Xerostomia

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Information
Disease name
Xerostomia
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT02057510 Active, not recruiting Observational Study of Dental Outcomes in Head and Neck Cancer Patients February 2014 June 30, 2024
NCT05885906 Active, not recruiting Phase 3 Aloe Vera Versus Thyme Honey Mouthwash in Management of Xerostomia in Type 2 Diabetics July 24, 2023 March 2024
NCT03874572 Active, not recruiting Phase 1 Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth March 18, 2019 December 1, 2025
NCT00001852 Completed Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome April 9, 1999 November 29, 2017
NCT00048685 Completed Study of Oral Bacteria in Patients With Dry Mouth November 2002 August 2004
NCT00068237 Completed Phase 2 Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer August 2003 December 2016
NCT00095927 Completed Phase 2 Randomized Amifostine For SCCHN May 2003 June 2008
NCT00233363 Completed Phase 2 Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome April 15, 2005 January 27, 2006
NCT00332618 Completed Efficacy Study of Oxygenated Glycerol Triesters to Treat Xerostomia September 2003 April 2004
NCT00350350 Completed OGT Spray in the Management of Xerostomia in the Elderly October 2003 December 2004
NCT00426543 Completed Phase 2 Effect of B-cell Depletion in Patients With Primary Sjögren's Syndrome January 2007 August 2010
NCT00430378 Completed N/A Acupuncture for Prevention of Radiation-Induced Xerostomia January 2007 May 27, 2021
NCT04901507 Completed N/A Effects of an External Oral Irrigation Device on Patients With Dry Mouth May 20, 2021 April 28, 2022
NCT00001598 Completed Phase 2 DHEA Treatment for Sjogren's Syndrome May 1997 June 2002
NCT00001599 Completed Phase 2 Pilot Study of Thalidomide to Treat Sjogren's Syndrome May 1997 June 2002
NCT01724333 Completed International Validation of the QLQ-OH17 for Oral Health December 2012 December 2015
NCT01823445 Completed N/A Xylitol Disk Use in Adults With Dry Mouth March 2013 August 2013
NCT01915966 Completed N/A Efficacy Study of a Ginger and Cardamom Gelatin for Xerostomy in Terminally Ill Patients April 2013
NCT02049112 Completed Phase 4 A New Oral salIvary equivAlent Compared to Two moisturizinG Mouth sprAys in Patients With xeRostomiA: NIAGARA Study January 2012 June 2013
NCT02066896 Completed N/A Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome May 2014 August 2016
NCT02067572 Completed N/A A Randomized Controlled Trial Evaluating the Effectiveness of a Salvia-based Mouthwash in Palliative Care March 12, 2014 September 8, 2016
NCT02107300 Completed N/A NeutraSal Treatment for Xerostomia in OSAS Patients Using CPAP Therapy November 2013 July 3, 2017
NCT02317172 Completed N/A Efficacy of Novel Edible Gel-based Artificial Saliva in Thai Geriatric Populations With Systemic Diseases October 2012 March 2013
NCT02375451 Completed Effect of Childhood Radioiodine Therapy on Salivary Function September 2014 September 2016
NCT02474095 Completed N/A Acupuncture-Like Transcutaneous Electrical Nerve Stimulation in Treating Radiation-Induced Xerostomia in Patients With Head and Neck Cancer November 4, 2014 October 12, 2019
NCT02513238 Completed Phase 2 Mesenchymal Stemcells for Radiation Induced Xerostomia August 8, 2015 April 6, 2017
NCT02587676 Completed Deterioration of Resilient Denture Liners and Patient Characteristics June 2013 December 2016
NCT02641912 Completed N/A Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms March 9, 2016 April 15, 2016
NCT02682199 Completed Prospective Evaluation of Patient Reported Xerostomia After Whole Brain Radiation October 2015 August 30, 2018
NCT02687087 Completed N/A A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy March 24, 2016 February 2, 2017
NCT02766127 Completed N/A Effect of a Self-adhering Material in Dental Hypersensitivity March 2012 December 2015
NCT02854358 Completed Phase 2 Efficacy of Traditional Persian Medicine Preparation Versus Artificial Saliva for Radiation Induced Xerostomia March 2015 February 2016
NCT02941276 Completed N/A A Trial Looking at Treating Dry Mouth After Radiotherapy for Head and Neck Cancer November 2011 November 2014
NCT03005041 Completed N/A Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects August 31, 2016 October 19, 2016
NCT03009786 Completed Validation of the French Version of the Xerostomia Inventory May 5, 2017 February 20, 2024
NCT03281486 Completed N/A "Hyaluronan" Formulation for Type 2 Diabetic Patients With Dry Mouth January 28, 2018 December 31, 2019
NCT03302676 Completed N/A The Use of Chewing Gum for Xerostomia and Hyposalivation After Radiotherapy for Oral and Oropharyngeal Tumors September 2016 January 2019
NCT03494985 Completed N/A A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water September 17, 2013 January 10, 2014
NCT03578900 Completed Phase 4 Quality of Life and Sjögren Syndrome January 1, 2013 December 31, 2016
NCT03595878 Completed N/A Trial of Parotid Sparing Whole Brain Radiation May 9, 2018 March 16, 2022
NCT03611283 Completed N/A Topical Management of Xerostomia With Dry Mouth Products October 3, 2016 November 30, 2017
NCT03647813 Completed Phase 2 Effects of Photobiomodulation in Salivary Analysis of Chronic Renal Failure Patients July 1, 2016 September 30, 2017
NCT03649789 Completed Periodontal Outcomes After Sanative Therapy August 1, 2018 May 1, 2019
NCT04007081 Completed N/A Salivary Gland Autotransplantation for Treatment of XRT Induced Xerostomia October 18, 2019 March 10, 2021
NCT04186806 Completed N/A Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray November 2, 2019 December 13, 2019
NCT04206826 Completed N/A Tolerance and Efficiency of an Intrabuccal Biological Film to Enhance Oral Dryness Sensation: The "PREDELFI" Clinical Pilot Study June 25, 2020 April 23, 2021
NCT04252209 Completed Phase 3 the Effect of Mixture of Natural Products As Salivary Substitutes in Treatment Of Xerostomia March 22, 2021 March 15, 2023
NCT04289051 Completed N/A Clinical Evaluation of Oral Rinse for Xerostomia August 19, 2020 February 4, 2021
NCT04554342 Completed N/A Testing of a Candy in Five Different Versions for the Additional Humidification of the Oral Cavity December 28, 2020 February 18, 2021
NCT04608773 Completed N/A Blinded Dry Mouth Spray Crossover Study January 14, 2021 June 30, 2023
NCT04661761 Completed N/A Influence of Two Paraffin Wax Chewing Gums of Different Consistency on the Stimulated Saliva Flow Rate June 17, 2020 April 24, 2022
NCT04738227 Completed N/A Effect of Low-level Laser Therapy on Salivary Flow, pH and Quality of Life in Irradiated Oropharyngeal Cancer Patients November 6, 2020 February 3, 2021
NCT00001523 Completed Structure and Functional Status of Parotid Glands Exposed to Therapeutic Irradiation May 1996 March 2000
NCT04986501 Completed N/A Clinical Evaluation of MucoPEG™ for Xerostomia May 2, 2022 November 15, 2022
NCT04996069 Completed N/A Exploratory Study on Effect of Whitening Agent With Emulsion Gel in Xerostomic Population August 9, 2021 April 26, 2022
NCT05058430 Completed N/A SaliPen Human Factors Study for OTC Labeling September 16, 2021 November 18, 2021
NCT05091216 Completed N/A The Effects of Traditional Chinese Medicine Mouthwash Solutions on the Oral Health of Leprosy Patients October 1, 2021 September 6, 2022
NCT05103124 Completed N/A GUM Hydral Mouthwash vs Placebo in the Management of Hyposalivation. November 3, 2020 July 26, 2022
NCT05247008 Completed N/A Effectiveness of Thyme Honey in Management of Xerostomia in ESRD September 10, 2021 October 10, 2021
NCT05342272 Completed Phase 3 Comparison of Gum® HydralTM Moisturizing Gel and Biotene® Oral Gel in Dry Mouth Sensation Reduction September 22, 2017 October 30, 2018
NCT05413993 Completed N/A Effect of Photobiomodulation on ph and Salivary Flow March 10, 2022 May 20, 2022
NCT05614843 Completed N/A Photobiomodulation Therapy in Patients With Head and Neck Cancer Post-Radiotherapy October 1, 2022 July 31, 2023
NCT05640362 Completed N/A Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial November 10, 2016 March 24, 2017
NCT05680064 Completed N/A The Effect of Chewing Gum, Exercises of the Tongue, Lip, Jaw on Salivation, Xerostomia, Dysphagia in Sjögren's Syndrome January 10, 2023 July 18, 2023
NCT05760092 Completed Phase 2 The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19.A Randomized Controlled Trial. March 1, 2023 March 8, 2024
NCT06217614 Completed N/A Beneficial Effects of Natural Products on Management of Xerostomia August 1, 2022 October 1, 2022
NCT00438048 Completed Phase 4 A Comparison of Orally Pilocarpine and Artificial Saliva in Xerostomy Treatment November 2006 May 2008
NCT00466388 Completed Phase 4 Study of the Effectiveness of Cevimeline on Oral Health in Patients With Radiation Induced Xerostomia May 2007 August 2009
NCT00509808 Completed Phase 4 Evaluation of an Electro-stimulator for the Treatment of Xerostomia January 2007 April 2010
NCT00595933 Completed Phase 1 Comparing Over-the-counter Dry Mouth Remedies After Radiation March 2005 June 2010
NCT00637793 Completed Phase 2 Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome February 2008 November 2008
NCT00656513 Completed Phase 2/Phase 3 Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer September 2008 November 2014
NCT00750828 Completed Gingival Wetness and Gingival Crevicular Fluid Volume in Patients With Dry Mouth January 2004 March 2008
NCT00852839 Completed Phase 2 A Safety and Efficacy Study of 552-02 in Subjects With Dry Mouth Associated With Sjogren's Syndrome February 2009 November 2009
NCT00873496 Completed Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients January 2005 January 2009
NCT00911768 Completed Phase 4 Effect of Korean Red Ginseng (KRG) on Dry Mouth September 2007 December 2008
NCT00966394 Completed Salivary Bacteria and Oral Health Status in Children With ADHD November 2009 May 2010
NCT01272570 Completed Oral Health and Oral Health-Related Quality of Life in Early Stage Breast Cancer Survivors September 2010 August 2013
NCT01316393 Completed Phase 4 Effects of Mucoprotective Product on Xerostomia February 2011 June 2011
NCT01369589 Completed Phase 1/Phase 2 An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness November 2010 April 2011
NCT01627626 Completed N/A Effect of 0.1% Pilocarpine Mouthwash on Xerostomia August 2011 March 2012
NCT01647737 Completed Phase 1/Phase 2 Green Tea Lozenges for the Management of Dry Mouth March 2011 June 2013
NCT01652001 Completed Phase 2/Phase 3 Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity January 2011 January 2014
NCT06122636 Enrolling by invitation N/A Efficacy of a Probiotic and Microbiological Analysis on Oral Complications Induced by Antineoplastic Therapies in Patients With HNC October 3, 2022 December 2024
NCT06201923 Not yet recruiting Phase 4 The Efficacy of Thyme Honey Mouth Rinse on Polypharmacy-induced Xerostomia January 2024 April 2024
NCT05289375 Not yet recruiting N/A Efficacy of the Vacucis Candida® Autovaccine April 30, 2024 December 31, 2025
NCT05872464 Not yet recruiting N/A Artificial Saliva Containing Cumin and Ginger Extract in Head and Neck Cancer Patients With Xerostomia July 1, 2023 September 26, 2023
NCT06276946 Not yet recruiting N/A Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia August 8, 2024 January 2029
NCT06392711 Not yet recruiting Phase 1 Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia June 2024 November 2028
NCT05857358 Not yet recruiting Phase 1/Phase 2 Safety and Potential Effect of Innovative Cell-based Therapy Using Adipose-derived Stromal Vascular Fraction in Patients With Autoimmune Xerostomia January 2024 August 2027
NCT05506137 Not yet recruiting Phase 3 Xerostomia in Patients With a Life-limiting Condition or Frailty January 2023 June 2025
NCT05759975 Recruiting N/A Effectiveness of Extraoral Photobiomodulation in Management of Oral Adverse Effects in Patients Undergoing HSCT January 13, 2023 June 30, 2024
NCT06287294 Recruiting An Investigation Into Taste Problems Associated With Xerostomia in Patients With Advanced Cancer August 30, 2023 December 31, 2024
NCT04645693 Recruiting The Impact of Oral Health in HIV Patients on Antiretroviral Therapy February 24, 2021 March 2025
NCT04222478 Recruiting N/A Interest of Auriculotherapy in the Treatment of Xerostomia December 4, 2019 December 4, 2024
NCT04584164 Recruiting N/A Interest of the Sialendoscopy Associated With a Local Injection of Corticosteroids in the Treatment of Radio-induced Xerostomia in Comparison With the Hygiene Rules October 19, 2020 December 6, 2025
NCT05964959 Recruiting N/A A Mouth Education Program for Dry Mouth June 15, 2023 May 2026
NCT05106608 Recruiting N/A Photobiomodulation Therapy Plus M-health in Head and Neck Cancer Patients: LAXER Study July 13, 2022 July 2025
NCT04392622 Recruiting Phase 1 d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma February 15, 2021 February 15, 2027
NCT05242991 Recruiting N/A Effectiveness of Photobiomodulation Protocols in Radiation-induced Oral Side Effects in H&N Cancer Patients March 1, 2021 October 1, 2024
NCT06194123 Recruiting N/A Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis February 1, 2024 February 1, 2026
NCT04880148 Recruiting N/A The Effectiveness of a Thyme and Honey Spray for Oral Toxicities November 3, 2021 September 1, 2024
NCT05820711 Recruiting Phase 1 Study Transplanting Bone Marrow Cells Into Salivary Glands to Treat Dry Mouth Caused by Radiation Therapy July 17, 2023 March 31, 2026
NCT06365047 Recruiting Phase 3 Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine July 1, 2024 June 1, 2027
NCT05187533 Recruiting N/A Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness January 15, 2022 December 31, 2023
NCT03578432 Terminated Early Phase 1 Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy May 4, 2018 November 15, 2019
NCT00503776 Terminated Phase 2 Chemo/XRT +/- Amifostine to Assess Outcomes Related to Xerostomia, Mucositis, & Dysphagia January 2006 August 2008
NCT00623129 Terminated N/A Electroacupuncture in Treating Chronic Dry Mouth Caused By Radiation Therapy in Patients With Head and Neck Cancer February 2006
NCT03601962 Terminated N/A Effects of Aqualief® in Patients With Xerostomia as Consequence of Radiotherapy for Head and Neck Cancer July 31, 2017 January 22, 2020
NCT01316770 Terminated Phase 2 Dexamethasone Irrigation of the Parotid Glands in Primary Sjögren's Syndrome Subjects May 1, 2011 April 17, 2017
NCT01682031 Terminated Phase 2 Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck Cancer Who Are Receiving Cisplatin and Radiation Therapy June 2009 June 2012
NCT03176368 Unknown status N/A Coconut Oil: Managing Radiation-Induced Xerostomia October 5, 2017 September 15, 2018
NCT00408759 Unknown status Phase 2 Hypnosis for Treating Xerostomia Following Radiotherapy in Head & Neck Cancer Patients November 2006 December 2006
NCT04756986 Unknown status N/A Malic Acid in Treatment of Xerostomia January 1, 2021 November 1, 2021
NCT03295019 Unknown status N/A "Hyaluronan" Formulation for Dry Mouth in Sleep Apnea Patients August 4, 2017 July 31, 2019
NCT02982577 Unknown status Phase 4 Effect of Pilocarpine in Patients With Xerostomia April 2016 July 2017
NCT04184908 Unknown status Phase 1 Clinical Study New Gel for Xerostomia October 1, 2019 December 31, 2020
NCT00422370 Unknown status N/A Lipid Based Food Additives for Treating Patients With Dry Mouth January 2007
NCT01579877 Unknown status N/A Treatment of Xerostomia by Herbal Preparation April 2012 November 2013
NCT05443022 Unknown status Phase 1/Phase 2 Photobiomodulation on the Salivary Glands of Patients With Xerostomia Induced by the Use of Benzodiazepines February 20, 2022 June 20, 2023
NCT04323384 Unknown status N/A The Effect of Biotene® on the Symptoms of Xerostomia and Mastication and Swallowing September 1, 2020 December 1, 2021
NCT03632096 Unknown status Phase 2 Photobiomodulation in Salivary Production of Patients With Xerostomy September 10, 2018 December 30, 2018
NCT01174329 Unknown status Phase 2/Phase 3 Treatment of Salivary Gland Hypofunction With Neuro- Electrostimulation August 2010
NCT00431925 Unknown status Can Cytokines Predict the Severity of Acute Mucositis and the Need for Gastrostomy Tubes (PEG)? May 2011
NCT00862550 Unknown status N/A Xerostomia Pilot Fudan: Acupuncture for Prevention of Radiation-Induced Xerostomia March 2009 March 2022
NCT03530735 Unknown status N/A Finger-prick Autologous Blood (FAB) for Use in Dry Mouth September 1, 2018 December 1, 2019
NCT04657913 Unknown status N/A Mouth Dryness and Thirst of Patients Undergone Major Abdominal Surgery February 1, 2020 January 31, 2021
NCT00081029 Unknown status Phase 3 Parotid-Sparing Intensity-Modulated Radiation Therapy Compared With Conventional Radiation Therapy in Treating Patients With Oropharyngeal or Hypopharyngeal Cancer Who Are at High Risk of Radiation-Induced Xerostomia January 2004
NCT02705937 Unknown status N/A Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications. September 13, 2017 March 2019
NCT03400969 Unknown status N/A Effectiveness of Three Different Oral Moisturizers in Palliative Care Patients. March 1, 2018 March 15, 2019
NCT01960101 Withdrawn N/A Development of a Milk Product Substitution for Patients Suffering From Xerostomia Caused by Medication October 2013
NCT01621048 Withdrawn Evaluation of Treatment Related Toxicity After Radiotherapy for Head and Neck Cancer June 2012 December 2016
NCT02522936 Withdrawn Phase 4 Use of Biotene Moisturizing Mouth Spray for Xerostomia Associated With Oral Oxybutynin Use August 1, 2018 December 30, 2019
NCT01532479 Withdrawn Saliva, Hyperbaric Oxygen Therapy, & Gland Function: A Prospective Study August 2015 January 2022
HPO alt_id (Human Phenotype Ontology)
HP:0002709
HPO alt_id (Human Phenotype Ontology)
HP:0100756
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0000217
MeSH unique ID (MeSH (Medical Subject Headings))
D014987