Annotation Detail

Information
Associated Genes
CTLA4
Associated Variants
CTLA4 p.Thr17Ala (p.T17A) ( ENST00000295854.10, ENST00000487393.1, ENST00000648405.2, ENST00000696049.1, ENST00000696479.1 )
CTLA4 p.Thr17Ser (p.T17S) ( ENST00000295854.10, ENST00000487393.1, ENST00000648405.2, ENST00000696049.1, ENST00000696479.1 )
Source Database
MMMP
Description
Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade
MMMP State
polymorphism rs231775
MMMP Molecule
CTLA4
MMMP Relationship
sensitivity to
MMMP Drug
Ipilimumab
MMMP Drug Alias
CTLA4 antibody (antagonist)
MMMP Model
5
MMMP Reference
Breunis WB, J Immunother 2008, 31:586-90
MMMP DNA/mRNA/Protein
DNA
Drugs
Drug NameSensitivitySupported
IpilimumabSensitivitytrue