Annotation Detail
Information
- Associated Genes
- TRAF2
- Associated Variants
- TRAF2 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- The findings identify p38, TNFalpha and NFkB as key players that efficiently sensitize melanoma cells to UVR, ribotoxic (anisomycin) and radiomimetic chemicals-induced apoptosis in response to aberrant TRAF2 signaling
- MMMP State
- downregulated by
- MMMP Molecule
- TRAF2
- MMMP Modifier
- TRAF2 dominant negative
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Actinomycin-D
- MMMP Model
- 3
- MMMP Reference
- Ivanov VN, Oncogene 2001, 20:2243-53
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Actinomycin-D | Sensitivity | true |