Annotation Detail
Information
- Associated Genes
- RAC2
- Associated Variants
-
RAC2 c.108-3812A>T
(
ENST00000249071.11,
ENST00000405484.5,
ENST00000406508.5 )
RAC2 rs13058338 ( ENST00000249071.11, ENST00000405484.5, ENST00000406508.5 ) - Source Database
- MMMP
- Description
- Non melanoma specific model (lymphoma). Increased cardiotoxicity. Phase III RCT comparing variants of the regimen CHOP (cyclophosphamide + doxorubicin + vincristine + prednisone)
- MMMP State
- polymorphism 7508T>A (rs13058338)
- MMMP Molecule
- RAC2
- MMMP Relationship
- toxicity increased for
- MMMP Drug
- Doxorubicin based regimens
- MMMP Model
- 5
- MMMP Reference
- Wojnowski L, Circulation 2005, 112:3754-62
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin based regimens | toxicity increased | true |