Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
- BRAF V600E
- Source Database
- MMMP
- Description
- Sorafenib: BRAF, CRAF, VEGFR and PDGFR inhibitor. Oncogenic mutationally activated BRAF acts through ERK activation
- MMMP State
- mut V600E
- MMMP Molecule
- BRAF
- MMMP Molecule Alias
- B-Raf
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Sorafenib
- MMMP Drug Alias
- Nexavar (R)
- MMMP Model
- 4
- MMMP Reference
- Karasarides M, Oncogene 2004, 23:6292-8
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sorafenib | Sensitivity | true |