hypogonadotropic hypogonadism
Information
- Disease name
- hypogonadotropic hypogonadism
- Disease ID
- DOID:0090070
- Description
- "A hypogonadism characterized by a impaired signalling by gonadotrpin relasing hormone." [url:https\://www.ncbi.nlm.nih.gov/pubmed/17761590]
Disease area statistics
Chromosome band
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04456296 | Completed | Phase 4 | A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism | June 30, 2020 | July 12, 2023 |
| NCT01438034 | Completed | Phase 1 | Kisspeptin in the Evaluation of Delayed Puberty | June 8, 2013 | September 10, 2021 |
| NCT01438073 | Completed | Phase 1 | Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling | September 2011 | April 2016 |
| NCT01623570 | Completed | N/A | Clinical Outcomes in WHO Type I Anovulatory Women Using r-hFSH+r-hLH in a 2:1 Ratio or hMG-HP | March 2011 | June 2012 |
| NCT01709331 | Completed | Phase 3 | A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937) | February 11, 2013 | April 8, 2015 |
| NCT02062307 | Completed | Bone Mineral Markers in Hypogonadism | August 2012 | August 2013 | |
| NCT02110368 | Completed | Phase 3 | Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditions | March 2014 | May 2014 |
| NCT02154477 | Completed | Phase 1/Phase 2 | Effect of Intranasal Insulin on LH Concentrations in Man | December 2014 | December 2017 |
| NCT00392756 | Completed | Phase 1 | Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS) | April 1989 | May 16, 2019 |
| NCT02730169 | Completed | Phase 2 | Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism | May 12, 2016 | May 19, 2018 |
| NCT02908074 | Completed | Phase 2 | A 6 Month Safety Extension Study of MBGS205 | November 15, 2016 | November 21, 2018 |
| NCT03019575 | Completed | Phase 3 | Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adolescent Males With Hypogonadotropic Hypogonadism (HH) (MK-8962-043) | February 2, 2017 | May 5, 2020 |
| NCT05752591 | Completed | Hypothalamic-pituitary Dysfunction in Diabetes | May 25, 2018 | March 14, 2024 | |
| NCT00494169 | Completed | Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders | January 1999 | February 2022 | |
| NCT00697814 | Completed | Phase 2 | Clomiphene in Males With Prolactinomas and Persistent Hypogonadism | June 2004 | June 2005 |
| NCT01403532 | Completed | Phase 4 | Sequential Therapy for Hypogonadotropic Hypogonadism | September 2009 | December 2012 |
| NCT04975334 | Enrolling by invitation | Phase 2 | Opioid Antagonism in Hypogonadotropic Hypogonadism | August 31, 2024 | May 31, 2025 |
| NCT06357442 | Not yet recruiting | Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant. | April 2024 | April 2025 | |
| NCT04252001 | Not yet recruiting | N/A | Growing up With the Young Endocrine Support System (YESS!) | December 1, 2024 | December 1, 2026 |
| NCT05633966 | Recruiting | Phase 1 | Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders | December 16, 2022 | December 2024 |
| NCT01952782 | Recruiting | Phase 1 | Neuropeptides in Human Reproduction | April 30, 2014 | August 2025 |
| NCT00914823 | Recruiting | Phase 1 | Kisspeptin Administration in the Adult | June 23, 2009 | August 2025 |
| NCT05971836 | Recruiting | The Molecular Basis of Inherited Reproductive Disorders | January 21, 2021 | March 2026 | |
| NCT05808647 | Recruiting | N/A | Low Energy Availability and Pituitary Function (LEAP Study) | April 2023 | January 2025 |
| NCT01601171 | Recruiting | Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate | March 2012 | March 2030 | |
| NCT04648969 | Recruiting | Phase 2 | Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism | January 20, 2021 | May 31, 2025 |
| NCT05896293 | Recruiting | Phase 2 | Kisspeptin Administration Subcutaneously to Patients With IHH | February 3, 2023 | June 30, 2027 |
| NCT02369796 | Terminated | Phase 2 | A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism | February 2015 | November 2015 |
| NCT01155518 | Terminated | Phase 2 | Hypogonadism in Young Men With Type 2 Diabetes | June 2010 | December 2013 |
| NCT00328926 | Terminated | Phase 4 | Luveris® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] Less Than [<] 1.2 International Unit Per Liter [IU/L]) | March 2006 | May 2012 |
| NCT03118479 | Terminated | Phase 1 | Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH) | May 2010 | September 1, 2010 |
| NCT05205837 | Terminated | Phase 4 | A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial | November 24, 2021 | August 15, 2023 |
| NCT05184374 | Unknown status | N/A | Efficacy of Prolonged GnRH Test in Male Adolescents With Postoperative HH | January 1, 2022 | December 31, 2022 |
| NCT02880280 | Unknown status | Phase 4 | Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism | August 2016 | December 2018 |
| NCT02705014 | Unknown status | N/A | Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome | January 2016 | August 2017 |
| NCT00456274 | Unknown status | N/A | Baselines in Reproductive Disorders | September 1999 | September 2020 |
| NCT00383656 | Unknown status | Phase 2 | Pulsatile GnRH in Anovulatory Infertility | January 1989 | September 2020 |
- Disase is a (Disease Ontology)
- DOID:1924
- Cross Reference ID (Disease Ontology)
- ICD10CM:E23.0
- Cross Reference ID (Disease Ontology)
- MIM:PS147950
- Cross Reference ID (Disease Ontology)
- ORDO:432
- Cross Reference ID (Disease Ontology)
- ORDO:478
- Exact Synonym (Disease Ontology)
- congenital idiopathic hypogonadotropic hypogonadism
- Exact Synonym (Disease Ontology)
- hypogonadotropism
- Exact Synonym (Disease Ontology)
- isolated congenital gonadotropin deficiency