sick sinus syndrome

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Information
Disease name
sick sinus syndrome
Disease ID
DOID:13884
Description
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
SCN5A 3 38,548,062 38,649,687 742
HCN4 15 73,319,859 73,368,958 4
SCN5A 3 38,548,062 38,649,687 2
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT00000561 Completed Phase 3 Mode Selection Trial in Sinus Node Dysfunction (MOST) June 1995 May 2002
NCT00161538 Completed Phase 4 Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation July 2000 June 2006
NCT00180557 Completed Phase 4 Austria Study - Analysis of Difference Between Active and Passive Fixation Leads September 2003 May 2007
NCT00284830 Completed N/A SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction January 2003 February 2008
NCT00286858 Completed Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing September 2006 December 2010
NCT00292539 Completed Prospective Registry of Pacemaker Patients Concerning Percentage of Right Ventricular Pacing, LVEF and NYHA Class February 2006 September 2006
NCT00478933 Completed N/A DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. February 2007 December 2012
NCT00627328 Completed The Atrial High Rate Episodes in Pacemaker Patients July 2000 September 2004
NCT00664807 Completed Medtronic Genetic Arrhythmia Markers for Early Detection (GAME Study) April 2008 May 2009
NCT00785564 Completed Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI) November 2007 September 2011
NCT01528657 Completed N/A Ventricular Pace Suppression Versus Intrinsic Rhythm Support Study December 2011 August 2015
NCT01609738 Completed Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum November 2012 February 2015
NCT02154750 Completed N/A AV Delay Optimization vs. Intrinsic Conduction in Pacemaker Patients With Long PR Intervals June 1, 2013 December 31, 2021
NCT02198781 Completed Right Ventricle (RV) Markers of Future Pacing Induced Ventricular Dysfunction - Pilot July 2014 August 2015
NCT02317068 Completed Phase 3 Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation January 2014 October 2015
NCT02809131 Completed Phase 3 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. April 1, 2016 September 30, 2021
NCT02954666 Completed N/A Second Study on Cardio-neuromodulation in Humans December 10, 2016 May 11, 2020
NCT03564860 Completed HBP Device EGM Data Collection July 17, 2018 September 30, 2020
NCT03843242 Completed N/A Evaluation of Ventricular Pacing Suppression Algorithms in Dual Chamber Pacemaker May 30, 2019 November 23, 2022
NCT04926792 Enrolling by invitation Taiwan Registry for Leadless Pacemaker January 19, 2022 December 31, 2024
NCT05575557 Recruiting N/A Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment November 1, 2022 April 1, 2025
NCT06288633 Recruiting N/A Cardioneuroablation for Bradyarrhythmia March 4, 2024 February 1, 2027
NCT01074749 Terminated N/A Optimal Sensing in Atrial Tachyarrhythmia's Study July 2010 July 2014
NCT01798043 Terminated N/A Impact of Septal Vs Apical Pacing on Right and Left Ventricular Performance January 2013 January 2016
NCT00475124 Terminated Phase 4 Virtual Clinic Pacemaker Follow-up May 2007 September 2012
NCT00236158 Terminated Phase 2/Phase 3 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome March 1999 July 2010
NCT04149886 Unknown status N/A Cardiac Ganglionated Plexus Ablation Before Permanent Pacemaker Implantation in Patients With Sick Sinus Syndrome October 28, 2019 October 27, 2021
NCT05186220 Unknown status N/A Cardioneuroablation Versus Pacemaker Implantation for the Treatment of Symptomatic Sinus Node Dysfunction November 1, 2021 November 1, 2023
NCT01477138 Unknown status RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome July 2011 December 2013
NCT03118440 Unknown status N/A Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation January 2013 December 2020
NCT00161551 Unknown status Phase 4 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) November 2004 December 2010
NCT01647490 Unknown status N/A Right Ventricular Lead Placement in a Pacemaker Population: Evaluation of Apical and Alternative Position April 2012 July 2015
NCT00224341 Unknown status Phase 4 Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation November 2003 November 2006
NCT00228241 Unknown status N/A Left Ventricular Function and Remodelling During Permanent Pacing September 2003 July 2006
NCT02314897 Unknown status N/A Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study January 2015 December 2018
NCT03118427 Unknown status N/A Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Double-chamber Pacemaker Implantation January 2013 December 2020
NCT01310920 Unknown status The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome February 2011
NCT01302717 Withdrawn N/A Left Ventricular Pacing to Avoid Cardiac Enlargement Study April 2010 December 31, 2019
Disase is a (Disease Ontology)
DOID:0050824
Cross Reference ID (Disease Ontology)
ICD10CM:I49.5
Cross Reference ID (Disease Ontology)
MESH:D012804
Cross Reference ID (Disease Ontology)
MIM:163800
Cross Reference ID (Disease Ontology)
MIM:608567
Cross Reference ID (Disease Ontology)
NCI:C62244
Cross Reference ID (Disease Ontology)
ORDO:166282
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:266307005
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0037052
Exact Synonym (Disease Ontology)
sinus node infection
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0011704
OMIM Phenotype Series Number (OMIM)
PS608567
ICD10 preferred id (Insert disease from ICD10)
D0007200
ICD10 class code (Insert disease from ICD10)
I49.5
MeSH unique ID (MeSH (Medical Subject Headings))
D012804