beta-thalassemia major
Information
- Disease name
- beta-thalassemia major
- Disease ID
- DOID:0080771
- Description
- "A beta thalassemia that is characterized by severe anemia and enlarged liver and spleen before 2 years of age." [url:https\://ghr.nlm.nih.gov/condition/beta-thalassemia, url:https\://pubmed.ncbi.nlm.nih.gov/12480689/, url:https\://www.ncbi.nlm.nih.gov/pubmed/19258591]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT00171301 | Completed | Phase 4 | Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration) | June 2005 | May 2008 |
| NCT02151526 | Completed | Phase 1/Phase 2 | A Study Evaluating the Safety and Efficacy of LentiGlobin BB305 Drug Product in β-Thalassemia Major (Also Referred to as Transfusion-dependent β-Thalassemia [TDT]) and Sickle Cell Disease | June 7, 2013 | February 26, 2019 |
| NCT02198508 | Completed | N/A | Clinical Trial of Deferasirox Combination Treatment With Deferiprone In Thalassaemia Patients | July 2007 | |
| NCT03653338 | Recruiting | Phase 1/Phase 2 | T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias | August 2, 2018 | August 1, 2026 |
| NCT06291961 | Recruiting | Phase 1 | A Safety and Efficacy Study Evaluating CS-101 in Subjects With β-Thalassemia Major | April 18, 2024 | July 2025 |
| NCT02342145 | Unknown status | Phase 4 | Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major | June 2014 | December 2018 |
| NCT00999349 | Unknown status | Phase 2/Phase 3 | Therapeutic Effects of Silymarin in Patients With B-thalassemia Major | March 2009 | |
| NCT01511848 | Unknown status | Phase 2/Phase 3 | Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload | February 2012 | February 2013 |
- Disase is a (Disease Ontology)
- DOID:12241
- Cross Reference ID (Disease Ontology)
- MIM:187550
- Cross Reference ID (Disease Ontology)
- NCI:C129699
- Cross Reference ID (Disease Ontology)
- ORDO:231214
- Exact Synonym (Disease Ontology)
- Cooley's anemia
- OrphaNumber from OrphaNet (Orphanet)
- 231214