Annotation Detail
Information
- Associated Genes
- DNMT1
- Associated Variants
- DNMT1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Inhibition of DNMT1 seems to act through demethylation of pro-apoptotic genes such as IFN-induced XAF1
- MMMP State
- downregulated by
- MMMP Molecule
- DNMT1
- MMMP Molecule Alias
- DNA methyl transferase 1
- MMMP Modifier
- DNMT1 antisense oligo
- MMMP Relationship
- sensitivity to
- MMMP Drug
- IFN alpha
- MMMP Drug Alias
- IFN alpha (2b)
- MMMP Model
- 3
- MMMP Reference
- Reu FJ, J Clin Oncol 2006, 24:3771-9
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| IFN alpha | Sensitivity | true |