Annotation Detail
Information
- Associated Genes
- AKT1
- Associated Variants
- AKT1 OVEREXPRESSION
- Source Database
- MMMP
- Description
- AG1478: EGFR inhibitor (tyrosine kinase receptor small molecule inhibitor). Overexpression of AKT protects WM9 melanoma cells from apoptosis induced by LY294002 or AG1478
- MMMP State
- upregulated by
- MMMP Molecule
- AKT
- MMMP Molecule Alias
- PKB
- MMMP Modifier
- AKT genetic engineering
- MMMP Relationship
- resistance to
- MMMP Drug
- AG1478
- MMMP Model
- 3
- MMMP Reference
- Ivanov VN, Oncogene 2005, 24:616-26
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| AG1478 | Resitance or Non-Reponse | true |