chronic myelomonocytic leukemia (Cancer)

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Information
Disease name
chronic myelomonocytic leukemia
Disease ID
DOID:0080188
Description
"A chronic leukemia characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood." [url:https\://en.wikipedia.org/wiki/Chronic_myelomonocytic_leukemia, url:https\://www.ncbi.nlm.nih.gov/pubmed/30367269, url:https\://www.ncbi.nlm.nih.gov/pubmed/31093889]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04761770 Active, not recruiting Phase 2 Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders February 15, 2021 February 2025
NCT05024994 Active, not recruiting Phase 2 A Study of E7820 in People With Bone Marrow (Myeloid) Cancers August 13, 2021 August 2024
NCT04609826 Active, not recruiting Phase 1 A Study of JNJ-74856665 in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) November 26, 2020 July 31, 2024
NCT04522895 Active, not recruiting Phase 2 IDH2-Post-Allo-Trial for Patients With IDH2-mut Myeloid Neoplasms After Allo-SCT August 27, 2020 August 30, 2024
NCT00843882 Active, not recruiting Phase 3 Lenalidomide With or Without Epoetin Alfa in Treating Patients With Myelodysplastic Syndrome and Anemia January 29, 2009 September 21, 2024
NCT02684162 Active, not recruiting Phase 2 Guadecitabine and Donor Lymphocyte Infusion in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapsing After Allogeneic Stem Cell Transplant June 22, 2016 December 31, 2024
NCT03722407 Active, not recruiting Phase 2 Ruxolitinib for the Treatment of Chronic Myelomonocytic Leukemia (CMML): A Phase 2 Expansion August 28, 2019 July 1, 2024
NCT03289910 Active, not recruiting Phase 2 Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia September 24, 2018 December 21, 2024
NCT01139970 Active, not recruiting Phase 1 Veliparib and Temozolomide in Treating Patients With Acute Leukemia May 21, 2010 February 22, 2025
NCT00392353 Active, not recruiting Phase 1/Phase 2 Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia November 22, 2006 September 30, 2024
NCT02935361 Active, not recruiting Phase 1/Phase 2 Guadecitabine and Atezolizumab in Treating Patients With Advanced Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia That Is Refractory or Relapsed November 2, 2016 November 30, 2025
NCT01522976 Active, not recruiting Phase 2 Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia March 1, 2012 March 7, 2025
NCT04473911 Active, not recruiting Phase 1 Haplo Peripheral Blood Sct In GVHD Prevention August 14, 2020 October 2024
NCT02566304 Active, not recruiting Phase 2 Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies November 13, 2015 February 13, 2024
NCT03404193 Active, not recruiting Phase 2 Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic Syndrome January 18, 2018 December 31, 2024
NCT00588991 Active, not recruiting Phase 1 Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders November 28, 2007 March 7, 2025
NCT01885689 Active, not recruiting Phase 2 Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia, Acute Leukemia in Remission, or Chronic Myelomonocytic Leukemia February 10, 2014 December 30, 2024
NCT03912064 Active, not recruiting Phase 1 A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT July 10, 2019 July 1, 2024
NCT03862157 Active, not recruiting Phase 1/Phase 2 Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia February 27, 2019 January 31, 2025
NCT03333486 Active, not recruiting Phase 2 Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer December 7, 2017 August 28, 2024
NCT00096122 Completed Phase 1/Phase 2 Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia September 2004 February 2010
NCT00098423 Completed Phase 1 Tanespimycin and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, Chronic Myelomonocytic Leukemia, or Myelodysplastic Syndromes November 2004
NCT00101179 Completed Phase 1 MS-275 and Azacitidine in Treating Patients With Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia November 3, 2004 February 3, 2014
NCT00112593 Completed N/A Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer November 1999
NCT00002798 Completed Phase 3 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome August 1996
NCT00136409 Completed Phase 2 A Study of Gleevec in Patients With Idiopathic Myelofibrosis or Chronic Myelomonocytic Leukemia (CMML) May 2002 December 2008
NCT00171912 Completed Phase 2 Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes September 2004 January 2012
NCT00283114 Completed Phase 1 A Safety Study of Lintuzumab in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome November 2005 January 2010
NCT00299156 Completed Phase 2 Oral Clofarabine Study in Patients With Myelodysplastic Syndrome March 2006 December 2012
NCT00313586 Completed Phase 2 Azacitidine With or Without Entinostat in Treating Patients With Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia August 2006 July 2013
NCT00351975 Completed Phase 1 Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases June 2006 March 2013
NCT00357305 Completed Phase 1 Vorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or Myelodysplastic Syndromes or Myeloproliferative Disorders May 2006
NCT00357708 Completed Phase 1 Vorinostat and Decitabine in Treating Patients With Relapsed, Refractory, or Poor-Prognosis Hematologic Cancer or Other Diseases June 2006
NCT00381550 Completed Phase 2 3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia August 2006 March 2011
NCT00397813 Completed Phase 2 Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders January 2006 March 2018
NCT00408681 Completed N/A Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant June 2006 May 1, 2015
NCT00451048 Completed Phase 2 Sunitinib in Treating Patients With Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia February 2007 October 2012
NCT00462605 Completed Phase 2 MS-275 and GM-CSF in Treating Patients With Myelodysplastic Syndrome and/or Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphocytic Leukemia April 2007 March 2011
NCT00489203 Completed Phase 2 Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer April 2007
NCT00719836 Completed Phase 1/Phase 2 A Phase 1/2 Study of SB1518 for the Treatment of Advanced Myeloid Malignancies August 2008 January 2012
NCT00795769 Completed Phase 2 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant August 8, 2008 June 10, 2009
NCT00799461 Completed Phase 3 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications August 2008
NCT00809250 Completed Phase 1 Vaccination With GM-K562 Cells in Patients With Advanced Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) After Allogeneic Hematopoetic Stem Cell Transplantation November 2008 January 2020
NCT00856388 Completed N/A Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders January 14, 2009 March 13, 2019
NCT00860574 Completed Phase 2 Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia February 2009
NCT00890747 Completed Phase 1 Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy August 2009
NCT00946647 Completed Phase 1/Phase 2 A Phase Ib/IIb, Open-label, Multi-center, Study of Oral Panobinostat Administered With 5-Azacitidine (in Adult Patients With Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML). December 2, 2009 April 29, 2019
NCT00988715 Completed Phase 1 Donor Peripheral Blood Stem Cell Transplant and Pretargeted Radioimmunotherapy in Treating Patients With High-Risk Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome April 21, 2010
NCT01048034 Completed Phase 2 Evaluation of Azacitidine in Transfusion Dependent Patients With Low-risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML) January 2010 August 2012
NCT01053494 Completed N/A Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer April 2010 February 2012
NCT01083706 Completed Phase 2 Azacitidine in Treating Patients With Relapsed Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant April 2010
NCT01093586 Completed Phase 2 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies September 2007 December 2015
NCT01098084 Completed Phase 2 Decitabine in Patients With Chronic Myelomonocytic Leukemia (CMML) November 2008 June 2009
NCT01101880 Completed Phase 2 Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm August 2010 July 2017
NCT01146210 Completed Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia May 2009 May 2016
NCT01165996 Completed Phase 1/Phase 2 Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome July 2010 August 2012
NCT01169012 Completed Phase 1 PK Study of Oral and IV Clofarabine in High Risk Myelodysplasia+Acute Leukemias September 2010 January 2013
NCT01199562 Completed Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant December 2010 December 2013
NCT01231919 Completed Phase 1 MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia January 2011
NCT01233921 Completed N/A Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer September 2010
NCT01241500 Completed Phase 3 Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess Blasts November 2010 October 3, 2018
NCT01251627 Completed Phase 2 Multicenter Study to Assess the Efficacy of Decitabine in the Treatment of Chronic Myelomonocytic Leukemia April 2010 June 2018
NCT01300572 Completed Phase 1 Yttrium-90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk AML, ALL, or MDS January 2012 November 22, 2019
NCT01305200 Completed Phase 3 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant March 2011 June 30, 2015
NCT01338987 Completed Phase 2 Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow Transplantation April 19, 2011 November 19, 2020
NCT01350947 Completed Phase 2 A Study of 5-Azacitidine (Vidaza®) in Patients With Chronic Myelomonocytic Leukemia April 2011 September 2014
NCT01384513 Completed Phase 2 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies August 4, 2011 November 16, 2022
NCT01398462 Completed Phase 1 Phase I Clinical Study of CWP232291 in Acute Myeloid Leukemia Patients July 2011 December 2015
NCT01404741 Completed Phase 2 5-azacytidine Treatment Versus 5-azacytidine Followed by Allogeneic Stem Cell Transplantation in Elderly Patients With Myelodysplastic Syndrome (MDS) July 2011 July 2021
NCT01427881 Completed Phase 2 Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies September 2011 July 2015
NCT01484015 Completed Phase 1 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia February 2011 October 2012
NCT01529827 Completed Phase 2 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies February 28, 2012 August 29, 2019
NCT01588015 Completed Phase 1 Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant October 29, 2012 February 2, 2024
NCT01595295 Completed Registry on Hypomethylating Agents in Myeloid Neoplasms February 9, 2009 December 31, 2021
NCT01629082 Completed Phase 1 Clofarabine Followed By Lenalidomide for High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia June 6, 2012 June 27, 2018
NCT01664897 Completed Phase 2 Erlotinib Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia May 16, 2013 October 25, 2018
NCT01736683 Completed Phase 2 Study of Sotatercept for the Treatment of Anemia in low-or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) or Non-proliferative Chronic Myelomonocytic Leukemia (CMML) November 28, 2012 April 30, 2018
NCT00118352 Completed Phase 2 Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer March 2005 May 26, 2015
NCT00005845 Completed Phase 1 Tipifarnib in Treating Patients With Myelodysplastic Syndromes June 2002
NCT00005942 Completed Phase 1/Phase 2 Liposomal Daunorubicin and SU5416 in Treating Patients With Hematologic Cancer That Has Not Responded to Initial Therapy March 2000
NCT00006251 Completed Phase 1/Phase 2 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer May 2000
NCT00008177 Completed Phase 1 Radiolabeled Monoclonal Antibody Therapy, Fludarabine Phosphate, and Low-Dose Total-Body Irradiation Followed by Donor Stem Cell Transplant and Immunosuppression Therapy in Treating Older Patients With Advanced Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes July 27, 1999 December 15, 2010
NCT00012376 Completed Phase 1 Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer March 2001
NCT00014235 Completed N/A Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies December 2000
NCT00015990 Completed Phase 2 Thalidomide in Treating Patients With Myelodysplastic Syndrome April 2001
NCT00025415 Completed Phase 1 Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction August 2001
NCT00027820 Completed Phase 1/Phase 2 Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer August 2001 September 5, 2004
NCT00038051 Completed Phase 1 Evaluation of the Anti-CD-33 Immunotoxin Hum-195/rGel in Patients With Advanced Myeloid Malignancies May 1999 February 2013
NCT00038675 Completed N/A Therapy of HES, PV, Atypical Chronic Myelocytic Leukemia (CML) or Chronic Myelomonocytic Leukemia (CMML), and Mastocytosis With Imatinib Mesylate June 2001 November 2013
NCT00039416 Completed Phase 2 Imatinib Mesylate in Treating Patients With Myelofibrosis April 2002
NCT00052520 Completed Phase 1/Phase 2 Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation September 2002 June 2013
NCT00067808 Completed Phase 2 Study of Three Different Schedules of Low-Dose Decitabine in Myelodysplastic Syndrome (MDS) October 2003 May 2009
NCT00078858 Completed Phase 1/Phase 2 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant September 2003
NCT00079313 Completed Phase 2 Imatinib (Gleevec(Registered Trademark)) to Treat Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia January 14, 2004 October 25, 2010
NCT00084916 Completed Phase 2 CCI-779 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Chronic Myelogenous Leukemia in Blastic Phase April 2004
NCT00087204 Completed Phase 1 Rebeccamycin Analog in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia May 2004
NCT00095797 Completed Phase 1 XK469R in Treating Patients With Refractory Hematologic Cancer October 2004
NCT01757639 Completed Phase 1 Ipilimumab in Treating Patients With Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia December 14, 2012
NCT01760655 Completed Phase 2 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies December 24, 2012 December 5, 2022
NCT01772420 Completed Phase 2 Phase II Study of Lenalidomide and Eltrombopag in Patients With Symptomatic Anemia October 2012 July 9, 2020
NCT01789255 Completed Phase 2 Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies June 2013 March 2014
NCT01812252 Completed Phase 2 Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant August 19, 2013 October 26, 2022
NCT01823198 Completed Phase 1/Phase 2 Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies June 11, 2013 May 10, 2022
NCT01831232 Completed N/A Idarubicin, Cytarabine, and Pravastatin Sodium in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes May 2013 January 2016
NCT01834248 Completed Phase 1 DEC-205/NY-ESO-1 Fusion Protein CDX-1401and Decitabine in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia July 30, 2013 March 21, 2016
NCT01872819 Completed N/A Treatment for Relapsed/Refractory AML Based on a High Throughput Drug Sensitivity Assay August 2, 2013 November 17, 2014
NCT01926587 Completed Phase 1/Phase 2 Phase II Part 2 Expansion of Oral Rigosertib in Combination With Azacitidine August 2013 February 16, 2021
NCT01928537 Completed Phase 3 Efficacy and Safety of IV Rigosertib in MDS Patients With Excess Blasts Progressing After Azacitidine or Decitabine August 2013 June 29, 2017
NCT02129101 Completed Phase 1 Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies May 2014 October 25, 2019
NCT02190695 Completed Phase 2 Leukemia SPORE Phase II DAC Study for R/R and Elderly Acute AML and MDS April 1, 2013 April 16, 2020
NCT02210858 Completed Phase 1/Phase 2 Tipifarnib in Treating Patients With Chronic Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or Undifferentiated Myeloproliferative Disorders May 2000 March 2017
NCT02268253 Completed Phase 2 Tagraxofusp (SL-401) in Patients With CMML or MF December 2014 March 7, 2023
NCT02367456 Completed Phase 1 A Combination Study of PF-04449913 (Glasdegib) and Azacitidine In Untreated MDS, AML and CMML Patients April 28, 2015 March 7, 2022
NCT02397720 Completed Phase 2 Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia April 7, 2015 October 9, 2023
NCT02553941 Completed Phase 1 Ibrutinib and Azacitidine for Treatment of Higher Risk Myelodysplastic Syndrome May 17, 2016 November 7, 2019
NCT02556931 Completed Phase 2 Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies December 2015 April 2021
NCT02649764 Completed Phase 1 Prexasertib (LY2606368), Cytarabine, and Fludarabine in Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome May 4, 2016 July 12, 2022
NCT02666950 Completed Phase 2 WEE1 Inhibitor AZD1775 With or Without Cytarabine in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome May 5, 2017 October 17, 2018
NCT02960646 Completed Phase 1 Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies January 18, 2017 February 13, 2023
NCT03018223 Completed Phase 1 Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCT January 31, 2017 March 18, 2021
NCT03047993 Completed Phase 1/Phase 2 Glutaminase Inhibitor CB-839 and Azacitidine in Treating Patients With Advanced Myelodysplastic Syndrome November 15, 2017 March 16, 2023
NCT03066648 Completed Phase 1 Study of PDR001 and/or MBG453 in Combination With Decitabine in Patients With AML or High Risk MDS July 6, 2017 September 8, 2023
NCT03072043 Completed Phase 1/Phase 2 Phase 1b/2 Safety and Efficacy of APR-246 w/Azacitidine for tx of TP53 Mutant Myeloid Neoplasms May 18, 2017 December 8, 2021
NCT03096782 Completed Phase 2 Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma October 13, 2017 September 20, 2022
NCT03263637 Completed Phase 1 Study to Assess Safety, Tolerability, Pharmacokinetics and Antitumor Activity of AZD4573 in Relapsed/Refractory Haematological Malignancies October 24, 2017 September 30, 2021
NCT03306264 Completed Phase 3 Study of ASTX727 vs IV Decitabine in MDS, CMML, and AML February 15, 2018 March 28, 2023
NCT03358719 Completed Phase 1 DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, Decitabine, and Nivolumab in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia March 27, 2018 August 25, 2021
NCT03363399 Completed Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression and Myelodysplastic Syndromes February 22, 2018 September 6, 2018
NCT03493646 Completed Phase 2 Evaluating in Vivo AZA Incorporation in Mononuclear Cells Following Vidaza or CC486 May 18, 2018 September 21, 2021
NCT03515512 Completed Phase 1 IDH2 Inhibition Using Enasidenib as Maintenance Therapy for IDH2-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation July 17, 2018 February 13, 2023
NCT03526666 Completed Ascorbic Acid Levels in MDS, AML, and CMML Patients November 1, 2017 October 31, 2018
NCT03734601 Completed Phase 2 Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation November 5, 2018 November 17, 2020
NCT03746041 Completed Phase 1 A Phase I Pilot Study of Abaloparatide + Bevacizumab in Myelodysplastic Syndromes February 14, 2019 June 6, 2022
NCT03813186 Completed Phase 1 Effect of Food on Blood Levels of ASTX727 November 8, 2018 December 16, 2019
NCT04146038 Completed Phase 2 Salsalate, Venetoclax, and Decitabine or Azacitidine for the Treatment of Acute Myeloid Leukemia or Advanced Myelodysplasia/Myeloproliferative Disease October 26, 2020 October 25, 2022
NCT04842604 Completed Phase 3 Continuation Study of B1371019(NCT03416179) and B1371012(NCT02367456) Evaluating Azacitidine With Or Without Glasdegib In Patients With Previously Untreated AML, MDS or CMML May 17, 2021 December 2, 2022
NCT05209152 Completed Phase 1 AMG 176 With Azacitidine in Subjects With Myelodysplastic Syndrome /Chronic Myelomonocytic Leukemia November 14, 2022 December 19, 2023
NCT04093570 Enrolling by invitation Phase 2 A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose), With a Food Effect Substudy at Select Study Centers September 30, 2019 December 31, 2024
NCT06355583 Not yet recruiting Phase 2 Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial April 15, 2024 May 1, 2027
NCT06439199 Not yet recruiting Biological, Prospective Study Evaluating the Dosage of Plasma Cytokines Including the FLT3 Ligand and IL6 of Patients Treated With Non-intensive Chemotherapy June 15, 2024 December 15, 2026
NCT05739409 Not yet recruiting N/A LILRB4 STAR-T Cell Therapy for Monocytic Leukemia February 2023 August 2024
NCT04953312 Not yet recruiting N/A Calprotectin, a Biomarker of COVID-19 Severity (CALPRO) January 2023 July 2024
NCT06111612 Not yet recruiting Intensive Conditioning With Thiotepa Combined With Bu/Flu/Ara-C in Allo-HSCT for Myeloid Malignancies With Extramedullary Involvement January 1, 2024 January 1, 2027
NCT06159491 Not yet recruiting Phase 1/Phase 2 Pacritinib in CMML January 2, 2024 May 2027
NCT06071624 Recruiting Phase 1 Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line Treatment for Chronic Myelomonocytic Leukemia, CMML. February 21, 2024 December 2043
NCT05031897 Recruiting Phase 2 Reduced-Intensity Conditioning for the Prevention of Treatment-Related Mortality in Patients Who Undergo a Hematopoietic Stem Cell Transplant October 25, 2021 October 1, 2024
NCT05038592 Recruiting Phase 1/Phase 2 Tagraxofusp and Decitabine for the Treatment of Chronic Myelomonocytic Leukemia March 4, 2022 January 29, 2025
NCT05600894 Recruiting Phase 2 Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm June 27, 2023 August 31, 2025
NCT05428969 Recruiting Phase 1/Phase 2 A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies (BEXMAB) June 2, 2022 December 31, 2024
NCT03672539 Recruiting Phase 2 Liposome-encapsulated Daunorubicin-Cytarabine and Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome November 7, 2018 November 30, 2025
NCT03683433 Recruiting Phase 2 Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation September 18, 2018 September 20, 2025
NCT05364762 Recruiting Phase 2 Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants November 23, 2022 April 28, 2024
NCT03418038 Recruiting Phase 2 Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia March 23, 2018 March 2026
NCT05233618 Recruiting Phase 1 Study of Tagraxofusp for Post-Transplant Maintenance for Patients With CD 123+ AML, MF and CMML (HSCT 002) July 13, 2022 October 1, 2026
NCT06001385 Recruiting Phase 2 HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis December 8, 2023 June 30, 2026
NCT04802161 Recruiting Phase 2 Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes August 24, 2022 December 31, 2024
NCT04888741 Recruiting Phase 2 Methods of T Cell Depletion Trial (MoTD) February 22, 2021 January 2026
NCT04937166 Recruiting Phase 1 A Study of Dual-SIgnaling Protein 107 (DSP107) for Patients With Hematological Malignancies January 13, 2022 December 2024
NCT04980404 Recruiting Phase 1 Inqovi Maintenance Therapy in Myeloid Neoplasms September 17, 2021 August 2024
NCT04708054 Recruiting Phase 2 Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS October 21, 2021 December 31, 2024
NCT04730258 Recruiting Phase 1/Phase 2 A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML April 16, 2021 January 2026
NCT05970822 Recruiting Phase 1 Study of BC3402 in Combination With Azacitidine in Patients With MDS and CMML June 18, 2023 December 2025
NCT05641259 Recruiting Phase 1 A Study to Assess Safety and Preliminary Efficacy of LP-108 Combined With Azacitidine In Subjects With AML, MDS, CMML February 14, 2023 December 31, 2025
NCT03964506 Recruiting Early Phase 1 Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant July 1, 2020 March 1, 2025
NCT03999723 Recruiting Phase 2 Combining Active and Passive DNA Hypomethylation September 11, 2019 December 2027
NCT06218628 Recruiting Phase 1 Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition April 5, 2024 August 27, 2030
NCT04160052 Recruiting Phase 1/Phase 2 Venetoclax and Azacitidine for the Treatment of High-Risk Recurrent or Refractory Myelodysplastic Syndrome October 1, 2019 December 31, 2025
NCT04167917 Recruiting Phase 1 NTX-301 in MDS/AML January 6, 2021 March 31, 2028
NCT04195633 Recruiting Phase 2 Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies January 25, 2021 December 31, 2026
NCT04239157 Recruiting Phase 2 A Phase II, Open-Label, Study of Subcutaneous Canakinumab, an Anti-IL-1β Human Monoclonal Antibody, for Patients With Low or Int-1 Risk IPSS/IPSS-R Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia August 25, 2020 December 31, 2026
NCT04358393 Recruiting Phase 1/Phase 2 A Study of APG-115 Alone or Combined With Azacitidine in Patients With AML, CMML, or MDS December 4, 2020 December 30, 2025
NCT05807932 Recruiting Phase 1/Phase 2 Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAML June 26, 2023 January 30, 2028
NCT04493138 Recruiting Phase 1/Phase 2 Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations July 21, 2020 December 31, 2025
NCT02727803 Recruiting Phase 2 Personalized NK Cell Therapy in CBT May 19, 2016 May 31, 2025
NCT03383575 Recruiting Phase 2 Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome January 17, 2018 February 28, 2025
NCT04581512 Recruiting Phase 1/Phase 2 Study to Evaluate the Safety and Tolerability of EP0042 November 2, 2020 December 2025
NCT05636514 Recruiting Phase 1 Combined Evaluation of Epigenetic and Sensitising Therapy in AML and MDS December 14, 2022 December 5, 2025
NCT04655755 Recruiting Phase 1/Phase 2 Venetoclax in Combination With ASTX727 for the Treatment of Treatment-Naive High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia January 19, 2021 July 20, 2026
NCT03326921 Suspended Phase 1 HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant February 23, 2018 July 16, 2028
NCT03128034 Suspended Phase 1/Phase 2 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia October 24, 2017 March 31, 2027
NCT03670966 Suspended Phase 1/Phase 2 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome July 10, 2019 March 20, 2027
NCT00387426 Terminated Phase 2 Sunitinib in Treating Patients With Idiopathic Myelofibrosis September 2006 February 2009
NCT01010256 Terminated The Expression of PTEN Protein and mRNA in Malignant Cells of Chronic Myelomonocytic Leukemia November 1, 2009 October 3, 2019
NCT00852709 Terminated Phase 1 Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Children With Relapsed or Refractory Acute Leukemias September 1, 2007 November 20, 2009
NCT00708721 Terminated Phase 1/Phase 2 Low-dose Oral Clofarabine for the Treatment of IPSS INT-1, INT-2 or HIGH Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia March 2008 November 2014
NCT00589316 Terminated Phase 1 Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Syndrome October 5, 2007 October 1, 2021
NCT01749111 Terminated Phase 3 Comparison Between Cyclophosphamide and Combination of Methotrexate + Calcineurin Inhibitor for GVHD Prophylaxis December 2012 August 2016
NCT00509249 Terminated Phase 2 Aflibercept in Treating Patients With Myelodysplastic Syndromes September 2007 December 2010
NCT01773395 Terminated Phase 2 GVAX vs. Placebo for MDS/AML After Allo HSCT January 8, 2013 November 24, 2021
NCT00119366 Terminated Phase 2 Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Total Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome May 2003 May 8, 2019
NCT00113321 Terminated Phase 2 Low-Dose Decitabine in Myelodysplastic Syndrome Post Azacytidine Failure March 2005 November 2008
NCT01620216 Terminated Phase 2 Targeted Therapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia May 11, 2012 April 30, 2017
NCT01908387 Terminated Phase 1 Phase 1 Study of CC-486 in Japanese Subjects With Hematological Neoplasms July 2013 July 2015
NCT00074750 Terminated Phase 1 Study of DT388GMCSF Fusion Protein in Acute Myelogenous Leukemia (AML) and Chronic Myelomonocytic Leukemia (CMML) December 2003 December 2004
NCT05107856 Terminated Phase 1 PRT1419 as Monotherapy or in Combination With Azacitidine or Venetoclax in R/R Myeloid or B-cell Malignancies March 22, 2022 January 19, 2024
NCT01159067 Terminated Phase 2 Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload July 2010 August 9, 2011
NCT03146871 Terminated Phase 2 Recombinant EphB4-HSA Fusion Protein and Azacitidine or Decitabine for Relapsed or Refractory Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Patients Previously Treated With a Hypomethylating Agent April 20, 2017 March 27, 2019
NCT01368757 Unknown status Phase 1/Phase 2 Lenalidomide in Patients With Chronic Myelomonocytic Leukemia June 2010 May 2015
NCT03588078 Unknown status Phase 1/Phase 2 Study of the Safety and Efficacy of APR-246 in Combination With Azacitidine September 15, 2018 May 15, 2021
NCT00885508 Unknown status Phase 2 A Study of the Efficacy and Safety of Lenalidomide Combined to Escalating Doses of Chemotherapy in Intermediate-2-or High Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) With Del 5q February 2009 December 2015
NCT03280888 Unknown status Relevance of Peripheral Cells in the Pathophysiology of Chronic Myelomonocytic Leukemia (CMML) November 5, 2014 November 5, 2018
NCT01133886 Unknown status Phase 2 Use of Decitabine in Myelodysplastic Syndrome (MDS) Following Azacitidine (AZA) Failure September 2010 September 2013
NCT01894477 Unknown status Phase 2 Treo/Flu/TBI With Donor Stem Cell Transplant for Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia November 2013 June 2022
NCT01558778 Withdrawn N/A Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant May 2012
NCT02564536 Withdrawn Phase 1 Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS) June 2017 June 30, 2020
NCT05246384 Withdrawn Phase 1/Phase 2 Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of RP7214 in Combination With Azacitidine in Patients With Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia and Acute Myeloid Leukemia January 2023 November 2025
NCT06085638 Withdrawn Phase 1/Phase 2 Phase I/II Study of SY-1425 (Tamibarotene) in Combination With Azacitidine and Venetoclax for Patients With Chronic Myelomonocytic Leukemia September 14, 2023 October 20, 2023
NCT03602898 Withdrawn Phase 2 Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation June 1, 2021 September 17, 2023
NCT05456269 Withdrawn Phase 1 A Study of Bisantrene Combined With Cytarabine or With Decitabine for Adult Subjects With Extramedullary AML and MDS July 29, 2022 August 31, 2023
NCT05895201 Withdrawn Phase 1/Phase 2 High-Dose Post-Transplant Cyclophosphamide, Bortezomib, and Sitagliptin for the Prevention of GVHD November 2023 December 2025
Disase is a (Disease Ontology)
DOID:1036
Cross Reference ID (Disease Ontology)
GARD:8225
Cross Reference ID (Disease Ontology)
ICDO:9945/3
Cross Reference ID (Disease Ontology)
NCI:C3178
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0012325