference ID (Disease Ontology)
MIM:612254
Cross Reference ID (Disease Ontology)
MIM:612378
Cross Reference ID (Disease Ontology)
MIM:613145
Cross Reference ID (Disease Ontology)
MIM:614420
Cross Reference ID (Disease Ontology)
NCI:C3201
Cross Reference ID (Disease Ontology)
ORDO:536
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:156450004
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0024141
Exact Synonym (Disease Ontology)
disseminated lupus erythematosus
Exact Synonym (Disease Ontology)
Lupus Erythematosus, systemic
Exact Synonym (Disease Ontology)
SLE - Lupus Erythematosus, systemic
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0002725
ICD10 preferred id (Insert disease from ICD10)
D0010455
ICD10 class code (Insert disease from ICD10)
M32