NUT midline carcinoma (Cancer)
Information
- Disease name
- NUT midline carcinoma
- Disease ID
- DOID:0060463
- Description
- "A carcinoma that is characterized by a BRD4-NUT translocation involving the rearrangement of the bromodomain-containing protein 4 (BRD4) and the gene encoding nuclear protein of the testis (NUT) at 15q14, BRD4-NUT t(15;19)(q14;q13.1) and arises from midline epithelial structures, most commonly the head, neck, and mediastinum." [url:https\://en.wikipedia.org/wiki/NUT_midline_carcinoma, url:https\://omim.org/entry/608749, url:https\://omim.org/entry/608963, url:https\://www.ncbi.nlm.nih.gov/pubmed/21221870, url:https\://www.ncbi.nlm.nih.gov/pubmed/25685583, url:https\://www.ncbi.nlm.nih.gov/pubmed/26378054, url:https\://www.ncbi.nlm.nih.gov/pubmed/26402248]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02259114 | Completed | Phase 1 | A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003) | October 23, 2014 | March 3, 2017 |
| NCT02307240 | Completed | Phase 1 | Open Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of CUDC-907 in Subjects With Advanced/Relapsed Solid Tumors | November 2014 | May 31, 2019 |
- Disase is a (Disease Ontology)
- DOID:305
- Cross Reference ID (Disease Ontology)
- NCI:C45716
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:733922002
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C1707291
- Exact Synonym (Disease Ontology)
- nuclear protein in testis midline carcinoma