gastroesophageal adenocarcinoma (Cancer)

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Information
Disease name
gastroesophageal adenocarcinoma
Disease ID
DOID:0080375
Description
"A gastroesophageal cancer that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue." [url:https\://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827797]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
NCT ID Status Phase Summary Start date Completion date
NCT04021108 Active, not recruiting Phase 2 Phase II Study of Short Course FOLFOX Chemotherapy With Either Nivolumab or Nivolumab + Radiation in the First Line Treatment of Metastatic or Unresectable Gastroesophageal Cancers (BMS Protocol CA209-76L) July 22, 2019 April 2026
NCT01045421 Completed Phase 1/Phase 2 Alisertib in Adults With Nonhematological Malignancies, Followed by Alisertib in Lung, Breast, Head and Neck or Gastroesophageal Malignancies February 2010 April 2014
NCT00073502 Completed Phase 2 Phase II Study of Single Agent OSI-7904L in Patients With Gastric or Gastroesophageal (GEJ) Cancer October 2003 October 2003
NCT01757171 Completed Phase 2 Phase II Study of Cabazitaxel in Refractory Metastatic Gastric or Gastroesophageal Adenocarcinoma December 2012 June 2017
NCT03639714 Completed Phase 1/Phase 2 A Study of a Personalized Neoantigen Cancer Vaccine February 13, 2019 November 10, 2022
NCT03794128 Completed A Study of Personalized Neoantigen Cancer Vaccines July 25, 2018 May 26, 2020
NCT06445972 Not yet recruiting Phase 1/Phase 2 Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06) July 1, 2024 October 27, 2028
NCT05733689 Not yet recruiting Phase 1 Response Adapted Neoadjuvant Therapy in Gastroesophageal Cancers (RANT-GC Trial) February 2025 February 2026
NCT05986227 Not yet recruiting Phase 1/Phase 2 The Sequential Combination of FOLFOX and Toripalimab for Perioperative Immuno-Oncology Therapy of HER2-negative Adenocarcinoma of the Esophagogastric Junction (Siewert I/II): August 1, 2023 July 1, 2026
NCT05977322 Recruiting Phase 1 A Phase I Study of [177Lu]Lu-FF58 in Patients With Advanced Solid Tumors. October 6, 2023 January 26, 2027
NCT05152147 Recruiting Phase 3 A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers December 2, 2021 February 1, 2026
NCT06043427 Recruiting Phase 2 Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma April 16, 2024 June 30, 2026
NCT05029882 Recruiting Phase 1 Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab October 13, 2021 November 23, 2025
NCT04712721 Recruiting Early Phase 1 Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins. October 14, 2021 June 26, 2024
NCT01182610 Terminated Phase 2 Panitumumab, Paclitaxel, Carboplatin and 5FU in the Treatment of Potentially Resectable Gastroesophageal Adenocarcinoma April 2011 March 2012
NCT04602117 Withdrawn Phase 1 ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer July 28, 2021 November 17, 2021
Disase is a (Disease Ontology)
DOID:0080374
Exact Synonym (Disease Ontology)
gastric and esophageal adenocarcinoma
Exact Synonym (Disease Ontology)
gastro-esophageal adenocarcinoma