Annotation Detail
Information
- Associated Genes
- ABCB1
- Associated Variants
- ABCB1 UNKNOWN
- Source Database
- MMMP
- Description
- Non melanoma specific model (miscellany). Increased hematologic toxicity for patients that were homozygous variant at the 2677 and 3435 loci
- MMMP State
- polymorphism 2677G>T/A + 3435C>T
- MMMP Molecule
- ABCB1
- MMMP Molecule Alias
- MDR1, P-gp
- MMMP Relationship
- toxicity increased for
- MMMP Drug
- Paclitaxel
- MMMP Drug Alias
- Taxol
- MMMP Model
- 5
- MMMP Reference
- Sissung TM, Eur J Cancer 2006, 42:2893-6
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | toxicity increased | true |