Annotation Detail
Information
- Associated Genes
- UGT1A1
- Associated Variants
- UGT1A1 UNKNOWN
- Source Database
- MMMP
- Description
- Non melanoma specific model (miscellany). This meta-analysis of 9 studies showed that the *28/*28 genotype is associated with higher hematologic toxicity for high/medium drug doeses (not for low dose)
- MMMP State
- genotype *28/*28
- MMMP Molecule
- UGT1A1
- MMMP Relationship
- toxicity increased for
- MMMP Drug
- Irinotecan
- MMMP Drug Alias
- CPT-11
- MMMP Model
- 7
- MMMP Reference
- Hoskins JM, J Natl Cancer Inst 2007, 99:1290-5
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Irinotecan | toxicity increased | true |