hypoparathyroidism
Information
- Disease name
- hypoparathyroidism
- Disease ID
- DOID:11199
- Description
- "A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood." [url:http\://en.wikipedia.org/wiki/Hypoparathyroidism, url:http\://ghr.nlm.nih.gov/glossary=hypoparathyroidism, url:http\://www.mayoclinic.org/diseases-conditions/hypoparathyroidism/basics/definition/con-20030780?_ga=1.221847067.2017809229.1415219956]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT01922440 | Active, not recruiting | A Registry for Participants With Chronic Hypoparathyroidism | July 30, 2013 | November 30, 2034 | |
| NCT05328076 | Active, not recruiting | Parathyroid Vascularization During Total Thyroidectomy Using Indocyanine Green Angiography | May 2, 2022 | May 2024 | |
| NCT04009291 | Active, not recruiting | Phase 2 | A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH in Adults With Hypoparathyroidism | August 27, 2019 | March 2025 |
| NCT04701203 | Active, not recruiting | Phase 3 | A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Daily in Adults With Hypoparathyroidism | February 16, 2021 | January 2025 |
| NCT05965167 | Active, not recruiting | Phase 1/Phase 2 | Assess Safety and Compare PK of New Oral hPTH(1-34) Tablet Formulations vs. EBP05 Tablets and Subcutaneous Forteo | May 11, 2023 | March 2024 |
| NCT05654701 | Available | Expanded Access Program of Palopegteriparatide in Patients With Hypoparathyroidism | |||
| NCT00730210 | Completed | Phase 2 | Treatment of Hypoparathyroidism With Subcutaneous PTH (1-84) Injections: Effects on Muscle Function and Quality of Life | June 2008 | August 2010 |
| NCT00732615 | Completed | Phase 3 | Use of NPSP558 in the Treatment of Hypoparathyroidism | December 18, 2008 | September 28, 2011 |
| NCT00743782 | Completed | Early Phase 1 | Comparing Pump With Subcutaneous Injection Delivery of PTH 1-34 in the Management of Chronic Hypoparathyroidism | August 22, 2008 | April 7, 2014 |
| NCT00793689 | Completed | Perioperative Parathormone Measurement and Sodium Bicarbonate Infusion Test After Total Thyroidectomy | March 2008 | October 2009 | |
| NCT00824226 | Completed | N/A | Magnesium Treatment in Hypoparathyroidism | January 2009 | August 2011 |
| NCT01268098 | Completed | Phase 3 | Study of Safety and Efficacy of a rhPTH[1-84] of Fixed Doses of 25 and 50 mcg in Adults With Hypoparathyroidism (RELAY) | February 9, 2011 | November 11, 2011 |
| NCT01297309 | Completed | Phase 3 | A Open-label Study Investigating the Safety and Tolerability of NPSP558, a Recombinant Human Parathyroid Hormone (rhPTH [1-84]), for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study (RACE) | April 6, 2011 | June 8, 2018 |
| NCT01455181 | Completed | Phase 3 | A Study to Investigate the Safety and Tolerability of NPSP558, for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study in Hungary | August 19, 2011 | April 26, 2012 |
| NCT01498341 | Completed | Hypoparathyroidism in Denmark | August 2011 | May 2012 | |
| NCT01815021 | Completed | Phase 1/Phase 2 | A Study Comparing Amorphous Calcium Carbonate (ACC) Versus Crystalline Calcium CCS) in Hypoparathyroidism Patients | April 2013 | June 2014 |
| NCT02152228 | Completed | Phase 2 | A Pilot Study to Assess the Safety and Efficacy of Oral PTH (1-34) in the Treatment of Hypoparathyroidism | July 2014 | July 2015 |
| NCT02781844 | Completed | Phase 1 | Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Participants With Hypoparathyroidism | April 3, 2017 | March 8, 2019 |
| NCT02910466 | Completed | Phase 4 | A Study of Extended Use of Recombinant Human Parathyroid Hormone (rhPTH(1-84)) in Hypoparathyroidism | October 27, 2016 | December 20, 2019 |
| NCT02924532 | Completed | Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total Thyroidectomy | February 2012 | ||
| NCT00001304 | Completed | Phase 2 | Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34 | October 1991 | April 2014 |
| NCT00004361 | Completed | Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects | July 1995 | ||
| NCT00356512 | Completed | Physiologic Regulation of FGF-23 | July 19, 2006 | ||
| NCT00473265 | Completed | Phase 2/Phase 3 | Bone Properties in Hypoparathyroidism: Effects of PTH | May 2004 | June 2014 |
| NCT00566488 | Completed | Phase 1 | Parathyroid and Thymus Transplantation in DiGeorge #931 | January 2005 | December 2019 |
| NCT00581828 | Completed | Phase 4 | Does Treatment of Hypovitaminosis D Increase Calcium Absorption? | January 2005 | December 2008 |
| NCT03150108 | Completed | Phase 1 | Study of rhPTH(1-84) in Japanese Healthy Subjects Compared With Matched Caucasian Healthy Adult Subjects | May 16, 2017 | June 26, 2017 |
| NCT03324880 | Completed | Phase 4 | A Study to Learn if Recombinant Human Parathyroid Hormone [rhPTH(1-84)] Can Improve Symptoms and Metabolic Control in Adults With Hypoparathyroidism (BALANCE) | January 24, 2018 | May 19, 2022 |
| NCT03437174 | Completed | Burden of Illness in Hypoparathyroidism | August 1, 2015 | January 1, 2018 | |
| NCT03516773 | Completed | Phase 2 | Oral PTH(1-34) PK and PD Study in Patients With Hypoparathyroidism | June 17, 2018 | February 24, 2019 |
| NCT03728959 | Completed | N/A | Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism. | September 12, 2018 | April 12, 2019 |
| NCT03747029 | Completed | Serum Calcium to Phosphorous (Ca/P) Ratio in the Diagnosis of Ca-P Metabolism Disorders: a Multicentre Study | November 28, 2017 | December 31, 2018 | |
| NCT04053647 | Completed | Quality of Life Evaluation (SF-36) in Patients With Permanent Hypoparathyroidism After Total Thyroidectomy (Qol-Hypopara) | February 5, 2020 | June 24, 2020 | |
| NCT04059380 | Completed | Evaluation of iMmune Function in Post-surgical and AuToimmune HYpoparathyroidism (EMPATHY) | May 13, 2019 | October 31, 2020 | |
| NCT04372225 | Completed | Predicting Risk Factors of Postoperative Hypocalcemia After Total Thyroidectomy | April 25, 2020 | April 25, 2020 | |
| NCT04569604 | Completed | QoL and Cognitive Function in Patients With Hypoparathyroidism | October 1, 2019 | December 1, 2021 | |
| NCT04671719 | Completed | Determination of Circulating Autotaxin in Patients With GNAS or PTH Abnormalities | March 10, 2021 | January 11, 2023 | |
| NCT04750460 | Completed | Phase 3 | Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa). | March 1, 2021 | February 16, 2022 |
| NCT05043584 | Completed | N/A | Near-infrared Autofluorescence (NIRAF)-Guided Total Thyroidectomy: Impact in Low-volume, Non-parathyroid Institutions | September 15, 2021 | December 1, 2023 |
| NCT05684029 | Completed | Near-Infrared Autofluorescence With PTH Test Strip as an SOP of Parathyroid in Thyroid Surgery | November 1, 2022 | October 31, 2023 | |
| NCT06449729 | Completed | Endocrine Determinants of Renal Function in Patients With Hypoparathyroidism | November 28, 2022 | April 28, 2023 | |
| NCT06419270 | Not yet recruiting | Cardiovascular, Renal, and Skeletal Complications in Patients With Post-Surgical Hypoparathyroidism | May 2024 | December 2028 | |
| NCT06445036 | Not yet recruiting | Tunisian Clinical Registry on Hypoparathyroidism and Pseudo-hypoparathyroidism. | September 1, 2024 | February 1, 2025 | |
| NCT05387070 | Recruiting | Phase 3 | PaTHway CHINA TRIAL: A Trial to Investigating the Safety, Tolerability and Efficacy of TransCon PTH in Adults With Hypoparathyroidism | July 28, 2021 | December 2025 |
| NCT06465108 | Recruiting | Phase 2 | Randomized, Double-Blind, Placebo-Controlled, Safety, Pharmacokinetics, and Efficacy of MBX 2109 in Patients With Hypoparathyroidism | June 7, 2024 | June 2025 |
| NCT05022667 | Recruiting | N/A | Assessing Benefits of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Total Thyroidectomy | December 1, 2021 | August 2024 |
| NCT05793853 | Recruiting | Hypoparathyroidism Natural History | August 25, 2022 | December 2026 | |
| NCT02838927 | Recruiting | Survey on Epidemiology of Hypoparathyroidism in France | July 2016 | September 2031 | |
| NCT05114980 | Recruiting | N/A | Parathyroid Allotransplantation in Medically Refractory Hypoparathyroidism | July 2024 | January 2027 |
| NCT05556629 | Recruiting | A Survey to Assess Participants' and Physicians' Knowledge, Attitudes and Behavior When Using NATPARA | September 1, 2015 | December 31, 2024 | |
| NCT00395538 | Terminated | Phase 3 | Effects of PTH Replacement on Bone in Hypoparathyroidism | October 30, 2006 | October 4, 2017 |
| NCT06288490 | Terminated | N/A | A Single Arm Study Comparing ACC Supplement to CCS in Management of Hypoparathyroidism | April 2013 | June 25, 2014 |
| NCT03364738 | Terminated | Phase 3 | Safety and Efficacy Study of rhPTH(1-84) in Subjects With Hypoparathyroidism | September 26, 2018 | April 14, 2020 |
| NCT04209179 | Terminated | Phase 1 | A Clinical Study Investigating the Safety, Tolerability, PK and PD of PCO371 in Patients With Hypoparathyroidism | July 23, 2020 | May 25, 2021 |
| NCT03514251 | Unknown status | N/A | Study on Application of Suturing Parathyroid Markers in Thyroid Cancer Surgery | April 1, 2018 | September 30, 2018 |
| NCT00856401 | Unknown status | Phase 3 | ADD-ON Study to Existing Hypoparathyroidism Studies | September 2010 | June 30, 2021 |
| NCT02986607 | Unknown status | Early Phase 1 | Corticosteroid Rhythms in Hypoparathyroid Patients | March 2016 | June 2018 |
| NCT04126941 | Unknown status | Monocentric Study on the Use of Teriparatide in Children With hypoparathyroïdism | June 1, 2019 | December 2020 | |
| NCT01199614 | Unknown status | Phase 3 | HEXT (Hypo EXTended): Effect of PTH on Skeleton in Hypoparathyroidism | December 2009 | December 31, 2020 |
| NCT01039714 | Unknown status | Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy | December 2009 | May 2010 |
- Disase is a (Disease Ontology)
- DOID:11201
- Cross Reference ID (Disease Ontology)
- GARD:6733
- Cross Reference ID (Disease Ontology)
- ICD10CM:E20
- Cross Reference ID (Disease Ontology)
- ICD9CM:252.1
- Cross Reference ID (Disease Ontology)
- MESH:D007011
- Cross Reference ID (Disease Ontology)
- NCI:C78350
- Cross Reference ID (Disease Ontology)
- ORDO:2238
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:154697005
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0020626
- HPO alt_id (Human Phenotype Ontology)
- HP:0000856
- HPO alt_id (Human Phenotype Ontology)
- HP:0008292
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0000829
- ICD10 preferred id (Insert disease from ICD10)
- D0003676
- ICD10 class code (Insert disease from ICD10)
- E20
- MeSH unique ID (MeSH (Medical Subject Headings))
- D007011