Annotation Detail
Information
- Associated Genes
- CREB1
- Associated Variants
- CREB1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Thapsigargin inhibits endoplasmic reticulum-dependent Ca2+ ATPase and thereby increases cytosolic Ca2+, which induces apoptosis
- MMMP State
- downregulated by
- MMMP Molecule
- CREB
- MMMP Molecule Alias
- cAMP response element binding protein
- MMMP Modifier
- CREB dominant negative
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Thapsigargin
- MMMP Model
- 3
- MMMP Reference
- Jean D, J Biol Chem 1998, 273:24884-90
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Thapsigargin | Sensitivity | true |