Annotation Detail

Information
Associated Genes
KIT
Associated Variants
KIT L576P
Source Database
MMMP
Description
The mutant melanoma cell line was sensitive to dasatinib. These data support the selective inhibitory effect of dasatinib against cells harboring the most common KIT mutation in melanoma, and thus has therapeutic implications for acrallentiginous, chronic sun-damaged, and mucosal melanomas
MMMP State
mut L576P (exon 11)
MMMP Molecule
KIT
MMMP Molecule Alias
c-KIT
MMMP Modifier
MMMP Modifier Alias
MMMP Relationship
sensitivity to
MMMP Drug
Dasatinib
MMMP Model
3
MMMP Reference
Woodman SE, Mol Cancer Ther 2009, 8:2079-85
MMMP DNA/mRNA/Protein
DNA
Drugs
Drug NameSensitivitySupported
DasatinibSensitivitytrue