Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
- BRAF V600E
- Source Database
- MMMP
- Description
- U0126: MEK inhibitor. ABT-737: BH3 mimetic. Treatment of B-RAF mutant human melanoma with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
- MMMP State
- mut V600E
- MMMP Molecule
- BRAF
- MMMP Molecule Alias
- B-Raf
- MMMP Relationship
- sensitivity to
- MMMP Drug
- PD0325901 + ABT-737
- MMMP Model
- 4
- MMMP Reference
- Cragg MS, J Clin Invest 2008, 118:3651-9
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| PD0325901 + ABT-737 | Sensitivity | true |