Heart Failure, Systolic
Information
- Disease name
- Heart Failure, Systolic
- Disease ID
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03511248 | Active, not recruiting | Phase 2 | Effect of Dietary Nitrate Ingestion in Heart Failure | June 1, 2018 | March 1, 2024 |
| NCT02438306 | Active, not recruiting | Phase 3 | CardiAMP™ Cell Therapy for Heart Failure Trial | December 2016 | December 2026 |
| NCT05647577 | Active, not recruiting | The Relationship Between Inflammatory ARTritis and CArdiac DIseAse | January 1, 2021 | March 1, 2033 | |
| NCT06084468 | Active, not recruiting | Cardiac Structure and Function in Patients With Cystic Fibrosis | January 1, 2023 | March 1, 2032 | |
| NCT02026505 | Completed | Evaluation of Cardiotoxic Effects of Bortezomib | March 1, 2014 | March 1, 2019 | |
| NCT02044211 | Completed | Phase 2/Phase 3 | Blended Collaborative Care for Heart Failure and Co-Morbid Depression | February 2014 | July 2020 |
| NCT02080000 | Completed | N/A | R-wave Optimisation in Cardiac Resynchronisation Therapy Study | February 2014 | March 2016 |
| NCT02334891 | Completed | Kyoto Congestive Heart Failure Study | October 2014 | March 30, 2021 | |
| NCT02401126 | Completed | Phase 4 | Effects of Dietary Nitrate Supplementation on Cardiorespiratory Control in Chronic Heart Failure | March 2015 | April 2016 |
| NCT05726565 | Completed | Impact of Cardiac Rehabilitation on Acute Heart Failure Patients With Cognitive Impairment | March 1, 2015 | July 30, 2022 | |
| NCT02810132 | Completed | Phase 2 | Effects of Metformin Treatment on Myocardial Efficiency in Patients With Heart Failure | January 20, 2017 | February 14, 2018 |
| NCT02862067 | Completed | SGLT2 Inhibition in Diabetes and Heart Failure | July 2016 | January 16, 2018 | |
| NCT02920918 | Completed | Phase 4 | Treatment of Diabetes in Patients With Systolic Heart Failure | October 2016 | September 2018 |
| NCT02946476 | Completed | Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients | November 2009 | December 2014 | |
| NCT03627585 | Completed | N/A | Reprogramming to Prevent Progressive Pacemaker-induced Remodelling | August 1, 2017 | August 6, 2019 |
| NCT01514773 | Completed | Patient and Physician Survey Determinants of Appropriate ICD Utilization | August 2011 | August 30, 2013 | |
| NCT01129635 | Completed | N/A | Optimal Coronary Sinus Lead Implantation Using Intracardiac Impedography and Magnetic Resonance Imaging | June 2010 | December 2014 |
| NCT01577446 | Completed | N/A | Narrow QRS Ischemic Patients Treated With Cardiac Resynchronization Therapy (NARROW CRT) | January 2008 | |
| NCT04064541 | Completed | N/A | Virtual Visits to Optimize Research Trial Offerings to HF Patients | August 1, 2019 | March 30, 2020 |
| NCT03917459 | Completed | Phase 3 | COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart Failure | April 16, 2019 | May 25, 2021 |
| NCT03677271 | Completed | N/A | A Novel Home-based Physical Activity Intervention for Stable Chronic Heart Failure Patients | December 16, 2015 | December 19, 2016 |
| NCT02973594 | Completed | Phase 4 | Pulse Reduction On Beta-blocker and Ivabradine Therapy | November 2016 | June 30, 2023 |
| NCT05589428 | Completed | N/A | Low-salt Bread in Heart Failure, Pilot Study | February 20, 2018 | January 1, 2020 |
| NCT02998697 | Completed | Phase 2/Phase 3 | Short Term Oral Iron Supplementation in Systolic Heart Failure Patients Suffering From Iron Deficiency Anemia | January 2016 | November 2016 |
| NCT05475028 | Completed | Network Medicine Approaches to Classify Heart Failure With PReserved Ejection Fraction by Signatures of DNA Methylation and Point-of-carE Risk calculaTors (PRESMET) | September 14, 2021 | June 14, 2022 | |
| NCT05387967 | Completed | Phase 4 | Safety and Tolerability of Sacubitril/Valsartan in Heart Failure Patient With Reduced Ejection Fraction | January 1, 2021 | September 30, 2021 |
| NCT03073356 | Completed | Phase 2 | Ketones in Heart Failure - Effects on Cardiac Efficiency | March 17, 2017 | November 16, 2017 |
| NCT03079518 | Completed | Phase 2 | Intravenous Iron in paTients With Heart failURe and Reduced Ejection fracTion (HFREF) pLus Iron dEficiency | March 10, 2017 | October 25, 2017 |
| NCT05140642 | Completed | N/A | Safety and Efficacy Study of AI LVEF | April 1, 2022 | June 29, 2022 |
| NCT04992832 | Completed | Phase 1/Phase 2 | Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Heart Failure With Reduced Ejection Fraction（PRIME-HFrEF Study） | July 28, 2021 | April 4, 2023 |
| NCT03122769 | Completed | Phase 1 | Cardiac Uptake of Metformin, Visualized by Positron Emission Tomography | December 1, 2017 | April 10, 2018 |
| NCT04839133 | Completed | N/A | Robotic-assisted Exercise Training in Heart Failure | March 31, 2021 | July 31, 2021 |
| NCT03183323 | Completed | N/A | Implementation of Telerehabilitation In Support of HOme-based Physical Exercise for Heart Failure | June 8, 2017 | February 28, 2021 |
| NCT03220659 | Completed | N/A | Optimising Pacemaker Therapy Using Multi-point Pacing (the OPT-MPP Study) | November 1, 2017 | November 1, 2020 |
| NCT04703361 | Completed | Phase 2 | Effects of Ketones and Niacin in Heart Failure Patients | February 15, 2021 | September 3, 2021 |
| NCT03305692 | Completed | N/A | ECG Belt vs. Echocardiographic Optimization of CRT | October 31, 2017 | August 17, 2021 |
| NCT03351283 | Completed | N/A | Effect of Sodium Intake on Brain Natriuretic Peptide Levels in Patients With Heart Failure | November 22, 2017 | August 1, 2020 |
| NCT03374891 | Completed | N/A | A Multicenter Trial of a Shared DECision Support Intervention for Patients Offered Implantable Cardioverter-DEfibrillators | May 28, 2018 | December 31, 2021 |
| NCT03387163 | Completed | Patient Reported Outcomes inVestigation Following Initiation of Drug Therapy With Entresto (Sacubitril/Valsartan) in Heart Failure | February 9, 2018 | June 21, 2019 | |
| NCT03387215 | Completed | Phase 1/Phase 2 | Randomized, Double-Blind, Placebo-Controlled, Safety and Tolerability Study of ITI-214 in Patients With Heart Failure | July 10, 2018 | March 16, 2020 |
| NCT03387813 | Completed | N/A | Hemodynamic-GUIDEd Management of Heart Failure | March 15, 2018 | May 17, 2023 |
| NCT04420481 | Completed | Phase 3 | Growth Hormone in Ischemic Heart Failure | April 28, 2004 | February 25, 2012 |
| NCT04281849 | Completed | N/A | Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) Program | June 15, 2020 | September 14, 2022 |
| NCT03423342 | Completed | Phase 1/Phase 2 | Nicotinamide Riboside in Systolic Heart Failure | May 19, 2016 | June 30, 2019 |
| NCT04145635 | Completed | N/A | The Aortix CRS Pilot Study | February 5, 2021 | March 9, 2023 |
| NCT04112576 | Completed | Physiological Signals, Activity and Posture for Surface Mounted Insertable Cardiac Monitor in Heart Failure Study | July 23, 2020 | May 11, 2022 | |
| NCT05802563 | Enrolling by invitation | Machine Learning Enabled Time Series Analysis in Medicine | May 24, 2022 | September 1, 2023 | |
| NCT03903107 | Enrolling by invitation | N/A | The Fluoroless-CSP Trial Using Electroanatomic Mapping | October 26, 2020 | September 2024 |
| NCT05925608 | Enrolling by invitation | Phase 1 | Clinical Trial of Human Allogenic Culture-expanded Bone Marrow-derived Mesenchymal Stem Cells (CardiALLO) | August 23, 2023 | December 2024 |
| NCT06434025 | Not yet recruiting | Phase 3 | IV Iron and SGLT2 Inhibitor on Ventricular Function and Myocardial Iron Content in Heart Failure With Iron Deficiency | May 24, 2024 | November 24, 2026 |
| NCT04705337 | Not yet recruiting | Phase 4 | Levosimendan In Ambulatory Heart Failure Patients | January 1, 2021 | December 31, 2024 |
| NCT05702970 | Not yet recruiting | Phase 4 | Beneficial Effects of Vitamin D Combined With Oral Iron Supplementation in Patients With Chronic Heart Failure and Iron Deficiency | January 15, 2024 | October 31, 2025 |
| NCT05988749 | Not yet recruiting | N/A | Digital Remote Home Monitoring for Heart Failure | September 1, 2024 | October 1, 2025 |
| NCT06240403 | Not yet recruiting | Phase 2 | Digoxin and Senolysis in Heart Failure and Diabetes Mellitus | September 1, 2024 | August 28, 2028 |
| NCT06332391 | Not yet recruiting | N/A | Paced Heart Rate Acceleration for Cardiac Conditioning | May 20, 2024 | November 30, 2028 |
| NCT06336746 | Not yet recruiting | Effects of Steep Trendelenburg and Pneumoperitoneum on Cardiac Performance. | May 1, 2024 | March 31, 2025 | |
| NCT05752760 | Recruiting | N/A | Pilot Study Lp299v Supplementation in Chronic Heart Failure | February 20, 2023 | March 1, 2025 |
| NCT04083690 | Recruiting | N/A | Multi-lead ECG to Effectively Optimize Resynchronization Devices: New CRT Recipients | October 11, 2019 | October 1, 2024 |
| NCT04179643 | Recruiting | Phase 1 | NAN-101 in Patients With Class III Heart Failure | November 20, 2019 | December 31, 2026 |
| NCT04201015 | Recruiting | Phase 2/Phase 3 | Optimising Pacing for Contractility 2 | June 1, 2020 | December 31, 2023 |
| NCT03398369 | Recruiting | N/A | Mechanistic Clinical Trial of Advanced Imaging for CRT | January 5, 2018 | January 15, 2025 |
| NCT04342832 | Recruiting | N/A | Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial Fibrillation | July 16, 2020 | September 1, 2024 |
| NCT04528004 | Recruiting | Early Phase 1 | Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure | September 26, 2020 | July 31, 2025 |
| NCT04529577 | Recruiting | N/A | His-bundle Pacing vs. Right Ventricular Apical Pacing in Patients With Reduced Ejection Fraction | December 1, 2020 | December 2025 |
| NCT04636892 | Recruiting | N/A | Evaluating Infrasonic Hemodynography | January 4, 2021 | December 1, 2025 |
| NCT04703842 | Recruiting | Phase 1/Phase 2 | Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction | September 23, 2021 | December 2028 |
| NCT06121323 | Recruiting | N/A | Physiological Effects of Lactate in Individuals With Chronic Heart Failure | November 22, 2023 | September 30, 2024 |
| NCT04763460 | Recruiting | N/A | Effects of CRT Optimization as Assessed by Cardiac MR | July 1, 2021 | April 1, 2025 |
| NCT04803175 | Recruiting | Sacubitril/Valsartan Versus Valsartan in Heart Failure With Improved Ejection Fraction | March 16, 2021 | February 2025 | |
| NCT04950218 | Recruiting | The Psoriasis Echo Study | September 1, 2021 | October 1, 2030 | |
| NCT05008692 | Recruiting | Apple-CPET Ted Rogers Understanding Exacerbations of Heart Failure | December 1, 2020 | December 2023 | |
| NCT05278429 | Recruiting | N/A | Robotic-assisted Exercise Training in Heart Failure With Reduced Ejection Fraction | November 1, 2021 | January 2025 |
| NCT05396313 | Recruiting | Prediction of Mortality After CIED Implantation (PM-CIED) | August 2004 | December 2022 | |
| NCT05632432 | Recruiting | N/A | Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery | April 1, 2024 | December 31, 2026 |
| NCT05677100 | Recruiting | N/A | Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure | August 23, 2023 | December 2025 |
| NCT05928026 | Recruiting | N/A | Financial Support in an Underserved and Low-Income Population With Heart Failure | June 9, 2023 | December 1, 2024 |
| NCT05933083 | Recruiting | N/A | MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation | October 27, 2023 | October 15, 2027 |
| NCT06324682 | Recruiting | ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing | January 1, 2023 | December 31, 2034 | |
| NCT05989945 | Recruiting | HIDRAdenitis Suppurativa and HEART Disease | August 1, 2023 | August 1, 2033 | |
| NCT06009276 | Recruiting | Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status | August 30, 2023 | August 7, 2024 | |
| NCT03797001 | Recruiting | Phase 2 | Interleukin-1 Blockade In Recently Decompensated Heart Failure - 2 | January 4, 2019 | June 30, 2024 |
| NCT04701112 | Suspended | N/A | Acute Hemodynamic Effects of Pacing the His Bundle in Heart Failure | September 1, 2021 | February 28, 2026 |
| NCT03755570 | Suspended | How is COGNItive Function Affected by Cardiac Resynchronisation Therapy? | June 21, 2019 | January 14, 2024 | |
| NCT03492788 | Terminated | N/A | Optimizing CRT With ECGI | December 28, 2017 | October 5, 2018 |
| NCT03425422 | Terminated | N/A | ANTHEM-HFrEF Pivotal Study | May 1, 2018 | May 31, 2023 |
| NCT05195931 | Terminated | Cardiac Output in Heart Failure Patients With Mechanical Pumps | June 8, 2021 | August 25, 2022 | |
| NCT03089502 | Terminated | N/A | Efficacy of Cardio-Oncology Rehabilitation Exercise for Women With Breast Cancer and Treatment Related Cardiotoxicity | April 1, 2018 | May 1, 2018 |
| NCT04264182 | Terminated | N/A | STandardized Ultra-conservative Or Physician-directed ICD Programming for Continuous Flow LVAD Support | February 3, 2020 | April 4, 2022 |
| NCT01872234 | Terminated | Phase 3 | MADIT ASIA Cardiac Resynchronization Trial | February 2014 | April 2014 |
| NCT03871699 | Unknown status | Phase 4 | Ferric Carboximaltose on Intra-myocardial Iron Load in Patients With Heart Failure | August 30, 2019 | February 28, 2021 |
| NCT02579200 | Unknown status | Phase 4 | Inspiratory Muscle Training for Breathless Patients With Chronic Obstructive Pulmonary Disease and Heart Failure | November 2015 | July 2017 |
| NCT03183011 | Unknown status | N/A | Cardiac Magnetic Resonance Imaging After Cardiac Resynchronization Therapy | November 1, 2016 | December 31, 2018 |
| NCT04902079 | Unknown status | Observational and Prospective Registry on Cardiac Contractility Modulation (CCM) Therapy | March 8, 2021 | December 31, 2023 | |
| NCT03640000 | Unknown status | N/A | Acute Changes in Bioimpedance During Cardiac Resynchronization Therapy | January 2015 | December 2021 |
| NCT03086746 | Unknown status | VItamin D as a Novel Determinant of Injurious Cardiac Remodelling After acuTE Myocardial Infarction | April 1, 2018 | June 1, 2020 | |
| NCT03768804 | Unknown status | N/A | SyncAV Study: Investigation of the Efficacy of the SyncAV Fusion Pacing Algorithm on Exercise | May 31, 2019 | December 2021 |
| NCT03553303 | Unknown status | Phase 4 | Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides, Angiotensin and Neprilysin | October 16, 2018 | May 2022 |
| NCT03537079 | Unknown status | N/A | Hypoxic Conditioning in Heart Failure | May 2020 | May 2022 |
| NCT04611594 | Unknown status | N/A | Fluid Restriction in Patients With Heart Failure | February 1, 2019 | June 1, 2021 |
| NCT01553045 | Unknown status | Reasons for Variations in Health Related Quality of Life and Symptom Burden in Patients With Atrial Fibrillation | November 2011 | June 2015 | |
| NCT02797340 | Unknown status | Phase 4 | Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure | January 11, 2016 | April 30, 2018 |
| NCT03573869 | Unknown status | N/A | Atrial FIbrillation Treatment With Cryoballoon in Heart failurE (AFICHE) | June 1, 2018 | June 1, 2022 |
| NCT04743063 | Unknown status | Prospective Monitoring of Angiotensin Receptor Neprilysin Inhibitor in Older Adults With Heart Failure and Frailty | January 14, 2021 | December 31, 2022 | |
| NCT02099903 | Unknown status | N/A | Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease | March 2014 | August 2015 |
| NCT04325867 | Unknown status | N/A | Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19 | March 31, 2020 | October 1, 2020 |
| NCT03830957 | Unknown status | N/A | Efficacy and Safety of Ivabradine to Reduce Heart Rate Prior to Coronary CT-angiography in Advanced Heart Failure: Comparison With β-Blocker | November 26, 2018 | December 2019 |
| NCT04522609 | Unknown status | N/A | Electrostimulation of Skeletal Muscles in Patients Listed for a Heart Transplant | September 2020 | November 2022 |
| NCT02960685 | Unknown status | Telesonography for Visually Estimating Ejection Fraction | November 2016 | ||
| NCT04570865 | Unknown status | Phase 4 | Dapagliflozin And Pulmonary Artery Hemodynamics in Heart Failure With Reduced Ejection Fraction Patients With CardioMEMS® | December 1, 2020 | February 1, 2022 |
| NCT03034551 | Withdrawn | N/A | Mobile App With Patient Financial Incentives for Adherence to Heart Failure Medications & Daily Self-Weighing | January 30, 2017 | December 31, 2019 |
| NCT02997670 | Withdrawn | N/A | Quartet Lead With Defibrillator Multisite Algorithmic Cardiac Resynchronisation Therapy Optimisation | July 1, 2019 | July 1, 2019 |
| NCT04872959 | Withdrawn | N/A | TRANSFORM Heart Failure With Reduced Ejection Fraction | October 2021 | May 2024 |
| NCT03062176 | Withdrawn | Phase 2 | Interleukin-1 Blockade for the Treatment of Heart Failure in Patients With Advanced Chronic Kidney Disease | April 3, 2017 | May 15, 2019 |
| NCT03392740 | Withdrawn | Phase 4 | Prophylactic Lisinopril to Prevent Anthracycline Cardiomyopathy. | March 15, 2018 | December 15, 2018 |
| NCT03227393 | Withdrawn | N/A | The Effect of Yoga on Cardiac Sympathetic Innervation Evaluated by I-123 mIBG | September 30, 2017 | October 27, 2017 |
- MeSH unique ID (MeSH (Medical Subject Headings))
- D054143