Annotation Detail
Information
- Associated Genes
- CYP3A4
- Associated Variants
- CYP3A4 OVEREXPRESSION
- Source Database
- MMMP
- Description
- Non melanoma specific model (miscellany). This RCT of irinotecan standard dosage versus dosage calculated on the basis of CYP3A4 activity (as defined by midazolam clearance test) showed less hematologic toxicity in the latter arm
- MMMP State
- active (high activity)
- MMMP Molecule
- CYP3A4
- MMMP Relationship
- toxicity decreased for
- MMMP Drug
- Irinotecan
- MMMP Drug Alias
- CPT-11
- MMMP Model
- 6
- MMMP Reference
- van der Bol JM, Clin Cancer Res 2010, 16:736-42
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Irinotecan | toxicity decrease | true |