Annotation Detail
Information
- Associated Genes
- NR3C1
- Associated Variants
- NR3C1 OVEREXPRESSION
- Source Database
- MMMP
- Description
- A phase II RCT showed that budesonide (an oral non-absorbed corticostroid) does not prevent dyarrhea in patients taking anti-CTLA4 ipilimumab
- MMMP State
- activated by
- MMMP Molecule
- Glucocorticoid receptor
- MMMP Molecule Alias
- NR3C1
- MMMP Modifier
- Budesonide
- MMMP Relationship
- toxicity unchanged for
- MMMP Drug
- Ipilimumab
- MMMP Drug Alias
- CTLA4 antibody (antagonist)
- MMMP Model
- 5
- MMMP Reference
- Weber J, Clin Cancer Res 2009, 15:5591-8
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Ipilimumab | toxicity unchanged | true |