Annotation Detail
Information
- Associated Genes
- CD47
- Associated Variants
- CD47 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- A morpholino oligonucleotide targeting CD47 (receptor for thrombospondin-1) confers radioresistance to human endothelial cells in vitro and protects soft tissue, bone marrow, and tumor-associated leukocytes in irradiated mice. In contrast, CD47 suppression in mice bearing melanoma prior to irradiation result in 89% smaller tumors. Thus, inhibiting CD47 signaling maintains the viability of normal tissues following irradiation while increasing the radiosensitivity of melanoma
- MMMP State
- inhibited by
- MMMP Molecule
- CD47
- MMMP Molecule Alias
- Thrombospondin-1 receptor
- MMMP Modifier
- CD47 antisense oligonucleotide
- MMMP Relationship
- toxicity decreased for
- MMMP Drug
- Radiotherapy
- MMMP Model
- 2
- MMMP Reference
- Maxhimer JB, Sci Transl Med 2009, 1:3ra7
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Radiotherapy | toxicity decrease | true |