Age-related macular degeneration
Information
- Disease name
- Age-related macular degeneration
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05536297 | Active, not recruiting | Phase 3 | Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophy | September 26, 2022 | March 31, 2025 |
| NCT04112667 | Active, not recruiting | Functionally Validated Structural Endpoints for Early AMD | October 7, 2019 | August 31, 2024 | |
| NCT03478878 | Active, not recruiting | Early Phase 1 | Vitamin A Palmitate Supplementation in Patients With Reticular Pseudodrusen (RPD) and Delayed Dark Adaptation | May 14, 2018 | September 1, 2024 |
| NCT02829606 | Active, not recruiting | N/A | Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV) | April 2016 | May 2024 |
| NCT05963646 | Active, not recruiting | Optical Coherence Tomography and Microperimetry Biomarker Evaluation in Patients With Geographic Atrophy Study | March 16, 2021 | December 31, 2023 | |
| NCT05380492 | Active, not recruiting | Phase 1/Phase 2 | Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration | November 17, 2022 | November 2025 |
| NCT05667441 | Active, not recruiting | N/A | Adherence to Lifestyle Changes for Age-related Macular Degeneration | August 1, 2021 | August 1, 2025 |
| NCT02286089 | Active, not recruiting | Phase 1/Phase 2 | Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration | April 1, 2015 | July 1, 2025 |
| NCT05265624 | Active, not recruiting | Phase 2 | The Moran AMD Genetic Testing Assessment Study | August 3, 2022 | August 30, 2024 |
| NCT05112861 | Active, not recruiting | Phase 3 | A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders | November 15, 2021 | March 2025 |
| NCT01782352 | Active, not recruiting | N/A | Age-related Macular Degeneration (AMD) in the Vitamin D and Omega-3 Trial (VITAL) | July 2010 | September 2024 |
| NCT05690880 | Active, not recruiting | ForeseeHome NRich Registry | December 15, 2022 | December 15, 2027 | |
| NCT05064865 | Active, not recruiting | N/A | Impact of Regular Consumption of Grapes on Eye Health in Singapore Older Adults | January 28, 2022 | October 2024 |
| NCT04356716 | Active, not recruiting | Phase 2 | Sildenafil for Treatment of Choroidal Ischemia | November 11, 2014 | December 2024 |
| NCT00594672 | Active, not recruiting | Age-Related Eye Disease Study (AREDS) Follow-Up | June 2, 2008 | ||
| NCT01678872 | Active, not recruiting | Phase 1 | A Follow-up Study to Evaluate the Safety of RetinoStat® in Patients With Age-Related Macular Degeneration | August 2012 | March 2029 |
| NCT05763940 | Active, not recruiting | N/A | Efficacy of OmegaBoost to Increase Omega-3 Levels in Healthy Individuals | May 25, 2022 | June 25, 2024 |
| NCT01352975 | Active, not recruiting | Study of Dark Adaptation in Age-Related Macular Degeneration | May 16, 2011 | ||
| NCT04269304 | Active, not recruiting | Deciphering AMD by Deep Phenotyping and Machine Learning- Prospective Study - PINNACLE | October 28, 2019 | June 2025 | |
| NCT01115387 | Active, not recruiting | GARM II: A Study on the Genetics of Age-related Maculopathy | October 6, 2011 | March 2027 | |
| NCT06391411 | Active, not recruiting | N/A | Effect of Micronutrient Supplementation on the Intestinal Microbiota in Patients With Age-related Macular Degeneration - The Gut-Retina-axis Study | March 1, 2021 | May 1, 2024 |
| NCT00500344 | Completed | Phase 1 | CAPTAIN:Choroidal Neovascularization Assessment by Pattern Electroretinography | July 2007 | March 2009 |
| NCT00517010 | Completed | Early Phase 1 | Pilot Study of Lucentis Combined With Proton Beam Irradiation in Treating Wet Age-related Macular Degeneration | May 2007 | June 2010 |
| NCT00527553 | Completed | N/A | The Effect of Eggs and Egg Products on Macular Pigment | October 2007 | February 2008 |
| NCT00539734 | Completed | N/A | Changes in Retinal Function After Intravitreal Ranibizumab for Age-related Macular Degeneration | August 2007 | February 2009 |
| NCT00556114 | Completed | A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging | January 2007 | July 2013 | |
| NCT00569140 | Completed | Phase 1 | A Phase 1, Safety, Tolerability and Pharmacokinetic Profile of Intravitreous Injections of E10030 (Anti-PDGF Pegylated Aptamer) in Subjects With Neovascular Age-Related Macular Degeneration | December 2007 | December 2008 |
| NCT00572039 | Completed | Phase 3 | Improving Function in Age-Related Macular Degeneration | August 2005 | June 2013 |
| NCT00590694 | Completed | Phase 2/Phase 3 | Lucentis for Age-related Macular Degeneration Pigment Epithelial Detachments | October 2006 | December 2009 |
| NCT00607750 | Completed | Phase 2 | Safety and Efficacy of ATG003 in Patients With AMD Receiving Anti-VEGF | May 2008 | May 2010 |
| NCT00680498 | Completed | Phase 4 | Combination Lucentis and Ocular Photodynamic Therapy With Visudyne, With Evaluation-based Retreatment | February 2007 | October 2009 |
| NCT00709527 | Completed | Phase 1 | ARC1905 (ANTI-C5 APTAMER) Given Either In Combination Therapy With Lucentis® 0.5 mg/Eye In Subjects With Neovascular Age-Related Macular Degeneration | July 2008 | March 2011 |
| NCT01165801 | Completed | Phase 4 | Size Progression of Macular Degeneration After Cataract Surgery | January 2002 | July 2010 |
| NCT00135837 | Completed | Phase 4 | Photodynamic Therapy in Occult-Only Lesions (POOL) | June 2003 | |
| NCT00140803 | Completed | Phase 2 | Study Of Combined VISUDYNE Therapy With Kenalog In CNV Secondary To Age-Related Macular Degeneration | October 2003 | January 2007 |
| NCT00215670 | Completed | Phase 2/Phase 3 | Study of the Safety, Tolerability and Pharmacokinetics of 1 Mg/Eye and 3 Mg/Eye Pegaptanib Sodium in Patients With Exudative Age-Related Macular Degeneration (AMD) | November 2002 | May 2006 |
| NCT00251459 | Completed | Phase 3 | A Study to Evaluate Ranibizumab in Subjects With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) | November 2005 | September 2007 |
| NCT00304954 | Completed | Phase 2 | Infliximab, Sirolimus and Daclizumab to Treat Age-Related Macular Degeneration | February 2006 | January 2010 |
| NCT00305630 | Completed | Phase 2/Phase 3 | Neovascular Age Related Macular Degeneration (AMD), Periocular Corticosteroids, and Photodynamic Therapy (PDT) | July 2002 | November 2005 |
| NCT00306488 | Completed | Phase 2 | OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degeneration | March 2006 | March 2010 |
| NCT00321997 | Completed | Phase 2/Phase 3 | A Clinical Trial to Explore Safety and Efficacy of Different Doses of Pegaptanib Sodium, Compared to Sham, in Patients With Wet AMD. | May 2001 | October 2007 |
| NCT00329277 | Completed | N/A | Detection of Topographic Residual Acuity in Patients With Age Related Macular Degeneration | April 2006 | January 2008 |
| NCT00342251 | Completed | Investigating Age-Related Macular Degeneration | June 20, 2003 | April 4, 2012 | |
| NCT00345176 | Completed | Phase 3 | Age-Related Eye Disease Study 2 (AREDS2) | September 2006 | October 2012 |
| NCT00348543 | Completed | N/A | Prophylactic Laser Treatment of Drusen Maculopathy | December 1999 | October 2006 |
| NCT00357578 | Completed | Genetic Study of Age-Related Macular Degeneration | April 14, 2000 | September 19, 2007 | |
| NCT00363714 | Completed | Phase 1/Phase 2 | A Dose Escalation Trial of an Intravitreal Injection of Sirna-027 in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) | November 2004 | April 2007 |
| NCT00393692 | Completed | Fundus Autofluorescence Imaging in Age-related Macular Degeneration Using Confocal Scanning Laser Ophthalmoscopy | August 2000 | October 2018 | |
| NCT00401713 | Completed | N/A | Transplantation of Autologous RPE Versus Translocation of Autologous RPE and Choroid in AMD | February 2004 | September 2008 |
| NCT00429962 | Completed | Phase 3 | Study Comparing Ranibizumab Monotherapy With Combined Verteporfin Therapy in Subfoveal CNV | July 2006 | June 2008 |
| NCT00463320 | Completed | Phase 1 | A Study To Evaluate The Safety, Tolerability And Pk Of Pazopanib Eye Drops In Healthy Adult And Elderly Subjects. | March 2007 | August 2007 |
| NCT00470678 | Completed | Phase 3 | EXTEND III - Efficacy and Safety of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD) | June 2007 | November 2008 |
| NCT00473928 | Completed | Phase 1 | Safety of Intravitreal POT-4 Therapy for Patients With Neovascular Age-Related Macular Degeneration (AMD) | May 2007 | February 2010 |
| NCT00797524 | Completed | Function and Structure Imaging in Different Retinal Diseases: Retinal Leakage Analyzer Versus Optical Coherence Tomography | November 2008 | October 2010 | |
| NCT00801541 | Completed | Characterization of Early Markers of Choroidal Neovascularization | December 2005 | June 2014 | |
| NCT00805233 | Completed | Phase 2 | Combination Ranibizumab and Bromfenac for Neovascular Age-related Macular Degeneration | December 2008 | September 2010 |
| NCT00805649 | Completed | Phase 4 | Combined Therapy in Age-Related Macular Degeneration (ARMD) | January 2006 | July 2008 |
| NCT00831961 | Completed | Antibiotic Resistant Patterns of Conjunctival and Nasophayngeal Flora After Repeated Exposure to Topical Antibiotics | January 2009 | ||
| NCT00879671 | Completed | N/A | Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients With Age-related Macular Degeneration | November 2006 | May 2011 |
| NCT00891735 | Completed | Phase 3 | A Study of Ranibizumab Administered Monthly or on an As-needed Basis in Patients With Subfoveal Neovascular Age-related Macular Degeneration (HARBOR) | July 2009 | August 2012 |
| NCT00935883 | Completed | Phase 2 | Complement Inhibition With Eculizumab for the Treatment of Non-Exudative Macular Degeneration (AMD) | July 2009 | August 2013 |
| NCT00950638 | Completed | Phase 1 | A Study of ARC1905 (Anti-C5 Aptamer) in Subjects With Dry Age-related Macular Degeneration | July 2009 | November 2012 |
| NCT00991666 | Completed | N/A | Association Between Laser Interferometric Measurement of Fundus Pulsation and Pneumotonometric Measurement of Pulsatile Ocular Blood Flow in Patients With Age-related Macular Degeneration | July 2001 | March 2011 |
| NCT01013376 | Completed | Phase 1 | A Pilot Study of the Safety of MC-1101 in Both Normal Volunteers and Patients With Early Dry AMD | August 2009 | August 2009 |
| NCT01016873 | Completed | Phase 2 | INTREPID - IRay Plus Anti-VEGF Treatment For Patients With Wet AMD | November 2009 | April 2014 |
| NCT01032109 | Completed | N/A | Photodynamic Therapy Alone Versus Combined With Intravitreal Bevacizumab for Age-related Macular Degeneration | October 2006 | May 2008 |
| NCT01033721 | Completed | Phase 1 | Phase I Study of Palomid 529 a Dual TORC1/2 Inhibitor of the PI3K/Akt/mTOR Pathway for Advanced Neovascular Age-Related Macular Degeneration | June 2010 | December 2011 |
| NCT01042860 | Completed | N/A | The Influence of Lutein Supplements on Age-related Macular Degeneration | August 2007 | August 2009 |
| NCT01080898 | Completed | Evaluation of Optical Coherence Tomography. | April 2010 | October 2010 | |
| NCT01083147 | Completed | Age-Related Macular Degeneration (AMD) - Beta Study Telemedicine Assessment | October 2009 | September 2010 | |
| NCT01089517 | Completed | Phase 2 | A Safety and Efficacy Study of E10030 (Anti-PDGF Pegylated Aptamer) Plus Lucentis for Neovascular Age-Related Macular Degeneration | March 2010 | June 2012 |
| NCT01108250 | Completed | N/A | LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population | April 2010 | August 2011 |
| NCT01136252 | Completed | Phase 2 | Intravitreal Adalimumab in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration | May 2010 | October 2011 |
| NCT01148511 | Completed | Phase 4 | Comparison of Safety, Effectiveness and Quality of Life Outcomes Between Labeled Versus "Treat and Extend" Regimen in Turkish Patients With Choroidal Neovascularisation Due to Age-related Macular Degeneration (AMD) | February 2010 | April 2012 |
| NCT01162746 | Completed | Phase 2 | Comparison of Ranibizumab Monotherapy and Ranibizumab Combination Therapies in Recurrent or Persistent Choroidal Neovascularization Secondary to Age-related Macular Degeneration | October 2011 | December 2015 |
| NCT01175395 | Completed | Phase 1/Phase 2 | 20089 TA+Lucentis Combo Intravitreal Injections for Treatment of Neovascular Age-related Macular Degeneration (AMD) | September 2010 | January 2013 |
| NCT01186432 | Completed | Phase 1 | Preliminary Safety and Efficacy of the PDS-1.0 in Patients With Neovascular Age Related Macular Degeneration (AMD) | August 2010 | April 2014 |
| NCT01226628 | Completed | Phase 1/Phase 2 | A Safety Study of CNTO 2476 in Patients With Age-Related Macular Degeneration | October 21, 2010 | May 31, 2017 |
| NCT01233115 | Completed | LOC387715/HTRA1 and the Combined Photodynamic Therapy With Intravitreal Bevacizumab in Polypoidal Choroidal Vasculopathy | October 2010 | August 2011 | |
| NCT01233128 | Completed | Vascular Endothelial Growth Factor (VEGF) & LOC387715/HTRA1 Polymorphism in Polypoidal Choroidal Vasculopathy | October 2010 | January 2012 | |
| NCT01245387 | Completed | Observational Study Of The Long-Term Effect Of Macugen In Patients With Wet Age-Related Macular Degeneration | August 2006 | December 2009 | |
| NCT01256827 | Completed | Seven Year Update of Macular Degeneration Patients | December 2010 | April 2013 | |
| NCT01269151 | Completed | N/A | Ranibizumab Short- and Log-term Effects on Retinal Function in wAMD | October 2010 | April 2014 |
| NCT01271270 | Completed | Phase 1 | Palomid 529 in Patients With Neovascular Age-Related Macular Degeneration | December 20, 2010 | September 20, 2012 |
| NCT01298674 | Completed | Epidemiological Study of the Prevalence of Age-Related Macular Degeneration in Portugal | August 2009 | October 2013 | |
| NCT01316198 | Completed | N/A | Effects of Xanthophylls on Optical Density | June 2010 | July 2011 |
| NCT01330797 | Completed | The Effect of Ranibizumab on Eye Lens Opacity in Cases With Age-Related Macular Degeneration | January 2009 | January 2011 | |
| NCT01350323 | Completed | N/A | Aqueous Vascular Endothelial Growth Factor (VEGF) Levels in Type 3 Neovascularization | May 2009 | September 2010 |
| NCT01397409 | Completed | Phase 2 | Evaluation of AGN-150998 in Exudative Age-related Macular Degeneration (AMD) | September 1, 2011 | April 30, 2014 |
| NCT01445548 | Completed | Phase 1/Phase 2 | Sirolimus for Advanced Age-Related Macular Degeneration | September 2011 | February 2014 |
| NCT01464710 | Completed | Genetic Assessment of Early to Late Macular Degeneration Study | April 2008 | January 2015 | |
| NCT01464723 | Completed | Phase 4 | Study EvAluating Genotypes While Using Lucentis 2 | May 2008 | January 2013 |
| NCT01480700 | Completed | N/A | Consumption of Eggs Rich in Lutein and Omega-3 Fatty Acids on the Macular Pigment | October 2011 | February 2013 |
| NCT01527500 | Completed | Phase 2 | Intravitreal LFG316 in Patients With Age-related Macular Degeneration (AMD) | January 25, 2012 | June 24, 2015 |
| NCT01528605 | Completed | N/A | Effects of Lutein and Zeaxanthin Supplementation on Early Age-related Macular Degeneration | June 2010 | December 2012 |
| NCT01546181 | Completed | Retinal Imaging by Adaptive Optics in Healthy Eyes and During Retinal and General Diseases | October 2010 | June 15, 2017 | |
| NCT01553474 | Completed | Blood and Saliva Sample Collection for AREDS 2 | February 24, 2012 | February 5, 2013 | |
| NCT01570790 | Completed | Phase 1/Phase 2 | Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration | May 2003 | June 2005 |
| NCT01573572 | Completed | Phase 4 | Extension Study to Gather Data on Effect of Macugen on the Corneal Endothelium | April 22, 2010 | November 14, 2019 |
| NCT01577342 | Completed | N/A | Determining the Effect of Antibiotic Drop Prophylaxis on the Conjunctival Flora | November 2010 | December 2011 |
| NCT01638858 | Completed | N/A | Treatment of Diabetic Macular Edema With 0.5mg Intraocular Ranibizumab (Lucentis) | October 2011 | |
| NCT01640171 | Completed | N/A | Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival | July 2012 | October 2013 |
| NCT01650948 | Completed | Genetic Load and Phenotype in Aggressive AMD | July 2012 | December 2013 | |
| NCT01682382 | Completed | Association of Macular Pigment Optical Density (MPOD) and Genetic Variants in Complement Factor H in Subjects With Choroidal Neovascular (CNV) | August 2012 | October 2013 | |
| NCT01692938 | Completed | Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO | October 2012 | November 2012 | |
| NCT01773954 | Completed | N/A | Repeated Eye Injections of Aflibercept for Treatment of Wet Age Related Macular Degeneration | February 2013 | March 2016 |
| NCT01778491 | Completed | AMD Phenotype and Genotype Study | November 5, 2012 | September 29, 2015 | |
| NCT01790802 | Completed | N/A | Laser Intervention in Early Age-Related Macular Degeneration Study | November 2011 | May 1, 2018 |
| NCT01799564 | Completed | N/A | Micropulse Laser for Geographic Atrophy | August 2012 | November 27, 2013 |
| NCT01824225 | Completed | Phase 4 | Study of PRN and Every 2months Intravitreal Aflibercept for Age Related Macular Degeneration | March 2013 | March 2015 |
| NCT01833325 | Completed | N/A | Proton Radiation Therapy for Macular Degeneration | May 2013 | February 2018 |
| NCT01835015 | Completed | Phase 1 | Pharmacokinetics of CLG561 in Patients With Advanced Age-Related Macular Degeneration | May 2013 | November 2014 |
| NCT01846273 | Completed | Phase 4 | Visual Outcome in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy (PCV) Treated With Either Ranibizumab as Monotherapy or Combined With Verteporfin Photodynamic Therapy (vPDT) | August 7, 2013 | March 2, 2017 |
| NCT01876147 | Completed | Visual and Functional Assessment in Low Vision Patients | August 2013 | March 2016 | |
| NCT01918553 | Completed | N/A | Cohort Study on the Age-related Macular Degeneration: Incidence and Research for Predisposing Factors | July 9, 2015 | February 23, 2017 |
| NCT01948830 | Completed | Phase 3 | Randomized Study for Efficacy and Safety of Ranibizumab 0.5mg in Treat-extend and Monthly Regimens in Patients With nAMD | December 17, 2013 | November 19, 2015 |
| NCT01996215 | Completed | Brain Connectivity in Age-Related Macular Degeneration | April 2014 | June 2018 | |
| NCT02022501 | Completed | Phase 1/Phase 2 | A Phase I/II Safety Study of DE-120 Injectable Solution for Age-related Macular Degeneration | January 2014 | April 21, 2016 |
| NCT02035722 | Completed | Phase 2/Phase 3 | Intravitreal Injections-related Anxiety | September 2011 | June 2014 |
| NCT02076919 | Completed | Phase 1 | First-in-Human Study of LHA510 in Elderly Subjects and Patients With Age-Related Macular Degeneration | February 2014 | June 2014 |
| NCT02090751 | Completed | Development of a Device to Measure Dark Adaptation | July 2014 | April 2015 | |
| NCT02118831 | Completed | Phase 1/Phase 2 | Systemic Pharmacokinetics Following Intravitreal Injections of Anti-VEGF | March 2012 | April 2014 |
| NCT02126423 | Completed | Resistance to Antibiotics in Patients Receiving Eye Injections | May 2014 | September 2014 | |
| NCT02130024 | Completed | Phase 4 | A Comparison of Ranibizumab and Aflibercept for the Development of Geographic Atrophy in (Wet) AMD Patients | April 11, 2014 | November 15, 2017 |
| NCT02130531 | Completed | Phase 1 | Pharmacokinetic and Pharmacodynamic Study of Emixustat in Subjects With Geographic Atrophy Associated With Dry Age-Related Macular Degeneration | April 2014 | November 2015 |
| NCT02140151 | Completed | Phase 1/Phase 2 | Prophylactic Ranibizumab for Exudative Age-related Macular Degeneration | September 17, 2014 | July 9, 2020 |
| NCT02224963 | Completed | N/A | Macular Degeneration and Aging Study | May 2009 | April 1, 2019 |
| NCT02225119 | Completed | The Focal Electro-Oculogram in Macular Disease | February 6, 2015 | February 28, 2020 | |
| NCT02230228 | Completed | Phase 1 | Phase 1 Safety Study of ALK-001 in Healthy Volunteers | April 2014 | February 2015 |
| NCT02255981 | Completed | N/A | Efficacy of Acupuncture in Macular Diseases | March 2013 | November 2016 |
| NCT02261194 | Completed | N/A | Effect of a Self-care Intervention on Depression in People With Age-related Macular Degeneration or Diabetic Retinopathy | October 2014 | February 2016 |
| NCT02291887 | Completed | Genetic Analysis of Patients Responsive to Ranibizumab But Resistant to Aflibercept | December 22, 2014 | July 1, 2015 | |
| NCT02302989 | Completed | Phase 1/Phase 2 | Prophylactic Ranibizumab for Exudative Age-Related Macular Degeneration | May 2015 | July 2018 |
| NCT02308215 | Completed | Retinal Therapy Guided by 3D OCT Image Analysis | July 2010 | July 5, 2018 | |
| NCT02314299 | Completed | Phase 1/Phase 2 | A Study of MTP-131 Topical Ophthalmic Solution in Subjects With Diabetic Macular Edema and Non-Exudative Intermediate Age-related Macular Degeneration | November 2014 | June 2015 |
| NCT02332343 | Completed | Sparing of the Fovea in Geographic Atrophy Progression | October 2014 | January 2017 | |
| NCT02337647 | Completed | N/A | Evaluation of the Distortion Correction Data Collection (DCDC) App Software | December 29, 2014 | June 1, 2016 |
| NCT02357342 | Completed | Phase 2 | Sirolimus Versus Anti-Vascular Endothelial Growth Factor (antiVEGF) for Wet AMD | April 2015 | January 2017 |
| NCT02358889 | Completed | Phase 2 | Study Evaluating Intravitreal hI-con1™ in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration | February 2015 | September 2016 |
| NCT02401945 | Completed | Phase 2 | A Safety and Efficacy Study of DE-120 Injectable Solution for Age-related Macular Degeneration | April 2015 | October 31, 2016 |
| NCT02422160 | Completed | Vision Outcomes Using Quantitative Optical Coherence Tomography Evaluation in Age Related Macular Degeneration | April 2015 | December 2021 | |
| NCT02463344 | Completed | Long Term Follow Up of Sub-retinal Transplantation of hESC Derived RPE Cells in Patients With AMD | February 25, 2013 | August 19, 2019 | |
| NCT02555306 | Completed | Phase 1/Phase 2 | A Phase I/II Safety, Tolerability, Immunogenicity, and Bioactivity Study of DE-122 Injectable Solution for Refractory Exudative Age-related Macular Degeneration | September 16, 2015 | August 2017 |
| NCT02564978 | Completed | Phase 2 | Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration | December 14, 2016 | March 8, 2023 |
| NCT02571972 | Completed | Phase 2 | Dorzolamide-timolol Drops With Injections to Treat AMD, RVO or DME. | February 1, 2015 | December 20, 2015 |
| NCT02577107 | Completed | Phase 4 | Head to Head Study of Anti-VEGF Treatment. | January 13, 2016 | July 9, 2016 |
| NCT02613572 | Completed | Phase 1/Phase 2 | Alpha Lipoic Acid in Geographic Atrophy | November 2015 | March 1, 2019 |
| NCT02684578 | Completed | Phase 2 | Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMD | April 2016 | October 2022 |
| NCT02707575 | Completed | Cytokeratin 8 Level in Age-related Macular Degeneration | April 26, 2016 | April 23, 2018 | |
| NCT02717026 | Completed | Multimodal Imaging of Retinal Vessels | July 2015 | January 2018 | |
| NCT02748824 | Completed | Five-year Incidence of Age-related Macular Degeneration in the Central Region of Portugal | July 2016 | October 31, 2017 | |
| NCT02762188 | Completed | N/A | Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD) | August 1, 2013 | January 18, 2018 |
| NCT02800356 | Completed | N/A | Subthreshold Laser Treatment for Reticular Pseudodrusen and Geographic Atrophy Secondary to AMD | June 2016 | September 1, 2019 |
| NCT02848313 | Completed | Phase 1 | An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects With Intermediate Age-Related Macular Degeneration | October 28, 2016 | April 10, 2018 |
| NCT02868086 | Completed | N/A | The Impact of Two Strategies in the Monitoring of Exudative ARMD on the Visual Acuity (by OCT B Scan or OCT Angiography) | October 21, 2016 | April 15, 2021 |
| NCT02914639 | Completed | Phase 1/Phase 2 | Safety and Exploratory Efficacy Study of SF0166 in the Treatment of Neovascular Age-Related Macular Degeneration (AMD) | October 5, 2016 | June 26, 2017 |
| NCT02941263 | Completed | Natural History of Geographic Atrophy Associated With Age-Related Macular Degeneration | March 8, 2017 | May 22, 2024 | |
| NCT02951351 | Completed | N/A | Topical Proparacaine Eye Drops to Improve the Experience of Patients Undergoing Intravitreal Injections | October 12, 2016 | February 2018 |
| NCT03022318 | Completed | Phase 2 | Carbidopa-levodopa in Neovascular AMD | May 2, 2017 | May 4, 2020 |
| NCT03023059 | Completed | Phase 2 | Dose Ranging Study of Carbidopa-levodopa | May 2, 2017 | May 4, 2020 |
| NCT03024424 | Completed | N/A | Value of Genetic Counseling and Testing for Patients Who Would Like to Know More About Their Personal Risk of AMD | March 2016 | August 10, 2017 |
| NCT03030729 | Completed | Macular Thickness Measurements Using Retinal-thickness OCT | March 14, 2017 | January 14, 2018 | |
| NCT03079570 | Completed | Flicker Fusion Thresholds Between Young and Old Subjects at Various Luminance Levels | August 23, 2016 | September 8, 2016 | |
| NCT03092492 | Completed | AMD Ryan Initiative Study (ARIS) | February 12, 2018 | November 7, 2022 | |
| NCT03150589 | Completed | Phase 3 | A Study to Compare SB11 (Proposed Ranibizumab Biosimilar) to Lucentis in Subjects With Neovascular Age-related Macular Degeneration (AMD) | March 14, 2018 | December 9, 2019 |
| NCT03166202 | Completed | Age-Related Macular Degeneration, Scotopic Dysfunction, and Driving Performance in a Simulator | September 1, 2018 | March 5, 2019 | |
| NCT03211234 | Completed | Phase 2 | Study Assessing the Efficacy and Safety of Intravitreal Injections of DE-122 in Combination With Lucentis® Compared to Lucentis® Monotherapy in Wet Age-related Macular Degeneration Subjects | July 5, 2017 | January 31, 2020 |
| NCT03242083 | Completed | Evaluate the Quality of Life of Patients With AMD | August 8, 2017 | December 3, 2019 | |
| NCT03374020 | Completed | Retinal Imaging Using NOTAL-OCT | January 17, 2017 | December 1, 2018 | |
| NCT03552770 | Completed | Phase 4 | Single or Combined Protocols for NV-AMD | November 23, 2014 | December 29, 2016 |
| NCT03633084 | Completed | Phase 1/Phase 2 | RBM-007 in Subjects witH ExudatIve Age-related Macular Degeneration | August 29, 2018 | June 26, 2019 |
| NCT03668054 | Completed | Phase 3 | Safety and Clinical Effectiveness of Intravitreal Bevacizumab (Lumiere®) in Patients With Wet Age-related Macular Degeneration (Wet AMD) | February 7, 2017 | May 30, 2018 |
| NCT03725501 | Completed | Phase 2 | Evaluation of the Safety and Efficacy of ALS-L1023 Administered in Combination With Ranibizumab in Patients With Wet-AMD | December 7, 2018 | June 22, 2021 |
| NCT03834753 | Completed | Phase 3 | A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD) | June 25, 2019 | July 8, 2021 |
| NCT03844074 | Completed | Phase 3 | A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD) | October 1, 2018 | August 13, 2020 |
| NCT03891875 | Completed | Phase 2 | ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-central GA | March 27, 2019 | April 14, 2022 |
| NCT03946085 | Completed | N/A | Evaluation of a New Eye-specific Multivitamin Formula in Participants at Risk of Age-related Macular Degeneration (AMD) | January 19, 2018 | November 1, 2018 |
| NCT03954626 | Completed | Phase 3 | Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD | June 7, 2019 | July 31, 2019 |
| NCT04005352 | Completed | Phase 3 | Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON) | September 25, 2019 | September 9, 2022 |
| NCT04018482 | Completed | Phase 4 | Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study) | July 16, 2019 | August 14, 2019 |
| NCT04151212 | Completed | Phase 1 | A Phase I Clinical Trial of BAT5906 Injection in Patients With Wet Age-related Macular Degeneration | October 30, 2018 | April 30, 2021 |
| NCT04196049 | Completed | Removal of Massive Subretinal Organized Blood Clot With Fragmatome | January 7, 2019 | November 29, 2019 | |
| NCT04241536 | Completed | N/A | Metabolomics: A Novel Tool for Investigating the Pathogenesis of Age-related Macular Degeneration | June 1, 2021 | November 29, 2022 |
| NCT04278300 | Completed | Study of the Discriminating Power of a Blood Biomarker for Omega-3 Polyunsaturated Fatty Acid Content of the Retina for Age-related Macular Degeneration (AMD) | February 11, 2020 | September 9, 2020 | |
| NCT04292756 | Completed | N/A | Triamcinolone Acetonide in Patients With Serous Pigment Epithelial Detachment | March 27, 2018 | December 31, 2020 |
| NCT04482465 | Completed | N/A | Omega 3 and Vitamin D Dosage in a Population With Moderate to High Risk of AMD | April 20, 2017 | October 5, 2017 |
| NCT04486963 | Completed | Phase 2 | A Phase Ⅱ Clinical Study of Sanhuangjingshimingwan in Wet( Neovascular)Age-related Macular Degeneration(wAMD) Subjects | July 24, 2020 | November 15, 2022 |
| NCT04516278 | Completed | Phase 3 | A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders | October 1, 2020 | February 10, 2021 |
| NCT04659512 | Completed | Recurrent Neovascular Age-related Macular Degeneration After Therapy Suspension | October 1, 2017 | June 6, 2020 | |
| NCT04679935 | Completed | Phase 4 | Efficacy and Safety of Two Different Brolucizumab 6 mg Dosing Regimens in Neovascular Age-related Macular Degeneration | July 13, 2021 | January 31, 2024 |
| NCT04693702 | Completed | Observational Study of Vision Improvement in Patients With Retinal Disorders | October 1, 2021 | March 16, 2022 | |
| NCT04836143 | Completed | Eyes That Do Not Meet the Eligibility Criteria of Clinical Trials on Age-Related Macular Degeneration: Proportion of the Real-World Patient Population and Reasons for Exclusion | August 26, 2019 | July 26, 2020 | |
| NCT04891835 | Completed | Analysis of naïve Patients With Age-related Macular Degeneration of the Neovascular Type and Treated With Aflibercept (Eylea®) in "Treat-and-extend" at CHU Brugmann | April 13, 2021 | September 22, 2021 | |
| NCT04894071 | Completed | Phase 1 | QA102 Phase 1 Study in Healthy Young and Older Adult Subjects | May 17, 2021 | November 15, 2021 |
| NCT05135195 | Completed | N/A | A Virtual Reality Platform Simulating Visual Impairment for Testing of Electronic Travel Aids and Performing Orientation and Mobility Training | October 24, 2021 | October 20, 2022 |
| NCT05196139 | Completed | Visual Outcome After Vitrectomy With Subretinal tPA Injection | April 1, 2021 | August 16, 2021 | |
| NCT05427994 | Completed | Assessing the Quality of Life and Social Support in Age-Related Macular Degeneration Patients | April 5, 2021 | July 27, 2022 | |
| NCT05437302 | Completed | N/A | Effectiveness of Prism Spectacles in Patients With Age Related Macular Degeneration | October 4, 2021 | May 31, 2022 |
| NCT05441072 | Completed | Validation of Bulbicam for DR- and AMD-patients | December 19, 2022 | June 15, 2023 | |
| NCT05587062 | Completed | Phase 3 | Efficacy and Safety of Aflibercept in Patients With Neovascular Age-related Macular Degeneration | October 1, 2019 | July 31, 2022 |
| NCT05615805 | Completed | N/A | The Effect of Ocular Rinse Volume on Surface Irritation After Intravitreal Injections | March 1, 2021 | October 1, 2021 |
| NCT05662943 | Completed | Outcomes of Tolerating Subretinal Fluid in Type 1 MNV and PCV | December 5, 2022 | November 30, 2023 | |
| NCT05678517 | Completed | Seven-year Outcomes Following Intensive Anti-VEGF Therapy in Wet AMD | January 1, 2010 | December 6, 2022 | |
| NCT05686421 | Completed | N/A | Comfortable and Stabilizing Chin & Forehead Rest Attachment for Slit Lamp Configurations | March 30, 2023 | April 28, 2023 |
| NCT05703867 | Completed | Phase 1/Phase 2 | Transpalpebral Microcurrent Stimulation for the Improvement of Visual Acuity in Patients With Macular Degeneration | January 1998 | December 1999 |
| NCT05710471 | Completed | Phase 4 | Treatment of Recalcitrant Neovascular AMD Using Brolocizumab With Immediate T&E | July 25, 2022 | August 30, 2023 |
| NCT05772780 | Completed | N/A | MP-3 Biofeedback Training and Central Vision Loss | October 1, 2021 | February 9, 2022 |
| NCT06178978 | Completed | Device for Age-related Macular Degeneration (AMD) | March 10, 2022 | March 25, 2022 | |
| NCT06213896 | Completed | Detecting Eye Diseases Via Hybrid Deep Learning Algorithms From Fundus Images | March 1, 2023 | April 18, 2024 | |
| NCT06330220 | Completed | Phase 4 | Visual Function Change in Wet Age-related Macular Degeneration Patients With Better Baseline Visual Acuity | February 10, 2021 | February 28, 2022 |
| NCT00725686 | Completed | Phase 1 | Study of PF-04523655 (REDD14NP) In Subjects With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (Wet AMD) | February 2007 | November 2010 |
| NCT00734721 | Completed | Phase 2 | Assessment of Psychological Strain and Perioperative Fear in Intravitreal Injections | December 1, 2007 | June 1, 2012 |
| NCT00766649 | Completed | Phase 1/Phase 2 | Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral GA Associated With AMD | October 2008 | July 2012 |
| NCT00769015 | Completed | Phase 3 | Low Vision Depression Prevention Trial for Age Related Macular Degeneration | June 2009 | June 2014 |
| NCT00782093 | Completed | Phase 1 | A Phase 1 Ascending and Parallel Group Trial to Establish the Safety, Tolerability and Pharmacokinetics Profile of Volociximab (Alpha 5 Beta 1 Integrin Antagonist) in Subjects With Neovascular Age- Related Macular Degeneration | October 2008 | June 2012 |
| NCT00787319 | Completed | Long-Term Non-Interventional Study (NIS) To Investigate The Safety And Effectiveness Of MACUGEN In Patients With Neovascular Age-Related Macular Degeneration Under Conditions Of Routine Clinical Practice | January 2010 | June 2012 | |
| NCT00791427 | Completed | ERG/EOG Study in AMD Patients Treated With Ranibizumab | November 2008 | September 2011 | |
| NCT05433766 | Enrolling by invitation | Patient-centred Smartphone AI for Protecting Vision in Macular Disease | March 8, 2023 | April 2024 | |
| NCT06264947 | Enrolling by invitation | N/A | Efficacy of Laser Acupuncture on Zanzhu (BL02) for Dry Age-related Macular Degeneration | January 26, 2024 | November 1, 2024 |
| NCT05187104 | Enrolling by invitation | Phase 1/Phase 2 | Treatment of Age-related Macular Degeneration Using Retinal Stem and Progenitor Cells | March 1, 2022 | December 31, 2023 |
| NCT05251636 | Not yet recruiting | Phase 3 | Adjunct Episcleral Brachytherapy for PCV | March 2025 | September 2028 |
| NCT06076720 | Not yet recruiting | N/A | Evaluation of New Head-mounted Visual Aids Among Patients With Low Vision | October 10, 2023 | October 10, 2024 |
| NCT05672979 | Not yet recruiting | Phase 3 | Prospective triAl of Modified Treat-and-extend Regimens With BroLucizumab in pachychOroid Neovasculopathy | January 1, 2023 | December 31, 2024 |
| NCT05465252 | Not yet recruiting | N/A | Effect of Omega-3 Fatty Acid Supplementation on Dry-AMD Progression | August 2022 | December 2024 |
| NCT06351670 | Not yet recruiting | Personalised Monitoring of Early and Intermediate Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression | July 2024 | July 2027 | |
| NCT05803785 | Not yet recruiting | Phase 1 | Safety of BBC1501 Intravitreal Injection in Patients With Neovascular Age-Related Macular Degeneration (nAMD) | June 2024 | October 2025 |
| NCT06465212 | Not yet recruiting | Personalized Shared Eye-care Identification of Age-related Macular Degeneration Using Artificial Intelligence and Telemedicine in a Prospective, Exploratory, Multinational, Multicentre Cross-sectional Study Matching Optometrist Office-based Sites With Clinical Supervision | July 2024 | July 2026 | |
| NCT05991986 | Not yet recruiting | Preparation of Patient Autologous Induced Pluripotent Stem Cell-derived Retinal Cells for AMD | August 2023 | July 31, 2026 | |
| NCT06351657 | Not yet recruiting | Personalized Monitoring of Non-foveal, Non-vision Compromising Atrophic Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression | July 2024 | July 2027 | |
| NCT06333873 | Not yet recruiting | N/A | Impact of Age-related Macular Degeneration on Daily Living Activitie | June 2024 | June 2029 |
| NCT06319872 | Not yet recruiting | Phase 1 | The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration | April 15, 2024 | April 15, 2025 |
| NCT06458595 | Not yet recruiting | Phase 1/Phase 2 | Safety and Tolerability of KH658 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD) | June 28, 2024 | December 28, 2026 |
| NCT05507840 | Not yet recruiting | N/A | Photobiomodulation for Dry Age Related Macula Degeneration | December 1, 2022 | December 1, 2027 |
| NCT05914233 | Not yet recruiting | N/A | Non-invasive Ultrasound Retinal Stimulation for Vision Restoration | June 15, 2024 | July 15, 2025 |
| NCT05941273 | Not yet recruiting | N/A | A Study of the SING IMT in an Israeli Cohort | July 30, 2023 | January 30, 2025 |
| NCT04268836 | Not yet recruiting | N/A | Vision Improvement for Patients With Age-Related Macular Degeneration | January 9, 2024 | May 1, 2025 |
| NCT04739319 | Recruiting | Project AMD: Comprehensive Characterisation of Age-Related Macular Degeneration and Its Progression | February 2, 2021 | November 2040 | |
| NCT05672121 | Recruiting | Phase 1/Phase 2 | Safety and Tolerability of KH631 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD) | February 6, 2023 | December 28, 2026 |
| NCT06046118 | Recruiting | N/A | Photobiomodulation in Dry Age Related Macular Degeneration | April 1, 2023 | December 31, 2024 |
| NCT04796545 | Recruiting | N/A | Post-market Clinical Investigation of the SING IMT System, Model NG SI IMT 3X in Patients With End-stage Age-related Macular Degeneration | September 13, 2022 | December 2028 |
| NCT05300724 | Recruiting | An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration | May 27, 2022 | September 30, 2026 | |
| NCT03225131 | Recruiting | Dark Adaptation in Participants With Age-Related Macular Degeneration | June 16, 2017 | December 31, 2029 | |
| NCT05355415 | Recruiting | Adaptive Optics Imaging of Outer Retinal Diseases | August 27, 2021 | April 25, 2024 | |
| NCT06394232 | Recruiting | Phase 1/Phase 2 | Safety & Efficacy of Eyecyte-RPE™ in Patients With Geographic Atrophy Secondary to Dry Age-related Macular Degeneration. | June 4, 2024 | December 2030 |
| NCT06190093 | Recruiting | Phase 3 | A 3-month Study to Assess the Safety and Effectiveness of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD) | January 24, 2024 | October 2024 |
| NCT06125977 | Recruiting | Impact of Non-Exudative Type 1 MNV on AMD Progression | January 30, 2023 | August 2027 | |
| NCT06355830 | Recruiting | Intermediate Age-related Macular Degeneration - Multimodal Analysis and Longitudinal Study | January 2, 2019 | June 2026 | |
| NCT03466177 | Recruiting | Multimodal Retinal Imaging in the Detection and Follow-up of Alzheimer's Disease | March 1, 2018 | December 31, 2025 | |
| NCT06164587 | Recruiting | Phase 1 | Evaluation of Kamuvudine-8 in Subjects With Geographic Atrophy | April 18, 2024 | April 2025 |
| NCT06373731 | Recruiting | Phase 3 | ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry AMD) | May 30, 2024 | August 2027 |
| NCT05542381 | Recruiting | N/A | The Role of Loteprednol in Reducing Post-Intravitreal Injection Related Pain | December 22, 2022 | December 1, 2024 |
| NCT06381596 | Recruiting | N/A | Retinal Fundus Flavoprotein Fluorescence in Age Related Macular Degeneration | April 16, 2024 | April 2025 |
| NCT05752045 | Recruiting | N/A | OphtAI Diagnostic Performance Validation for Automated Screening of Eye Diseases | June 28, 2023 | March 2024 |
| NCT06174181 | Recruiting | N/A | Preventive TREatment of Dry Eye in Patients Receiving Repeated Intravitreal Injections for Age-related Macular Degeneration | October 9, 2023 | October 9, 2025 |
| NCT06087458 | Recruiting | Phase 1/Phase 2 | Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration | June 21, 2023 | October 2027 |
| NCT05757674 | Recruiting | Analysis of the Intestinal Microbiome in Patients With Wet Age-related Macular Degeneration | January 10, 2020 | June 20, 2023 | |
| NCT05091476 | Recruiting | N/A | OcuDyne System in the Treatment of AMD | July 25, 2022 | April 30, 2024 |
| NCT03752840 | Recruiting | N/A | Village-Integrated Eye Worker Trial II | April 21, 2019 | December 31, 2024 |
| NCT05569226 | Recruiting | OKKO Health Hyperacuity, Contrast and Colour Game Validation in Age-related Macular Degeneration | November 1, 2022 | June 1, 2023 | |
| NCT05675150 | Recruiting | N/A | Expressive Arts-based Intervention for Adults With Age-related Visual Impairment | May 1, 2023 | December 31, 2025 |
| NCT05438732 | Recruiting | N/A | Multicenter Clinical Study of the SING-IMT in Patients With Late-stage AMD | June 16, 2022 | June 2024 |
| NCT06237127 | Recruiting | N/A | Effects of Goji vs. Fiber on Macular Degeneration | April 29, 2024 | June 30, 2027 |
| NCT03848663 | Recruiting | N/A | Visual Remapping to Aid Reading With Field Loss | February 1, 2022 | November 30, 2024 |
| NCT03178149 | Recruiting | Phase 1 | A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration | July 13, 2018 | January 31, 2026 |
| NCT01496625 | Recruiting | National Eye Institute Biorepository for Retinal Diseases | June 18, 2012 | ||
| NCT03011541 | Recruiting | N/A | Stem Cell Ophthalmology Treatment Study II | January 2016 | July 31, 2026 |
| NCT05494775 | Recruiting | N/A | Effect of Corona Virus on Intravitreal Injections | February 1, 2019 | July 30, 2023 |
| NCT05893537 | Recruiting | Phase 2 | Study to Evaluate the Efficacy and Safety of Oral CT1812 in Participants With Geographic Atrophy (GA) Secondary to Dry Age-Related Macular Degeneration (AMD). | June 16, 2023 | August 15, 2027 |
| NCT05913063 | Recruiting | N/A | Direct Discrimination of Quantum States by the Human Eye | June 26, 2023 | October 1, 2024 |
| NCT06241625 | Recruiting | N/A | Virtual Reality Based Vision Test in Patients With AMD | October 20, 2022 | July 2024 |
| NCT06347107 | Recruiting | N/A | Robotic Subretinal tPA Injection Study | April 2024 | December 2025 |
| NCT05635266 | Recruiting | Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives | October 26, 2021 | October 2025 | |
| NCT05200624 | Recruiting | N/A | Subthreshold Laser Treatment in Intermediate Age-related Macular Degeneration With Nascent Geographic Atrophy Study | December 13, 2021 | December 31, 2024 |
| NCT05657301 | Recruiting | Phase 1 | Safety and Tolerability of KH631 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration | October 16, 2023 | September 2027 |
| NCT05222997 | Recruiting | Therapy of Age-related Macular Degeneration | February 28, 2022 | April 30, 2023 | |
| NCT05959005 | Recruiting | Progression of Early Atrophic Lesions | October 20, 2023 | December 31, 2028 | |
| NCT05230537 | Recruiting | Phase 2 | A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration | February 17, 2022 | October 12, 2026 |
| NCT05984927 | Recruiting | Phase 1/Phase 2 | NG101 AAV Gene Therapy in Subjects With Wet Age-Related Macular Degeneration | September 8, 2023 | January 2030 |
| NCT05390840 | Recruiting | Phase 2 | A Study to Investigate the Effect on Central Macular Thickness of Treatment With MG-O-1002 Eye Drops in Participants Aged Over 45 With Neovascular Age-related Macular Degeneration (nAMD) | August 9, 2022 | March 2024 |
| NCT05262244 | Recruiting | Phase 1 | Targeted Fluorescence Imaging in AMD | October 28, 2022 | September 30, 2023 |
| NCT05447650 | Recruiting | N/A | Microcurrent Stimulation Therapy for Nonexudative Age-related Macular Degeneration (i-SIGHT) | April 12, 2022 | March 2024 |
| NCT06015633 | Recruiting | Ocular, Vascular, and Genetic Findings in AMD Patients | October 15, 2023 | December 31, 2024 | |
| NCT01866371 | Recruiting | High Resolution Retinal Imaging | May 2013 | December 2027 | |
| NCT02452385 | Suspended | Phase 1 | Phase 1 Study of CM082 in Patients With wAMD | March 2015 | June 2020 |
| NCT01944839 | Terminated | Phase 3 | A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Lucentis® Compared to Lucentis® Monotherapy | August 2013 | December 2016 |
| NCT02088151 | Terminated | N/A | Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the Retina | June 2010 | February 1, 2022 |
| NCT02137915 | Terminated | Long-Term Follow-up Safety Study of Human Central Nervous System Stem Cells in Subjects With Geographic Atrophy of Age-Related Macular Degeneration | April 2014 | May 2016 | |
| NCT02214628 | Terminated | Phase 2 | Phase 2A Open Label Safety Study of Fovista® (Anti-PDGF BB) Regimen Administered in Combination With Anti-VEGF Therapy to Study Sub-Retinal Fibrosis in Neovascular AMD | July 2014 | December 2016 |
| NCT00695318 | Terminated | Phase 2 | Fluocinolone Acetonide Intravitreal Inserts in Geographic Atrophy | December 2008 | |
| NCT02226835 | Terminated | Study of Retinal Findings in People With Signs and Symptoms of Alzheimer s Disease Enrolled in 09-M-0198 | August 13, 2014 | January 24, 2017 | |
| NCT00423189 | Terminated | Phase 4 | Lucentis Utilizing Visudyne (LUV Trial) Combination Therapy in the Treatment of Age-Related Macular Degeneration | January 2007 | January 2009 |
| NCT00001310 | Terminated | Tissue Studies of Human Eye Diseases | March 5, 1992 | September 16, 2015 | |
| NCT02387957 | Terminated | Phase 2 | A 24 Month Phase 2a Open Label, Randomized Study of Avastin®, Lucentis®, or Eylea® (Anti-VEGF Therapy) Administered in Combination With Fovista® (Anti-PDGF BB Pegylated Aptamer) | April 26, 2016 | January 2017 |
| NCT00712491 | Terminated | Phase 1/Phase 2 | Phase 1/2 Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Age-Related Macular Degeneration | September 2008 | March 2010 |
| NCT02467634 | Terminated | Phase 2 | Study of HUCNS-SC Subretinal Transplantation in Subjects With GA of AMD | June 2015 | May 2016 |
| NCT02510885 | Terminated | N/A | SD-OCT Angiography | July 2015 | March 11, 2019 |
| NCT00395057 | Terminated | Phase 2 | A Study Using Intravitreal Injections of a Small Interfering RNA in Patients With Age-Related Macular Degeneration | January 2007 | February 2009 |
| NCT02626377 | Terminated | N/A | Multicenter Prospective Cohort of Informal Caregivers in Burgundy and Franche-Comté | October 2015 | May 2019 |
| NCT02625376 | Terminated | N/A | Resveratrol for Exudative Age-Related Macular Degeneration | August 6, 2015 | November 9, 2016 |
| NCT03710564 | Terminated | Phase 3 | Study of Safety and Efficacy of Brolucizumab 6 mg Dosed Every 4 Weeks Compared to Aflibercept 2 mg Dosed Every 4 Weeks in Patients With Retinal Fluid Despite Frequent Anti-VEGF Injections | October 30, 2018 | July 1, 2021 |
| NCT00857259 | Terminated | Phase 2 | The Efficacy of Oral Everolimus in Patients With Neovascular Age-related Macular Degeneration | February 2009 | |
| NCT01319188 | Terminated | Phase 4 | Ranibizumab and the Risk of Arterial Thromboembolic Events | June 2010 | April 2015 |
| NCT01337414 | Terminated | N/A | Tools to Optimize Patient Presentation After Onset of Exudative Age-Related Macular Degeneration (AMD) | May 1, 2010 | March 26, 2015 |
| NCT00890097 | Terminated | Phase 3 | Geographic Atrophy Treatment Evaluation | April 2009 | May 2012 |
| NCT01402544 | Terminated | Phase 2/Phase 3 | Clinical Assessment Of Age-related Macular Degeneration Patients After Early Diagnosis and Treatment With Ranibizumab | July 2011 | March 2015 |
| NCT00090532 | Terminated | Phase 1/Phase 2 | A Study Of The Safety And Efficacy Of AG-013,958 In Subjects With Subfoveal Choroidal Neovascularization Associated With Age-Related Macular Degeneration | January 2004 | August 2006 |
| NCT03869684 | Terminated | Phase 2 | A Study to Assess the Safety, Tolerability and Effectiveness of MT-0814 for the Treatment of Age-related Macular Degeneration | February 25, 2019 | April 24, 2020 |
| NCT03935126 | Terminated | Global Atrophie Biomarker Evaluation Study (GABiE) | May 7, 2019 | May 14, 2020 | |
| NCT00987129 | Terminated | Omega 6:Omega 3 Ratio and Progression of Age-related Macular Degeneration (AMD). | March 2012 | December 2014 | |
| NCT00599846 | Terminated | The Natural History of Geographic Atrophy Progression (GAP) Study | December 2007 | ||
| NCT00478439 | Terminated | Phase 4 | Investigation of Macular Pigment Augmentation on Dark Adaptation | December 2007 | October 2010 |
| NCT01717937 | Terminated | Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging | February 2013 | June 2013 | |
| NCT00134667 | Terminated | Phase 4 | Macugen (Pegaptanib Sodium) Alone, Versus Macugen in Combination With PDT (Photodynamic Therapy) With Visudyne (Verteporfin) in Patients With Age-Related Macular Degeneration (AMD) | March 2005 | October 2008 |
| NCT00347906 | Terminated | N/A | Photodynamic Therapy (PDT) Versus Transpupillary Thermotherapy (TTT) in Occult Choroidal Neovascularization (CNV) in Age-related Macular Degeneration (AMD) | November 2003 | September 2005 |
| NCT00464347 | Terminated | Phase 2 | TAC-PF, Avastin® in Combination With Photodynamic Therapy to Treat Age Related Macular Degeneration | January 2007 | September 2007 |
| NCT01830790 | Terminated | Phase 2 | Effects of Sildenafil on Choroidal Thickness in AMD | March 2013 | May 2014 |
| NCT04276610 | Terminated | N/A | Words on the Brain: Can Reading Rehabilitation for Age-Related Vision Impairment Improve Cognitive Functioning? | May 16, 2017 | March 28, 2023 |
| NCT00766337 | Terminated | Phase 2 | Phase 2 Study of an Ocular Sirolimus (Rapamycin) Formulation in Combination With Lucentis® in Patients With Age-Related Macular Degeneration | December 2008 | March 2010 |
| NCT01940887 | Terminated | Phase 3 | A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Either Avastin® or Eylea® Compared to Avastin® or Eylea® Monotherapy | May 2014 | September 2017 |
| NCT01940900 | Terminated | Phase 3 | A Phase 3 Safety and Efficacy Study of Fovista® (E10030) Intravitreous Administration in Combination With Lucentis® Compared to Lucentis® Monotherapy | August 2013 | December 2016 |
| NCT00403884 | Unknown status | N/A | Selective RPE Laser Treatment (SRT) for Various Macular Diseases | October 2004 | August 2010 |
| NCT02727881 | Unknown status | Phase 3 | Efficacy and Safety Study of Squalamine Ophthalmic Solution in Subjects With Neovascular AMD | April 12, 2016 | December 2017 |
| NCT02802657 | Unknown status | Phase 4 | Efficacy and Safety of "Treat-and-Extend" Regimen Versus "Pro Re Nata" of Conbercept in Age-related Macular Degeneration | September 2016 | September 2020 |
| NCT00788177 | Unknown status | Phase 3 | Subretinal Macugen® for Neovascular Age-Related Macular Degeneration | November 2008 | December 2012 |
| NCT02864472 | Unknown status | Phase 4 | Comparison of PDT Combination With Ranibizumab vs. Ranibizumab Monotherapy in Persistent PCV With Initial Loading Dose | September 2016 | January 2019 |
| NCT02960828 | Unknown status | N/A | "Stop Early Age-related Macular Degeneration (AMD) From Vision Loss Eternally" Study | January 2016 | December 2020 |
| NCT00951288 | Unknown status | Phase 1/Phase 2 | Effect of Saffron Supplementation on Macular Cone-mediated Function in Age-related Macular Degeneration | June 2009 | December 2015 |
| NCT03011554 | Unknown status | N/A | Telescope Exchange Study | March 22, 2017 | December 31, 2022 |
| NCT01048476 | Unknown status | Phase 1/Phase 2 | Effects of Lutein and Zeaxanthin Supplementation on Age-related Macular Degeneration | September 2009 | October 2012 |
| NCT03104608 | Unknown status | N/A | Automatic Self Transcending Meditation (ASTM) for Patients With Severe Age Related Macular Degeneration (AMD) | June 1, 2018 | December 1, 2019 |
| NCT03128463 | Unknown status | Pharmacogenomic Study on Anti-VEGF Medicine in Treatment of Macular Neovascular Diseases | February 28, 2017 | December 31, 2018 | |
| NCT01174407 | Unknown status | Implication of CD35, CD21 and CD55 in Exudative Age-related Macular Degeneration | September 2008 | August 2010 | |
| NCT01217762 | Unknown status | Phase 1 | Safety & Tolerability of the IRay System in Subjects With Exudative Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) | July 2008 | October 2014 |
| NCT00279695 | Unknown status | Ultrasonic Evaluation of Ocular Tissues | January 1996 | June 2010 | |
| NCT00485394 | Unknown status | Phase 2 | The OMEGA Study: Use of Eye Drops to Treat Geographic Atrophy Associated With Age-Related Macular Degeneration (Dry AMD) | June 2007 | |
| NCT03571100 | Unknown status | Early Phase 1 | Comfort and Antimicrobial Efficacy of Chlorhexidine vs Betadine for Intravitreal Injections | May 7, 2018 | May 6, 2019 |
| NCT03710863 | Unknown status | Phase 2 | Safety and Tolerability of Oral CM082 in Patients With wAMD | November 22, 2018 | January 1, 2022 |
| NCT00627718 | Unknown status | N/A | Assessment of Macular Edema Using HRT Technique | April 2008 | July 2009 |
| NCT00148551 | Unknown status | Phase 2/Phase 3 | Triamcinolone Acetonide as an Adjunctive to VPDT in ARMD. | January 2004 | March 2008 |
| NCT03838679 | Unknown status | Imaging of the Angiofibrotic Switch in Neovascular AMD | May 1, 2019 | April 28, 2022 | |
| NCT01521065 | Unknown status | Phase 2 | An Open-label Study to Evaluate the Clinical and Economic Benefits of I-Ray in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration | September 2012 | October 2016 |
| NCT03882606 | Unknown status | N/A | Implantation of SML in Patients With Dry Age-related Macular Degeneration and Myopic Maculopathy | May 22, 2019 | June 1, 2020 |
| NCT01531842 | Unknown status | N/A | A Research Study to Evaluate the Effects of Repeated Intravitreal Injections on Bacteria Around the Eye | August 2011 | August 2013 |
| NCT04032808 | Unknown status | Evaluation of the Performance of Self-monitoring Optimized by Therapeutic Education in the Recurrence of Wet Age-related Macular Degeneration (AMD) | July 10, 2019 | July 10, 2021 | |
| NCT04087356 | Unknown status | Age-related Macular Degeneration (AMD) and Cardiovascular Disease | August 2, 2019 | December 20, 2020 | |
| NCT04101604 | Unknown status | Biomarkers of Common Eye Diseases | September 26, 2019 | October 1, 2021 | |
| NCT01676506 | Unknown status | N/A | Genetic Polymorphisms in Ranibizumab Treatment in Wet Age-Related Macular Degeneration (AMD) | October 2011 | October 2015 |
| NCT04142164 | Unknown status | N/A | Computer-based Tutorial and Automated Speech Recognition for Intravitreal Drug Injections | October 24, 2019 | January 1, 2024 |
| NCT01777984 | Unknown status | Impact of Visceral Fat on the Pathogenesis of Age-related Macular Degeneration | December 2009 | December 2013 | |
| NCT00568191 | Unknown status | Stratus Versus Cirrus OCT in AMD | October 2007 | December 2007 | |
| NCT00455871 | Unknown status | N/A | Study of Treatment Effects of Combination Therapy of Lucentis Plus Reduced Fluence PDT With Visudyne in Patients With Exudative AMD | April 2007 | October 2010 |
| NCT01879501 | Unknown status | N/A | Living Successfully With Chronic Eye Diseases | January 2013 | January 2015 |
| NCT04735263 | Unknown status | Phase 2 | Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD | February 4, 2021 | January 1, 2024 |
| NCT02102880 | Unknown status | N/A | The Role of Complement Factor H Polymorphism in the Regulation of Choroidal Vascular Tone in Young Healthy Subjects | March 2015 | September 2, 2023 |
| NCT05062486 | Unknown status | Phase 2 | A Study to Evaluate the Safety and Efficacy of RQC for AMD | July 22, 2021 | February 2023 |
| NCT00443911 | Unknown status | Rheohemapheresis and Lutein Supplementation in the Non-Exsudative Form of Age-Related Macular Degeneration | March 2007 | May 2012 | |
| NCT02248324 | Unknown status | Association of Previously Verified Gene Polymorphisms With AMD in Turkish Population | November 2012 | November 2017 | |
| NCT00533754 | Unknown status | N/A | Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population | July 2006 | November 2007 |
| NCT05220085 | Unknown status | Beovu Experience UZ Leuven | December 1, 2020 | April 1, 2022 | |
| NCT02345317 | Unknown status | Reticular Pseudodrusen Progression Study | December 2014 | ||
| NCT02372916 | Unknown status | Geographic Atrophy and Intravitreal Ranibizumab Injections | November 2014 | ||
| NCT02462889 | Unknown status | Phase 2 | IAI Versus Sham as Prophylaxis Against Conversion to Neovascular AMD | June 2015 | December 2018 |
| NCT05391074 | Unknown status | N/A | Oral Postbiotics in Patients With Macular Atrophy | December 1, 2020 | June 1, 2024 |
| NCT02588378 | Unknown status | The Role of Inflammation in AMD and Related Disorders | April 2015 | May 2020 | |
| NCT02599064 | Unknown status | Phase 1/Phase 2 | Evaluating RXI-109 to Reduce the Progression of Subretinal Fibrosis in Subjects With NVAMD | November 2015 | May 2018 |
| NCT02873351 | Withdrawn | Phase 2 | A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration | September 2019 | December 2020 |
| NCT01339949 | Withdrawn | N/A | Study to Evaluate the Safety and Effectiveness of IRay in Wet Age-related Macular Degeneration (AMD) Patients With Recurrent Leakage Secondary to Choroidal Neovascularisation (CNV) | June 2011 | October 2014 |
| NCT00390026 | Withdrawn | Phase 3 | The Avastin vs Visudyne for Neovascular AMD Study | November 2006 | November 2008 |
| NCT00487838 | Withdrawn | Effects of Sun Filters on Age-related Macular Degeneration in People With Lens Implants | June 14, 2007 | May 4, 2012 | |
| NCT01177644 | Withdrawn | Phase 1 | Safety and Preliminary Efficacy Study of PDS-1.0 in Patients With Neovascular AMD | January 2011 | |
| NCT00813514 | Withdrawn | N/A | Does Vascular Endothelial Growth Factor (VEGF) or Complement Factor H Gene Polymorphism Play a Role in the Treatment Success With VEGF Inhibitors in Patients With Choroidal NeoVascularization (CNV)? | January 2009 | November 2014 |
| NCT02511613 | Withdrawn | Phase 2 | Effect of Squalamine Lactate Ophthalmic Solution, 0.2% in Subjects With Neovascular Age-Related Macular Degeneration | July 2015 | April 2016 |
| NCT02563782 | Withdrawn | Phase 2 | Study to Evaluate Sub-retinal Transplantation of Retinal Pigmented Epithelial Cells in Patients With Dry AMD | August 24, 2015 | May 5, 2017 |
| NCT01830608 | Withdrawn | Risk Factors for Drusen Progression | January 2015 | March 2015 |