Annotation Detail

Information
Associated Genes
RPS6KA1
Associated Variants
RPS6KA1 UNKNOWN
Source Database
MMMP
Description
Pretreatment pS6 levels correlated with sensitivity to the PI3K inhibitor, LY294002, whereas PI3K and pAkt did not, suggesting that full activation of the PI3K pathway is needed for sensitivity to PI3K inhibition
MMMP State
phosphorylated (Ser-235, Ser-240)
MMMP Molecule
RSK1
MMMP Molecule Alias
Ribosomal S6 kinase (RS6K)
MMMP Relationship
sensitivity to
MMMP Drug
LY294002
MMMP Drug Alias
AKT inhibitor
MMMP Model
3
MMMP Reference
Aziz SA, Clin Cancer Res 2009, 15:3029-36
MMMP DNA/mRNA/Protein
protein
Drugs
Drug NameSensitivitySupported
LY294002Sensitivitytrue