Annotation Detail
Information
- Associated Genes
- NCF4
- Associated Variants
-
NC_000022.11:g.36860804G>A
NCF4 rs1883112
NCF4 rs1883112 - Source Database
- MMMP
- Description
- Non melanoma specific model (lymphoma). Increased cardiotoxicity. Phase III RCT comparing variants of the regimen CHOP (cyclophosphamide + doxorubicin + vincristine + prednisone)
- MMMP State
- genotype A/A of polymorphism rs1883112
- MMMP Molecule
- NCF4
- MMMP Molecule Alias
- p40phox
- MMMP Relationship
- toxicity increased for
- MMMP Drug
- Doxorubicin based regimens
- MMMP Model
- 5
- MMMP Reference
- Wojnowski L, Circulation 2005, 112:3754-62
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Doxorubicin based regimens | toxicity increased | true |