Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
- BRAF V600E
- Source Database
- MMMP
- Description
- 17-AAG is a HSP90 inhibitor that works against melanoma cells independently of the BRAF mutational status (mutated vs wild type)
- MMMP State
- mut V600E
- MMMP Molecule
- BRAF
- MMMP Molecule Alias
- B-Raf
- MMMP Relationship
- no relationship with
- MMMP Drug
- 17-AAG
- MMMP Drug Alias
- Tanespimycin (17-allylamino-17-demethoxygeldanamycin)
- MMMP Model
- 3
- MMMP Reference
- Grbovic OM, Proc Natl Acad Sci USA 2006, 103:57-62
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| 17-AAG | Resitance or Non-Reponse | true |