Annotation Detail
Information
- Associated Genes
- SOCS1
- Associated Variants
- SOCS1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- In vivo studies demonstrate that suppressor of cytokine signaling 1 (SOCS1) acts as a suppressor of melanoma metastatic potential, likely by inhibiting the activity of STAT3 (which leads to increased expression of MMP-2, bFGF and VEGF)
- MMMP State
- downregulated
- MMMP Molecule
- SOCS1
- MMMP Molecule Alias
- Suppressor of cytokine signaling 1
- MMMP Relationship
- sensitivity to
- MMMP Drug
- SOCS1 gene therapy
- MMMP Model
- 4
- MMMP Reference
- Huang FJ, Cancer Res 2008, 68:9634-42
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| SOCS1 gene therapy | Sensitivity | true |