transthyretin amyloidosis
Information
- Disease name
- transthyretin amyloidosis
- Disease ID
- DOID:0050638
- Description
- "An amyloidosis that is characterized by a loss of sensation in the extremities, cardiomyopathy, nephropathy, vitreous opacities, and CNS amyloidosis resulting from abnormal deposits of amyloid protein in the body's organs and tissues and has_material_basis_in autosomal dominant inheritance of mutations in the TTR gene." [url:http\://en.wikipedia.org/wiki/Transthyretin-related_hereditary_amyloidosis, url:http\://ghr.nlm.nih.gov/condition/transthyretin-amyloidosis, url:http\://www.ncbi.nlm.nih.gov/books/NBK1194/, url:http\://www.orpha.net/consor4.01/www/cgi-bin/OC_Exp.php?lng=EN&Expert=85451, url:http\://www.paramiloidose.com/en/paramiloidose.php?a=2&id=25, url:https\://www.ncbi.nlm.nih.gov/books/NBK1194/, url:https\://www.ncbi.nlm.nih.gov/pubmed/19372706]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03759379 | Active, not recruiting | Phase 3 | HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis) | February 14, 2019 | October 2026 |
| NCT03431896 | Active, not recruiting | Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis | February 1, 2018 | December 31, 2026 | |
| NCT00628745 | Completed | Transthyretin Amyloidosis Outcome Survey (THAOS) | January 4, 2008 | June 16, 2023 | |
| NCT02792790 | Completed | Carpal Tunnel Syndrome and Amyloid Cardiomyopathy | March 2016 | December 2, 2021 | |
| NCT03190577 | Completed | N/A | Assessment of the Prevalence of TTR Amyloid Neuropathy in a Population of Patients With Neuropathy of Unknown Aetiology | September 21, 2017 | May 23, 2022 |
| NCT01171859 | Completed | Phase 2 | Safety, Efficacy and Pharmacokinetics of Doxycycline Plus Tauroursodeoxycholic Acid in Transthyretin Amyloidosis | July 2010 | October 2015 |
| NCT03352089 | Completed | Positron Emission Tomography / Magnetic Resonance Imaging in Aortic Stenosis | November 1, 2017 | August 23, 2018 | |
| NCT03588468 | Completed | N/A | Expanding the Biomarkers in Familial Amyloid Neuropathy: MRI and Motor Unit Estimation by Electrophysiological Study | September 20, 2018 | December 18, 2019 |
| NCT03591757 | Completed | Early Phase 1 | Short-term Effects of TOLCAPONE on Transthyretin Stability in Subjects With Leptomeningeal TTR Amyloidosis (ATTR) | October 30, 2018 | April 26, 2019 |
| NCT03923920 | Completed | Screening for Systemic Amyloidosis Via the Ligamentum Flavum | May 1, 2019 | December 2, 2021 | |
| NCT05075798 | Completed | Study of Cerebral MRI Anomalies in Mutated Transthyretin Amyloidosis Patients | October 25, 2021 | May 31, 2022 | |
| NCT02016365 | Completed | Phase 2 | Safety and Efficacy Study of Doxycycline/UrsoDeoxyCholicAcid on Disease Progression in ATTR Amyloidosis | February 2012 | December 2014 |
| NCT03860935 | Completed | Phase 3 | Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy | March 19, 2019 | May 11, 2023 |
| NCT03862807 | Completed | Phase 3 | Patisiran in Patients With Hereditary Transthyretin-mediated Amyloidosis (hATTR Amyloidosis) Disease Progression Post-Liver Transplant | March 27, 2019 | October 20, 2020 |
| NCT03886155 | Completed | Cardiac Amyloidosis Screening at Trigger Finger Release | May 1, 2019 | December 2, 2021 | |
| NCT04569903 | Not yet recruiting | N/A | Evaluation of a Claims-based Algorithm for the Identification of Transthyretin-mediated Amyloidosis (ATTR) Amyloidosis in Medical Records | April 2024 | February 2026 |
| NCT06345235 | Recruiting | New Biomarkers and Plasma Prothrombotic Potential in Cardiac Transthyretin Amyloidosis | July 11, 2023 | July 11, 2024 | |
| NCT03237494 | Recruiting | TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive Subjects | July 20, 2017 | April 30, 2025 | |
| NCT04276220 | Recruiting | N/A | Prevalence of wtATTR-CM After Carpal Tunnel Release Surgery | April 1, 2020 | January 2026 |
| NCT05635045 | Recruiting | Phase 2 | Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTR | July 8, 2022 | September 1, 2024 |
| NCT05758493 | Recruiting | Phase 2 | Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis | January 10, 2023 | July 10, 2024 |
| NCT05814380 | Recruiting | The Regional Scintigraphic DPD Uptake in Cardiac Transthyretin Amyloidosis. | May 4, 2020 | March 1, 2024 | |
| NCT05873868 | Recruiting | Myocardial Effects in Patients With ATTRv With Polyneuropathy Treated With Patisiran or Vutrisiran | April 12, 2024 | July 2026 | |
| NCT06291805 | Recruiting | Phenotyping and Characterization of wtATTR-CM (TRACE 1) | February 20, 2024 | December 2025 | |
| NCT04899180 | Recruiting | Early Phase 1 | Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis | July 14, 2023 | August 2024 |
| NCT05023889 | Recruiting | Early Phase 1 | Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran Therapy | August 3, 2022 | December 2024 |
| NCT05409833 | Recruiting | Systemic Transthyretin Amyloidosis: Carpal Tunnel Syndrome in a Portuguese Population | June 1, 2020 | June 1, 2025 | |
| NCT05577819 | Recruiting | N/A | Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF | October 2, 2020 | December 31, 2024 |
| NCT04611204 | Terminated | Transthyretin Cardiac Amyloidosis in Patients With Idiopathic Carpal Tunnel Syndrome Referred for Release Surgery | October 1, 2020 | February 23, 2023 | |
| NCT04563286 | Unknown status | Patient-Reported Outcome Measures in Wild-Type and Variant Cardiac Transthyretin Amyloidosis | February 22, 2020 | June 22, 2022 | |
| NCT04513600 | Unknown status | ATTR-Cardiomyopathy Stabilization Following Tafamidis Therapy | August 1, 2020 | August 1, 2023 | |
| NCT04963985 | Unknown status | Phase 4 | The Effect of Tafamidis on Transthyretin Stabilization, Safety, Tolerability and Efficacy in Transthyretin Amyloid Polyneuropathy Patients | June 1, 2021 | June 1, 2023 |
| NCT02713880 | Withdrawn | Biomarker for Transthyretin-Related Familial Amyloidotic Polyneuropathy (BioTRAP) | August 20, 2018 | December 1, 2019 |
- Disase is a (Disease Ontology)
- DOID:9120
- Cross Reference ID (Disease Ontology)
- GARD:656
- Cross Reference ID (Disease Ontology)
- ICD10CM:E85.82
- Cross Reference ID (Disease Ontology)
- MIM:105210
- Cross Reference ID (Disease Ontology)
- ORDO:85447
- Exact Synonym (Disease Ontology)
- Amyloidosis, hereditary, transthyretin-related
- Exact Synonym (Disease Ontology)
- ATTR amyloidosis
- Exact Synonym (Disease Ontology)
- ATTRm amyloidosis
- Exact Synonym (Disease Ontology)
- Corino de Andrade's disease
- Exact Synonym (Disease Ontology)
- familial amyloid polyneuropathy
- Exact Synonym (Disease Ontology)
- Familial transthyretin amyloidosis
- Exact Synonym (Disease Ontology)
- paramyloidosis
- Exact Synonym (Disease Ontology)
- transthyretin-related hereditary amyloidosis
- Exact Synonym (Disease Ontology)
- TTR amyloidosis