Annotation Detail
Information
- Associated Genes
- ABCC2
- Associated Variants
- ABCC2 p.Cys1515Tyr (p.C1515Y) ( ENST00000647814.1 )
- Source Database
- MMMP
- Description
- Non melanoma specific model (lymphoma). Increased cardiotoxicity. Phase III RCT comparing variants of the regimen CHOP (cyclophosphamide + doxorubicin + vincristine + prednisone)
- MMMP State
- polymorphism Cys1515Tyr (rs8187710)
- MMMP Molecule
- ABCC2
- MMMP Molecule Alias
- MRP2
- MMMP Relationship
- toxicity increased for
- MMMP Drug
- Doxorubicin based regimens
- MMMP Model
- 5
- MMMP Reference
- Wojnowski L, Circulation 2005, 112:3754-62
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin based regimens | toxicity increased | true |