Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
- BRAF V600E
- Source Database
- MMMP
- Description
- PLX4032 is a BRAF inhibitor with high selectivity for mutated BRAF V600E. While PLX4032 has antitumor effect against BRAF V600E melanoma cells, it can activate the ERK pathway and enhances cell migration and proliferation of BRAF wild type melanoma cells
- MMMP State
- mut V600E
- MMMP Molecule
- BRAF
- MMMP Molecule Alias
- B-Raf
- MMMP Relationship
- sensitivity to
- MMMP Drug
- PLX4032
- MMMP Drug Alias
- RG7204
- MMMP Model
- 3
- MMMP Reference
- Halaban R, Pigment Cell Melanoma Res 2010, 23:190-200
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| PLX4032 | Sensitivity | true |