Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
- TP53 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Sodium butyrate (an HDAC inhibitor) mediates apoptosis in melanoma cells through a p53-mediated pathway (including Bax upregulation)
- MMMP State
- downregulated by
- MMMP Molecule
- p53
- MMMP Molecule Alias
- TP53
- MMMP Modifier
- p53 siRNA
- MMMP Relationship
- resistance to
- MMMP Drug
- Butyric acid
- MMMP Drug Alias
- HDAC inhibitor
- MMMP Model
- 3
- MMMP Reference
- Bandyopadhyay D, Cancer Res 2004, 64:7706-10
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Butyric acid | Resitance or Non-Reponse | true |