Stargardt disease
Information
- Disease name
- Stargardt disease
- Disease ID
- DOID:0050817
- Description
- "An age related macular degeneration that is characterized by progressive vision loss usually to the point of legal blindness." [url:http\://en.wikipedia.org/wiki/Stargardt_disease]
Disease area statistics
Chromosome band
| Gene symbol | Chromosome | Start | Stop | The number of variant |
|---|---|---|---|---|
| ABCA4 | 1 | 93,992,834 | 94,121,148 | 6 |
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT04909398 | Completed | N/A | Pupil Dynamics and Color Vision for the Detection of Eye Diseases | March 22, 2018 | May 22, 2019 |
| NCT05417126 | Completed | Phase 2 | Safety and Effects of a Single Intravitreal Injection of vMCO-010 Optogenetic Therapy in Subjects With Stargardt Disease | July 5, 2022 | September 28, 2023 |
| NCT02410122 | Completed | The Natural History of the Progression of Atrophy Secondary to Stargardt Disease Type 4: PROM1-Related Macular Dystrophy | December 2014 | March 2018 | |
| NCT05904444 | Completed | N/A | The Effect of Duration Between Sessions on Microperimetric Biofeedback Training in Patients With Maculopathies | August 15, 2018 | April 30, 2023 |
| NCT02230228 | Completed | Phase 1 | Phase 1 Safety Study of ALK-001 in Healthy Volunteers | April 2014 | February 2015 |
| NCT03772665 | Completed | Phase 3 | Safety and Efficacy of Emixustat in Stargardt Disease | January 7, 2019 | June 23, 2022 |
| NCT01977846 | Completed | A Natural History of the Progression of Stargardt Disease: Retrospective and Prospective Studies | August 2013 | February 2017 | |
| NCT05266014 | Completed | Phase 1/Phase 2 | This is a Dose-finding Study Followed by 2-year Extension Study to Evaluate Safety and Tolerability of Tinlarebant in Adolescent Subjects With Stargardt Disease | March 12, 2021 | August 15, 2023 |
| NCT06377150 | Completed | Stargardt Disease in Childhood | April 1, 2022 | March 31, 2024 | |
| NCT02255981 | Completed | N/A | Efficacy of Acupuncture in Macular Diseases | March 2013 | November 2016 |
| NCT03033108 | Completed | Phase 2 | Pharmacodynamic Study of Emixustat Hydrochloride in Subjects With Macular Atrophy Secondary to Stargardt Disease | January 2017 | December 2017 |
| NCT06048185 | Enrolling by invitation | Non-interventional Long Term Follow-up Study of Participants Previously Enrolled in the STARLIGHT Study | October 19, 2023 | July 2027 | |
| NCT04239625 | Enrolling by invitation | Phase 2 | Open-Label Extension: Tolerability and Effects of ALK-001 on Stargardt Disease (TEASE) | December 20, 2019 | December 2026 |
| NCT06319872 | Not yet recruiting | Phase 1 | The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration | April 15, 2024 | April 15, 2025 |
| NCT06445322 | Recruiting | Prescreening Study to Identify Potential Participants for ACDN-01 Clinical Trials | May 30, 2024 | August 31, 2030 | |
| NCT02402660 | Recruiting | Phase 2 | Phase 2 Tolerability and Effects of ALK-001 on Stargardt Disease | August 2015 | March 2025 |
| NCT02435940 | Recruiting | Inherited Retinal Degenerative Disease Registry | June 2014 | June 2037 | |
| NCT03011541 | Recruiting | N/A | Stem Cell Ophthalmology Treatment Study II | January 2016 | July 31, 2026 |
| NCT04545736 | Recruiting | Phase 1/Phase 2 | Oral Metformin for Treatment of ABCA4 Retinopathy | November 23, 2020 | August 31, 2027 |
| NCT05674058 | Recruiting | Function and Imaging Assessments for G1961E-associated Stargardt Disease | November 1, 2022 | October 31, 2025 | |
| NCT05956626 | Recruiting | Phase 1/Phase 2 | Study to Assess the Safety and Efficacy of OCU410ST for Stargardt Disease | August 25, 2023 | October 28, 2025 |
| NCT06435000 | Recruiting | An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene | March 29, 2024 | February 2027 | |
| NCT01676766 | Terminated | Novel Quantification Methods for Fluorescence to Detect Progression in Stargardt Disease | September 2012 | October 2016 | |
| NCT02875704 | Terminated | Oxidative Stress In Stargardt Disease, Age Related Macular Degeneration and Diabetic Retinopathy | January 3, 2017 | September 22, 2022 |
- Disase is a (Disease Ontology)
- DOID:10871
- Cross Reference ID (Disease Ontology)
- GARD:181
- Cross Reference ID (Disease Ontology)
- MESH:D000080362
- Cross Reference ID (Disease Ontology)
- MIM:248200
- Cross Reference ID (Disease Ontology)
- MIM:600110
- Cross Reference ID (Disease Ontology)
- MIM:603786
- Exact Synonym (Disease Ontology)
- STARGARDT DISEASE 1
- OrphaNumber from OrphaNet (Orphanet)
- 827