Lennox-Gastaut syndrome
Information
- Disease name
- Lennox-Gastaut syndrome
- Disease ID
- DOID:0050561
- Description
- "A childhood electroclinical syndrome that is characterized by frequent seizures and intellectual disability that present in early childhood." [url:https\://ghr.nlm.nih.gov/condition/lennox-gastaut-syndrome]
Disease area statistics
Chromosome band
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05626634 | Active, not recruiting | Phase 2 | Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy | November 8, 2022 | October 2024 |
| NCT00004776 | Completed | Phase 3 | Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut Syndrome | November 1993 | |
| NCT00552045 | Completed | Epilepsy Phenome/Genome Project | November 2007 | October 2018 | |
| NCT01146951 | Completed | Phase 3 | A Placebo-Controlled, Double-Blind Comparative Study of E2080 in Lennox-Gastaut Syndrome Patients (Study E2080-J081-304) | June 2010 | August 2011 |
| NCT01151540 | Completed | Phase 3 | A Long Term Extension Study of E2080 in Lennox-Gastaut Patients | November 2010 | August 2013 |
| NCT01160770 | Completed | Phase 3 | Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut Syndrome | December 2005 | February 2012 |
| NCT01405053 | Completed | Phase 3 | Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic Drugs | June 16, 2011 | November 2, 2015 |
| NCT01991041 | Completed | European Registry of Anti-Epileptic Drug Use in Patients With Lennox-Gastaut Syndrome (LGS) | June 2008 | November 2015 | |
| NCT02175173 | Completed | Post-marketing Surveillance of Long-term Administration of Inovelon Tablets in Patients With Lennox-Gastaut Syndrome | June 13, 2013 | November 2, 2022 | |
| NCT00004729 | Completed | N/A | Ketogenic Diet for Child Epilepsy and Seizure Control | July 1997 | |
| NCT02224690 | Completed | Phase 3 | A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults | April 28, 2015 | March 18, 2016 |
| NCT02224573 | Completed | Phase 3 | An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Adults With Dravet or Lennox-Gastaut Syndromes | June 11, 2015 | September 24, 2020 |
| NCT02731300 | Completed | Phase 4 | Transcranial Direct Current Stimulation, Treatment of Childhood Drug-Resistant Lennox-Gastaut Syndrome, A Pilot Study | August 2010 | December 2013 |
| NCT03650452 | Completed | Phase 2 | A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies | August 8, 2018 | July 20, 2020 |
| NCT02815540 | Terminated | Phase 1/Phase 2 | The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe Epilepsy | February 16, 2017 | December 1, 2018 |
| NCT02632149 | Unknown status | Early Phase 1 | Trial to Assess Vagus Nerve Stimulation Therapy in Children With Lennox-Gastaut Syndrome | October 2016 | |
| NCT04133480 | Withdrawn | Phase 4 | Investigation of Cognitive Outcomes With Cannabidiol Oral Solution | October 2020 | December 2021 |
| NCT03254680 | Withdrawn | N/A | Turmeric as Treatment in Epilepsy | March 2018 | November 2018 |
| NCT01370486 | Withdrawn | Phase 4 | Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects | August 2011 | January 2012 |
| NCT02318537 | Withdrawn | Phase 3 | Cannabidiol Oral Solution as an Adjunctive Therapy for Treatment of Participants With Inadequately Controlled Lennox-Gastaut Syndrome | December 30, 2017 | June 30, 2018 |
- Disase is a (Disease Ontology)
- DOID:0050704
- Cross Reference ID (Disease Ontology)
- GARD:9912
- Cross Reference ID (Disease Ontology)
- MESH:D065768
- Cross Reference ID (Disease Ontology)
- MIM:606369
- Cross Reference ID (Disease Ontology)
- ORDO:2382
- Exact Synonym (Disease Ontology)
- Lennox syndrome
- OrphaNumber from OrphaNet (Orphanet)
- 2382