open-angle glaucoma
Information
- Disease name
- open-angle glaucoma
- Disease ID
- DOID:1067
- Description
- "A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage." [url:http\://en.wikipedia.org/wiki/Glaucoma, url:http\://www.merckmanuals.com/professional/eye_disorders/glaucoma/primary_open-angle_glaucoma.html]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03850782 | Active, not recruiting | Phase 3 | Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-Angle Glaucoma or Ocular Hypertension | February 28, 2019 | August 9, 2025 |
| NCT03904381 | Active, not recruiting | Phase 4 | Efficacy and Safety of XEN® Gel Stent and Post-operative Management in Patients With Open Angle Glaucoma | January 1, 2016 | January 1, 2025 |
| NCT05338606 | Available | Expanded Access to Bimatoprost (Durysta) | |||
| NCT00047528 | Completed | Phase 3 | Phase 3 Study to Evaluate IOP Lowering Therapy in Open Angle Glaucoma and Ocular Hypertension C-02-41 | January 2001 | November 2003 |
| NCT00047541 | Completed | Phase 3 | Phase 3 Study to Evaluate IOP Lowering Therapy in Open Angle Glaucoma and Ocular Hypertension C-01-70 | February 2001 | November 2003 |
| NCT00047593 | Completed | Phase 3 | Phase 3 Study Comparing IOP Lowering in OAG or OH in Japanese Subjects C-01-98 | January 2000 | July 2004 |
| NCT00061529 | Completed | Phase 3 | A Phase III Study of Brimonidine Tartrate Ophthalmic Solution, 0.15% in Patients With Open-Angle Glaucoma or Ocular Hypertension | January 2003 | July 2004 |
| NCT00069706 | Completed | Phase 2 | Phase II Safety and Efficacy Study to Evaluate a Glaucoma Therapy in Open-angle Glaucoma or Ocular Hypertension Patients | July 2003 | October 2003 |
| NCT00069719 | Completed | Phase 2 | Phase II Safety and Efficacy Study to Evaluate a Glaucoma Therapy in Open-Angle Glaucoma or Ocular Hypertension Patients | February 1999 | August 2003 |
| NCT00141882 | Completed | Phase 3 | Memantine in Patients With Chronic Glaucoma | March 1999 | August 2006 |
| NCT00168350 | Completed | Phase 3 | Memantine in Patients With Chronic Glaucoma | March 2000 | September 2006 |
| NCT00273429 | Completed | Phase 4 | Cosopt Versus Xalatan | April 2005 | December 2005 |
| NCT00273442 | Completed | Phase 4 | Assessing Cosopt Switch Patients | November 2005 | April 2007 |
| NCT00273455 | Completed | Phase 4 | Lumigan Versus Cosopt | January 2006 | May 2007 |
| NCT00273481 | Completed | Phase 4 | Cosopt Versus Xalacom | September 2005 | April 2007 |
| NCT00287521 | Completed | Phase 2 | A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension | November 2005 | February 2006 |
| NCT00288951 | Completed | Phase 3 | Phase III Safety and Efficacy Study to Evaluate a Glaucoma Therapy in Open-Angle Glaucoma or Ocular Hypertension Patients | October 2004 | June 2005 |
| NCT00293761 | Completed | Phase 3 | A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension | January 2006 | May 2006 |
| NCT00293787 | Completed | Phase 3 | A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension | June 2004 | August 2005 |
| NCT00293800 | Completed | Phase 3 | A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension | July 2004 | December 2005 |
| NCT00304785 | Completed | Phase 4 | Latanoprost Versus Fotil | May 2005 | October 2007 |
| NCT00308945 | Completed | Phase 4 | Influence of Prostaglandins on Ocular Blood Flow in Glaucoma Patients | November 2003 | February 2005 |
| NCT00314158 | Completed | Phase 3 | A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension | November 2005 | January 2007 |
| NCT00314171 | Completed | Phase 3 | A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension | October 2005 | August 2007 |
| NCT00320203 | Completed | Phase 2 | Anecortave Acetate in Patients With Open-angle Glaucoma | March 2006 | January 2008 |
| NCT00323284 | Completed | Phase 3 | A Study of the Trabecular Micro-bypass Stent in Combination With Cataract Surgery in Subjects With Open Angle Glaucoma | June 2005 | March 2010 |
| NCT00326014 | Completed | Phase 4 | A Study of the Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects. | April 2003 | December 2009 |
| NCT00326040 | Completed | Phase 4 | A Study of the Glaukos Trabecular Micro-Bypass Stent in Refractory Open Angle Glaucoma Subjects | April 2003 | August 2007 |
| NCT00326066 | Completed | N/A | A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients. | February 2005 | May 2013 |
| NCT01699464 | Completed | Phase 2 | A Study Assessing the Safety and Ocular Hypotensive Efficacy of AR-12286 in Patients With Elevated Intraocular Pressure for 3 Months | October 2012 | April 2013 |
| NCT00000144 | Completed | Phase 3 | Glaucoma Laser Trial (GLT) Glaucoma Laser Trial Followup Study (GLTFS) | January 1984 | |
| NCT00047515 | Completed | Phase 3 | Phase 3 Study to Evaluate IOP Lowering Therapy in Open Angle Glaucoma and Ocular Hypertension C-01-69 | January 2001 | December 2003 |
| NCT01453855 | Completed | Phase 3 | Travoprost 3-Month Safety and Efficacy Study | November 2011 | August 2012 |
| NCT01455467 | Completed | N/A | Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery | September 2011 | October 18, 2019 |
| NCT01456390 | Completed | N/A | Open-Angle Glaucoma Subjects With One Prior Trabeculectomy Treated Concurrently With One Suprachoroidal Stent and Two Trabecular Micro-bypass Stents | September 2011 | March 26, 2019 |
| NCT01464424 | Completed | Phase 4 | Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-Angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN® Z) or Bimatoprost 0.01% (LUMIGAN®) | October 2011 | June 2012 |
| NCT01487655 | Completed | Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Glaucoma Patients | September 2011 | December 2011 | |
| NCT01493427 | Completed | Phase 4 | Efficacy of Changing to TRAVATAN® From Prior Therapy | December 2011 | February 2013 |
| NCT01510145 | Completed | Phase 4 | Efficacy of Changing to TRAVATAN® From Prior Therapy | February 2012 | May 2013 |
| NCT01568008 | Completed | Observational Study of Lumigan® 0.01% for Treatment of Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) | October 2011 | September 2012 | |
| NCT01749904 | Completed | Phase 3 | Comparing Safety and Efficacy of BOL-303259-X With Timolol Maleate in Subjects With Open-Angle Glaucoma or Ocular Hypertension | January 31, 2013 | September 30, 2015 |
| NCT01749930 | Completed | Phase 3 | Comparing the Safety and Efficacy of BOL-303259-X Ophthalmic Solution With Timolol Maleate Ophthalmic Solution in Subjects With Open-Angle Glaucoma or Ocular Hypertension | January 2013 | May 2015 |
| NCT01978600 | Completed | Phase 4 | Evaluation of Intraocular Pressure Using Simbrinza™ in Patients With Open-Angle Glaucoma or Ocular Hypertension | October 2013 | March 2014 |
| NCT02014142 | Completed | Phase 2 | A Phase 2 Single-Masked, Randomized Study of Latanoprost PPDS in Ocular Hypertension or Open-Angle Glaucoma | December 2013 | December 2016 |
| NCT02179008 | Completed | Phase 2 | Multi-center Phase II Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension | June 2014 | January 2015 |
| NCT02207491 | Completed | Phase 3 | Double-masked Study of AR-13324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension | July 2014 | March 2015 |
| NCT02207621 | Completed | Phase 3 | Evaluation of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma and Ocular Hypertension | July 2014 | March 2016 |
| NCT02325518 | Completed | Phase 4 | Comparison of Intraocular Pressure (IOP)-Lowering Efficacy and Safety of AZORGA® Ophthalmic Suspension and COSOPT® Ophthalmic Solution | December 2014 | December 2015 |
| NCT02339584 | Completed | Phase 3 | Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT) | April 14, 2015 | November 1, 2016 |
| NCT02348476 | Completed | A Study of Simbrinza™ Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension | November 2014 | April 2015 | |
| NCT02419508 | Completed | Phase 4 | SIMBRINZA® Suspension BID as an Adjunctive to Prostaglandin Analogue (PGA) | August 7, 2015 | February 27, 2018 |
| NCT02558374 | Completed | Phase 3 | Double-masked Study of Netarsudil (AR-13324) Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension | September 2015 | December 2016 |
| NCT02558400 | Completed | Phase 3 | Double-masked Study of PG324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension | September 18, 2015 | June 30, 2017 |
| NCT02638181 | Completed | N/A | The Expression of Matrix Metalloproteinase 13, Tissue Inhibitor of Metalloproteinases 3, and Calcium-sensing Receptor in Human Trabecular Meshwork | July 2013 | December 2015 |
| NCT02674854 | Completed | Phase 3 | Double-masked Study of PG324 Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension | February 2016 | March 2017 |
| NCT02742649 | Completed | Phase 1/Phase 2 | A Study to Evaluate Efficacy and Safety of a Fixed Combination Ocular Insert in Participants With Open-angle Glaucoma or Ocular Hypertension | April 30, 2016 | December 31, 2016 |
| NCT02743780 | Completed | Phase 1/Phase 2 | A Three Part Study of MGV354 in Ocular Hypertension or Glaucoma | March 2, 2016 | September 20, 2016 |
| NCT02873806 | Completed | Phase 4 | Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents | March 2013 | November 8, 2019 |
| NCT03267134 | Completed | N/A | Hydrus Microstent for Refractory Open-Angle Glaucoma | August 1, 2017 | December 16, 2022 |
| NCT03488550 | Completed | Phase 1 | Single-dose Study of ANX007 in Participants With Primary Open-angle Glaucoma | March 23, 2018 | August 3, 2018 |
| NCT03604328 | Completed | Phase 1 | Safety and Tolerability of a Prostaglandin Ocular Implant for Treatment of Open Angle Glaucoma | July 24, 2018 | June 15, 2020 |
| NCT04285580 | Completed | Phase 3 | A Phase 3b Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension | June 11, 2020 | May 14, 2022 |
| NCT04910100 | Completed | Phase 2 | Nebivolol 0.5, 1.0, or Timolol 0.5 Suspension Compared to Timolol 0.5 Solution to Treat Glaucoma/Ocular Hypertension | April 15, 2021 | April 29, 2022 |
| NCT00326092 | Completed | Phase 2 | A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension | May 2006 | August 2006 |
| NCT00372931 | Completed | Phase 2 | A Phase II Study of AL-37807 to Treat Open-Angle Glaucoma or Ocular Hypertension | May 2006 | |
| NCT00397241 | Completed | Phase 4 | 24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations | September 2006 | December 2007 |
| NCT00451152 | Completed | Phase 2 | Safety and Efficacy of Anecortave Acetate in Patients With Open-Angle Glaucoma | March 2007 | July 2009 |
| NCT00457795 | Completed | Phase 4 | 24-hour IOP-lowering Effect of Brimonidine 0.1% | December 2006 | February 2009 |
| NCT00465621 | Completed | Phase 2 | Dose Response Study of AL-37807 Ophthalmic Solution in Patients With Open-Angle Glaucoma or Ocular Hypertension | March 2007 | |
| NCT00465803 | Completed | Phase 3 | A Phase IIIb Study of DuoTrav to Treat Glaucoma or Ocular Hypertension | March 2007 | |
| NCT00481208 | Completed | Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma | March 2006 | November 2006 | |
| NCT00508469 | Completed | Phase 4 | Adherence Assessment With Travalert Dosing Aid | October 2007 | January 2010 |
| NCT00527501 | Completed | Phase 2 | IOP Lowering Efficacy of Travoprost/Brinzolamide Fixed Combination Ophthalmic Suspension in Patients With Open-Angle Glaucoma or Ocular Hypertension | August 2007 | December 2007 |
| NCT00527592 | Completed | Phase 4 | A Single Dose Comfort Comparison of Travatan Z in One Eye Versus Xalatan in the Opposite Eye in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension | May 2007 | August 2008 |
| NCT00596791 | Completed | Phase 3 | Ocular Signs and Symptoms in Glaucoma Patients Switched From Latanoprost 0.005% to Preservative Free Tafluprost Eye Drops | January 2008 | August 2008 |
| NCT00620256 | Completed | Phase 2 | Adjunctive Study of AL-37807 Ophthalmic Suspension | November 2007 | July 2008 |
| NCT00637130 | Completed | Phase 2 | Safety and Intraocular Pressure (IOP) Lowering Efficacy of Low Dose Travoprost | October 2007 | |
| NCT00643669 | Completed | Phase 2 | 24 Hour IOP Lowering Efficacy of AL-3789 | February 2008 | |
| NCT00650338 | Completed | Phase 2 | Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension | March 2008 | October 2008 |
| NCT00656240 | Completed | Phase 2 | To Investigate the Safety and Efficacy of DE-104 Ophthalmic Solution to Treat Open-Angle Glaucoma or Ocular Hypertension | ||
| NCT00657579 | Completed | Phase 2 | Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-Angle Glaucoma or Ocular Hypertension | ||
| NCT00670033 | Completed | Phase 2 | Travoprost New Formulations in Patients With Open-Angle Glaucoma or Ocular Hypertension | April 2008 | September 2008 |
| NCT00672997 | Completed | Phase 3 | A Phase III Study of Travoprost/Timolol Combination in Patients With Open-Angle Glaucoma or Ocular Hypertension | May 2008 | December 2008 |
| NCT00690794 | Completed | Phase 3 | Travatan Z in Ocular Surface Health in Patients With Open-Angle Glaucoma or Ocular Hypertension | July 2008 | May 2009 |
| NCT00691639 | Completed | Collection of Blood Specimens From Patients in AL-3789 Studies for Elevated Intraocular Pressure (IOP) | March 2008 | ||
| NCT00691717 | Completed | Phase 2/Phase 3 | Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension | June 2008 | September 2009 |
| NCT00698945 | Completed | Phase 4 | Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG) | June 2008 | November 2008 |
| NCT00716742 | Completed | Safety and Efficacy Study of Bimatoprost, Latanoprost, and Travoprost in Patients With Elevated Intraocular Pressure (IOP) and Open-angle Glaucoma (OAG) | September 2004 | September 2009 | |
| NCT00721968 | Completed | Phase 3 | Safety and Efficacy of the GTS400 Stent in Conjunction With Cataract | March 2007 | August 2012 |
| NCT00759239 | Completed | Phase 4 | Phase IV Randomised Double-masked Clinical Trial: Assessing Morning Versus Evening Dosing of a Fixed Dose Combination of Travoprost 0.004% / Timolol Maleate 0.5% in Patients With Primary Open-angle Glaucoma or Ocular Hypertension | September 2008 | January 2011 |
| NCT00760539 | Completed | Phase 3 | Safety and Efficacy of Travoprost/Timolol BAC-free | June 2008 | December 2008 |
| NCT00761319 | Completed | Phase 3 | Phase III Clinical Trial of TRAVATAN Z in Ocular Surface Health | October 2008 | September 2009 |
| NCT00761709 | Completed | Phase 2 | Safety and Intraocular Pressure (IOP)-Lowering Efficacy of AL-39256 in Patients With Open-Angle Glaucoma or Ocular Hypertension | July 2009 | October 2009 |
| NCT00798759 | Completed | Phase 4 | Examination of Ocular Surface Effects With Administration of Travatan Z and XALATAN | December 2008 | May 2009 |
| NCT00803387 | Completed | Dry Eye and Irritation Comparison of Latanoprost With the Preservative Versus Travoprost Without Preservative | April 2008 | September 2008 | |
| NCT00803803 | Completed | Phase 4 | Dose, Effects and Characteristics of Pilocarpine | August 1978 | December 1979 |
| NCT00821002 | Completed | Phase 2 | A Phase 2 Study of Punctal Placement of the Latanoprost Punctal Plug Delivery System (L-PPDS) | January 2009 | November 2009 |
| NCT00822055 | Completed | Phase 4 | Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension | May 2005 | November 2006 |
| NCT00822081 | Completed | Phase 4 | Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension | January 2005 | April 2006 |
| NCT00823043 | Completed | A Comfort Survey of Open-angle Glaucoma or Ocular Hypertension Patients Treated With 2 Drugs | January 2009 | July 2009 | |
| NCT00828906 | Completed | Phase 4 | DuoTrav® Eye Drops As Replacement Therapy Program | February 2009 | |
| NCT00856622 | Completed | Phase 3 | A Study Demonstrating The Effect Of Latanoprost In Combination With Timolol, Latanoprost Alone And Timolol Alone On Eye Pressure In Open Angle Glaucoma Or Ocular Hypertension In Patients | August 1997 | June 1999 |
| NCT00868894 | Completed | Phase 1/Phase 2 | Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension | March 2009 | June 2010 |
| NCT00872651 | Completed | Phase 3 | Travoprost 0.004%/Timolol 0.5% Versus Latanoprost 0.005%/Timolol in Chinese Patients With Open-Angle Glaucoma or Ocular Hypertension | January 2010 | November 2011 |
| NCT00887029 | Completed | Phase 4 | A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma | January 2009 | November 2009 |
| NCT00918346 | Completed | Phase 3 | Pharmacodynamics of Tafluprost 0.0015% Eye Drops: a Comparison Between the Preserved and Unpreserved Formulation | September 2005 | April 2006 |
| NCT00928590 | Completed | Phase 3 | Safety Study of DuoTrav APS in Patients With Open-Angle Glaucoma or Ocular Hypertension | July 2009 | November 2010 |
| NCT01016691 | Completed | Phase 2 | Safety and Efficacy of a Drug Delivery System in Glaucoma | October 2009 | |
| NCT01026831 | Completed | Phase 3 | Preservative-Free MK2452 (Tafluprost) for Open-Angle Glaucoma/Ocular Hypertension (MK2452-001)(COMPLETED) | January 6, 2010 | September 17, 2010 |
| NCT01037036 | Completed | Phase 2 | A Study of the L-PPDS With Adjunctive Xalatan® Eye Drops in Subjects With OH or OAG | December 2009 | July 2010 |
| NCT01068964 | Completed | N/A | Safety and Efficacy of Bimatoprost Timolol Ophthalmic Solution in Patients With Open Angle Glaucoma or Ocular Hypertension | February 1, 2010 | September 1, 2010 |
| NCT01087671 | Completed | Phase 3 | Ocular Signs and Symptoms in Glaucoma Patients Switched From Latanoprost to Preservative Free Tafluprost Eye Drops | April 2010 | October 2010 |
| NCT01157364 | Completed | Phase 1/Phase 2 | Safety and Efficacy of a New Ophthalmic Formulation of Bimatoprost in Patients With Open Angle Glaucoma and Ocular Hypertension | September 23, 2010 | August 9, 2016 |
| NCT01279083 | Completed | Phase 1/Phase 2 | Safety and Efficacy Trial to Treat Open-Angle Glaucoma or Ocular Hypertension | January 2011 | February 2012 |
| NCT01292460 | Completed | Phase 3 | Tafluprost-Timolol Preservative-free Fixed Dose Combination (FDC) Superiority Study Against Monotherapies | February 2011 | September 2012 |
| NCT01297517 | Completed | Phase 3 | Efficacy and Safety Study of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% and Brimonidine 0.2% | February 2011 | March 2012 |
| NCT01297920 | Completed | Phase 3 | Three Month Efficacy/Safety Study With a 3-Month Safety Extension of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% or Brimonidine 0.2% | March 2011 | June 2012 |
| NCT01298687 | Completed | Phase 2 | Divided Dose of TRAVATAN® | February 2011 | April 2011 |
| NCT01306461 | Completed | Phase 3 | Tafluprost-Timolol Fixed Dose Combination Non-Inferiority Study Against Concomitant Administrations | March 2011 | May 2012 |
| NCT01309204 | Completed | Phase 3 | Brinzolamide/Brimonidine Twice a Day (BID) Fixed Combination (FC) vs Brinzolamide BID Plus Brimonidine BID in Patients With Open Angle Glaucoma or Ocular Hypertension | May 2011 | January 2013 |
| NCT01310777 | Completed | Phase 3 | Brinzolamide/Brimonidine Twice a Day (BID) Fixed Combination (FC) vs Brinzolamide BID and Brimonidine BID in Patients With Open Angle Glaucoma or Ocular Hypertension | May 2011 | January 2013 |
| NCT01327599 | Completed | Phase 4 | Efficacy of Changing to DUOTRAV® From Prior Therapy | August 2011 | November 2012 |
| NCT01340014 | Completed | Phase 4 | Patient Preference Comparison of AZARGA Versus COSOPT | September 2011 | October 2012 |
| NCT01357616 | Completed | Phase 3 | Fixed Combination Brinzolamide 1%/Timolol 0.5% Versus Brinzolamide 1% + Timolol 0.5% in Open-Angle Glaucoma or Ocular Hypertension | November 2010 | January 2013 |
| NCT01369771 | Completed | Phase 4 | The Effects of Preservative-free Prostaglandin Eye Drops in Sign and Symptoms on the Eyes of Patients With Glaucoma | August 2010 | June 2012 |
| NCT01415401 | Completed | Phase 4 | Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in Canada | September 2011 | June 2013 |
| NCT01426867 | Completed | Phase 2 | A Comfort Study of Brinzolamide 1% / Brimonidine 0.2% Fixed Combination, Brinzolamide 1% and Brimonidine 0.2% | September 2011 | November 2011 |
| NCT01443988 | Completed | Phase 4 | Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent)or Travoprost | September 2011 | April 2017 |
| NCT01444040 | Completed | Phase 4 | Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent Inject) or Travoprost | September 2011 | March 28, 2019 |
| NCT01444105 | Completed | N/A | Open-angle Glaucoma Subjects on One Ocular Hypotensive Medication Randomized to Treatment With Two Trabecular Micro-bypass Stents or Selective Laser Trabeculoplasty | September 2011 | April 9, 2019 |
| NCT03891446 | Enrolling by invitation | Phase 3 | Long-term Safety and Efficacy Extension Trial of Bimatoprost SR | March 27, 2019 | August 7, 2026 |
| NCT06267274 | Not yet recruiting | Phase 1 | A Randomized, Double-blind, Parallel-group, Two-arm, Multiple Dose, Multicenter, Bioequivalence Study With Clinical Endpoint in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both Eyes | April 1, 2024 | May 1, 2025 |
| NCT05822245 | Recruiting | Phase 1/Phase 2 | A Study of PER-001 in Participants With Open-Angle Glaucoma | May 25, 2023 | January 31, 2026 |
| NCT04499248 | Recruiting | Phase 1/Phase 2 | AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension | November 16, 2020 | August 30, 2027 |
| NCT05411198 | Recruiting | Phase 3 | Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma | July 22, 2022 | August 15, 2025 |
| NCT04499157 | Recruiting | N/A | Effect of MEMOPTIC on Visual Field of Patients Followed for a Chronic Open-angle Glaucoma | August 1, 2020 | August 2023 |
| NCT04647214 | Recruiting | 18 Month Prospective Efficacy and Safety Study of Bimatoprost Intracameral Implant (DURYSTA) | March 3, 2021 | July 23, 2024 | |
| NCT05821855 | Recruiting | Phase 4 | A Study to Evaluate Adverse Events and Change in Disease Activity With the XEN45 Glaucoma Treatment System Implantation In Adult Participants With Open-Angle Glaucoma in China | December 8, 2023 | July 13, 2030 |
| NCT02928289 | Terminated | N/A | Randomized Study of the Safety and Effectiveness of the Sight Sciences VISCO™360 Viscosurgical System Versus SLT in Primary Open Angle Glaucoma (VISCO360 Study) | January 23, 2017 | January 17, 2019 |
| NCT01312454 | Terminated | Phase 2 | Safety and Intraocular Pressure (IOP) Lowering Effect of AL-59412C | June 2011 | January 2012 |
| NCT02730871 | Terminated | Phase 4 | Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV® | June 24, 2016 | July 13, 2018 |
| NCT01781962 | Terminated | A Study of Quantitative Assessments of Angle Width in Chinese Patients With Open-angle Glaucoma and/or Ocular Hypertension | January 2013 | June 2013 | |
| NCT01485822 | Terminated | A Multicenter Study of the Pigmentation in the Trabecular Meshwork After Two Years of Treatment With TRAVATAN 0.004% Ophthalmic Solution | July 2004 | February 2012 | |
| NCT02984813 | Terminated | Phase 1 | Safety and Efficacy of Anti-Oxidants and Anti-inflammatory Agents in Glaucoma and Diabetic Retinopathy | April 15, 2016 | January 15, 2017 |
| NCT00961649 | Terminated | Phase 2 | Safety and Efficacy of Brinzolamide/Brimonidine Fixed Combination | October 2009 | February 2010 |
| NCT00788541 | Terminated | Phase 2 | A Dose-Volume Study of a Treatment for Elevated IOP Due to Open-Angle Glaucoma or Ocular Hypertension | December 2008 | September 2009 |
| NCT00047554 | Terminated | Study of TRAVATAN in Subjects With Iris Pigmentation Changes | May 2003 | June 2012 | |
| NCT00047606 | Terminated | Phase 4 | Phase 4 Study Comparing IOP Lowering in OAG or OH in Caucasian or Japanese Subjects C-02-32 | August 2002 | November 2003 |
| NCT00804323 | Terminated | N/A | PASCAL Trabeculoplasty | December 2007 | December 2009 |
| NCT00471068 | Terminated | Phase 4 | Study of Travatan and Cosopt in Primary Open-Angle Glaucoma or Ocular Hypertension | March 2007 | |
| NCT01174420 | Unknown status | N/A | Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Trabeculectomy: A Study in Germany | November 2009 | November 2011 |
| NCT01511094 | Unknown status | Phase 2/Phase 3 | Goniocurettage as First Choice of Surgical Treatment in Chronic Open-Angle Glaucoma: Outcomes and Complications | June 2009 | January 2012 |
| NCT00000132 | Unknown status | Phase 3 | Early Manifest Glaucoma Trial (EMGT) | October 1992 | |
| NCT00000149 | Unknown status | Phase 3 | Collaborative Initial Glaucoma Treatment Study (CIGTS) | October 1993 | |
| NCT02410148 | Unknown status | N/A | aICP in Glaucoma and Papilledema | April 2015 | March 2017 |
| NCT00326079 | Unknown status | Phase 4 | A Study of the Glaukos Trabecular Micro-bypass Stent in Open Angle Glaucoma Subjects 1 Stent Versus 2 | August 2004 | May 2013 |
| NCT00705770 | Withdrawn | Phase 2/Phase 3 | A Multi-Dose Study With a Treatment for Open-Angle Glaucoma | May 2008 | July 2008 |
| NCT03648229 | Withdrawn | Phase 4 | African Glaucoma Laser Trial | September 1, 2019 | June 30, 2024 |
| NCT01510132 | Withdrawn | Phase 4 | Travacom Post Marketing Surveillance Study | January 2012 | January 2012 |
| NCT00862472 | Withdrawn | Phase 3 | Safety and Efficacy Study of DuoTrav APS Versus DuoTrav | March 2009 | June 2009 |
| NCT00815373 | Withdrawn | N/A | The Effects of Cosopt® Vs Xalacom® on Ocular Hemodynamics and Intraocular Pressure (IOP) in Primary Open-angle Glaucoma (POAG) | December 2008 | June 2012 |
- Disase is a (Disease Ontology)
- DOID:1686
- Cross Reference ID (Disease Ontology)
- EFO:0004190
- Cross Reference ID (Disease Ontology)
- ICD10CM:H40.1
- Cross Reference ID (Disease Ontology)
- ICD9CM:365.1
- Cross Reference ID (Disease Ontology)
- MESH:D005902
- Cross Reference ID (Disease Ontology)
- MIM:137750
- Cross Reference ID (Disease Ontology)
- MIM:177700
- Cross Reference ID (Disease Ontology)
- MIM:602429
- Cross Reference ID (Disease Ontology)
- MIM:603383
- Cross Reference ID (Disease Ontology)
- MIM:606689
- Cross Reference ID (Disease Ontology)
- MIM:608695
- Cross Reference ID (Disease Ontology)
- MIM:608696
- Cross Reference ID (Disease Ontology)
- MIM:609745
- Cross Reference ID (Disease Ontology)
- MIM:609887
- Cross Reference ID (Disease Ontology)
- MIM:610535
- Cross Reference ID (Disease Ontology)
- MIM:611274
- Cross Reference ID (Disease Ontology)
- MIM:611276
- Cross Reference ID (Disease Ontology)
- MIM:613100
- Cross Reference ID (Disease Ontology)
- NCI:C34641
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:84494001
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0017612
- Exact Synonym (Disease Ontology)
- glaucoma simplex
- Exact Synonym (Disease Ontology)
- open angle glaucoma
- Exact Synonym (Disease Ontology)
- pigmentary glaucoma
- Exact Synonym (Disease Ontology)
- Wide-angle glaucoma