Annotation Detail
Information
- Associated Genes
- ABCB1
- Associated Variants
- ABCB1 UNKNOWN
- Source Database
- MMMP
- Description
- Non melanoma specific model (lung cancer). This genotype was associated with increased gastrointestinal toxicity
- MMMP State
- genotype T/T of SNP C3435T
- MMMP Molecule
- ABCB1
- MMMP Molecule Alias
- MDR1, P-gp
- MMMP Relationship
- toxicity increased for
- MMMP Drug
- Cisplatin + Irinotecan
- MMMP Model
- 5
- MMMP Reference
- Lara PN, J Clin Oncol 2009, 27:2530-5
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cisplatin + Irinotecan | toxicity increased | true |