postural orthostatic tachycardia syndrome
Information
- Disease name
- postural orthostatic tachycardia syndrome
- Disease ID
- DOID:0111154
- Description
- "A heart conduction disease characterized by orthostatic intolerance that has_material_basis_in heterozygous mutation in the SLC6A2 gene on chromosome 16q12.2." [url:https\://rarediseases.info.nih.gov/diseases/9597/postural-orthostatic-tachycardia-syndrome, url:https\://www.ncbi.nlm.nih.gov/pubmed/23580201]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00962728 | Active, not recruiting | N/A | Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS) | July 2009 | December 2025 |
| NCT02281097 | Active, not recruiting | N/A | Transdermal Vagal Stimulation for POTS | June 2013 | December 2025 |
| NCT02196376 | Active, not recruiting | Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome | July 2014 | July 2025 | |
| NCT05094622 | Active, not recruiting | N/A | Physical Training in Patients With POTS After Covid-19 | January 10, 2022 | December 2024 |
| NCT01563107 | Completed | N/A | Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome | March 2012 | December 2020 |
| NCT01617616 | Completed | Tilt Table With Suspected Postural Orthostatic Tachycardia Syndrome (POTS) Subjects | March 2012 | February 12, 2014 | |
| NCT02171988 | Completed | Phase 4 | Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS) | March 2014 | December 2016 |
| NCT04875949 | Completed | N/A | Anti-Cholinergic Receptors Antibodies, Autonomic Profile and Dysautonomia Symptoms in PAF, ALS and POTS (DISAUT-AB) | April 2016 | April 2019 |
| NCT06054958 | Completed | POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/CFS | December 6, 2021 | November 22, 2022 | |
| NCT01367977 | Completed | Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life | May 2011 | April 2015 | |
| NCT01547117 | Completed | N/A | Dietary Salt in Postural Tachycardia Syndrome | March 2012 | December 2021 |
| NCT03974737 | Completed | CRI in POTS in Adolescents | June 1, 2019 | September 22, 2020 | |
| NCT04345432 | Completed | N/A | Gabapentin Treatment of Postural Tachycardia Syndrome (PoTS) | January 2014 | September 2017 |
| NCT04603157 | Completed | N/A | Remote Self-training Program for Patients With Postural Orthostatic Tachycardia Syndrome | January 1, 2020 | February 18, 2022 |
| NCT00728026 | Completed | Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome (CVS), Irritable Bowel Syndrome (IBS),Postural Orthostatic Tachycardia Syndrome (POTS), Functional Abdominal Pain (FAP) or Chronic Nausea | June 2008 | September 16, 2016 | |
| NCT05633407 | Completed | Phase 2 | Efficacy and Safety Study of Efgartigimod in Adults With Post-COVID-19 POTS | September 23, 2022 | April 18, 2024 |
| NCT03182725 | Completed | Phase 3 | Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome | February 6, 2018 | May 8, 2020 |
| NCT05404672 | Completed | N/A | Breathing Exercises With And Without Aerobic Training In Patients With Postural Orthostatic Tachycardia Syndrome | June 1, 2022 | January 15, 2023 |
| NCT03674541 | Completed | Phase 2 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | January 14, 2020 | December 20, 2021 |
| NCT03930914 | Completed | N/A | Vagus Nerve Stimulation in Treatment of Postural Orthostatic Tachycardia Syndrome | November 4, 2019 | December 7, 2021 |
| NCT05877534 | Enrolling by invitation | N/A | Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized Controlled Study | May 25, 2023 | June 1, 2025 |
| NCT02725060 | Enrolling by invitation | N/A | Autoimmune Basis for Postural Tachycardia Syndrome | February 2016 | December 2024 |
| NCT05914649 | Not yet recruiting | N/A | NC Testing in LC & POTS | June 1, 2024 | December 31, 2029 |
| NCT05363514 | Not yet recruiting | Phase 4 | Low Dose Naltrexone Use in Patients With POTS | January 2025 | December 2028 |
| NCT06292104 | Recruiting | Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS) | March 5, 2024 | January 2029 | |
| NCT04881318 | Recruiting | N/A | Compression Garments in the Community With POTS | May 17, 2021 | December 31, 2024 |
| NCT05212129 | Recruiting | N/A | Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome | April 5, 2021 | December 31, 2024 |
| NCT05344599 | Recruiting | Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome | January 19, 2022 | June 30, 2024 | |
| NCT05741112 | Recruiting | N/A | The Long COVID-19 Wearable Device Study | November 16, 2023 | December 1, 2025 |
| NCT05923840 | Recruiting | N/A | Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome With Orthostatic Hyperpnea and Hypocapnia | September 23, 2022 | August 31, 2024 |
| NCT05924646 | Recruiting | N/A | CAlgary SAlt for POTS | May 7, 2024 | December 31, 2028 |
| NCT06133075 | Recruiting | Phase 2 | Using Mirabegron to Increase BP in Patients With POTS | December 22, 2023 | November 21, 2026 |
| NCT06268288 | Recruiting | N/A | Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | February 14, 2024 | July 2024 |
| NCT00608725 | Recruiting | N/A | Pathophysiology of Orthostatic Intolerance | December 1996 | December 2025 |
| NCT05454137 | Recruiting | N/A | A Shared Medical Appointment Intervention for Quality of Life Improvement in POTS | November 1, 2023 | October 1, 2024 |
| NCT05481177 | Recruiting | Phase 4 | Ivabradine for Long-Term Effects of COVID-19 With POTS Cohort | June 14, 2023 | September 1, 2024 |
| NCT05555771 | Recruiting | N/A | Paediatric Syncope in the Emergency Department | September 3, 2022 | September 30, 2024 |
| NCT05633693 | Recruiting | N/A | Postural Sway and Counterpressure Maneuvers for Pediatric Syncope | April 17, 2023 | June 2025 |
| NCT01771484 | Terminated | Phase 1 | High Sodium Diet and External Abdominal Compression in POTS | December 2012 | January 2017 |
| NCT01978535 | Terminated | Phase 1/Phase 2 | Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS) | December 17, 2014 | September 8, 2017 |
| NCT03070730 | Terminated | Phase 1/Phase 2 | Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And Antagonist | August 15, 2011 | July 28, 2014 |
| NCT00865917 | Unknown status | Phase 2 | Cardiovascular Effects of Selective I(f)-Channel Blockade | November 2008 | December 2010 |
| NCT04855266 | Withdrawn | Phase 2 | Iron Sucrose in Patients With Iron Deficiency and POTS | April 2021 | May 2023 |
| NCT03365414 | Withdrawn | Phase 3 | A Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe POTS | January 2022 | March 2024 |
- Disase is a (Disease Ontology)
- DOID:10273
- Cross Reference ID (Disease Ontology)
- GARD:9597
- Cross Reference ID (Disease Ontology)
- ICD10CM:I95.1
- Cross Reference ID (Disease Ontology)
- MESH:D054972
- Cross Reference ID (Disease Ontology)
- MIM:604715
- Cross Reference ID (Disease Ontology)
- ORDO:443236
- Exact Synonym (Disease Ontology)
- familial orthostatic tachycardia due to norepinephrine transporter deficiency
- Exact Synonym (Disease Ontology)
- irritable heart
- Exact Synonym (Disease Ontology)
- mitral valve prolapse syndrome
- Exact Synonym (Disease Ontology)
- orhtostatic intolerance
- Exact Synonym (Disease Ontology)
- orthostatic intolerance due to NET deficiency
- Exact Synonym (Disease Ontology)
- postural tachycardia syndrome due to NET deficiency
- Exact Synonym (Disease Ontology)
- soldiers heart
- MedGen concept unique identifier (MedGen Concept name)
- C1299624
- MedGen unique identifier (MedGen Concept name)
- 226970
- MeSH unique ID (MeSH (Medical Subject Headings))
- D054972